Fatih Demirci | Anadolu University (original) (raw)
Papers by Fatih Demirci
Natural Product Communications, May 1, 2011
Public reporting burden for the collection of information is estimated to average 1 hour per resp... more Public reporting burden for the collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden, to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to a penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number.
Zeitschrift Fur Naturforschung C, 2004
The cyclic monoterpene ketone (Ð)-carvone was metabolized by the plant pathogenic fungus Absidia ... more The cyclic monoterpene ketone (Ð)-carvone was metabolized by the plant pathogenic fungus Absidia glauca. After 4 days of incubation, the diol 10-hydroxy-(+)-neodihydrocarveol was formed. The absolute configuration and structure of the crystalline substance was identified by means of X-ray diffraction and by spectroscopic techniques (MS, IR and NMR). The antimicrobial activity of the substrate and metabolite was assayed with human pathogenic microorganisms.
Flavour and Fragrance Journal, Nov 1, 2000
FLAVOUR AND FRAGRANCE JOURNAL Flavour Fra`r[ J[ 1999^ 04] 277289 "1999# ... Essential oil c... more FLAVOUR AND FRAGRANCE JOURNAL Flavour Fra`r[ J[ 1999^ 04] 277289 "1999# ... Essential oil constituents of the spice Cinnamomum tamala ... Aftab Ahmed1, M. Iqbal Choudhary2, Afgan Farooq2, Betu® l Demirci3, Fatih Demirci3, and K. Hu® snu® Can Baser3
Anadolu University Journal of Science and Technology C Life Sciences and Biotechnology, Jun 7, 2011
... Mehlika Dilek ALTINTOP 1 , Fatih DEMİRCİ2 ... In the past years, some azole derivatives were ... more ... Mehlika Dilek ALTINTOP 1 , Fatih DEMİRCİ2 ... In the past years, some azole derivatives were devel-oped as novel antimicrobial agents, for example, Linezolid and Eperezolid are currently used for the treatment of multidrug-resistant Gram-positive infections (Bayrak et al. ...
Journal of Enzyme Inhibition and Medicinal Chemistry, Sep 1, 2008
The increasing clinical importance of drug-resistant fungal pathogens has urged additional need t... more The increasing clinical importance of drug-resistant fungal pathogens has urged additional need to fungal research and new antifungal compound development. For this purpose, some N-(1-benzyl-2-phenylethylidene)-N'-[4-(aryl)thiazol-2-yl]hydrazone (1a-e) and N-(1-phenylbutylidene)-N'-[4-(aryl)thiazol-2-yl]hydrazone (2a-e) derivatives were synthesised and evaluated for antifungal activity. Their antifungal activities against standard and clinical strands of Candida albicans, Candida glabrata, Candida utilis, Candida tropicalis, Candida krusei, Candida zeylanoides, and Candida parapsilosis were investigated. A significant level of activity was observed.
Natural Product Communications, Sep 1, 2010
Turkish Journal of Chemistry, Sep 3, 2014
Http Dx Doi Org 10 1080 10412905 2006 9699194, Nov 28, 2011
Hypericum bupleuroides Griseb. (Guttiferae) was collected from the north eastern region of Turkey... more Hypericum bupleuroides Griseb. (Guttiferae) was collected from the north eastern region of Turkey. The aerial parts were subjected to microdistillation for the isolation of volatiles that were subsequently analyzed by GC and GC/MS. The investigation resulted in the characterization of 30 components representing 92% of the total volatiles. Sesquiterpenes such as β-sesquiphellandrene (33.2%) and β-caryophyllene (20.2%) were assigned as major compounds.
Records of Natural Products, 2012
Water-distilled essential oils from aerial parts of Tanacetum densum (L.) Heywood ssp. eginense H... more Water-distilled essential oils from aerial parts of Tanacetum densum (L.) Heywood ssp. eginense Heywood, from Turkey was analysed by GC and GC-MS. T. densum ssp. eginense flower, stem and leaf oils were characterized with camphor (30.9% , 25.7%, 27.7%), 1,8-Cineole (12.4% flower oil), camphene (10.6%, %7.0, flower and leaf oils), bornyl acetate, (9.4%, 11.8%, stem and leaf oils), α-pinene (7.0%, %5.3, flower and leaf oils), borneol (5.1%, 5.2%, stem and leaf oils), neodihydrocarveol (5.1%, flower oil). An unidentified compound was also present in flower, stem and leaf oils (11.5%, 27.2%, 20.5%). A comparison is done with the previous investigations on the other subspecies of T. densum and the differences were investigated. Flower and stem oils did not show any significant activity to the tested microorganisms when compared to positive control chloramphenicol. Flower and stem oils both showed cytotoxicity to Vibrio fischeri.
Journal of Oleo Science, Jun 1, 2010
Water-distilled essential oils from flowers and stems of Tanacetum argyrophyllum var. argyrophyll... more Water-distilled essential oils from flowers and stems of Tanacetum argyrophyllum var. argyrophyllum from Turkey were analyzed by GC and GC/MS. The flower oil of T. argyrophyllum var. argyrophyllum was characterized with camphor 29.7%, borneol 12.0%, 1,8-cineole 8.4% and bornyl acetate 6.1%. Stem oil was characterized with camphor 26.6%, 1,8-cineole 17.5%, and borneol 15.0%. Our previous research and literature on the essential oil of this plant reported oils with high thujone content unlike the present study. Antibacterial activity of the oils were evaluated for five Gram-positive and five Gram-negative bacteria by using a broth microdilution assay. The highest inhibitory activity was observed against Bacillus cereus for stem oil (125 g/mL) when compared with positive control chloramphenicol it showed the same inhibition potency. However, the same oil showed lower inhibitory activity against B. subtilis. The flower oil did not show significant activity against the tested microorganisms. DPPH radical scavenging activity of the T. argyrophyllum var. argyrophyllum oil was investigated at 15 and 10 mg/mL concentrations. However, the oils did not show any significant activity when compared to positive control -tocopherol. Both of the oils showed toxicity to Vibrio fischeri in the TLC-bioluminescence assay.
Planta Medica, Oct 1, 2000
The fruits of endemic Prangos uechtritzii Boiss. & Hausskn. (Umbelliferae) were subjected... more The fruits of endemic Prangos uechtritzii Boiss. & Hausskn. (Umbelliferae) were subjected to hydrodistillation and microdistillation. The resulting volatiles were investigated by GC-MS to determine the composition of the essential oils. 109 compounds representing 86.7% and thirty-two compounds representing 90.0% were identified and isolated by two different techniques, respectively. Column chromatography of the essential oil yielded a new bisabolene ether (7-epi-1,2-dehydrosesquicineole), which was characterized by spectral methods (GC-FTIR, 1D-, 2D NMR and HRESIMS).
Natural Product Communications, 2013
Isophorone (3,5,5-trimethyl-2-cyclohexen-1-one), a monoterpene, and the structurally related 1,8-... more Isophorone (3,5,5-trimethyl-2-cyclohexen-1-one), a monoterpene, and the structurally related 1,8-cineole and camphor, have demonstrated a protective effect against cancer, biological activity against a variety of microorganisms, and anti-oxidant properties. The derivatization of isophorone is, therefore, an important field of xenobiochemistry, pharmacology and toxicology. The aim of this study was to obtain derivatives of isophorone through microbial biotransformation and evaluate the biotransformation metabolites as potential antimicrobial agents. Incubation of isophorone with the fungi Alternaria alternata and Neurospora crassa afforded 4a-hydroxy- and 7-hydroxy-isophorone as transformation metabolites. The antimicrobial activities of isophorone and the metabolites were evaluated in vitro both by using agar dilution and microdilution methods. However, no significant antibacterial activity was observed when compared with those of standard substances.
Zeitschrift Fur Naturforschung C, 2001
Letters in Drug Design Amp Discovery, 2014
ABSTRACT The synthesis of twelve new pyrimidine hydrazone derivatives and subsequent evaluation o... more ABSTRACT The synthesis of twelve new pyrimidine hydrazone derivatives and subsequent evaluation of their antimicrobial activities were the aims of this present work. The intermediate product 2-[(pyrimidin-2-yl)thio]acetohydrazide was refluxed with different aromatic aldehydes/ketones in ethanol to yield N’-(arylidene)-2-[(pyrimidine-5-yl)thio]- acetohydrazide derivatives (3a-l). The structures of the compounds were elucidated by NMR, FTIR, MS, and elemental analyses. Additionally the final compounds (3a-l) were evaluated for their antimicrobial activity using a microdilution method against a panel of pathogenic Gram positive, Gram negative, and fungus strains, i.e. Escherichia coli, Pseudomonas aeruginosa, Salmonella typhimurium, Bacillus cereus, Bacillus subtilis, Serrratia marcescens, Staphylococcus epidermidis, and Candida utilis. Compound N’-(2-pyrilidene)-2-[(pyrimidine-5-yl)thio]acetohydrazide (3a) possessing a 2- pyridyl moiety was found to be the most active (MIC= 31.25-250 µg/mL) derivative toward the tested microorganisms.
The synthesis of a new series of 1-[(benzazole-2-yl)thioacetyl]-3,5-diaryl-2-pyrazoline derivativ... more The synthesis of a new series of 1-[(benzazole-2-yl)thioacetyl]-3,5-diaryl-2-pyrazoline derivatives was obtained by reacting 1-(chloroacetyl)-3,5-diaryl-pyrazolines with 2-mercaptobenzimidazole/benzoxazole/benzothiazole. The chemical structures of the compounds were elucidated by (1)H-NMR, (13)C-NMR, and FAB(+)-MS spectral data. Their antifungal activities against Candida albicans, Candida glabrata, Candida utilis, Candida tropicalis, Candida krusei, and Candida parapsilosis were investigated. A significant level of activity was observed.
Planta Medica, Jul 1, 2002
Essential oil obtained by micro-distillation and hydrodistillation of the endemic Ferulago thirke... more Essential oil obtained by micro-distillation and hydrodistillation of the endemic Ferulago thirkeana (Boiss.) Boiss. (Apiaceae) was analysed by GC/MS. An unknown component isolated from the essential oil was characterized by chromato-spectral techniques (1D-, 2D-NMR, HRMS, IR and UV) as (1 S)-2,6,6-trimethyl-4-oxobicyclo[3.1.1]hept-2-enyl(2 E)-2-methylbut-2-enoate (= ferulagone or 1-angeloyloxyverbenone) (1). Biological activities of the essential oil and the purified major component (1) were tested against various human pathogenic microorganisms resulting in moderate inhibition (62.5 - 125 microg/ml).
Natural Product Communications, May 1, 2011
Public reporting burden for the collection of information is estimated to average 1 hour per resp... more Public reporting burden for the collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden, to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to a penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number.
Zeitschrift Fur Naturforschung C, 2004
The cyclic monoterpene ketone (Ð)-carvone was metabolized by the plant pathogenic fungus Absidia ... more The cyclic monoterpene ketone (Ð)-carvone was metabolized by the plant pathogenic fungus Absidia glauca. After 4 days of incubation, the diol 10-hydroxy-(+)-neodihydrocarveol was formed. The absolute configuration and structure of the crystalline substance was identified by means of X-ray diffraction and by spectroscopic techniques (MS, IR and NMR). The antimicrobial activity of the substrate and metabolite was assayed with human pathogenic microorganisms.
Flavour and Fragrance Journal, Nov 1, 2000
FLAVOUR AND FRAGRANCE JOURNAL Flavour Fra`r[ J[ 1999^ 04] 277289 "1999# ... Essential oil c... more FLAVOUR AND FRAGRANCE JOURNAL Flavour Fra`r[ J[ 1999^ 04] 277289 "1999# ... Essential oil constituents of the spice Cinnamomum tamala ... Aftab Ahmed1, M. Iqbal Choudhary2, Afgan Farooq2, Betu® l Demirci3, Fatih Demirci3, and K. Hu® snu® Can Baser3
Anadolu University Journal of Science and Technology C Life Sciences and Biotechnology, Jun 7, 2011
... Mehlika Dilek ALTINTOP 1 , Fatih DEMİRCİ2 ... In the past years, some azole derivatives were ... more ... Mehlika Dilek ALTINTOP 1 , Fatih DEMİRCİ2 ... In the past years, some azole derivatives were devel-oped as novel antimicrobial agents, for example, Linezolid and Eperezolid are currently used for the treatment of multidrug-resistant Gram-positive infections (Bayrak et al. ...
Journal of Enzyme Inhibition and Medicinal Chemistry, Sep 1, 2008
The increasing clinical importance of drug-resistant fungal pathogens has urged additional need t... more The increasing clinical importance of drug-resistant fungal pathogens has urged additional need to fungal research and new antifungal compound development. For this purpose, some N-(1-benzyl-2-phenylethylidene)-N'-[4-(aryl)thiazol-2-yl]hydrazone (1a-e) and N-(1-phenylbutylidene)-N'-[4-(aryl)thiazol-2-yl]hydrazone (2a-e) derivatives were synthesised and evaluated for antifungal activity. Their antifungal activities against standard and clinical strands of Candida albicans, Candida glabrata, Candida utilis, Candida tropicalis, Candida krusei, Candida zeylanoides, and Candida parapsilosis were investigated. A significant level of activity was observed.
Natural Product Communications, Sep 1, 2010
Turkish Journal of Chemistry, Sep 3, 2014
Http Dx Doi Org 10 1080 10412905 2006 9699194, Nov 28, 2011
Hypericum bupleuroides Griseb. (Guttiferae) was collected from the north eastern region of Turkey... more Hypericum bupleuroides Griseb. (Guttiferae) was collected from the north eastern region of Turkey. The aerial parts were subjected to microdistillation for the isolation of volatiles that were subsequently analyzed by GC and GC/MS. The investigation resulted in the characterization of 30 components representing 92% of the total volatiles. Sesquiterpenes such as β-sesquiphellandrene (33.2%) and β-caryophyllene (20.2%) were assigned as major compounds.
Records of Natural Products, 2012
Water-distilled essential oils from aerial parts of Tanacetum densum (L.) Heywood ssp. eginense H... more Water-distilled essential oils from aerial parts of Tanacetum densum (L.) Heywood ssp. eginense Heywood, from Turkey was analysed by GC and GC-MS. T. densum ssp. eginense flower, stem and leaf oils were characterized with camphor (30.9% , 25.7%, 27.7%), 1,8-Cineole (12.4% flower oil), camphene (10.6%, %7.0, flower and leaf oils), bornyl acetate, (9.4%, 11.8%, stem and leaf oils), α-pinene (7.0%, %5.3, flower and leaf oils), borneol (5.1%, 5.2%, stem and leaf oils), neodihydrocarveol (5.1%, flower oil). An unidentified compound was also present in flower, stem and leaf oils (11.5%, 27.2%, 20.5%). A comparison is done with the previous investigations on the other subspecies of T. densum and the differences were investigated. Flower and stem oils did not show any significant activity to the tested microorganisms when compared to positive control chloramphenicol. Flower and stem oils both showed cytotoxicity to Vibrio fischeri.
Journal of Oleo Science, Jun 1, 2010
Water-distilled essential oils from flowers and stems of Tanacetum argyrophyllum var. argyrophyll... more Water-distilled essential oils from flowers and stems of Tanacetum argyrophyllum var. argyrophyllum from Turkey were analyzed by GC and GC/MS. The flower oil of T. argyrophyllum var. argyrophyllum was characterized with camphor 29.7%, borneol 12.0%, 1,8-cineole 8.4% and bornyl acetate 6.1%. Stem oil was characterized with camphor 26.6%, 1,8-cineole 17.5%, and borneol 15.0%. Our previous research and literature on the essential oil of this plant reported oils with high thujone content unlike the present study. Antibacterial activity of the oils were evaluated for five Gram-positive and five Gram-negative bacteria by using a broth microdilution assay. The highest inhibitory activity was observed against Bacillus cereus for stem oil (125 g/mL) when compared with positive control chloramphenicol it showed the same inhibition potency. However, the same oil showed lower inhibitory activity against B. subtilis. The flower oil did not show significant activity against the tested microorganisms. DPPH radical scavenging activity of the T. argyrophyllum var. argyrophyllum oil was investigated at 15 and 10 mg/mL concentrations. However, the oils did not show any significant activity when compared to positive control -tocopherol. Both of the oils showed toxicity to Vibrio fischeri in the TLC-bioluminescence assay.
Planta Medica, Oct 1, 2000
The fruits of endemic Prangos uechtritzii Boiss. & Hausskn. (Umbelliferae) were subjected... more The fruits of endemic Prangos uechtritzii Boiss. & Hausskn. (Umbelliferae) were subjected to hydrodistillation and microdistillation. The resulting volatiles were investigated by GC-MS to determine the composition of the essential oils. 109 compounds representing 86.7% and thirty-two compounds representing 90.0% were identified and isolated by two different techniques, respectively. Column chromatography of the essential oil yielded a new bisabolene ether (7-epi-1,2-dehydrosesquicineole), which was characterized by spectral methods (GC-FTIR, 1D-, 2D NMR and HRESIMS).
Natural Product Communications, 2013
Isophorone (3,5,5-trimethyl-2-cyclohexen-1-one), a monoterpene, and the structurally related 1,8-... more Isophorone (3,5,5-trimethyl-2-cyclohexen-1-one), a monoterpene, and the structurally related 1,8-cineole and camphor, have demonstrated a protective effect against cancer, biological activity against a variety of microorganisms, and anti-oxidant properties. The derivatization of isophorone is, therefore, an important field of xenobiochemistry, pharmacology and toxicology. The aim of this study was to obtain derivatives of isophorone through microbial biotransformation and evaluate the biotransformation metabolites as potential antimicrobial agents. Incubation of isophorone with the fungi Alternaria alternata and Neurospora crassa afforded 4a-hydroxy- and 7-hydroxy-isophorone as transformation metabolites. The antimicrobial activities of isophorone and the metabolites were evaluated in vitro both by using agar dilution and microdilution methods. However, no significant antibacterial activity was observed when compared with those of standard substances.
Zeitschrift Fur Naturforschung C, 2001
Letters in Drug Design Amp Discovery, 2014
ABSTRACT The synthesis of twelve new pyrimidine hydrazone derivatives and subsequent evaluation o... more ABSTRACT The synthesis of twelve new pyrimidine hydrazone derivatives and subsequent evaluation of their antimicrobial activities were the aims of this present work. The intermediate product 2-[(pyrimidin-2-yl)thio]acetohydrazide was refluxed with different aromatic aldehydes/ketones in ethanol to yield N’-(arylidene)-2-[(pyrimidine-5-yl)thio]- acetohydrazide derivatives (3a-l). The structures of the compounds were elucidated by NMR, FTIR, MS, and elemental analyses. Additionally the final compounds (3a-l) were evaluated for their antimicrobial activity using a microdilution method against a panel of pathogenic Gram positive, Gram negative, and fungus strains, i.e. Escherichia coli, Pseudomonas aeruginosa, Salmonella typhimurium, Bacillus cereus, Bacillus subtilis, Serrratia marcescens, Staphylococcus epidermidis, and Candida utilis. Compound N’-(2-pyrilidene)-2-[(pyrimidine-5-yl)thio]acetohydrazide (3a) possessing a 2- pyridyl moiety was found to be the most active (MIC= 31.25-250 µg/mL) derivative toward the tested microorganisms.
The synthesis of a new series of 1-[(benzazole-2-yl)thioacetyl]-3,5-diaryl-2-pyrazoline derivativ... more The synthesis of a new series of 1-[(benzazole-2-yl)thioacetyl]-3,5-diaryl-2-pyrazoline derivatives was obtained by reacting 1-(chloroacetyl)-3,5-diaryl-pyrazolines with 2-mercaptobenzimidazole/benzoxazole/benzothiazole. The chemical structures of the compounds were elucidated by (1)H-NMR, (13)C-NMR, and FAB(+)-MS spectral data. Their antifungal activities against Candida albicans, Candida glabrata, Candida utilis, Candida tropicalis, Candida krusei, and Candida parapsilosis were investigated. A significant level of activity was observed.
Planta Medica, Jul 1, 2002
Essential oil obtained by micro-distillation and hydrodistillation of the endemic Ferulago thirke... more Essential oil obtained by micro-distillation and hydrodistillation of the endemic Ferulago thirkeana (Boiss.) Boiss. (Apiaceae) was analysed by GC/MS. An unknown component isolated from the essential oil was characterized by chromato-spectral techniques (1D-, 2D-NMR, HRMS, IR and UV) as (1 S)-2,6,6-trimethyl-4-oxobicyclo[3.1.1]hept-2-enyl(2 E)-2-methylbut-2-enoate (= ferulagone or 1-angeloyloxyverbenone) (1). Biological activities of the essential oil and the purified major component (1) were tested against various human pathogenic microorganisms resulting in moderate inhibition (62.5 - 125 microg/ml).