Abid A Jamali | Aga Khan University (original) (raw)
Papers by Abid A Jamali
Advances in Clinical Toxicology
Background: Poisoning ranked 2nd among commonest injury and 3rd most common pediatric ED visits. ... more Background: Poisoning ranked 2nd among commonest injury and 3rd most common pediatric ED visits. National health survey of Pakistan estimated 4.3% unintentional poising among children <5 years of age. Most studies focus on types of poisoning; only a few highlighted the factors associated with ingestion. We try to document factors behind common pediatric household unintentional poisoning from the largest tertiary care teaching hospital of the country. Methods: Descriptive case series study, with a questionnaire-based non-probability consecutive sampling, conducted at the ED of National Institute of Child Health (NICH), Karachi during 2017-2018. The sample size was 253. Inclusion criteria were children of either gender aged 12 or below with a clear history of unintentional ingestion of poison. Results: We found male predominance (52%) and the common age was below 5 years. Most children were exposed to poison either during the afternoon or by early evening (79.05%), and mother/careg...
Caspian Journal of Pediatrics (CJP), 2022
Background and Objective: Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD) is characterized... more Background and Objective: Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD) is characterized by hypocalcemia, hyperphosphatemia and abnormal vitamin D (VD) metabolism resulting in high parathyroid hormone secretion. The objective of the study was to determine VD status in children with CKD-MBD and the effect of cholecalciferol therapy in these children.
BMC Public Health, 2012
Background Occupational risk factors are one of the major causes of respiratory illnesses and sym... more Background Occupational risk factors are one of the major causes of respiratory illnesses and symptoms, and account for 13% of chronic obstructive pulmonary disease and 11% of asthma worldwide. Majority of brick kilns in Pakistan use wood and coal for baking the bricks which makes the brick kiln workers susceptible to high exposure of air pollution. This study was designed to describe frequency of chronic respiratory symptoms and illnesses and study the association between these symptoms and different types of work. Methods This was a questionnaire based cross sectional survey conducted among the brick kiln workers in Larkana and Dadu districts, Sindh, Pakistan. A total of 340 adult men were assessed using translated version of the American Thoracic Society Division of Lung Disease (ATS-DLD) questionnaire. Logistic regression analysis was done to determine the relationship between various socio-demographic and occupational factors (age, education, type of work, number of years at wo...
INTRODUCTION:: Approximately 20 to 30% of all anomalies identified in the prenatal period are con... more INTRODUCTION:: Approximately 20 to 30% of all anomalies identified in the prenatal period are congenital anomalies of the kidney and urinary tract (CAKUT). Widespread antenatal screening has resulted in increased detection of anomalies of the kidneys and urinary tract. There are limited studies on the postnatal confirmation of these antenatally detected renal malformations. Moreover, there is no local data available in this regard. So, we conducted the study so that we can obtain local data as well as we can plan management and prevention protocols for such chronically, and sometimes critically, ill neonates. MATERIALS AND METHODS:: It was a cross-sectional study conducted at the neonatal intensive care unit (NICU) at the National Institute of Child Health, Karachi during 2017-2018. The sample size was 100 cases. The sampling technique was non-probability consecutive sampling. All neonates aged 1-28 days of either gender admitted in NICU with antenatal diagnosis of congenital renal ...
Phosphine Gas Poisoning in Children: A Case Series Study from Tertiary Health Care Center of Karachi, Pakistan, 2022
Phosphine poisoning is an uncommon but hazardous public health issue. It is widely used as chemic... more Phosphine poisoning is an uncommon but hazardous public health issue. It is widely used as chemical insecticide and pesticide domestically and exposure to this chemical, mostly accidental among children, may lead to fatal symptoms if not managed immediately. Previous studies have explored the mechanism of its deleterious effect. However, literature on presentation of phosphine poisoning is sparse. We observed a short case series form a family who was exposed to phosphine gas from aluminum phosphide tablets that were used for fumigation purpose in bedroom. Family locked the house for six hours only and then used that bedroom without proper cleaning and removal of the chemical from the house. No adequate aeration of the room before use was done. Detail history from parents was taken and clinical details were identified however further details were noted from their medical records. We identified three cases of phosphine poisoning during this exposure. One of the babies was brought dead, with history of acute onset nausea and vomiting followed by increasing paleness, sweating and questionable seizure episode along with loss of body posture and unresponsiveness. Other two girls presented with generalized weakness, nausea, vomiting and lethargy since morning. Both sisters were admitted to pediatric intensive care unit for less than one week and were managed symptomatically along with magnesium sulfate. The objective of this case series study is to bring in attention of the families, health care community and the stake holders for the need to replace harmful insecticide fumigation practices with the safer ones, as phosphine gas can cause late onset of clinical feature and sudden death, probably because of fatal myocarditis as observed by echocardiography in both survived girls. Whenever fumigation is done parents/family members be provided with proper written guidelines that along with fumigation process and reuse of the house must mention possible side effects. Moreover, to increase public awareness, proper labeling and precautions should be written on all commonly sold pesticides and the constituent of hazardous compounds they contain.
Vitamin D deficiency in children with Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD) and factors affecting response to cholecalciferol therapy: A quasi-experimental study from low-middle income setting, 2022
Background and Objective: Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD) is characterized... more Background and Objective: Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD) is characterized by hypocalcemia, hyperphosphatemia and abnormal vitamin D (VD) metabolism resulting in high parathyroid hormone secretion. The objective of the study was to determine VD status in children with CKD-MBD and the effect of cholecalciferol therapy in these children.
Frequency, Outcome and Socio-Demographic Factors of Common Unintentional Childhood Poisoning, from a Tertiary Health-Care Teaching Hospital of a Low-Income Setting, 2022
Background: Poisoning ranked 2nd among commonest injury and 3rd most common pediatric ED visits. ... more Background: Poisoning ranked 2nd among commonest injury and 3rd most common pediatric ED visits. National health survey of Pakistan estimated 4.3% unintentional poising among children <5 years of age. Most studies focus on types of poisoning; only a few highlighted the factors associated with ingestion. We try to document factors behind common pediatric household unintentional poisoning from the largest tertiary care teaching hospital of the country. Methods: Descriptive case series study, with a questionnaire-based non-probability consecutive sampling, conducted at the ED of National Institute of Child Health (NICH), Karachi during 2017-2018. The sample size was 253. Inclusion criteria were children of either gender aged 12 or below with a clear history of unintentional ingestion of poison. Results: We found male predominance (52%) and the common age was below 5 years. Most children were exposed to poison either during the afternoon or by early evening (79.05%), and mother/caregiver was not present around the child in 68% of cases. In 79% of cases mothers either had tenth grade or below education. A joint family system was present in 84 % of cases. Poor family class was found in 49% of cases. The most commonly ingested poisons were drugs (33.78%). The majority of the children were admitted (60.09%). Conclusion: Socio-demographic factors have a significant effect on childhood poisoning and by addressing them we can decrease unintentional poisoning cases in children.
Advances in Clinical Toxicology
Background: Poisoning ranked 2nd among commonest injury and 3rd most common pediatric ED visits. ... more Background: Poisoning ranked 2nd among commonest injury and 3rd most common pediatric ED visits. National health survey of Pakistan estimated 4.3% unintentional poising among children <5 years of age. Most studies focus on types of poisoning; only a few highlighted the factors associated with ingestion. We try to document factors behind common pediatric household unintentional poisoning from the largest tertiary care teaching hospital of the country. Methods: Descriptive case series study, with a questionnaire-based non-probability consecutive sampling, conducted at the ED of National Institute of Child Health (NICH), Karachi during 2017-2018. The sample size was 253. Inclusion criteria were children of either gender aged 12 or below with a clear history of unintentional ingestion of poison. Results: We found male predominance (52%) and the common age was below 5 years. Most children were exposed to poison either during the afternoon or by early evening (79.05%), and mother/careg...
Caspian Journal of Pediatrics (CJP), 2022
Background and Objective: Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD) is characterized... more Background and Objective: Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD) is characterized by hypocalcemia, hyperphosphatemia and abnormal vitamin D (VD) metabolism resulting in high parathyroid hormone secretion. The objective of the study was to determine VD status in children with CKD-MBD and the effect of cholecalciferol therapy in these children.
BMC Public Health, 2012
Background Occupational risk factors are one of the major causes of respiratory illnesses and sym... more Background Occupational risk factors are one of the major causes of respiratory illnesses and symptoms, and account for 13% of chronic obstructive pulmonary disease and 11% of asthma worldwide. Majority of brick kilns in Pakistan use wood and coal for baking the bricks which makes the brick kiln workers susceptible to high exposure of air pollution. This study was designed to describe frequency of chronic respiratory symptoms and illnesses and study the association between these symptoms and different types of work. Methods This was a questionnaire based cross sectional survey conducted among the brick kiln workers in Larkana and Dadu districts, Sindh, Pakistan. A total of 340 adult men were assessed using translated version of the American Thoracic Society Division of Lung Disease (ATS-DLD) questionnaire. Logistic regression analysis was done to determine the relationship between various socio-demographic and occupational factors (age, education, type of work, number of years at wo...
INTRODUCTION:: Approximately 20 to 30% of all anomalies identified in the prenatal period are con... more INTRODUCTION:: Approximately 20 to 30% of all anomalies identified in the prenatal period are congenital anomalies of the kidney and urinary tract (CAKUT). Widespread antenatal screening has resulted in increased detection of anomalies of the kidneys and urinary tract. There are limited studies on the postnatal confirmation of these antenatally detected renal malformations. Moreover, there is no local data available in this regard. So, we conducted the study so that we can obtain local data as well as we can plan management and prevention protocols for such chronically, and sometimes critically, ill neonates. MATERIALS AND METHODS:: It was a cross-sectional study conducted at the neonatal intensive care unit (NICU) at the National Institute of Child Health, Karachi during 2017-2018. The sample size was 100 cases. The sampling technique was non-probability consecutive sampling. All neonates aged 1-28 days of either gender admitted in NICU with antenatal diagnosis of congenital renal ...
Phosphine Gas Poisoning in Children: A Case Series Study from Tertiary Health Care Center of Karachi, Pakistan, 2022
Phosphine poisoning is an uncommon but hazardous public health issue. It is widely used as chemic... more Phosphine poisoning is an uncommon but hazardous public health issue. It is widely used as chemical insecticide and pesticide domestically and exposure to this chemical, mostly accidental among children, may lead to fatal symptoms if not managed immediately. Previous studies have explored the mechanism of its deleterious effect. However, literature on presentation of phosphine poisoning is sparse. We observed a short case series form a family who was exposed to phosphine gas from aluminum phosphide tablets that were used for fumigation purpose in bedroom. Family locked the house for six hours only and then used that bedroom without proper cleaning and removal of the chemical from the house. No adequate aeration of the room before use was done. Detail history from parents was taken and clinical details were identified however further details were noted from their medical records. We identified three cases of phosphine poisoning during this exposure. One of the babies was brought dead, with history of acute onset nausea and vomiting followed by increasing paleness, sweating and questionable seizure episode along with loss of body posture and unresponsiveness. Other two girls presented with generalized weakness, nausea, vomiting and lethargy since morning. Both sisters were admitted to pediatric intensive care unit for less than one week and were managed symptomatically along with magnesium sulfate. The objective of this case series study is to bring in attention of the families, health care community and the stake holders for the need to replace harmful insecticide fumigation practices with the safer ones, as phosphine gas can cause late onset of clinical feature and sudden death, probably because of fatal myocarditis as observed by echocardiography in both survived girls. Whenever fumigation is done parents/family members be provided with proper written guidelines that along with fumigation process and reuse of the house must mention possible side effects. Moreover, to increase public awareness, proper labeling and precautions should be written on all commonly sold pesticides and the constituent of hazardous compounds they contain.
Vitamin D deficiency in children with Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD) and factors affecting response to cholecalciferol therapy: A quasi-experimental study from low-middle income setting, 2022
Background and Objective: Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD) is characterized... more Background and Objective: Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD) is characterized by hypocalcemia, hyperphosphatemia and abnormal vitamin D (VD) metabolism resulting in high parathyroid hormone secretion. The objective of the study was to determine VD status in children with CKD-MBD and the effect of cholecalciferol therapy in these children.
Frequency, Outcome and Socio-Demographic Factors of Common Unintentional Childhood Poisoning, from a Tertiary Health-Care Teaching Hospital of a Low-Income Setting, 2022
Background: Poisoning ranked 2nd among commonest injury and 3rd most common pediatric ED visits. ... more Background: Poisoning ranked 2nd among commonest injury and 3rd most common pediatric ED visits. National health survey of Pakistan estimated 4.3% unintentional poising among children <5 years of age. Most studies focus on types of poisoning; only a few highlighted the factors associated with ingestion. We try to document factors behind common pediatric household unintentional poisoning from the largest tertiary care teaching hospital of the country. Methods: Descriptive case series study, with a questionnaire-based non-probability consecutive sampling, conducted at the ED of National Institute of Child Health (NICH), Karachi during 2017-2018. The sample size was 253. Inclusion criteria were children of either gender aged 12 or below with a clear history of unintentional ingestion of poison. Results: We found male predominance (52%) and the common age was below 5 years. Most children were exposed to poison either during the afternoon or by early evening (79.05%), and mother/caregiver was not present around the child in 68% of cases. In 79% of cases mothers either had tenth grade or below education. A joint family system was present in 84 % of cases. Poor family class was found in 49% of cases. The most commonly ingested poisons were drugs (33.78%). The majority of the children were admitted (60.09%). Conclusion: Socio-demographic factors have a significant effect on childhood poisoning and by addressing them we can decrease unintentional poisoning cases in children.