N. Coskunfirat | Akdeniz University (original) (raw)

Papers by N. Coskunfirat

Research paper thumbnail of Intraoperative ventilator settings and their association with postoperative pulmonary complications in neurosurgical patients: post-hoc analysis of LAS VEGAS study

BMC Anesthesiology, 2020

Background: Limited information is available regarding intraoperative ventilator settings and the... more Background: Limited information is available regarding intraoperative ventilator settings and the incidence of postoperative pulmonary complications (PPCs) in patients undergoing neurosurgical procedures. The aim of this post-hoc analysis of the 'Multicentre Local ASsessment of VEntilatory management during General Anaesthesia for Surgery' (LAS VEGAS) study was to examine the ventilator settings of patients undergoing neurosurgical procedures, and to explore the association between perioperative variables and the development of PPCs in neurosurgical patients. Methods: Post-hoc analysis of LAS VEGAS study, restricted to patients undergoing neurosurgery. Patients were stratified into groups based on the type of surgery (brain and spine), the occurrence of PPCs and the assess respiratory risk in surgical patients in Catalonia (ARISCAT) score risk for PPCs. Results: Seven hundred eighty-four patients were included in the analysis; 408 patients (52%) underwent spine surgery and 376 patients (48%) brain surgery. Median tidal volume (V T) was 8 ml [Interquartile Range, IQR = 7.3-9] per predicted body weight; median positive end-expiratory pressure (PEEP) was 5 [3 to 5] cmH 2 0. Planned recruitment manoeuvres were used in the 6.9% of patients. No differences in ventilator settings were found among the subgroups. PPCs occurred in 81 patients (10.3%). Duration of anaesthesia (odds ratio, 1.295 [95% confidence interval 1.067 to 1.572]; p = 0.009) and higher age for the brain group (odds ratio, 0.000 [0.000 to 0.189]; p = 0.031), but not intraoperative ventilator settings were independently associated with development of PPCs. Conclusions: Neurosurgical patients are ventilated with low V T and low PEEP, while recruitment manoeuvres are seldom applied. Intraoperative ventilator settings are not associated with PPCs.

Research paper thumbnail of Akut b6brek yetersizlifii tizerine hayvan modelleri

yogunbakimderg.com

Page 1. Akut b6brek yetersizlifii tizerine hayvan modelleri Animal models of acute renal failure N... more Page 1. Akut b6brek yetersizlifii tizerine hayvan modelleri Animal models of acute renal failure Nesil Coskunfirat, Melike Cengiz, Murat Yilmaz Akdeniz ... Tfibfil sekresyon ve emilim fonksiyonlarindaki degisiklikler, hasarlanma ve insandaki tamir mekanizmalari hakkinda bilgi ...

Research paper thumbnail of Intraoperative mechanical ventilation practice in thoracic surgery patients and its association with postoperative pulmonary complications: results of a multicenter prospective observational study

Research paper thumbnail of Epidemiology, practice of ventilation and outcome for patients at increased risk of postoperative pulmonary complications: LAS VEGAS - an observational study in 29 countries

European journal of anaesthesiology, Aug 1, 2017

Limited information exists about the epidemiology and outcome of surgical patients at increased r... more Limited information exists about the epidemiology and outcome of surgical patients at increased risk of postoperative pulmonary complications (PPCs), and how intraoperative ventilation was managed in these patients. To determine the incidence of surgical patients at increased risk of PPCs, and to compare the intraoperative ventilation management and postoperative outcomes with patients at low risk of PPCs. This was a prospective international 1-week observational study using the 'Assess Respiratory Risk in Surgical Patients in Catalonia risk score' (ARISCAT score) for PPC for risk stratification. Adult patients requiring intraoperative ventilation during general anaesthesia for surgery in 146 hospitals across 29 countries. The primary outcome was the incidence of patients at increased risk of PPCs based on the ARISCAT score. Secondary outcomes included intraoperative ventilatory management and clinical outcomes. A total of 9864 patients fulfilled the inclusion criteria. The ...

Research paper thumbnail of Epidemiology, practice of ventilation and outcome for patients at increased risk of postoperative pulmonary complications: LAS VEGAS - an observational study in 29 countries

European journal of anaesthesiology, Aug 1, 2017

Limited information exists about the epidemiology and outcome of surgical patients at increased r... more Limited information exists about the epidemiology and outcome of surgical patients at increased risk of postoperative pulmonary complications (PPCs), and how intraoperative ventilation was managed in these patients. To determine the incidence of surgical patients at increased risk of PPCs, and to compare the intraoperative ventilation management and postoperative outcomes with patients at low risk of PPCs. This was a prospective international 1-week observational study using the 'Assess Respiratory Risk in Surgical Patients in Catalonia risk score' (ARISCAT score) for PPC for risk stratification. Adult patients requiring intraoperative ventilation during general anaesthesia for surgery in 146 hospitals across 29 countries. The primary outcome was the incidence of patients at increased risk of PPCs based on the ARISCAT score. Secondary outcomes included intraoperative ventilatory management and clinical outcomes. A total of 9864 patients fulfilled the inclusion criteria. The ...

Research paper thumbnail of Homocysteine levels after nitrous oxide anesthesia for living-related donor renal transplantation: a randomized, controlled, double-blind study

Transplantation proceedings, 2015

Nitrous oxide anesthesia increases postoperative homocysteine concentrations. Renal transplantati... more Nitrous oxide anesthesia increases postoperative homocysteine concentrations. Renal transplantation candidates present with higher homocysteine levels than patients with no renal disease. We designed this study to investigate if homocysteine levels are higher in subjects receiving nitrous oxide for renal transplantation compared with subjects undergoing nitrous oxide free anesthesia. Data from 59 patients scheduled for living-related donor renal transplantation surgery were analyzed in this randomized, controlled, blinded, parallel-group, longitudinal trial. Patients were assigned to receive general anesthesia with (flowmeter was set at 2 L/min nitrous oxide and 1 L/min oxygen) or without nitrous oxide (2 L/min air and 1 L/min oxygen). We evaluated levels of total homocysteine and known determinants, including creatinine, folate, vitamin B12, albumin, and lipids. We evaluated factor V and von Willebrand factor (vWF) to determine endothelial dysfunction and creatinine kinase myocardi...

Research paper thumbnail of 201. Effects of intravenous dexmedetomidine or morphine premedication on characteristics of spinal block with ropivacaine plus neostigmine

Regional Anesthesia & Pain Medicine, 2005

Research paper thumbnail of Abstract PR586

Anesthesia & Analgesia, 2016

Research paper thumbnail of Effects of intravenous dexmedetomidine or morphine premedication on characteristics of spinal block with ropivacaine plus neostigmine

Regional Anesthesia and Pain Medicine, 2005

Research paper thumbnail of Combination of epidural anesthesia and general anesthesia attenuates stress response to renal transplantation surgery

Transplantation proceedings, 2012

Choice of the anesthestic technique can reduce or even eliminate stress responses to surgery and ... more Choice of the anesthestic technique can reduce or even eliminate stress responses to surgery and decrease the incidence of complications. Our aim was to compare a combination of epidural anesthesia+general anesthesia with general anesthesia alone as regards perioperative insulin resistance and inflammatory activation among renal transplant recipients. Forty-six nondiabetic patients undergoing renal transplantation were prospectively randomized to the epidural anesthesia + general anesthesia group (n = 21), or general anesthesia alone group (n = 25). Plasma levels of glucose, insulin, interleukin (IL)-6, tumour necrosis factor (TNF)-α, resistin, and adiponectin were measured at baseline (T1), end of surgery (T2), postoperative first hour (T3), postoperative second hour (T4) and postoperative 24th hour (T5). Homeostasis model assessment-estimated insulin resistance (HOMA-IR) scores were calculated at every time point that the blood samples were collected. Glucose levels (P < .001) ...

Research paper thumbnail of Association between night-time surgery and occurrence of intraoperative adverse events and postoperative pulmonary complications

British Journal of Anaesthesia

,6 for the LAS VEGAS* investigators**, the PROVE Network*** and the Clinical Trial Network of the... more ,6 for the LAS VEGAS* investigators**, the PROVE Network*** and the Clinical Trial Network of the European Society of Anaesthesiology *'Local ASsessment of VEntilatory management during General Anaesthesia for Surgery' study **Collaborators are listed in the online supplement ***PROtective VEntilation Network (www.provenet.eu

Research paper thumbnail of Association between night-time surgery and occurrence of intraoperative adverse events and postoperative pulmonary complications

British Journal of Anaesthesia

,6 for the LAS VEGAS* investigators**, the PROVE Network*** and the Clinical Trial Network of the... more ,6 for the LAS VEGAS* investigators**, the PROVE Network*** and the Clinical Trial Network of the European Society of Anaesthesiology *'Local ASsessment of VEntilatory management during General Anaesthesia for Surgery' study **Collaborators are listed in the online supplement ***PROtective VEntilation Network (www.provenet.eu

Research paper thumbnail of Comparison of Epidural and Combined Spinal-Epidural Analgesia in the Management of Labour without Pain

Journal of International Medical Research, 2006

The effects of combined spinal-epidural analgesia (CSEA) and epidural analgesia (EA) were studied... more The effects of combined spinal-epidural analgesia (CSEA) and epidural analgesia (EA) were studied in 50 healthy parturients randomly allocated to receive bupivacaine plus fentanyl either epidurally, or intrathecally and epidurally. Significant differences from baseline values were seen in systolic blood pressure at all time-points except for 4 h in the EA group and at 3 and 4 h in the CSEA group. Significant differences from baseline values were seen in diastolic blood pressure at 1, 2, 3 and 4 h in the EA group, whereas no significant differences from baseline were seen in the CSEA group. Pain scores in both groups were significantly decreased compared with baseline and all scores, except at 2h, were significantly lower in the CSEA group compared with the EA group. The duration of labour and total amount of drugs used were significantly decreased and cervical dilatation was faster with CSEA compared with EA. In conclusion, CSEA was associated with more rapid onset of analgesia and faster progress in cervical dilatation compared with EA, and can be used safely for labour analgesia.

Research paper thumbnail of Effects of hyperbaric spinal ropivacaine for caesarean section

European Journal of Anaesthesiology, 2005

Adding various opioids to the local anaesthetic solution administrated intrathecally improves the... more Adding various opioids to the local anaesthetic solution administrated intrathecally improves the analgesic potency of spinal analgesia. The purpose of this study was to evaluate the efficacy and safety of intrathecal fentanyl 10 microg added to 15 mg hyperbaric ropivacaine in patients undergoing caesarean section under spinal anaesthesia. Thirty-seven healthy, full-term parturients were randomly assigned into two groups: Group S (saline group, n=17) received 15 mg hyperbaric ropivacaine in 2.5 mL + 0.5 mL saline; Group F (fentanyl group, n=20) received 15 mg hyperbaric ropivacaine in 2.5 mL + 10 microg fentanyl in 0.5 mL, intrathecally. Characteristics of spinal block, intraoperative quality of spinal anaesthesia, time to first feeling of pain (complete analgesia), time to first request of analgesics postoperatively (effective analgesia), side-effects and fetal outcomes were evaluated. Regression of sensory block to L5 was significantly prolonged in the fentanyl group compared with the saline group (P = 0.001). Time to the first feeling of pain (130.6 +/- 15.8 min vs. 154.3 +/- 31.1 min; P = 0.008) and the first analgesic requirement (161.2 +/- 32.6 min vs. 213.0 +/- 29.3 min; P &lt; 0.001) were significantly shorter in the saline group compared with the fentanyl group. Side-effects, umbilical arterial and venous blood gases did not differ between the groups. Apgar scores were similar in both groups and no infants had an Apgar score &lt; or =7 at 5 min. The addition of fentanyl 10 microg, to hyperbaric ropivacaine 15 mg, for spinal anaesthesia increased the duration of analgesia in the early postoperative period in patients undergoing caesarean delivery.

Research paper thumbnail of Homocysteine levels in the early postoperative period after renal transplantation with or without nitrous oxide

European Journal of Anaesthesiology, 2012

Research paper thumbnail of Our first experience in thoracoscopic esophagectomy in prone position

European Journal of Anaesthesiology, 2013

Research paper thumbnail of PHARMACOLOGY CLINICAL

British Journal of Anaesthesia, 2012

Research paper thumbnail of Homocysteine levels after nitrous oxide anesthesia for living-related donor renal transplantation: a randomized, controlled, double-blind study

Transplantation proceedings, 2015

Nitrous oxide anesthesia increases postoperative homocysteine concentrations. Renal transplantati... more Nitrous oxide anesthesia increases postoperative homocysteine concentrations. Renal transplantation candidates present with higher homocysteine levels than patients with no renal disease. We designed this study to investigate if homocysteine levels are higher in subjects receiving nitrous oxide for renal transplantation compared with subjects undergoing nitrous oxide free anesthesia. Data from 59 patients scheduled for living-related donor renal transplantation surgery were analyzed in this randomized, controlled, blinded, parallel-group, longitudinal trial. Patients were assigned to receive general anesthesia with (flowmeter was set at 2 L/min nitrous oxide and 1 L/min oxygen) or without nitrous oxide (2 L/min air and 1 L/min oxygen). We evaluated levels of total homocysteine and known determinants, including creatinine, folate, vitamin B12, albumin, and lipids. We evaluated factor V and von Willebrand factor (vWF) to determine endothelial dysfunction and creatinine kinase myocardi...

Research paper thumbnail of Intraoperative ventilator settings and their association with postoperative pulmonary complications in neurosurgical patients: post-hoc analysis of LAS VEGAS study

BMC Anesthesiology, 2020

Background: Limited information is available regarding intraoperative ventilator settings and the... more Background: Limited information is available regarding intraoperative ventilator settings and the incidence of postoperative pulmonary complications (PPCs) in patients undergoing neurosurgical procedures. The aim of this post-hoc analysis of the 'Multicentre Local ASsessment of VEntilatory management during General Anaesthesia for Surgery' (LAS VEGAS) study was to examine the ventilator settings of patients undergoing neurosurgical procedures, and to explore the association between perioperative variables and the development of PPCs in neurosurgical patients. Methods: Post-hoc analysis of LAS VEGAS study, restricted to patients undergoing neurosurgery. Patients were stratified into groups based on the type of surgery (brain and spine), the occurrence of PPCs and the assess respiratory risk in surgical patients in Catalonia (ARISCAT) score risk for PPCs. Results: Seven hundred eighty-four patients were included in the analysis; 408 patients (52%) underwent spine surgery and 376 patients (48%) brain surgery. Median tidal volume (V T) was 8 ml [Interquartile Range, IQR = 7.3-9] per predicted body weight; median positive end-expiratory pressure (PEEP) was 5 [3 to 5] cmH 2 0. Planned recruitment manoeuvres were used in the 6.9% of patients. No differences in ventilator settings were found among the subgroups. PPCs occurred in 81 patients (10.3%). Duration of anaesthesia (odds ratio, 1.295 [95% confidence interval 1.067 to 1.572]; p = 0.009) and higher age for the brain group (odds ratio, 0.000 [0.000 to 0.189]; p = 0.031), but not intraoperative ventilator settings were independently associated with development of PPCs. Conclusions: Neurosurgical patients are ventilated with low V T and low PEEP, while recruitment manoeuvres are seldom applied. Intraoperative ventilator settings are not associated with PPCs.

Research paper thumbnail of Akut b6brek yetersizlifii tizerine hayvan modelleri

yogunbakimderg.com

Page 1. Akut b6brek yetersizlifii tizerine hayvan modelleri Animal models of acute renal failure N... more Page 1. Akut b6brek yetersizlifii tizerine hayvan modelleri Animal models of acute renal failure Nesil Coskunfirat, Melike Cengiz, Murat Yilmaz Akdeniz ... Tfibfil sekresyon ve emilim fonksiyonlarindaki degisiklikler, hasarlanma ve insandaki tamir mekanizmalari hakkinda bilgi ...

Research paper thumbnail of Intraoperative mechanical ventilation practice in thoracic surgery patients and its association with postoperative pulmonary complications: results of a multicenter prospective observational study

Research paper thumbnail of Epidemiology, practice of ventilation and outcome for patients at increased risk of postoperative pulmonary complications: LAS VEGAS - an observational study in 29 countries

European journal of anaesthesiology, Aug 1, 2017

Limited information exists about the epidemiology and outcome of surgical patients at increased r... more Limited information exists about the epidemiology and outcome of surgical patients at increased risk of postoperative pulmonary complications (PPCs), and how intraoperative ventilation was managed in these patients. To determine the incidence of surgical patients at increased risk of PPCs, and to compare the intraoperative ventilation management and postoperative outcomes with patients at low risk of PPCs. This was a prospective international 1-week observational study using the 'Assess Respiratory Risk in Surgical Patients in Catalonia risk score' (ARISCAT score) for PPC for risk stratification. Adult patients requiring intraoperative ventilation during general anaesthesia for surgery in 146 hospitals across 29 countries. The primary outcome was the incidence of patients at increased risk of PPCs based on the ARISCAT score. Secondary outcomes included intraoperative ventilatory management and clinical outcomes. A total of 9864 patients fulfilled the inclusion criteria. The ...

Research paper thumbnail of Epidemiology, practice of ventilation and outcome for patients at increased risk of postoperative pulmonary complications: LAS VEGAS - an observational study in 29 countries

European journal of anaesthesiology, Aug 1, 2017

Limited information exists about the epidemiology and outcome of surgical patients at increased r... more Limited information exists about the epidemiology and outcome of surgical patients at increased risk of postoperative pulmonary complications (PPCs), and how intraoperative ventilation was managed in these patients. To determine the incidence of surgical patients at increased risk of PPCs, and to compare the intraoperative ventilation management and postoperative outcomes with patients at low risk of PPCs. This was a prospective international 1-week observational study using the 'Assess Respiratory Risk in Surgical Patients in Catalonia risk score' (ARISCAT score) for PPC for risk stratification. Adult patients requiring intraoperative ventilation during general anaesthesia for surgery in 146 hospitals across 29 countries. The primary outcome was the incidence of patients at increased risk of PPCs based on the ARISCAT score. Secondary outcomes included intraoperative ventilatory management and clinical outcomes. A total of 9864 patients fulfilled the inclusion criteria. The ...

Research paper thumbnail of Homocysteine levels after nitrous oxide anesthesia for living-related donor renal transplantation: a randomized, controlled, double-blind study

Transplantation proceedings, 2015

Nitrous oxide anesthesia increases postoperative homocysteine concentrations. Renal transplantati... more Nitrous oxide anesthesia increases postoperative homocysteine concentrations. Renal transplantation candidates present with higher homocysteine levels than patients with no renal disease. We designed this study to investigate if homocysteine levels are higher in subjects receiving nitrous oxide for renal transplantation compared with subjects undergoing nitrous oxide free anesthesia. Data from 59 patients scheduled for living-related donor renal transplantation surgery were analyzed in this randomized, controlled, blinded, parallel-group, longitudinal trial. Patients were assigned to receive general anesthesia with (flowmeter was set at 2 L/min nitrous oxide and 1 L/min oxygen) or without nitrous oxide (2 L/min air and 1 L/min oxygen). We evaluated levels of total homocysteine and known determinants, including creatinine, folate, vitamin B12, albumin, and lipids. We evaluated factor V and von Willebrand factor (vWF) to determine endothelial dysfunction and creatinine kinase myocardi...

Research paper thumbnail of 201. Effects of intravenous dexmedetomidine or morphine premedication on characteristics of spinal block with ropivacaine plus neostigmine

Regional Anesthesia & Pain Medicine, 2005

Research paper thumbnail of Abstract PR586

Anesthesia & Analgesia, 2016

Research paper thumbnail of Effects of intravenous dexmedetomidine or morphine premedication on characteristics of spinal block with ropivacaine plus neostigmine

Regional Anesthesia and Pain Medicine, 2005

Research paper thumbnail of Combination of epidural anesthesia and general anesthesia attenuates stress response to renal transplantation surgery

Transplantation proceedings, 2012

Choice of the anesthestic technique can reduce or even eliminate stress responses to surgery and ... more Choice of the anesthestic technique can reduce or even eliminate stress responses to surgery and decrease the incidence of complications. Our aim was to compare a combination of epidural anesthesia+general anesthesia with general anesthesia alone as regards perioperative insulin resistance and inflammatory activation among renal transplant recipients. Forty-six nondiabetic patients undergoing renal transplantation were prospectively randomized to the epidural anesthesia + general anesthesia group (n = 21), or general anesthesia alone group (n = 25). Plasma levels of glucose, insulin, interleukin (IL)-6, tumour necrosis factor (TNF)-α, resistin, and adiponectin were measured at baseline (T1), end of surgery (T2), postoperative first hour (T3), postoperative second hour (T4) and postoperative 24th hour (T5). Homeostasis model assessment-estimated insulin resistance (HOMA-IR) scores were calculated at every time point that the blood samples were collected. Glucose levels (P < .001) ...

Research paper thumbnail of Association between night-time surgery and occurrence of intraoperative adverse events and postoperative pulmonary complications

British Journal of Anaesthesia

,6 for the LAS VEGAS* investigators**, the PROVE Network*** and the Clinical Trial Network of the... more ,6 for the LAS VEGAS* investigators**, the PROVE Network*** and the Clinical Trial Network of the European Society of Anaesthesiology *'Local ASsessment of VEntilatory management during General Anaesthesia for Surgery' study **Collaborators are listed in the online supplement ***PROtective VEntilation Network (www.provenet.eu

Research paper thumbnail of Association between night-time surgery and occurrence of intraoperative adverse events and postoperative pulmonary complications

British Journal of Anaesthesia

,6 for the LAS VEGAS* investigators**, the PROVE Network*** and the Clinical Trial Network of the... more ,6 for the LAS VEGAS* investigators**, the PROVE Network*** and the Clinical Trial Network of the European Society of Anaesthesiology *'Local ASsessment of VEntilatory management during General Anaesthesia for Surgery' study **Collaborators are listed in the online supplement ***PROtective VEntilation Network (www.provenet.eu

Research paper thumbnail of Comparison of Epidural and Combined Spinal-Epidural Analgesia in the Management of Labour without Pain

Journal of International Medical Research, 2006

The effects of combined spinal-epidural analgesia (CSEA) and epidural analgesia (EA) were studied... more The effects of combined spinal-epidural analgesia (CSEA) and epidural analgesia (EA) were studied in 50 healthy parturients randomly allocated to receive bupivacaine plus fentanyl either epidurally, or intrathecally and epidurally. Significant differences from baseline values were seen in systolic blood pressure at all time-points except for 4 h in the EA group and at 3 and 4 h in the CSEA group. Significant differences from baseline values were seen in diastolic blood pressure at 1, 2, 3 and 4 h in the EA group, whereas no significant differences from baseline were seen in the CSEA group. Pain scores in both groups were significantly decreased compared with baseline and all scores, except at 2h, were significantly lower in the CSEA group compared with the EA group. The duration of labour and total amount of drugs used were significantly decreased and cervical dilatation was faster with CSEA compared with EA. In conclusion, CSEA was associated with more rapid onset of analgesia and faster progress in cervical dilatation compared with EA, and can be used safely for labour analgesia.

Research paper thumbnail of Effects of hyperbaric spinal ropivacaine for caesarean section

European Journal of Anaesthesiology, 2005

Adding various opioids to the local anaesthetic solution administrated intrathecally improves the... more Adding various opioids to the local anaesthetic solution administrated intrathecally improves the analgesic potency of spinal analgesia. The purpose of this study was to evaluate the efficacy and safety of intrathecal fentanyl 10 microg added to 15 mg hyperbaric ropivacaine in patients undergoing caesarean section under spinal anaesthesia. Thirty-seven healthy, full-term parturients were randomly assigned into two groups: Group S (saline group, n=17) received 15 mg hyperbaric ropivacaine in 2.5 mL + 0.5 mL saline; Group F (fentanyl group, n=20) received 15 mg hyperbaric ropivacaine in 2.5 mL + 10 microg fentanyl in 0.5 mL, intrathecally. Characteristics of spinal block, intraoperative quality of spinal anaesthesia, time to first feeling of pain (complete analgesia), time to first request of analgesics postoperatively (effective analgesia), side-effects and fetal outcomes were evaluated. Regression of sensory block to L5 was significantly prolonged in the fentanyl group compared with the saline group (P = 0.001). Time to the first feeling of pain (130.6 +/- 15.8 min vs. 154.3 +/- 31.1 min; P = 0.008) and the first analgesic requirement (161.2 +/- 32.6 min vs. 213.0 +/- 29.3 min; P &lt; 0.001) were significantly shorter in the saline group compared with the fentanyl group. Side-effects, umbilical arterial and venous blood gases did not differ between the groups. Apgar scores were similar in both groups and no infants had an Apgar score &lt; or =7 at 5 min. The addition of fentanyl 10 microg, to hyperbaric ropivacaine 15 mg, for spinal anaesthesia increased the duration of analgesia in the early postoperative period in patients undergoing caesarean delivery.

Research paper thumbnail of Homocysteine levels in the early postoperative period after renal transplantation with or without nitrous oxide

European Journal of Anaesthesiology, 2012

Research paper thumbnail of Our first experience in thoracoscopic esophagectomy in prone position

European Journal of Anaesthesiology, 2013

Research paper thumbnail of PHARMACOLOGY CLINICAL

British Journal of Anaesthesia, 2012

Research paper thumbnail of Homocysteine levels after nitrous oxide anesthesia for living-related donor renal transplantation: a randomized, controlled, double-blind study

Transplantation proceedings, 2015

Nitrous oxide anesthesia increases postoperative homocysteine concentrations. Renal transplantati... more Nitrous oxide anesthesia increases postoperative homocysteine concentrations. Renal transplantation candidates present with higher homocysteine levels than patients with no renal disease. We designed this study to investigate if homocysteine levels are higher in subjects receiving nitrous oxide for renal transplantation compared with subjects undergoing nitrous oxide free anesthesia. Data from 59 patients scheduled for living-related donor renal transplantation surgery were analyzed in this randomized, controlled, blinded, parallel-group, longitudinal trial. Patients were assigned to receive general anesthesia with (flowmeter was set at 2 L/min nitrous oxide and 1 L/min oxygen) or without nitrous oxide (2 L/min air and 1 L/min oxygen). We evaluated levels of total homocysteine and known determinants, including creatinine, folate, vitamin B12, albumin, and lipids. We evaluated factor V and von Willebrand factor (vWF) to determine endothelial dysfunction and creatinine kinase myocardi...