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Research paper thumbnail of Membrane stabilizing activity ? a possible mechanism of action for the anti-inflammatory activity of wood oil

Fitoterapia, 1999

The volatile oil of the wood of Cedrus deodara (50 and 100 mg/kg, p.o.) produced a significant in... more The volatile oil of the wood of Cedrus deodara (50 and 100 mg/kg, p.o.) produced a significant inhibition of compound 48/80 and nystatin-induced rat paw edema. It also inhibited heat- as well as hypotonic solution-induced haemolysis of erythrocytes in vitro. The anti-inflammatory activity of the oil could be due to its membrane stabilizing action.

Research paper thumbnail of Membrane stabilizing activity — a possible mechanism of action for the anti-inflammatory activity of Cedrus deodara wood oil

The volatile oil of the wood of Cedrus deodara (50 and 100 mg/kg, p.o.) produced a significant in... more The volatile oil of the wood of Cedrus deodara (50 and 100 mg/kg, p.o.) produced a significant inhibition of compound 48/80 and nystatin-induced rat paw edema. It also inhibited heat- as well as hypotonic solution-induced haemolysis of erythrocytes in vitro. The anti-inflammatory activity of the oil could be due to its membrane stabilizing action.

Research paper thumbnail of Studies on the anti-inflammatory and analgesic activity of Cedrus deodara (Roxb.) Loud. wood oil

Journal of Ethnopharmacology, 1999

The volatile oil extracted by steam distillation of the wood of Cedrus deodara was examined for i... more The volatile oil extracted by steam distillation of the wood of Cedrus deodara was examined for its oral anti-inflammatory and analgesic activity at the doses of 50 and 100 mg/kg body weight. It produced significant inhibition of carrageenan-induced rat paw edema and of both exudative–proliferative and chronic phases of inflammation in adjuvant arthritic rats at doses of 50 and 100 mg/kg body weight. The oil at both tested doses was found to possess analgesic activity against acetic acid-induced writhing and hot plate reaction in mice.

Research paper thumbnail of Preliminary studies on the immunomodulatory activity of Cedrus deodara wood oil

Fitoterapia, 1999

The volatile oil of Cedrus deodara wood, administered orally at doses of 50 and 100 mg/kg, signif... more The volatile oil of Cedrus deodara wood, administered orally at doses of 50 and 100 mg/kg, significantly inhibited neutrophil adhesion to nylon fibers, indicating inhibition of process of margination in the blood vessels. It also significantly inhibited Type III hypersensitivity reaction, i.e. Arthus reaction induced by methylated bovine serum albumin, and Type IV, i.e. delayed type hypersensitivity reaction induced by sheep erythrocytes and oxazolone, indicating an inhibitory effect on humoral and cell-mediated immune responses.

Research paper thumbnail of REPRINTED FROM: T H E C O L L E C T E D PA P E R S O FENGLISH TRANSLATION OF SELECTED TEXTS A lfred Engel, TRA NS LAT OR Engelbe rt S chuc k ing, CONS U LTAN T

Research paper thumbnail of Membrane stabilizing activity ? a possible mechanism of action for the anti-inflammatory activity of wood oil

Fitoterapia, 1999

The volatile oil of the wood of Cedrus deodara (50 and 100 mg/kg, p.o.) produced a significant in... more The volatile oil of the wood of Cedrus deodara (50 and 100 mg/kg, p.o.) produced a significant inhibition of compound 48/80 and nystatin-induced rat paw edema. It also inhibited heat- as well as hypotonic solution-induced haemolysis of erythrocytes in vitro. The anti-inflammatory activity of the oil could be due to its membrane stabilizing action.

Research paper thumbnail of Membrane stabilizing activity — a possible mechanism of action for the anti-inflammatory activity of Cedrus deodara wood oil

The volatile oil of the wood of Cedrus deodara (50 and 100 mg/kg, p.o.) produced a significant in... more The volatile oil of the wood of Cedrus deodara (50 and 100 mg/kg, p.o.) produced a significant inhibition of compound 48/80 and nystatin-induced rat paw edema. It also inhibited heat- as well as hypotonic solution-induced haemolysis of erythrocytes in vitro. The anti-inflammatory activity of the oil could be due to its membrane stabilizing action.

Research paper thumbnail of Studies on the anti-inflammatory and analgesic activity of Cedrus deodara (Roxb.) Loud. wood oil

Journal of Ethnopharmacology, 1999

The volatile oil extracted by steam distillation of the wood of Cedrus deodara was examined for i... more The volatile oil extracted by steam distillation of the wood of Cedrus deodara was examined for its oral anti-inflammatory and analgesic activity at the doses of 50 and 100 mg/kg body weight. It produced significant inhibition of carrageenan-induced rat paw edema and of both exudative–proliferative and chronic phases of inflammation in adjuvant arthritic rats at doses of 50 and 100 mg/kg body weight. The oil at both tested doses was found to possess analgesic activity against acetic acid-induced writhing and hot plate reaction in mice.

Research paper thumbnail of Preliminary studies on the immunomodulatory activity of Cedrus deodara wood oil

Fitoterapia, 1999

The volatile oil of Cedrus deodara wood, administered orally at doses of 50 and 100 mg/kg, signif... more The volatile oil of Cedrus deodara wood, administered orally at doses of 50 and 100 mg/kg, significantly inhibited neutrophil adhesion to nylon fibers, indicating inhibition of process of margination in the blood vessels. It also significantly inhibited Type III hypersensitivity reaction, i.e. Arthus reaction induced by methylated bovine serum albumin, and Type IV, i.e. delayed type hypersensitivity reaction induced by sheep erythrocytes and oxazolone, indicating an inhibitory effect on humoral and cell-mediated immune responses.

Research paper thumbnail of REPRINTED FROM: T H E C O L L E C T E D PA P E R S O FENGLISH TRANSLATION OF SELECTED TEXTS A lfred Engel, TRA NS LAT OR Engelbe rt S chuc k ing, CONS U LTAN T

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