abdul barek | American International University-Bangladesh (original) (raw)

Papers by abdul barek

Advances in information security, Dec 30, 2022

Health Science Reports

Background: Monkeypox is a viral zoonotic disease caused by the monkeypox virus, a double-strande... more Background: Monkeypox is a viral zoonotic disease caused by the monkeypox virus, a double-stranded DNA-enveloped virus that can be transmitted from animal to human or human to human. Consequently, it emerged as the most important orthopoxvirus for public health. Based on available online literature, this study reviewed the majority of the data representing the outbreak, diagnosis, treatment, and prevention of monkeypox. Methods: The literature search was conducted between July 5 and September 15, 2022. In addition to reviewing the databases of World Health Organization (WHO), Centers for Disease Control and Prevention (CDC), Africa CDC, and United Kingdom Health Security Agency monkey pox advice, 43 papers were studied in depth. Results and Discussion: Human monkeypox was first identified in 1970 in a child in the Democratic Republic of the Congo. Until May 6, 2022, it was endemic in West and Central African countries and infrequently occurred outside of Africa. However, many cases have been identified in several nonendemic countries since May 13, 2022, with no prior human or animal travel from endemic areas; that was the first time to document the cases and long-term transmission in countries with no epidemiological ties to endemic African countries. Seven travel-related human monkeypox cases were recorded outside of Africa from September 2018 to November 2021: one in Israel, one in Singapore, and two in the US Youth are most affected. Monkeypox's unanticipated development in places with no known epidemiological linkages raises concerns about the virus's evolution, which permits undetected transmission for a long period. Conclusion: Monkeypox is no longer a rare, self-limiting disease limited to endemic countries. Its ever-changing epidemiology and transmission dynamics have increased the possibility of its evolving into a much deadlier pathogen. Therefore, improved surveillance and detailed case and contact investigation are required to comprehend the ever-changing epidemiology of monkeypox.

Genes, Mar 29, 2023

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Rape is a common social problem having great implication on the Victim, family, Judiciary and sta... more Rape is a common social problem having great implication on the Victim, family, Judiciary and state. However it is very difficult to prove the actual rape because it is difficult to establish whether it is a consented sex or actual rape. 176 cases of alleged rape were studied during the period of 2003-2006 at the SBMC, Barisal. Of these, 130 cases had consented sexual intercourse. 46 victims were subjected to rape. Cases include different age groups, their occupations, living areas, time of arrival for medicolegal examination have been studied. Most of the cases were students. An alarming number of victims were subjected to gang rape. Examination and reporting of the cases with have been discussed.

Review question / Objective: Several case control studies were conducted on the the connection of... more Review question / Objective: Several case control studies were conducted on the the connection of TNFAIP8 and TNFAIP2 gene polymorphisms with cancer and outcome is not consistent. A meta analysis combining these case control studies may give us a clear scenario of the connection of TNFAIP8 and TNFAIP2 gene polymorphisms with cancer development. The review question is 'what is the link between TNFAIP8 (rs11064, rs1045241, rs1045242, rs3813308), TNFAIP8L1 (rs1060555), and TNFAIP2 (rs710100, rs8126) polymorphisms with cancer risk?'. Condition being studied: Different types of cancer patients and healthy controls were evaluated to detect the cancer risk in the individual case -control studies. We performed a meta analysis of these case control studies to get a pulled outcome risk.

The International Journal of Biological Markers

Several genetic association studies have analyzed the link between the catalase ( CAT) C262T vari... more Several genetic association studies have analyzed the link between the catalase ( CAT) C262T variant and different cancers, but the findings remain controversial. Our research centered on establishing a comprehensive correlation between the C262T variant and different cancers. This study was conducted using RevMan 5.4 software following the PRISMA 2020 guidelines. For this meta-analysis, 53 case-control studies (18,258 cases and 47,476 controls) were chosen. The analysis revealed that three genetic models were statistically linked ( P < 0.05) to overall cancer susceptibility in codominant model 2 (COD2): odds ratio (OR) = 1.16, COD3: OR = 1.21, recessive model (RM): OR = 1.20). After stratification by ethnicity, a significant link ( P < 0.05) was found in Caucasians (COD2: OR = 1.18, COD3: OR = 1.17, over-dominant model (ODM): OR = 1.19) and Asians (COD3: OR = 1.49). Subgroup analyses revealed a significant correlation ( P < 0.05) with blood-and-bone-marrow-related cancer, ...

Autism Spectrum Disorder and Alzheimer's Disease, 2021

Journal of Ethnopharmacology, 2021

ETHNOPHARMACOLOGICAL RELEVANCE Aeginetia indica (Linn.), commonly known as aankuri bankuri, guan-... more ETHNOPHARMACOLOGICAL RELEVANCE Aeginetia indica (Linn.), commonly known as aankuri bankuri, guan-jen-huang, forest ghost flower, dok din daeng, dapong tubo; is a root parasitic plant of the Orobanchaceae family native to South and South-East Asian region. Different parts of the plant are traditionally used to treat fever, pain, inflammation, arthritis, cough, diabetes, and chronic liver disease. Local practitioners often recommend this plant as a folk remedy for dermal swelling, painful menstrual periods, wounds, and knee pain. However, the antipyretic and analgesic activity of A. indica have never been investigated. AIM OF THE STUDY The present study was aimed to evaluate the analgesic and antipyretic potential of Aeginetia indica plant extract to verify its effectiveness as reported in traditional uses. MATERIALS AND METHODS Preliminary phytochemical analysis of Aeginetia indica crude extract was performed using previously established methods and antioxidant capacity was determined by phosphomolybdenum assay. In vivo analgesic activity of Aeginetia indica methanol extract (AiME) was evaluated by acetic acid-induced writhing test, formalin-induced paw licking test, and hot plate test model. The antipyretic activity was studied in Baker's yeast induced pyrexia model. RESULTS Phytochemicals screening revealed cardiac glycosides, saponins, phenols, tannins, and flavonoids in the crude extract of Aeginetia indica. Total phenolic and flavonoid content were recorded as 101 ± 1.1 mg GAE/g of the extract and 35 ± 0.8 mg QE/g of the extract, respectively. The total antioxidant capacity observed in phosphomolybdenum assay was 68.3 ± 1.3 mg ascorbic acid equivalent per gram of the extract. AiME showed significant dose-dependent analgesic activity against acetic acid-induced writhing, formalin-induced paw licking, and hot plate pain model. A higher dose of A. indica (200 mg/kg) produced significant (P < 0.001) inhibition of writhing by 69% whereas, standard aspirin showed maximum 85.6% inhibition. AiME at all doses showed a significant (P < 0.001) decrease of paw licking time in both early neurogenic and late inflammatory pain phase of formalin-induced licking test. In the hot plate test, AiME at a 200 mg/kg dose produced antinociceptive activity (55.18%) higher than the standard ketorolac (49.88%) at 1h. However, after 2h, ketorolac showed a maximum effect of 62.66% and AiME 200 mg/kg showed a 60.24% effect. A significant (P < 0.001) reduction of rectal temperature (4.54°F↓) was recorded for AiME 200 mg/kg, which was higher than the standard paracetamol (3.86F°↓) after 24 h of treatment. CONCLUSION The in vivo investigational studies' results demonstrated promising analgesic and antipyretic activities of A. indica, which supported the claim of its folk uses.

MicroRNA, 2021

Background: The prevalence of Cervical Cancer (CC) is disproportionately higher in developing cou... more Background: The prevalence of Cervical Cancer (CC) is disproportionately higher in developing countries. It is the second most frequent cancer type among Bangladeshi women and the major cause of morbidity and mortality. However, no previous data reported the association of miR-218-2 gene polymorphisms in Bangladeshi cervical cancer patients. Aim: This case-control study was designed to find the link between the rs11134527 polymorphism in miR-218-2 and CC. Methods: A total of 488 subjects were recruited, comprising 256 cervical cancer patients and 232 healthy females. Genotyping was conducted with the tetra-primer ARMS-PCR technique to detect the association. Results: The results of genotype data showed that rs11134527 was in the Hardy-Weinberg equilibrium in both CC cases and controls (P >0.05). Overall, the polymorphism was found to be significantly associated with an increased risk of cervical cancer with AG genotype (AG vs. GG: OR = 2.26, 95% Cl = 1.40-3.66, P = 0.0008), AA ge...

International Journal of Innovation and Applied Studies, 2019

Branded drugs are more expensive than locally marketed drugs. The aim of this present study was t... more Branded drugs are more expensive than locally marketed drugs. The aim of this present study was to evaluate and compare dissolution pattern of locally branded drug products of Levocetirizine dihydrochloride of regional pharmaceutical companies available in Bangladesh with the reputed brand of Levocetirizine 2HCl (Purotrol®) marketed by Square pharmaceuticals Ltd. Four different brands of Levocetirizine 2HCl tablets and Purotrol® were collected from a reputed pharmacy store, then evaluated and compared subsequently. Five tablets from each of the brands were used for the in-vitro dissolution study. Cumulative drug release was measured up to 30 minutes for all the brands. Differential factor, f1 and similarity factor, f2 were determined. Significant difference was observed for in-vitro drug release pattern of local brands with respect to Purotrol®. Here it was found that the values of f1 are 25.11, 26.08 and 15.52 for brand B, C, and D respectively so it is not acceptable. Only brand A...

Purpose: The present study aimed to compare and analyze the sex-specific epidemiological, clinica... more Purpose: The present study aimed to compare and analyze the sex-specific epidemiological, clinical characteristics, comorbidities, and other information of confirmed COVID-19 patients from the southeast region in Bangladesh for the first time. Methods: 385 lab-confirmed cases were studied out of a total of 2471 tested samples between June 5 and September 10, 2020. RT-PCR was used for COVID-19 identification and SPSS (version 25) for statistical data analysis. Results: We found that male patients were roughly affected compared to females patients (male 74.30% vs. female 25.7%) with an average age of 34.86 +/- 15.442 years, and B (+ve) blood group has been identified as a high-risk factor for COVID-19 infection. Workplace, local market, and bank were signified as sex-specific risk zone (p < 0.001). Pre-existing medical conditions such as diabetes, hypertension, cardiovascular and respiratory diseases were identified among the patients. Less than half of the confirmed COVID-19 cases...

Future Journal of Pharmaceutical Sciences, 2021

Background Now, eating disorders and obesity and their correlations are danger signal in worldwid... more Background Now, eating disorders and obesity and their correlations are danger signal in worldwide which is caused by multifactor and associated with significant mortality and morbidity. Main body Every aspect of a patient’s life is influenced by eating disorders and obesity and their correlations. Due to frequent seeing of obese patients, eating disorders have been included in the review as they can sometimes be associated with obesity. However, it should be noted that most patients having eating disorder are at risk to be obese or overweight. This research explores the risk factors for the two disorders, as well as the assessment of medical complications and treatment recommendations for the disorders. In these two disorders, there is also a correlation. The essential consideration is that eating disorders are impulse-control disorders which are similar to addictive behaviors in some aspects. So it is a crying need to treat a patient with obesity and eating disorders simultaneousl...

Heliyon, 2020

Severe acute respiratory coronavirus 2 (SARS-CoV-2) cases are overgrowing globally and now become... more Severe acute respiratory coronavirus 2 (SARS-CoV-2) cases are overgrowing globally and now become a pandemic. A meta-analysis was conducted to evaluate the impact of age, sex, comorbidities, and clinical characteristics on the severity of COVID-19 to help diagnose and evaluate the current outbreak in clinical decisionmaking. Methods: PubMed, ScienceDirect, and BMC were searched to collect data about demographic, clinical characteristics, and comorbidities of COVID-19 patients. Meta-analysis was conducted with Review Manager 5.3. Publication bias was assessed using Egger's test and Begg-Mazumdar's rank correlation. Results: Fifty-five studies were included in this meta-analysis, including 10014 patients with SARS-CoV-2 infection. Male cases and cases with an age of !50 years (OR ¼ 2.41, p < 0.00001; RR ¼ 3.36, p ¼ 0.0002, respectively) were severely affected by SARS-CoV-2. Patients having age!65 years are not associated (p ¼ 0.110) with the severity of COVID-19. Presence of at least one comorbidity or hypertension, diabetes, cerebrovascular disease, cardiovascular diseases, respiratory disease, malignancy, chronic kidney disease and chronic liver diseases individually increased the severity of COVID-19 cases significantly (OR ¼ 3.13, p < 0.00001; OR ¼ 2.35, p < 0.00001; OR ¼ 2.42, p < 0.00001; OR ¼ 3.78, p < 0.00001; OR ¼ 3.33, p < 0.00001; OR ¼ 2.58, p < 0.00001; OR ¼ 2.32, p < 0.00001; OR ¼ 2.27, p ¼ 0.0007; OR ¼ 1.70, p ¼ 0.003, respectively). Clinical manifestation such as fever, cough, fatigue, anorexia, dyspnea, chest tightness, hemoptysis, diarrhea and abdominal pain (OR ¼ 1.68, p ¼ 0.0001; OR ¼ 1.41, p ¼ 0.004; OR ¼ 1.26, p ¼ 0.03; OR ¼ 2.38, p < 0.0001; OR ¼ 4.30, p < 0.00001; OR ¼ 2.11, p ¼ 0.002; OR ¼ 4.93, p < 0.0001; OR ¼ 1.35, p ¼ 0.03; OR ¼ 2.38, p ¼ 0.008, respectively) were significantly associated with the severity of cases. No association of severity was found with myalgia, pharyngalgia, nausea, vomiting, headache, dizziness and sore throat (p > 0.05). No publication bias was found in case of age (!50 years, age!65 years), comorbidities and clinical manifestations. Conclusions: Males patients and elderly or older patients (age !50 years) are at higher risk of developing severity, whereas comorbidities and clinical manifestations could significantly affect the prognosis and severity of COVID-19.