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Papers by joshua morara nyangeri
Journal of Burn Care & …, Jan 1, 1982
Page 1. Myth, Magic, Witchcraft, or Fact? Aloe vera Revisited* Martin C. Robson, MD, FACS; John P... more Page 1. Myth, Magic, Witchcraft, or Fact? Aloe vera Revisited* Martin C. Robson, MD, FACS; John P. Heggers, PhD, MT (AMT), BCLD; William ...
Oncology nursing …, Jan 1, 2001
To determine whether the use of mild soap and aloe vera gel versus mild soap alone would decrease... more To determine whether the use of mild soap and aloe vera gel versus mild soap alone would decrease the incidence of skin reactions in patients undergoing radiation therapy. Prospective, randomized, blinded clinical trial. Radiation therapy outpatient clinic in a cancer center affiliated with a major teaching medical facility. The mean age of the participants was 56 years. The group consisted of Caucasians (74%) and African Americans (26%). The ethnic mix was non-Hispanic (65%) and Hispanic (35%). Prophylactic skin care began on the first day of radiation therapy. Patients cleansed the area with mild, unscented soap. Patients randomized into the experimental arm of the trial were instructed to liberally apply aloe vera gel to the area at various intervals throughout the day. At low cumulative dose levels < or = 2,700 cGy, no difference existed in the effect of adding aloe. When the cumulative dose was high (> 2,700 cGy), the median time was five weeks prior to any skin changes in the aloe/soap arm versus three weeks in the soap only arm. When the cumulative dose increases over time, there seems to be a protective effect of adding aloe to the soap regimen. Skin products used to treat radiation dermatitis vary among institutions. Nurses should be aware that some patients may be predisposed to skin problems. Nurses must be aware of newly developed products and research regarding these products so that effective treatment can be instituted.
Journal of the Medical …, Jan 1, 2000
To demonstrate the microcirculatory and wound healing effects of Aloe vera on induced second degr... more To demonstrate the microcirculatory and wound healing effects of Aloe vera on induced second degree burn wounds in rats. A total of 48 male Wistar rats were equally divided into 4 groups as follows: sham controls, untreated burn-wound rats, those treated with once-daily application of normal saline (NSS) and those treated with once-daily application of lyophilized Aloe vera gel. The animals in each group were equally subdivided into 2 subgroups for the study of cutaneous microcirculation and wound healing on day 7 and 14 after burn. Dorsal skinfold chamber preparation and intravital fluorescence microscopic technique were performed to examine dermal microvascular changes, including arteriolar diameter, postcapillary venular permeability and leukocyte adhesion on postcapillary venules. On day 7, the vasodilation and increased postcapillary venular permeability as encountered in the untreated burn were found to be reduced significantly (p < 0.05) in both the NSS- and Aloe vera-treated groups, but to a greater extent in the latter. Leukocyte adhesion was not different among the untreated, NSS- and Aloe vera-treated groups. On day 14, vasoconstriction occurred after the wound had been left untreated. Only in the Aloe vera-treated groups, was arteriolar diameter increased up to normal condition and postcapillary venular permeability was not different from the sham controls. The amount of leukocyte adhesion was also less observed compared to the untreated and NSS- treated groups. Besides, the healing area of the Aloe vera-treated wound was better than that of the untreated and NSS- treated groups during 7 and 14 days after burn. Aloe vera could exhibit the actions of both anti-inflammation and wound healing promotion when applied on a second degree burn wound.
Immunopharmacology, Jan 1, 1996
Journal of Ethnopharmacology, Jan 1, 1999
Journal of ethnopharmacology, Jan 1, 1986
The mucilaginous gel from the parenchymatous cells in the leaf pulp of Aloe vera has been used si... more The mucilaginous gel from the parenchymatous cells in the leaf pulp of Aloe vera has been used since early times for a host of curative purposes. This gel should be distinguished clearly from the bitter yellow exudate originating from the bundle sheath cells, which is used for its purgative effects. Aloe vera gel has come to play a prominent role as a contemporary folk remedy, and numerous optimistic, and in some cases extravagant, claims have been made for its medicinal properties. Modern clinical use of the gel began in the 1930s, with reports of successful treatment of X-ray and radium burns, which led to further experimental studies using laboratory animals in the following decades. The reports of these experiments and the numerous favourable case histories did not give conclusive evidence, since although positive results were usually described, much of the work suffered from poor experimental design and insufficiently large test samples. In addition some conflicting or inconsistent results were obtained. With the recent resurgence of interest in Aloe vera gel, however, new experimental work has indicated the possibility of distinct physiological effects. Chemical analysis has shown the gel to contain various carbohydrate polymers, notably either glucomannans or pectic acid, along with a range of other organic and inorganic components. Although many physiological properties of the gel have been described, there is no certain correlation between these and the identified gel components.
Biotechnology …, Jan 1, 2006
The British Journal of General Practice, Jan 1, 1999
J Am Podiatr Med Assoc, Jan 1, 1989
Journal of Burn Care & …, Jan 1, 1982
Page 1. Myth, Magic, Witchcraft, or Fact? Aloe vera Revisited* Martin C. Robson, MD, FACS; John P... more Page 1. Myth, Magic, Witchcraft, or Fact? Aloe vera Revisited* Martin C. Robson, MD, FACS; John P. Heggers, PhD, MT (AMT), BCLD; William ...
Oncology nursing …, Jan 1, 2001
To determine whether the use of mild soap and aloe vera gel versus mild soap alone would decrease... more To determine whether the use of mild soap and aloe vera gel versus mild soap alone would decrease the incidence of skin reactions in patients undergoing radiation therapy. Prospective, randomized, blinded clinical trial. Radiation therapy outpatient clinic in a cancer center affiliated with a major teaching medical facility. The mean age of the participants was 56 years. The group consisted of Caucasians (74%) and African Americans (26%). The ethnic mix was non-Hispanic (65%) and Hispanic (35%). Prophylactic skin care began on the first day of radiation therapy. Patients cleansed the area with mild, unscented soap. Patients randomized into the experimental arm of the trial were instructed to liberally apply aloe vera gel to the area at various intervals throughout the day. At low cumulative dose levels &amp;amp;amp;amp;amp;lt; or = 2,700 cGy, no difference existed in the effect of adding aloe. When the cumulative dose was high (&amp;amp;amp;amp;amp;gt; 2,700 cGy), the median time was five weeks prior to any skin changes in the aloe/soap arm versus three weeks in the soap only arm. When the cumulative dose increases over time, there seems to be a protective effect of adding aloe to the soap regimen. Skin products used to treat radiation dermatitis vary among institutions. Nurses should be aware that some patients may be predisposed to skin problems. Nurses must be aware of newly developed products and research regarding these products so that effective treatment can be instituted.
Journal of the Medical …, Jan 1, 2000
To demonstrate the microcirculatory and wound healing effects of Aloe vera on induced second degr... more To demonstrate the microcirculatory and wound healing effects of Aloe vera on induced second degree burn wounds in rats. A total of 48 male Wistar rats were equally divided into 4 groups as follows: sham controls, untreated burn-wound rats, those treated with once-daily application of normal saline (NSS) and those treated with once-daily application of lyophilized Aloe vera gel. The animals in each group were equally subdivided into 2 subgroups for the study of cutaneous microcirculation and wound healing on day 7 and 14 after burn. Dorsal skinfold chamber preparation and intravital fluorescence microscopic technique were performed to examine dermal microvascular changes, including arteriolar diameter, postcapillary venular permeability and leukocyte adhesion on postcapillary venules. On day 7, the vasodilation and increased postcapillary venular permeability as encountered in the untreated burn were found to be reduced significantly (p < 0.05) in both the NSS- and Aloe vera-treated groups, but to a greater extent in the latter. Leukocyte adhesion was not different among the untreated, NSS- and Aloe vera-treated groups. On day 14, vasoconstriction occurred after the wound had been left untreated. Only in the Aloe vera-treated groups, was arteriolar diameter increased up to normal condition and postcapillary venular permeability was not different from the sham controls. The amount of leukocyte adhesion was also less observed compared to the untreated and NSS- treated groups. Besides, the healing area of the Aloe vera-treated wound was better than that of the untreated and NSS- treated groups during 7 and 14 days after burn. Aloe vera could exhibit the actions of both anti-inflammation and wound healing promotion when applied on a second degree burn wound.
Immunopharmacology, Jan 1, 1996
Journal of Ethnopharmacology, Jan 1, 1999
Journal of ethnopharmacology, Jan 1, 1986
The mucilaginous gel from the parenchymatous cells in the leaf pulp of Aloe vera has been used si... more The mucilaginous gel from the parenchymatous cells in the leaf pulp of Aloe vera has been used since early times for a host of curative purposes. This gel should be distinguished clearly from the bitter yellow exudate originating from the bundle sheath cells, which is used for its purgative effects. Aloe vera gel has come to play a prominent role as a contemporary folk remedy, and numerous optimistic, and in some cases extravagant, claims have been made for its medicinal properties. Modern clinical use of the gel began in the 1930s, with reports of successful treatment of X-ray and radium burns, which led to further experimental studies using laboratory animals in the following decades. The reports of these experiments and the numerous favourable case histories did not give conclusive evidence, since although positive results were usually described, much of the work suffered from poor experimental design and insufficiently large test samples. In addition some conflicting or inconsistent results were obtained. With the recent resurgence of interest in Aloe vera gel, however, new experimental work has indicated the possibility of distinct physiological effects. Chemical analysis has shown the gel to contain various carbohydrate polymers, notably either glucomannans or pectic acid, along with a range of other organic and inorganic components. Although many physiological properties of the gel have been described, there is no certain correlation between these and the identified gel components.
Biotechnology …, Jan 1, 2006
The British Journal of General Practice, Jan 1, 1999
J Am Podiatr Med Assoc, Jan 1, 1989