Dr. Shalini Jaiswal | Amity University (original) (raw)

Papers by Dr. Shalini Jaiswal

An expeditious mineral (Montmorillonite K-10 clay) catalysed cyclocondensation of chloroacetic ac... more An expeditious mineral (Montmorillonite K-10 clay) catalysed cyclocondensation of chloroacetic acid with arylthiourea followed by Knoevenagel condensation with aromatic aldehyde in presence of sodium acetate under solvent-free microwave irradiation yields 3-aryl-5-benzylideno-2-thiohydantoins 4(a-l). Compounds 4 (a-l) with hydrazine hydrate in glacial acetic acid furnishe the intermediate acetyl hydrazone of 4(a-l) which on cycloisomerisation under reaction conditions give 1,8-diaryl-4,8-dihydro-1-acetylpyrazolo[3,4-c]imidazol-2-thiones 5(al). On glycosylation with 1,2,3,5-tetra-O-acetyl-β-D-furanose in presence p-toluene sulfonic acid under microwave irradiation followed by deacetylation with NaOMe / MeOH compounds 5 (a-l) yields, 1,8-diaryl-3(β-D-ribofuranosyl)-4,8-dihydro-1acetyl[3,4-c]imidazol-2-thione 6(a-l).

There is a growing need for more environmentally acceptable processes in the chemical industry. T... more There is a growing need for more environmentally acceptable processes in the chemical industry. The fields of combinatorial and automated medicinal chemistry have emerged to meet the increasing requirement of new compounds for drug discovery. Microwave-assisted organic synthesis is an enabling technology for accelerating drug discovery and development processes. In the family of heterocyclic compounds nitrogen containing heterocycles are an important class of compounds in the medicinal chemistry and also contributed to the society from biological and industrial point which helps to understand life processes. Thiosemicarbazide belongs to thiourea group, whose biological activity is due to the presence of aldehyde or ketone moiety. Thiosemicarbazide derivatives exhibit a great variety of biological activities, such as antitumor, antifungal , antibacterial , and antiviral. Here we developed a, novel, solvent free, microwave assisted synthesis of hitherto unknown 5-subtituted-2aryl benzalamino-1, 3, 4thiadiazole 4a-h with excellent yield.

Imidazole drugs have broad applications in many areas of clinical medicine. The literature reveal... more Imidazole drugs have broad applications in many areas of clinical medicine. The literature reveals that anticancer and antimicrobial properties of imidazole were associated with substitutions at 1 position. Due to the growing awareness about environmental pollution and environmental legislation, recent years have witnessed a phenomenal increase in the application of microwave irradiation (MW) in organic synthesis. Use of mineral supported reagent assisted by microwave irradiation under solvent-free condition provides environmentally benign protocol with additional advantages such as enhanced reaction rate, higher yields of pure product, easier workup, better selectivity, improved ease of manipulation, rapid optimization of reactions in parallel which fulfil basic principles of green chemistry. Encouraged by above reports and as part of our research programme for development of eco-friendly synthetic protocol for biologically active compounds as well as in pursuing of our work on new solvent-free cyclisation process we developed a novel K-10 clay catalysed, MW activated synthesis of 2-thioxoimidazole-4-one N-nucleosides. Interestingly it is the first example of microwave induced synthesis of 2-Thioxoimidazole-4-one N-nucleosides. The key element in our approach is the utilization of α-haloacid as a bifunctional building block whose application to the construction of various heterocycles of chemical and biological interest is well documented. An expeditious mineral (montmorillonite K-10) catalysed cyclocondensation of α-halo carboxylic acid and aryl amine on ribosyl/deoxyribosyl thiourea under solvent-free microwave irradiation to yield 2thioxoimidazole-4-one N-nucleosides. Transformation of ribosyl/deoxyribosyl thiourea under reaction conditions into isothiocyanate followed by nucleophilic addition of aryl amine on isothiocyanate generated aryl substituted ribosyl/deoxyribosyl thiourea which in turn underwent cyclocondensation with bifunctional α-halo acid through a dipolar complex to yield 2-thioxoimidazole-4-one Nnucleosides.

EnergyRN: Bioenergy (Topic), 2018

Biodiesel generation is a promising and vital field of research in light of the fact that the sig... more Biodiesel generation is a promising and vital field of research in light of the fact that the significance it picks up from the rising oil cost and its natural points of interest. Biodiesel has turned into a solution of traditional fuel as a future sustainable power source. As an optional fuel in diesel motors, it is ending up progressively critical because of reducing oil holds and the natural results of fumes gases from oil fuelled motors. The cost is very low as we are using waste cooking oil was utilized as feedstock. The adaption of persistent trans esterification procedure and recuperation of superb glycerol from biodiesel are essential choices to bring down the cost of biodiesel. There are four essential approaches to make biodiesel, coordinate utilize and mixing, small scale emulsions, warm breaking (pyrolysis) and trans esterification. The usage of fluid fills, for example, biodiesel created from utilized cooking oil by trans esterification process speaks to a standout amon...

The development of simple, efficient and general synthetic method for biological active compounds... more The development of simple, efficient and general synthetic method for biological active compounds is one of the major challenges in organic synthesis. The importance of benzimidazole compound arises, because they are found in many biologically active compounds. Recently, several methods have been developed, for the synthesis of benzimidazole derivative like use of catalyst such as sulphur, ultrasonic, Lewis acids like pyridinium-p-toluenesulfonate, ionic liquids like polyaniline-sulfate and Zeolite. But, all of this reported method has several disadvantages such as, use of organic solvents, harsh reaction conditions, prolonged reaction times, use of expensive reagents. To overcome all these disadvantages here we report a practical, inexpensive and green method for the synthesis of benzimidazole derivatives under solvent free-condition.This growth of green chemistry holds significant potential for a reduction of the byproduct & waste production and a lowering of the energy costs. The one pot condensation of ophenylenediamine 1 with substituted/ unsubstituted thiourea 2 under microwave irradiation in solvent-free condition gave substituted/ unsubstituted benzimidazole-2-thione derivative 3a-g with excellent yield is described here.

Clean Energy Production Technologies, 2022

2021 International Conference on Technological Advancements and Innovations (ICTAI)

NMR was originally developed to check the structure of relatively tiny molecules, but it has sinc... more NMR was originally developed to check the structure of relatively tiny molecules, but it has since grown in popularity and become a useful technique to find out structure on compounds. NMR can reveal the 3D structures of tiny compounds, high-molecular-weight compound, and delicacy of enzyme processes, all of which can help with drug development.The conventional procedure for the title heterocyclic compound is unsuitable since it necessitates long reaction durations, the use of proprietary and potentially hazardous solvents, and low yield. As a result, we established a simpler and advantageous technique for synthesizing title medication under moderate and environmentally favorable reaction circumstances. Microwave aided organic synthesis is projected to have a broader application in organic synthesis due to its operational simplicity, universality, and efficacy.There is growing attention of eco-friendly chemicals and microwave irradiation technique. This method of synthesis gained reputation in now days due of simplicity and no use of hazardous chemicals. Organic synthesis without hazardous solvent like dioxin or strongly acidic keeps the environment pollution free. When two or more heterocyclic nuclei are combined, the biological profile is generally enhanced. Characterization of all compounds are completed by 1HNMR Spectroscopy by spinning of 1 H-nuclei.

AIJR Abstracts, Feb 6, 2021

EPRA international journal of multidisciplinary research, Jul 5, 2021

Asian Journal of Applied Science and Technology

The group of patients on December 2019 in Wuhan, Hubei Province, China was struck by fever and li... more The group of patients on December 2019 in Wuhan, Hubei Province, China was struck by fever and littleness of breath. In January 7, 2020, the cause of the outburst is recognized as severe serious respiratory syndrome coronavirus 2 (SARS-CoV-2) and is isolated by the Chinese authorities. As of April 04, 2022, total 489,779,062 established cases of coronavirus disease of 2019 was 489,779,062. COVID-19 spreads as soon as an infected individual exhales virus-containing droplets and other persons breathe in these droplets, or they may deposit on their different body part like eyes, noses, mouth and noses. To prevent its spread, various restrictions have been imposed which in turn has increased the use of technology in various sectors like education, healthcare, etc. This paper aims to shed some light on the growth, advantages and disadvantages of technology as seen during the pandemic and is an in-depth analysis of growth of online grocery & medicine delivery services, online payment meth...

2022 2nd International Conference on Innovative Practices in Technology and Management (ICIPTM)

Laser is one of the exceptional inventions of the last century. Laser has become a valuable tool ... more Laser is one of the exceptional inventions of the last century. Laser has become a valuable tool in a variety of fields starting with communication to medical. As we all know Lasers have unlocked fresh fields of science and technology. Laser seems to be very helpful in reducing the difficulty and thus provide a better platform and easier to accomplish our task. Lasers have affected many areas in many ways. As we all know that pandemic situation is here to and affect every individual in a different way. In this article on the basics of Laser we have explained the aspects of threshold behavior and exponential growth on Laser and Covid-19 and also socio-economic impact of covid-19.

2021 International Conference on Technological Advancements and Innovations (ICTAI)

Nanotechnology has been produced for being utilized as a part of numerous fields of studies toget... more Nanotechnology has been produced for being utilized as a part of numerous fields of studies together with physical science, science, material science, designing, and software engineering. We recognize the nanotechnology improvement group and desires of nanotechnology in the field of software engineering and the present advancement, openings happened as of late in this article. This review paper gives brief data regarding the examination occurred till this date and furthermore tells regarding the advantages of nano technology utilizing Nano tubes set up of silicon chip that will be utilized as a part of the CPU’s of PC. Also tells us about the use of quantum dot in recent TV technologies.

Heterocyclic nucleus shows a vital contribution in medicinal chemistry. Imidazole has occupied a ... more Heterocyclic nucleus shows a vital contribution in medicinal chemistry. Imidazole has occupied a unique position in heterocyclic chemistry, and its derivatives also shows considerable role in pharmaceutical chemistry. Infectious diseases and the increasing number of microbial pathogens resistant to many antibiotics and chemotherapeutics still make the treatment of infection disease an important universe problem. Despite many antibiotics and chemotherapeutics drugs are available, but still there is requirement of discovery of new drugs with improved antimicrobial properties and resistance power. The heterocyclic compound Benzimidazole derivatives are formed by the fusion of benzene and imidazole rings which containing nitrogen, oxygen, sulphur. The major challenges for medicinal chemistry the development of simple, effective and eco friendly method for the synthesis of heterocyclic compound with enhance antimicrobial activity. Now a day various methods have been proposed for the prep...

2021 2nd International Conference on Intelligent Engineering and Management (ICIEM), 2021

The current worldwide organizations request quicker, safer and bigger limit communication framewo... more The current worldwide organizations request quicker, safer and bigger limit communication frameworks for their organization activities. Fiber optic innovation is relied upon to have a significant impact in this development. From medical services frameworks to the marine climate, fiber optic cable is ending up being a vital segment of mechanical foundation. Fiber optic link gatherings are likewise assuming an undeniably fundamental part in domestic applications. Mortgage holders presently expect rapid web access as a component of their everyday lives, and telecom and information industry pioneers are going to fiber optic innovation as a perfect, solid approach to offer anticipated types of assistance. Fiber optic innovation is overwhelming the market from quite a while because information rate is high, noteworthy distance transmission capacity. Fiber optic innovation is being demonstrated to be a greatly improved innovation than metal wire. Also there is less loss in signal and they are unsusceptible to obstruction. Less dormancy is a principle necessity in numerous applications, for example, exchanging of algorithmic superconductor and cloud computing etc. Fiber optics is utilized as information transmission medium in the vast bulk of the telecom organizations. This paper offers a blueprint of fiber optic correspondence frameworks along with their key advances, and conjointly talks about their mechanical pattern towards group of people yet to come.

There is a growing need for more environmentally acceptable processes in the chemical industry. T... more There is a growing need for more environmentally acceptable processes in the chemical industry. The fields of combinatorial and automated medicinal chemistry have emerged to meet the increasing requirement of new compounds for drug discovery. Microwave-assisted organic synthesis is an enabling technology for accelerating drug discovery and development processes. In the family of heterocyclic compounds nitrogen containing heterocycles are an important class of compounds in the medicinal chemistry and also contributed to the society from biological and industrial point which helps to understand life processes. Thiosemicarbazide belongs to thiourea group, whose biological activity is due to the presence of aldehyde or ketone moiety. Thiosemicarbazide derivatives exhibit a great variety of biological activities, such as antitumor, antifungal , antibacterial , and antiviral. Here we developed a, novel, solvent free, microwave assisted synthesis of hitherto unknown 5-subtituted-2aryl benz...

An expeditious mineral (Montmorillonite K-10 clay) catalysed cyclo- condensation of chloroacetic ... more An expeditious mineral (Montmorillonite K-10 clay) catalysed cyclo- condensation of chloroacetic acid with arylthiourea followed by Knoevenagel condensation with aromatic aldehyde in presence of sodium acetate under solvent-free microwave irradiation yields 3-aryl-5-benzylideno-2-thiohydantoins 4(a-l). Compounds 4 (a-l) with hydrazine hydrate in glacial acetic acid furnishe the intermediate acetyl hydrazone of 4(a-l) which on cycloisomerisation under reaction conditions give 1,8-diaryl-4,8-dihydro-1-acetylpyrazolo(3,4-c)imidazol-2-thiones 5(a- l). On glycosylation with 1,2,3,5-tetra-O-acetyl-β-D-furanose in presence p-toluene sulfonic acid under microwave irradiation followed by deacetylation with NaOMe / MeOH compounds 5 (a-l) yields, 1,8-diaryl-3(β-D-ribofuranosyl)-4,8-dihydro-1- acetyl(3,4-c)imidazol-2-thione 6(a-l).

Imidazole drugs have broad applications in many areas of clinical medicine. The literature reveal... more Imidazole drugs have broad applications in many areas of clinical medicine. The literature reveals that anticancer and antimicrobial properties of imidazole were associated with substitutions at 1 position. Due to the growing awareness about environmental pollution and environmental legislation, recent years have witnessed a phenomenal increase in the application of microwave irradiation (MW) in organic synthesis. Use of mineral supported reagent assisted by microwave irradiation under solvent-free condition provides environmentally benign protocol with additional advantages such as enhanced reaction rate, higher yields of pure product, easier workup, better selectivity, improved ease of manipulation, rapid optimization of reactions in parallel which fulfil basic principles of green chemistry. Encouraged by above reports and as part of our research programme for development of eco-friendly synthetic protocol for biologically active compounds as well as in pursuing of our work on new...

BMJ case reports, Jan 2, 2013

Cysticercosis in humans is caused by Taenia solium larvae infestation. Oral cysticercosis is a ra... more Cysticercosis in humans is caused by Taenia solium larvae infestation. Oral cysticercosis is a rare condition and is challenging to diagnose. We present a case of masseter cysticercosis in a young woman who presented with painful recurrent cheek swelling. Diagnosis confirmed it after neuroimaging and histopathological examination of the excised lesion from masseter muscle.

An expeditious mineral (Montmorillonite K-10 clay) catalysed cyclocondensation of chloroacetic ac... more An expeditious mineral (Montmorillonite K-10 clay) catalysed cyclocondensation of chloroacetic acid with arylthiourea followed by Knoevenagel condensation with aromatic aldehyde in presence of sodium acetate under solvent-free microwave irradiation yields 3-aryl-5-benzylideno-2-thiohydantoins 4(a-l). Compounds 4 (a-l) with hydrazine hydrate in glacial acetic acid furnishe the intermediate acetyl hydrazone of 4(a-l) which on cycloisomerisation under reaction conditions give 1,8-diaryl-4,8-dihydro-1-acetylpyrazolo[3,4-c]imidazol-2-thiones 5(al). On glycosylation with 1,2,3,5-tetra-O-acetyl-β-D-furanose in presence p-toluene sulfonic acid under microwave irradiation followed by deacetylation with NaOMe / MeOH compounds 5 (a-l) yields, 1,8-diaryl-3(β-D-ribofuranosyl)-4,8-dihydro-1acetyl[3,4-c]imidazol-2-thione 6(a-l).

There is a growing need for more environmentally acceptable processes in the chemical industry. T... more There is a growing need for more environmentally acceptable processes in the chemical industry. The fields of combinatorial and automated medicinal chemistry have emerged to meet the increasing requirement of new compounds for drug discovery. Microwave-assisted organic synthesis is an enabling technology for accelerating drug discovery and development processes. In the family of heterocyclic compounds nitrogen containing heterocycles are an important class of compounds in the medicinal chemistry and also contributed to the society from biological and industrial point which helps to understand life processes. Thiosemicarbazide belongs to thiourea group, whose biological activity is due to the presence of aldehyde or ketone moiety. Thiosemicarbazide derivatives exhibit a great variety of biological activities, such as antitumor, antifungal , antibacterial , and antiviral. Here we developed a, novel, solvent free, microwave assisted synthesis of hitherto unknown 5-subtituted-2aryl benzalamino-1, 3, 4thiadiazole 4a-h with excellent yield.

Imidazole drugs have broad applications in many areas of clinical medicine. The literature reveal... more Imidazole drugs have broad applications in many areas of clinical medicine. The literature reveals that anticancer and antimicrobial properties of imidazole were associated with substitutions at 1 position. Due to the growing awareness about environmental pollution and environmental legislation, recent years have witnessed a phenomenal increase in the application of microwave irradiation (MW) in organic synthesis. Use of mineral supported reagent assisted by microwave irradiation under solvent-free condition provides environmentally benign protocol with additional advantages such as enhanced reaction rate, higher yields of pure product, easier workup, better selectivity, improved ease of manipulation, rapid optimization of reactions in parallel which fulfil basic principles of green chemistry. Encouraged by above reports and as part of our research programme for development of eco-friendly synthetic protocol for biologically active compounds as well as in pursuing of our work on new solvent-free cyclisation process we developed a novel K-10 clay catalysed, MW activated synthesis of 2-thioxoimidazole-4-one N-nucleosides. Interestingly it is the first example of microwave induced synthesis of 2-Thioxoimidazole-4-one N-nucleosides. The key element in our approach is the utilization of α-haloacid as a bifunctional building block whose application to the construction of various heterocycles of chemical and biological interest is well documented. An expeditious mineral (montmorillonite K-10) catalysed cyclocondensation of α-halo carboxylic acid and aryl amine on ribosyl/deoxyribosyl thiourea under solvent-free microwave irradiation to yield 2thioxoimidazole-4-one N-nucleosides. Transformation of ribosyl/deoxyribosyl thiourea under reaction conditions into isothiocyanate followed by nucleophilic addition of aryl amine on isothiocyanate generated aryl substituted ribosyl/deoxyribosyl thiourea which in turn underwent cyclocondensation with bifunctional α-halo acid through a dipolar complex to yield 2-thioxoimidazole-4-one Nnucleosides.

EnergyRN: Bioenergy (Topic), 2018

Biodiesel generation is a promising and vital field of research in light of the fact that the sig... more Biodiesel generation is a promising and vital field of research in light of the fact that the significance it picks up from the rising oil cost and its natural points of interest. Biodiesel has turned into a solution of traditional fuel as a future sustainable power source. As an optional fuel in diesel motors, it is ending up progressively critical because of reducing oil holds and the natural results of fumes gases from oil fuelled motors. The cost is very low as we are using waste cooking oil was utilized as feedstock. The adaption of persistent trans esterification procedure and recuperation of superb glycerol from biodiesel are essential choices to bring down the cost of biodiesel. There are four essential approaches to make biodiesel, coordinate utilize and mixing, small scale emulsions, warm breaking (pyrolysis) and trans esterification. The usage of fluid fills, for example, biodiesel created from utilized cooking oil by trans esterification process speaks to a standout amon...

The development of simple, efficient and general synthetic method for biological active compounds... more The development of simple, efficient and general synthetic method for biological active compounds is one of the major challenges in organic synthesis. The importance of benzimidazole compound arises, because they are found in many biologically active compounds. Recently, several methods have been developed, for the synthesis of benzimidazole derivative like use of catalyst such as sulphur, ultrasonic, Lewis acids like pyridinium-p-toluenesulfonate, ionic liquids like polyaniline-sulfate and Zeolite. But, all of this reported method has several disadvantages such as, use of organic solvents, harsh reaction conditions, prolonged reaction times, use of expensive reagents. To overcome all these disadvantages here we report a practical, inexpensive and green method for the synthesis of benzimidazole derivatives under solvent free-condition.This growth of green chemistry holds significant potential for a reduction of the byproduct & waste production and a lowering of the energy costs. The one pot condensation of ophenylenediamine 1 with substituted/ unsubstituted thiourea 2 under microwave irradiation in solvent-free condition gave substituted/ unsubstituted benzimidazole-2-thione derivative 3a-g with excellent yield is described here.

Clean Energy Production Technologies, 2022

2021 International Conference on Technological Advancements and Innovations (ICTAI)

NMR was originally developed to check the structure of relatively tiny molecules, but it has sinc... more NMR was originally developed to check the structure of relatively tiny molecules, but it has since grown in popularity and become a useful technique to find out structure on compounds. NMR can reveal the 3D structures of tiny compounds, high-molecular-weight compound, and delicacy of enzyme processes, all of which can help with drug development.The conventional procedure for the title heterocyclic compound is unsuitable since it necessitates long reaction durations, the use of proprietary and potentially hazardous solvents, and low yield. As a result, we established a simpler and advantageous technique for synthesizing title medication under moderate and environmentally favorable reaction circumstances. Microwave aided organic synthesis is projected to have a broader application in organic synthesis due to its operational simplicity, universality, and efficacy.There is growing attention of eco-friendly chemicals and microwave irradiation technique. This method of synthesis gained reputation in now days due of simplicity and no use of hazardous chemicals. Organic synthesis without hazardous solvent like dioxin or strongly acidic keeps the environment pollution free. When two or more heterocyclic nuclei are combined, the biological profile is generally enhanced. Characterization of all compounds are completed by 1HNMR Spectroscopy by spinning of 1 H-nuclei.

AIJR Abstracts, Feb 6, 2021

EPRA international journal of multidisciplinary research, Jul 5, 2021

Asian Journal of Applied Science and Technology

The group of patients on December 2019 in Wuhan, Hubei Province, China was struck by fever and li... more The group of patients on December 2019 in Wuhan, Hubei Province, China was struck by fever and littleness of breath. In January 7, 2020, the cause of the outburst is recognized as severe serious respiratory syndrome coronavirus 2 (SARS-CoV-2) and is isolated by the Chinese authorities. As of April 04, 2022, total 489,779,062 established cases of coronavirus disease of 2019 was 489,779,062. COVID-19 spreads as soon as an infected individual exhales virus-containing droplets and other persons breathe in these droplets, or they may deposit on their different body part like eyes, noses, mouth and noses. To prevent its spread, various restrictions have been imposed which in turn has increased the use of technology in various sectors like education, healthcare, etc. This paper aims to shed some light on the growth, advantages and disadvantages of technology as seen during the pandemic and is an in-depth analysis of growth of online grocery & medicine delivery services, online payment meth...

2022 2nd International Conference on Innovative Practices in Technology and Management (ICIPTM)

Laser is one of the exceptional inventions of the last century. Laser has become a valuable tool ... more Laser is one of the exceptional inventions of the last century. Laser has become a valuable tool in a variety of fields starting with communication to medical. As we all know Lasers have unlocked fresh fields of science and technology. Laser seems to be very helpful in reducing the difficulty and thus provide a better platform and easier to accomplish our task. Lasers have affected many areas in many ways. As we all know that pandemic situation is here to and affect every individual in a different way. In this article on the basics of Laser we have explained the aspects of threshold behavior and exponential growth on Laser and Covid-19 and also socio-economic impact of covid-19.

2021 International Conference on Technological Advancements and Innovations (ICTAI)

Nanotechnology has been produced for being utilized as a part of numerous fields of studies toget... more Nanotechnology has been produced for being utilized as a part of numerous fields of studies together with physical science, science, material science, designing, and software engineering. We recognize the nanotechnology improvement group and desires of nanotechnology in the field of software engineering and the present advancement, openings happened as of late in this article. This review paper gives brief data regarding the examination occurred till this date and furthermore tells regarding the advantages of nano technology utilizing Nano tubes set up of silicon chip that will be utilized as a part of the CPU’s of PC. Also tells us about the use of quantum dot in recent TV technologies.

Heterocyclic nucleus shows a vital contribution in medicinal chemistry. Imidazole has occupied a ... more Heterocyclic nucleus shows a vital contribution in medicinal chemistry. Imidazole has occupied a unique position in heterocyclic chemistry, and its derivatives also shows considerable role in pharmaceutical chemistry. Infectious diseases and the increasing number of microbial pathogens resistant to many antibiotics and chemotherapeutics still make the treatment of infection disease an important universe problem. Despite many antibiotics and chemotherapeutics drugs are available, but still there is requirement of discovery of new drugs with improved antimicrobial properties and resistance power. The heterocyclic compound Benzimidazole derivatives are formed by the fusion of benzene and imidazole rings which containing nitrogen, oxygen, sulphur. The major challenges for medicinal chemistry the development of simple, effective and eco friendly method for the synthesis of heterocyclic compound with enhance antimicrobial activity. Now a day various methods have been proposed for the prep...

2021 2nd International Conference on Intelligent Engineering and Management (ICIEM), 2021

The current worldwide organizations request quicker, safer and bigger limit communication framewo... more The current worldwide organizations request quicker, safer and bigger limit communication frameworks for their organization activities. Fiber optic innovation is relied upon to have a significant impact in this development. From medical services frameworks to the marine climate, fiber optic cable is ending up being a vital segment of mechanical foundation. Fiber optic link gatherings are likewise assuming an undeniably fundamental part in domestic applications. Mortgage holders presently expect rapid web access as a component of their everyday lives, and telecom and information industry pioneers are going to fiber optic innovation as a perfect, solid approach to offer anticipated types of assistance. Fiber optic innovation is overwhelming the market from quite a while because information rate is high, noteworthy distance transmission capacity. Fiber optic innovation is being demonstrated to be a greatly improved innovation than metal wire. Also there is less loss in signal and they are unsusceptible to obstruction. Less dormancy is a principle necessity in numerous applications, for example, exchanging of algorithmic superconductor and cloud computing etc. Fiber optics is utilized as information transmission medium in the vast bulk of the telecom organizations. This paper offers a blueprint of fiber optic correspondence frameworks along with their key advances, and conjointly talks about their mechanical pattern towards group of people yet to come.

There is a growing need for more environmentally acceptable processes in the chemical industry. T... more There is a growing need for more environmentally acceptable processes in the chemical industry. The fields of combinatorial and automated medicinal chemistry have emerged to meet the increasing requirement of new compounds for drug discovery. Microwave-assisted organic synthesis is an enabling technology for accelerating drug discovery and development processes. In the family of heterocyclic compounds nitrogen containing heterocycles are an important class of compounds in the medicinal chemistry and also contributed to the society from biological and industrial point which helps to understand life processes. Thiosemicarbazide belongs to thiourea group, whose biological activity is due to the presence of aldehyde or ketone moiety. Thiosemicarbazide derivatives exhibit a great variety of biological activities, such as antitumor, antifungal , antibacterial , and antiviral. Here we developed a, novel, solvent free, microwave assisted synthesis of hitherto unknown 5-subtituted-2aryl benz...

An expeditious mineral (Montmorillonite K-10 clay) catalysed cyclo- condensation of chloroacetic ... more An expeditious mineral (Montmorillonite K-10 clay) catalysed cyclo- condensation of chloroacetic acid with arylthiourea followed by Knoevenagel condensation with aromatic aldehyde in presence of sodium acetate under solvent-free microwave irradiation yields 3-aryl-5-benzylideno-2-thiohydantoins 4(a-l). Compounds 4 (a-l) with hydrazine hydrate in glacial acetic acid furnishe the intermediate acetyl hydrazone of 4(a-l) which on cycloisomerisation under reaction conditions give 1,8-diaryl-4,8-dihydro-1-acetylpyrazolo(3,4-c)imidazol-2-thiones 5(a- l). On glycosylation with 1,2,3,5-tetra-O-acetyl-β-D-furanose in presence p-toluene sulfonic acid under microwave irradiation followed by deacetylation with NaOMe / MeOH compounds 5 (a-l) yields, 1,8-diaryl-3(β-D-ribofuranosyl)-4,8-dihydro-1- acetyl(3,4-c)imidazol-2-thione 6(a-l).

Imidazole drugs have broad applications in many areas of clinical medicine. The literature reveal... more Imidazole drugs have broad applications in many areas of clinical medicine. The literature reveals that anticancer and antimicrobial properties of imidazole were associated with substitutions at 1 position. Due to the growing awareness about environmental pollution and environmental legislation, recent years have witnessed a phenomenal increase in the application of microwave irradiation (MW) in organic synthesis. Use of mineral supported reagent assisted by microwave irradiation under solvent-free condition provides environmentally benign protocol with additional advantages such as enhanced reaction rate, higher yields of pure product, easier workup, better selectivity, improved ease of manipulation, rapid optimization of reactions in parallel which fulfil basic principles of green chemistry. Encouraged by above reports and as part of our research programme for development of eco-friendly synthetic protocol for biologically active compounds as well as in pursuing of our work on new...

BMJ case reports, Jan 2, 2013

Cysticercosis in humans is caused by Taenia solium larvae infestation. Oral cysticercosis is a ra... more Cysticercosis in humans is caused by Taenia solium larvae infestation. Oral cysticercosis is a rare condition and is challenging to diagnose. We present a case of masseter cysticercosis in a young woman who presented with painful recurrent cheek swelling. Diagnosis confirmed it after neuroimaging and histopathological examination of the excised lesion from masseter muscle.