Hany Assaad | Alexandria University (original) (raw)
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TOBB University of Economics and Technology
King Mongkut's Institute of Technology Ladkrabang (KMITL)
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Papers by Hany Assaad
Research and Opinion in Anesthesia & Intensive Care /Research and Opinion in Anesthesia & Intensive Care, 2024
Journal of Hypertension, 2018
of clinical outcomes, but systolic BPV and diastolic BPV did not predict clinical event. In survi... more of clinical outcomes, but systolic BPV and diastolic BPV did not predict clinical event. In survival analysis, there was also no association between systolic/ diastolic BPV and the composite clinical outcomes. Conclusions: In contrast with other clinical entity, these fi ndings suggest that visit-to-visit BPV is not associated with clinical outcomes in heart failure patients.
Alexandria Scientific Nursing Journal, 2019
Critically care nurses play an important role to investigate and early detect suspected complicat... more Critically care nurses play an important role to investigate and early detect suspected complications from the intubation process such as post-extubation dysphagia. Post-extubation dysphagia has negative consequences which can be classified into physiological such as malnutrition and/or dehydration, chocking, chest infection and aspiration pneumonia, in addition to psychological, and economic consequences as post-extubation dysphagia could increase the consumption of supplies, human resources, workload and the overall cost of care. There are many factors that contribute to the development of post-extubation dysphagia, which include: physiological changes related factors; age, pathological related factors; initial diagnosis and comorbidies and therapeutic related factors; presence of tracheal and gastric tube, in addition to some medications that may lead to dysphagia. Objective: Identify factors contributing to post-extubation dysphagia in critically ill patients. Setting: This stud...
Alexandria Journal of Medicine, 2020
Introduction: As the coronavirus disease (COVID-19) spreads worldwide, awaiting the development o... more Introduction: As the coronavirus disease (COVID-19) spreads worldwide, awaiting the development of a vaccine, researchers are looking among the arsenal of available drugs, for a potential cure or medication to improve patients' outcome. A highly elevated levels of cytokines in COVID-19 patients requiring ICU admission, has suggested that a "cytokine storm" was associated with disease severity. Methods: We summarize published key findings about imatinib, aiming to rationalize its use as a potential pharmacologic treatment for COVID-19. Results: Data from cellular, animal models and clinical trials, showed a beneficial role of tyrosine kinase inhibitors in the regulation of inflammation, the maintenance of endothelial barrier integrity, as well as the expression of antiviral properties. This data is especially derived from imatinib, the most studied Abl family kinase inhibitor, that is currently in clinical use for multiple medical conditions. Discussion: Based on this encouraging data, we hypothesize that imatinib might be beneficial for the treatment of patients with SARS-CoV-2 pneumonia, in the aim of preventing disease progression into the severe phenotype of hypoxic respiratory failure and acute respiratory distress syndrome. This concept can be considered for evaluation in a randomized controlled study.
Research and Opinion in Anesthesia & Intensive Care /Research and Opinion in Anesthesia & Intensive Care, 2024
Journal of Hypertension, 2018
of clinical outcomes, but systolic BPV and diastolic BPV did not predict clinical event. In survi... more of clinical outcomes, but systolic BPV and diastolic BPV did not predict clinical event. In survival analysis, there was also no association between systolic/ diastolic BPV and the composite clinical outcomes. Conclusions: In contrast with other clinical entity, these fi ndings suggest that visit-to-visit BPV is not associated with clinical outcomes in heart failure patients.
Alexandria Scientific Nursing Journal, 2019
Critically care nurses play an important role to investigate and early detect suspected complicat... more Critically care nurses play an important role to investigate and early detect suspected complications from the intubation process such as post-extubation dysphagia. Post-extubation dysphagia has negative consequences which can be classified into physiological such as malnutrition and/or dehydration, chocking, chest infection and aspiration pneumonia, in addition to psychological, and economic consequences as post-extubation dysphagia could increase the consumption of supplies, human resources, workload and the overall cost of care. There are many factors that contribute to the development of post-extubation dysphagia, which include: physiological changes related factors; age, pathological related factors; initial diagnosis and comorbidies and therapeutic related factors; presence of tracheal and gastric tube, in addition to some medications that may lead to dysphagia. Objective: Identify factors contributing to post-extubation dysphagia in critically ill patients. Setting: This stud...
Alexandria Journal of Medicine, 2020
Introduction: As the coronavirus disease (COVID-19) spreads worldwide, awaiting the development o... more Introduction: As the coronavirus disease (COVID-19) spreads worldwide, awaiting the development of a vaccine, researchers are looking among the arsenal of available drugs, for a potential cure or medication to improve patients' outcome. A highly elevated levels of cytokines in COVID-19 patients requiring ICU admission, has suggested that a "cytokine storm" was associated with disease severity. Methods: We summarize published key findings about imatinib, aiming to rationalize its use as a potential pharmacologic treatment for COVID-19. Results: Data from cellular, animal models and clinical trials, showed a beneficial role of tyrosine kinase inhibitors in the regulation of inflammation, the maintenance of endothelial barrier integrity, as well as the expression of antiviral properties. This data is especially derived from imatinib, the most studied Abl family kinase inhibitor, that is currently in clinical use for multiple medical conditions. Discussion: Based on this encouraging data, we hypothesize that imatinib might be beneficial for the treatment of patients with SARS-CoV-2 pneumonia, in the aim of preventing disease progression into the severe phenotype of hypoxic respiratory failure and acute respiratory distress syndrome. This concept can be considered for evaluation in a randomized controlled study.