Canan Çelik | Ankara University (original) (raw)
Papers by Canan Çelik
Archives of Rheumatology, 2018
The European Research Journal, 2018
Turkish Neurosurgery, 2015
factors may overlap. Of these factors, psychosocial factors such as depression, poor coping, anxi... more factors may overlap. Of these factors, psychosocial factors such as depression, poor coping, anxiety, somatization, and hypochondriasis have been associated with the development of FBSS (5,17). It may also be considered as a part of a biopsychosocial problem. Additionally, secondary gain, loss of employment or inability to work may contribute to the decreased quality of life and coping with pain, and may result in an increase in disability. Although the ideal timing of the █ INTRODUCTION F ailed back surgery syndrome (FBSS) is defined as persistent low back and/or leg pain after spinal surgery. The incidence of FBSS ranges between 10% and 40% and can increase up to 50% in microlaminectomy series (5, 31,32). The underlying causes of persistent postsurgical pain may be related to perioperative factors, and further, these AIm: Some psychometric properties may predict the development of failed back surgery syndrome (FBSS). The aim of this study was to determine the pain, disability, and depression severity in patients diagnosed with FBSS, and to determine the temperament and character subgroups in comparison with control group. mATERIAl and mEThODS: Thirty-eight patients diagnosed with FBSS, and 35 patients with favourable outcome after lumbar spinal surgery were included to the study. Pain intensity, disability, depression scores, temperament and character profile were determined by the visual analogue scale (VAS),
Aim: This study was planned in order to answer the question whether the development of heterotopi... more Aim: This study was planned in order to answer the question whether the development of heterotopic ossification (HO) following spinal cord injury (SCI) can be estimated by human leukocyte antigens (HLA). Methods: Major Histocompatibility Complex (MHC) class I molecules of heterotopic ossification patients with SCI (20 patients) was compared with 20 healthy controls. The typing of the histocompatibility antigens was performed using the microcytotoxicity test. Results: The HLA A2 locus was present in 11 patients (36.7%), while this ratio was 28.9% in the control group. While HLA A28 locus was present in 4 patients (13.3%), this ratio was 2.6% in the control group. The presence of HLA B18 locus in the patient group was less than the ratio seen in the control group. When these HLA types were analyzed in the study groups, there was no statistically significant difference in between these groups. Conclusion: It was concluded that MHC class I molecules were not predictive of HO development in
Ege Tıp Dergisi, 2015
Amaç: Kardiyovasküler (KVS) hastalıklar, dünya çapında önde gelen ölüm sebeplerindendir. Epidemiy... more Amaç: Kardiyovasküler (KVS) hastalıklar, dünya çapında önde gelen ölüm sebeplerindendir. Epidemiyolojik çalışmalarda serum 25 Hidroksi D vitamini (25-OH D) ile KVS hastalık risk faktörlerinden olan lipid profili arasında negatif korelasyon olduğu gösterilmiştir. Bununla birlikte 25-OH D vitamin düzeyi ile hastalık arasındaki ilişkinin nedensel olup olmadığı veya sadece yaşam tarzı ile ilişkili bir belirteç olduğu durumu belirsizdir. Vitamin D takviyesinin serum lipid profili üzerine etkileri araştıran plasebo kontrollü çalışmalar farklı sonuçlar vermiştir. Bu çalışmanın amacı serum vitamin D konsantrasyonu ile lipid profili arasındaki ilişkiyi araştırmaktır. Gereç ve Yöntem: Fiziksel Tıp ve Rehabilitasyon polikliniğine ağrı şikayetiyle başvuran 204 hasta çalışmaya dahil edildi. Hastaların demografik özellikleri kaydedildi. Açlık serum 25-OH D vitamini, total kolesterol, LDL, HDL ve trigliserid konsantrasyonları ölçüldü. Bulgular: Hastaların ortalama 25-OH D düzeyleri 10.6±6.5 ng/mL, D vitamini eksikliği prevalansı %92.2 idi. Hastalar 25-OH D vitamin düzeylerine göre <20 ng/mL, 20-30 ng/mL ve >30 ng/mL olmak üzere 3 gruba ayrıldı. Yüksek D vitamini konsantrasyonu olan hastalarda D vitamini eksikliği olan hastalara göre serum total kolesterol, TG ve LDL düzeyleri düşük ve HDL düzeyi daha yüksek olmasına rağmen, bu fark istatistiksel olarak anlamlı değildi (p > 0.05). Sonuç: D vitamini eksikliği prevalansı ve uygun olmayan lipid profilinin olumsuz etkileri göz önüne alındığında, yüksek riskli toplumlarda D vitamini durumunun incelenmesi, düzeltilmesi ve korunmasının uygun olacağı görüşündeyiz.
TURKISH JOURNAL OF MEDICAL SCIENCES, 2019
Türk Osteoporoz Dergisi, 2017
Karahan ve ark. D Vitamin ve Kas İskelet Sistemi Ağrıları Öz Objective: In this study, it was aim... more Karahan ve ark. D Vitamin ve Kas İskelet Sistemi Ağrıları Öz Objective: In this study, it was aimed to evaluate the relationship between vitamin D level and pain severity, localization and duration in patients with non-specific musculoskeletal pain. Materials and Methods: Patients who applied to physical medicine and rehabilitation outpatient clinics due to non-specific muscle pain in 19 centers in Turkey were retrospectively screened. Three thousand four hundred fourpatients were included in the study, whose pain level was determined by visual analog scale (VAS) and the painful region, duration of pain and vitamin D level were reached. D group was found to be D deficient (group 1) when 25 (OH)D level was 20 ng/mL or less and group D 2 (vitamin D deficiency) was higher than 30 ng/mL (group 3). The groups were compared in terms of pain duration, localization and severity. In addition, the correlations of pain localization, severity and duration with vitamin D levels were examined. Results: D vitamin deficiency was detected in 2202 (70.9%) of 3 thousand four hundred and four registered patients, and it was found that vitamin D deficiency in 516 (16.6%) and normal vitamin D in 386 (12.4%). The groups were similar in terms of age, body mass index, income level, duration of complaint, education level, family type and working status (p>0.05). There was no statistically significant difference between groups in terms of VAS, pain localization and duration scores (p>0.05). Conclusion: Our study shows that vitamin D deficiency in patients with nonspecific musculoskeletal pain is not associated with the severity and duration of pain.
International Physical Medicine & Rehabilitation Journal, 2017
Parkinson's disease (PD) is often associated with cognitive impairment and frequent falls. Althou... more Parkinson's disease (PD) is often associated with cognitive impairment and frequent falls. Although the cause of frequent falls is not clearly understood, cognitive impairment is thought to be the cause of frequent falls and these frequent falls can lead to serious complications such as traumatic arthritis. Traumatic arthritis is a wellknown condition that develops in the joints as a result of recurrent trauma. Here we presented a 61-year-old female patient with PD who suffered from severe pain, limitation, swelling, temperature increase and erythema of right knee also difficulty of gait. In the result of all the detailed evaluations made, conservative treatment-resistant traumatic monoarthritis and osteonecrosis were diagnosed due to recurrent falls of the patient and the patient was directed to surgical treatment. The patient's falls were ongoing due to cognitive impairment and PD and she continued to suffer from pain and swelling despite performing unicompartmental (lateral compartment) knee arthroplasty. As a result of consultations with orthopaedists we decided to perform a total knee arthroplasty on the patient. After surgery, the patient was admitted to our rehabilitation clinic for orthopedic and PD rehabilitation program. During the rehabilitation program, the symptoms of swelling and pain in the patient's knee improved and the frequency of falls decreased. The patient's rehabilitation program still continues in our clinic.
The European Research Journal, 2019
Türk Osteoporoz Dergisi, 2017
Objective: The aim of the study was to evaluate cognitive functioning in adult women with low lev... more Objective: The aim of the study was to evaluate cognitive functioning in adult women with low level vitamin D and to investigate the relationship between vitamin D and cognitive functioning. Materials and Methods: Seventy-one women patients aged 18-50 with 25-OH vitamin D 3 level <30 ng/mL referred to outpatient clinic were enrolled in the study. 25-OH vitamin D 3 level, calcium, phosphate, alkaline phosphatase, parathyroid hormone (PTH) blood levels were studied in all the patients. Mini Mental State Examination (MMSE) and Montreal Cognitive Assessment (MOCA) were used to assess cognitive functioning. The patients were divided into 2 groups according to vitamin D levels: <10 ng/mL (group 1, n=34) and between 11-29 ng/mL (group 2, n=37). Results: There was no significant difference between the group 1 and 2 for demographic and clinical characteristics except for vitamin D and PTH (p>0.05). Patients in group 1 had their vitamin D levels significantly lower and PTH levels higher than group 2 (p<0.05). There was no significant difference in MOCA and MMSE scores between the groups (p>0.05). Although there was a relationship between education and MOCA and MMSE scores, we didn't find any significant relationship between age and vitamin D levels and MOCA and MMSE scores. Conclusion: Although approximately 50% of adult women whose vitamin D levels were low had reduced cognitive function, there was no relationship between vitamin D levels and cognitive functions.
Noro Psikiyatri Arsivi, 2017
Introduction: Cerebral palsy (CP) is the most common significant motor impairment in childhood. C... more Introduction: Cerebral palsy (CP) is the most common significant motor impairment in childhood. CP is defined as a primary disorder of posture and movement; however, intellectual impairment is prevalent in children with CP. The purpose of this study was to examine the intelligence level associated with gross motor function and hand function, type of CP, the presence of comorbid disorders such as epilepsy, and other factors. Methods: In total, 107 children with CP were included. Age, gender, prenatal/natal/postnatal risk factors, type of CP, and presence of other neurodevelopmental disorders were recorded as demographic findings. Intellectual functions of the patients were determined by clinical assessment, adaptive function of daily life, and individualized, standardized intelligence testing. The gross motor function and hand function of the patients were classified using the "Gross Motor Function Classification System" and "Bimanual Fine Motor Function" measurements, respectively. Results: The mean age of the patients was 8.10±3.43 years (2-16 years). The study included 63 (58.9%) male patients and 44 (41.1%) female patients. During clinical typing, 80.4% of the patients were spastic, 11.2% were mixed, 4.7% were dyskinetic, and 3.7% were ataxic. Intellectual functioning tests found 26.2% of the children within the intellectual norm and that 10% of the children had a borderline intellectual disability, 16% of them had a mild intellectual disability, 17% of them had a moderate intellectual disability, and 30.8% of them had a severe intellectual disability. No significant relationship was determined between the CP type and intellectual functioning (p>0.05). Intellectual functioning was found to be significantly correlated with hand functions and motor levels (p<0.001). Factors related with intellectual functioning were neonatal convulsion, epilepsy, and speech disorders. Conclusion: Intelligence assessment should be an essential part of CP evaluation and research. There is not enough reliable knowledge, unanimity regarding validity data, and population-specific norms in the intelligence assessments of children with CP. Research is required to assess properly intelligence for children with CP.
Türk Osteoporoz Dergisi, 2016
Journal of Stroke and Cerebrovascular Diseases, 2015
NeuroRehabilitation, 2011
Critical illness polyneuropathy (CIP) is defined as a common complication of critically ilness pa... more Critical illness polyneuropathy (CIP) is defined as a common complication of critically ilness patients who were admitted to the intensive care unit due to sepsis, multiple trauma and/or multi-organ failure. We aimed to present a patient who was diagnosed as CIP. He was admitted to our outpatient clinic due to weakness and pain in his lower extremities. He had been followed in an intensive care unit due to suicid five months ago. There were symmetrically and predominantly muscle weakness, sensory impairment, absence of deep tendon reflexes in his lower extremities. Electrophysiological evaluation demonstrated motor and sensory axonal distal polyneuropathy predominantly in lower extremities. At follow up, he had high fever, and elevated acute phase responses. Therefore source of infection was investigated and was suspected to a diagnosis of infective endocarditis. He was discharged to be hospitalized in cardiology clinic. With this case, we think that physiatrists should take into co...
Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi, 2011
Sum mary Bardet-Biedl syndrome is an autosomal recessive disorder characterized by rod-cone dystr... more Sum mary Bardet-Biedl syndrome is an autosomal recessive disorder characterized by rod-cone dystrophy of the retina, mental retardation, obesity, polydactyly and hypogonadism, as well as renal abnormalities. Laurence-Moon syndrome, as a distinct entity, is rare and the features include spastic paraplegia in the absence of polydactyly, obesity, and renal involvement, though cranial symptoms are very unusual. We aimed to report a patient who exhibited characteristic features of Bardet-Biedl syndrome in addition to brachial amyotrophy, and cerebellar and cerebral cortical atrophy.
Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi, 2010
Su um mm ma ar ry y O Ob bj je ec ct ti iv ve e: : Sexual dysfunction (SD) is an important, but g... more Su um mm ma ar ry y O Ob bj je ec ct ti iv ve e: : Sexual dysfunction (SD) is an important, but generally underestimated symptom in the course of multiple sclerosis (MS). The aim of this study was to investigate the factors related to SD in MS patients. M Ma at te er ri ia al ls s a an nd d M Me et th ho od ds s: : Twenty-one MS patients with and 21 MS patients without SD were included in this study. Age, SD duration, disease duration, marital status, educational status, bladder and bowel dysfunction, disability, independence, cognitive performances and psychological functioning and sexual function scales have also been assessed. R Re es su ul lt ts s: : SD correlated with age (p=0.029), disease duration (p=0.045), bladder dysfunction (X 2 =0.011; p=0.012). Positive correlations were found between disease duration and 5-point sexual function scale in SD patient (rs=0.419; p=0.027). However, SD did not correlated with bowel dysfunction (X 2 =0.469; p=0.418), disability (p=0.190), level of independence (p=0.146) and cognitive performances (p=0.212). The brain stem involvement was higher in patients with SD (X 2 =0.001; p=0.001). C Co on nc cl lu us si io on n: : The prevalence of SD increases with the patient age and prolonged disease duration. SD is related to bladder dysfunction and brain stem involvement. However, increased disability does not affect SD. Turk J Phys Med Rehab 2010;56:130-4. K Ke ey y W Wo or rd ds s: : Multiple sclerosis, sexual dysfunction Ö Öz ze et t A Am ma aç ç: : Seksüel disfonksiyon (SD), multipl skleroz (MS) seyri s›ras›nda görülen ancak genellikle gözard› edilen bir semptomdur. Bu çal›flman›n amac› MS'li hastalarda görülen SD ile iliflkili faktörlerin araflt›r›lmas›d›r. G Ge er re eç ç v ve e Y Yö ön nt te em m: : Çal›flmaya MS'ye ba¤l› SD'si bulunan 21 hasta ve bulunmayan 21 hasta dahil edildi. Yafl, SD süresi, hastal›k süresi, medeni durum, e¤itim durumu, mesane ve barsak disfonksiyonu varl›¤›, disabilite, konginitif performans, psikolojik fonksiyonlar ve seksüel durum de¤erlendirildi. B Bu ul lg gu ul la ar r: : SD varl›¤›; yafl, hastal›k süresi ve mesane disfonksiyonu varl›¤› ile koreleydi (s›ras›yla p=0,029, p=0,045, X 2 =0,011; p=0,012). Hastal›k süresi ve 5 puanl›k seksüel fonksiyon skalas› aras›nda, SD olan hastalarda pozitif korelasyon bulundu (rs=0,419; p=0,027). Buna ra¤men SD varl›¤› ile barsak disfonksiyonu varl›¤› (X 2 =0,469; p=0,418), disabilite düzeyi (p=0,190) ve kognitif performans (p=0,212) düzeyi korele bulunmad›. SD'lu hastalarda beyin sap› tutulumu daha yüksekti (X 2 =0,001; p=0,001). S So on nu uç ç: : SD s›kl›¤› hasta yafl› ve hastal›k süresi art›kça artmaktad›r. SD mesane disfonksiyonu ve beyin sap› tutulumu ile iliflkilidir. Ancak disabilite düzeyinin artmas› SD'nin görülme s›kl›¤›nda art›fla neden olmamaktad›r.
Türkiye Fiziksel Tip ve Rehabilitasyon Dergisi, 2014
Amaç: Omurilik yaralanmalı bireylerin rehabilitasyonunda kalça diz ayak bileği ayak ortezi, metal... more Amaç: Omurilik yaralanmalı bireylerin rehabilitasyonunda kalça diz ayak bileği ayak ortezi, metal veya plastik ayak bileği-ayak ortezi, posterior shell gibi ortezler, koltuk değneği, kanadyen, walker, baston gibi el destekleri, lokomasyonu sağlayan tekerlekli iskemleler sıkça kullanılmaktadır. Bu çalışmada hastanede rehabilitasyon uygulanmış omurilik yaralanmalı bireylerin, taburculuk sonrasındaki ortez kullanımı alışkanlıklarını değerlendirmeyi ve ortezlerle ilgili yaşanan sorunları ortaya koymayı amaçladık. Gereç ve Yöntemler: İlk olarak yetmiş bir hastanın hastane kayıtları incelendi. Telefonla ulaşılabilen 46 hastayla [34 erkek (%74), 12 kadın (%26)] sorgulama formuna dayanarak görüşüldü. Bulgular: Yaşları (ortalama±SD), 35±12,9 yıl; olay süreleri 43±27 aydı. Ortalama ortez kullanım indeksi (ortez kullanım süresi/ortezin reçete edilme süresi) 0,7±0,3'tü. Ortez verilmiş 41 hastadan ortezini kullananların oranı %73 (n:30), kullanmayanların oranı ise %27 (n:11) idi. Ortez bırakma oranı, inkomplet omurilik yaralanmalı hastalarla (%82) komplet yaralanmalılar (%18) karşılaştırıldığında belirgin olarak yüksekti (p=0,038). Ortezde değişiklik yapma oranı ortezini kullanan grupta (%53) ortezini kullanmayanlara (%9) göre belirgin yüksekti (p=0,014). Lojistik regresyon analizinde sakral korunmanın varlığı ortez kullanımını azaltıcı yönde etkili bulundu (p=0,040). Ortezi bırakma nedenlerinin çoğunluğu spastisite, ortezin sıkı veya eskimiş olması, psikolojik rahatsızlık gibi değiştirilebilir nedenlerdi. Sonuç: Bizim sonuçlarımız, sakral korunması olan hastaların ortez kullanımını sonlandırma ihtimallerinin daha fazla olabildiğini ve ortezlerde yapılan değişikliklerin ortezini düzenli kullanan hastalar için bir gereklilik olduğunu düşündürmektedir. Tekerlekli sandalye, ambulasyonun temel şeklidir ve omurilik yaralanmalı hastalar tarafından düzenli olarak kullanılmaktadır.
Spine, 2010
Study Design. Case report. Objectives. To report a case with paraplegia caused by spinal hydatid ... more Study Design. Case report. Objectives. To report a case with paraplegia caused by spinal hydatid cyst. Summary of Background Data. Hydatid cyst is a disease caused by larval Echinococcus granulosus tapeworm. Spinal hydatid cyst rarely leads to severe neurologic problems. Methods. A 34-year-old male patient was referred to our outpatient clinic due to back and low back pain, progressive weakness and numbness in both lower extremities, and a prediagnosis of lumbar disc hernia. He had spastic paraplegia, and thorax magnetic resonance imaging revealed a lobulated cystic lesion with extradural intraspinal localization. Results. After surgery and following 2 months of rehabilitation program, the patient showed a dramatic clinical improvement. Conclusion. By this case, it is emphasized that spinal hydatid cyst should come to mind in the differential diagnosis of spinal cord compression, and the importance of prevention, early diagnosis, and treatment is highlighted because of high mortality and morbidity.
Rheumatology International, 2005
The pathogenesis of reflex sympathetic dystrophy (RSD) is not completely understood. However, an ... more The pathogenesis of reflex sympathetic dystrophy (RSD) is not completely understood. However, an excessive regional inflammation, sensitization of primary somatosensory afferents, and sensitization of spinal neurons are considered to have a role in the pathogenesis of RSD. The underlying pathophysiology relating the clinical picture may help to determine the pharmacotherapeutic approach for an individual patient. Scintigraphy using radiolabelled human polyclonal non-specific immunoglobulin (HIG) has been recognized as a useful tool for the localization of inflammatory disorders. Thirty-six consecutive RSD patients associated with hemiplegia were included in this study. All the patients in this study had three phases bone scan and Tc-99m HIG scintigraphy. On admission, of 36 patients with positive bone scan, 30 had positive Tc-99m HIG scan. All the patients were symptomatic at the time of bone scanning. On the contrary, 24 out of 36 patients subsequently became asymptomatic at an 8-month re-evaluation period. Tc-99m HIG scintigraphy is a non-invasive complementary method for the determination of ongoing inflammatory reactions which also aids the clinicians to predict the response to anti-inflammatory therapy at the very early phase of RSD associated with hemiplegia. This preliminary study may be a source of inspiration for further studies with larger series and longer follow-up .
Archives of Rheumatology, 2018
The European Research Journal, 2018
Turkish Neurosurgery, 2015
factors may overlap. Of these factors, psychosocial factors such as depression, poor coping, anxi... more factors may overlap. Of these factors, psychosocial factors such as depression, poor coping, anxiety, somatization, and hypochondriasis have been associated with the development of FBSS (5,17). It may also be considered as a part of a biopsychosocial problem. Additionally, secondary gain, loss of employment or inability to work may contribute to the decreased quality of life and coping with pain, and may result in an increase in disability. Although the ideal timing of the █ INTRODUCTION F ailed back surgery syndrome (FBSS) is defined as persistent low back and/or leg pain after spinal surgery. The incidence of FBSS ranges between 10% and 40% and can increase up to 50% in microlaminectomy series (5, 31,32). The underlying causes of persistent postsurgical pain may be related to perioperative factors, and further, these AIm: Some psychometric properties may predict the development of failed back surgery syndrome (FBSS). The aim of this study was to determine the pain, disability, and depression severity in patients diagnosed with FBSS, and to determine the temperament and character subgroups in comparison with control group. mATERIAl and mEThODS: Thirty-eight patients diagnosed with FBSS, and 35 patients with favourable outcome after lumbar spinal surgery were included to the study. Pain intensity, disability, depression scores, temperament and character profile were determined by the visual analogue scale (VAS),
Aim: This study was planned in order to answer the question whether the development of heterotopi... more Aim: This study was planned in order to answer the question whether the development of heterotopic ossification (HO) following spinal cord injury (SCI) can be estimated by human leukocyte antigens (HLA). Methods: Major Histocompatibility Complex (MHC) class I molecules of heterotopic ossification patients with SCI (20 patients) was compared with 20 healthy controls. The typing of the histocompatibility antigens was performed using the microcytotoxicity test. Results: The HLA A2 locus was present in 11 patients (36.7%), while this ratio was 28.9% in the control group. While HLA A28 locus was present in 4 patients (13.3%), this ratio was 2.6% in the control group. The presence of HLA B18 locus in the patient group was less than the ratio seen in the control group. When these HLA types were analyzed in the study groups, there was no statistically significant difference in between these groups. Conclusion: It was concluded that MHC class I molecules were not predictive of HO development in
Ege Tıp Dergisi, 2015
Amaç: Kardiyovasküler (KVS) hastalıklar, dünya çapında önde gelen ölüm sebeplerindendir. Epidemiy... more Amaç: Kardiyovasküler (KVS) hastalıklar, dünya çapında önde gelen ölüm sebeplerindendir. Epidemiyolojik çalışmalarda serum 25 Hidroksi D vitamini (25-OH D) ile KVS hastalık risk faktörlerinden olan lipid profili arasında negatif korelasyon olduğu gösterilmiştir. Bununla birlikte 25-OH D vitamin düzeyi ile hastalık arasındaki ilişkinin nedensel olup olmadığı veya sadece yaşam tarzı ile ilişkili bir belirteç olduğu durumu belirsizdir. Vitamin D takviyesinin serum lipid profili üzerine etkileri araştıran plasebo kontrollü çalışmalar farklı sonuçlar vermiştir. Bu çalışmanın amacı serum vitamin D konsantrasyonu ile lipid profili arasındaki ilişkiyi araştırmaktır. Gereç ve Yöntem: Fiziksel Tıp ve Rehabilitasyon polikliniğine ağrı şikayetiyle başvuran 204 hasta çalışmaya dahil edildi. Hastaların demografik özellikleri kaydedildi. Açlık serum 25-OH D vitamini, total kolesterol, LDL, HDL ve trigliserid konsantrasyonları ölçüldü. Bulgular: Hastaların ortalama 25-OH D düzeyleri 10.6±6.5 ng/mL, D vitamini eksikliği prevalansı %92.2 idi. Hastalar 25-OH D vitamin düzeylerine göre <20 ng/mL, 20-30 ng/mL ve >30 ng/mL olmak üzere 3 gruba ayrıldı. Yüksek D vitamini konsantrasyonu olan hastalarda D vitamini eksikliği olan hastalara göre serum total kolesterol, TG ve LDL düzeyleri düşük ve HDL düzeyi daha yüksek olmasına rağmen, bu fark istatistiksel olarak anlamlı değildi (p > 0.05). Sonuç: D vitamini eksikliği prevalansı ve uygun olmayan lipid profilinin olumsuz etkileri göz önüne alındığında, yüksek riskli toplumlarda D vitamini durumunun incelenmesi, düzeltilmesi ve korunmasının uygun olacağı görüşündeyiz.
TURKISH JOURNAL OF MEDICAL SCIENCES, 2019
Türk Osteoporoz Dergisi, 2017
Karahan ve ark. D Vitamin ve Kas İskelet Sistemi Ağrıları Öz Objective: In this study, it was aim... more Karahan ve ark. D Vitamin ve Kas İskelet Sistemi Ağrıları Öz Objective: In this study, it was aimed to evaluate the relationship between vitamin D level and pain severity, localization and duration in patients with non-specific musculoskeletal pain. Materials and Methods: Patients who applied to physical medicine and rehabilitation outpatient clinics due to non-specific muscle pain in 19 centers in Turkey were retrospectively screened. Three thousand four hundred fourpatients were included in the study, whose pain level was determined by visual analog scale (VAS) and the painful region, duration of pain and vitamin D level were reached. D group was found to be D deficient (group 1) when 25 (OH)D level was 20 ng/mL or less and group D 2 (vitamin D deficiency) was higher than 30 ng/mL (group 3). The groups were compared in terms of pain duration, localization and severity. In addition, the correlations of pain localization, severity and duration with vitamin D levels were examined. Results: D vitamin deficiency was detected in 2202 (70.9%) of 3 thousand four hundred and four registered patients, and it was found that vitamin D deficiency in 516 (16.6%) and normal vitamin D in 386 (12.4%). The groups were similar in terms of age, body mass index, income level, duration of complaint, education level, family type and working status (p>0.05). There was no statistically significant difference between groups in terms of VAS, pain localization and duration scores (p>0.05). Conclusion: Our study shows that vitamin D deficiency in patients with nonspecific musculoskeletal pain is not associated with the severity and duration of pain.
International Physical Medicine & Rehabilitation Journal, 2017
Parkinson's disease (PD) is often associated with cognitive impairment and frequent falls. Althou... more Parkinson's disease (PD) is often associated with cognitive impairment and frequent falls. Although the cause of frequent falls is not clearly understood, cognitive impairment is thought to be the cause of frequent falls and these frequent falls can lead to serious complications such as traumatic arthritis. Traumatic arthritis is a wellknown condition that develops in the joints as a result of recurrent trauma. Here we presented a 61-year-old female patient with PD who suffered from severe pain, limitation, swelling, temperature increase and erythema of right knee also difficulty of gait. In the result of all the detailed evaluations made, conservative treatment-resistant traumatic monoarthritis and osteonecrosis were diagnosed due to recurrent falls of the patient and the patient was directed to surgical treatment. The patient's falls were ongoing due to cognitive impairment and PD and she continued to suffer from pain and swelling despite performing unicompartmental (lateral compartment) knee arthroplasty. As a result of consultations with orthopaedists we decided to perform a total knee arthroplasty on the patient. After surgery, the patient was admitted to our rehabilitation clinic for orthopedic and PD rehabilitation program. During the rehabilitation program, the symptoms of swelling and pain in the patient's knee improved and the frequency of falls decreased. The patient's rehabilitation program still continues in our clinic.
The European Research Journal, 2019
Türk Osteoporoz Dergisi, 2017
Objective: The aim of the study was to evaluate cognitive functioning in adult women with low lev... more Objective: The aim of the study was to evaluate cognitive functioning in adult women with low level vitamin D and to investigate the relationship between vitamin D and cognitive functioning. Materials and Methods: Seventy-one women patients aged 18-50 with 25-OH vitamin D 3 level <30 ng/mL referred to outpatient clinic were enrolled in the study. 25-OH vitamin D 3 level, calcium, phosphate, alkaline phosphatase, parathyroid hormone (PTH) blood levels were studied in all the patients. Mini Mental State Examination (MMSE) and Montreal Cognitive Assessment (MOCA) were used to assess cognitive functioning. The patients were divided into 2 groups according to vitamin D levels: <10 ng/mL (group 1, n=34) and between 11-29 ng/mL (group 2, n=37). Results: There was no significant difference between the group 1 and 2 for demographic and clinical characteristics except for vitamin D and PTH (p>0.05). Patients in group 1 had their vitamin D levels significantly lower and PTH levels higher than group 2 (p<0.05). There was no significant difference in MOCA and MMSE scores between the groups (p>0.05). Although there was a relationship between education and MOCA and MMSE scores, we didn't find any significant relationship between age and vitamin D levels and MOCA and MMSE scores. Conclusion: Although approximately 50% of adult women whose vitamin D levels were low had reduced cognitive function, there was no relationship between vitamin D levels and cognitive functions.
Noro Psikiyatri Arsivi, 2017
Introduction: Cerebral palsy (CP) is the most common significant motor impairment in childhood. C... more Introduction: Cerebral palsy (CP) is the most common significant motor impairment in childhood. CP is defined as a primary disorder of posture and movement; however, intellectual impairment is prevalent in children with CP. The purpose of this study was to examine the intelligence level associated with gross motor function and hand function, type of CP, the presence of comorbid disorders such as epilepsy, and other factors. Methods: In total, 107 children with CP were included. Age, gender, prenatal/natal/postnatal risk factors, type of CP, and presence of other neurodevelopmental disorders were recorded as demographic findings. Intellectual functions of the patients were determined by clinical assessment, adaptive function of daily life, and individualized, standardized intelligence testing. The gross motor function and hand function of the patients were classified using the "Gross Motor Function Classification System" and "Bimanual Fine Motor Function" measurements, respectively. Results: The mean age of the patients was 8.10±3.43 years (2-16 years). The study included 63 (58.9%) male patients and 44 (41.1%) female patients. During clinical typing, 80.4% of the patients were spastic, 11.2% were mixed, 4.7% were dyskinetic, and 3.7% were ataxic. Intellectual functioning tests found 26.2% of the children within the intellectual norm and that 10% of the children had a borderline intellectual disability, 16% of them had a mild intellectual disability, 17% of them had a moderate intellectual disability, and 30.8% of them had a severe intellectual disability. No significant relationship was determined between the CP type and intellectual functioning (p>0.05). Intellectual functioning was found to be significantly correlated with hand functions and motor levels (p<0.001). Factors related with intellectual functioning were neonatal convulsion, epilepsy, and speech disorders. Conclusion: Intelligence assessment should be an essential part of CP evaluation and research. There is not enough reliable knowledge, unanimity regarding validity data, and population-specific norms in the intelligence assessments of children with CP. Research is required to assess properly intelligence for children with CP.
Türk Osteoporoz Dergisi, 2016
Journal of Stroke and Cerebrovascular Diseases, 2015
NeuroRehabilitation, 2011
Critical illness polyneuropathy (CIP) is defined as a common complication of critically ilness pa... more Critical illness polyneuropathy (CIP) is defined as a common complication of critically ilness patients who were admitted to the intensive care unit due to sepsis, multiple trauma and/or multi-organ failure. We aimed to present a patient who was diagnosed as CIP. He was admitted to our outpatient clinic due to weakness and pain in his lower extremities. He had been followed in an intensive care unit due to suicid five months ago. There were symmetrically and predominantly muscle weakness, sensory impairment, absence of deep tendon reflexes in his lower extremities. Electrophysiological evaluation demonstrated motor and sensory axonal distal polyneuropathy predominantly in lower extremities. At follow up, he had high fever, and elevated acute phase responses. Therefore source of infection was investigated and was suspected to a diagnosis of infective endocarditis. He was discharged to be hospitalized in cardiology clinic. With this case, we think that physiatrists should take into co...
Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi, 2011
Sum mary Bardet-Biedl syndrome is an autosomal recessive disorder characterized by rod-cone dystr... more Sum mary Bardet-Biedl syndrome is an autosomal recessive disorder characterized by rod-cone dystrophy of the retina, mental retardation, obesity, polydactyly and hypogonadism, as well as renal abnormalities. Laurence-Moon syndrome, as a distinct entity, is rare and the features include spastic paraplegia in the absence of polydactyly, obesity, and renal involvement, though cranial symptoms are very unusual. We aimed to report a patient who exhibited characteristic features of Bardet-Biedl syndrome in addition to brachial amyotrophy, and cerebellar and cerebral cortical atrophy.
Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi, 2010
Su um mm ma ar ry y O Ob bj je ec ct ti iv ve e: : Sexual dysfunction (SD) is an important, but g... more Su um mm ma ar ry y O Ob bj je ec ct ti iv ve e: : Sexual dysfunction (SD) is an important, but generally underestimated symptom in the course of multiple sclerosis (MS). The aim of this study was to investigate the factors related to SD in MS patients. M Ma at te er ri ia al ls s a an nd d M Me et th ho od ds s: : Twenty-one MS patients with and 21 MS patients without SD were included in this study. Age, SD duration, disease duration, marital status, educational status, bladder and bowel dysfunction, disability, independence, cognitive performances and psychological functioning and sexual function scales have also been assessed. R Re es su ul lt ts s: : SD correlated with age (p=0.029), disease duration (p=0.045), bladder dysfunction (X 2 =0.011; p=0.012). Positive correlations were found between disease duration and 5-point sexual function scale in SD patient (rs=0.419; p=0.027). However, SD did not correlated with bowel dysfunction (X 2 =0.469; p=0.418), disability (p=0.190), level of independence (p=0.146) and cognitive performances (p=0.212). The brain stem involvement was higher in patients with SD (X 2 =0.001; p=0.001). C Co on nc cl lu us si io on n: : The prevalence of SD increases with the patient age and prolonged disease duration. SD is related to bladder dysfunction and brain stem involvement. However, increased disability does not affect SD. Turk J Phys Med Rehab 2010;56:130-4. K Ke ey y W Wo or rd ds s: : Multiple sclerosis, sexual dysfunction Ö Öz ze et t A Am ma aç ç: : Seksüel disfonksiyon (SD), multipl skleroz (MS) seyri s›ras›nda görülen ancak genellikle gözard› edilen bir semptomdur. Bu çal›flman›n amac› MS'li hastalarda görülen SD ile iliflkili faktörlerin araflt›r›lmas›d›r. G Ge er re eç ç v ve e Y Yö ön nt te em m: : Çal›flmaya MS'ye ba¤l› SD'si bulunan 21 hasta ve bulunmayan 21 hasta dahil edildi. Yafl, SD süresi, hastal›k süresi, medeni durum, e¤itim durumu, mesane ve barsak disfonksiyonu varl›¤›, disabilite, konginitif performans, psikolojik fonksiyonlar ve seksüel durum de¤erlendirildi. B Bu ul lg gu ul la ar r: : SD varl›¤›; yafl, hastal›k süresi ve mesane disfonksiyonu varl›¤› ile koreleydi (s›ras›yla p=0,029, p=0,045, X 2 =0,011; p=0,012). Hastal›k süresi ve 5 puanl›k seksüel fonksiyon skalas› aras›nda, SD olan hastalarda pozitif korelasyon bulundu (rs=0,419; p=0,027). Buna ra¤men SD varl›¤› ile barsak disfonksiyonu varl›¤› (X 2 =0,469; p=0,418), disabilite düzeyi (p=0,190) ve kognitif performans (p=0,212) düzeyi korele bulunmad›. SD'lu hastalarda beyin sap› tutulumu daha yüksekti (X 2 =0,001; p=0,001). S So on nu uç ç: : SD s›kl›¤› hasta yafl› ve hastal›k süresi art›kça artmaktad›r. SD mesane disfonksiyonu ve beyin sap› tutulumu ile iliflkilidir. Ancak disabilite düzeyinin artmas› SD'nin görülme s›kl›¤›nda art›fla neden olmamaktad›r.
Türkiye Fiziksel Tip ve Rehabilitasyon Dergisi, 2014
Amaç: Omurilik yaralanmalı bireylerin rehabilitasyonunda kalça diz ayak bileği ayak ortezi, metal... more Amaç: Omurilik yaralanmalı bireylerin rehabilitasyonunda kalça diz ayak bileği ayak ortezi, metal veya plastik ayak bileği-ayak ortezi, posterior shell gibi ortezler, koltuk değneği, kanadyen, walker, baston gibi el destekleri, lokomasyonu sağlayan tekerlekli iskemleler sıkça kullanılmaktadır. Bu çalışmada hastanede rehabilitasyon uygulanmış omurilik yaralanmalı bireylerin, taburculuk sonrasındaki ortez kullanımı alışkanlıklarını değerlendirmeyi ve ortezlerle ilgili yaşanan sorunları ortaya koymayı amaçladık. Gereç ve Yöntemler: İlk olarak yetmiş bir hastanın hastane kayıtları incelendi. Telefonla ulaşılabilen 46 hastayla [34 erkek (%74), 12 kadın (%26)] sorgulama formuna dayanarak görüşüldü. Bulgular: Yaşları (ortalama±SD), 35±12,9 yıl; olay süreleri 43±27 aydı. Ortalama ortez kullanım indeksi (ortez kullanım süresi/ortezin reçete edilme süresi) 0,7±0,3'tü. Ortez verilmiş 41 hastadan ortezini kullananların oranı %73 (n:30), kullanmayanların oranı ise %27 (n:11) idi. Ortez bırakma oranı, inkomplet omurilik yaralanmalı hastalarla (%82) komplet yaralanmalılar (%18) karşılaştırıldığında belirgin olarak yüksekti (p=0,038). Ortezde değişiklik yapma oranı ortezini kullanan grupta (%53) ortezini kullanmayanlara (%9) göre belirgin yüksekti (p=0,014). Lojistik regresyon analizinde sakral korunmanın varlığı ortez kullanımını azaltıcı yönde etkili bulundu (p=0,040). Ortezi bırakma nedenlerinin çoğunluğu spastisite, ortezin sıkı veya eskimiş olması, psikolojik rahatsızlık gibi değiştirilebilir nedenlerdi. Sonuç: Bizim sonuçlarımız, sakral korunması olan hastaların ortez kullanımını sonlandırma ihtimallerinin daha fazla olabildiğini ve ortezlerde yapılan değişikliklerin ortezini düzenli kullanan hastalar için bir gereklilik olduğunu düşündürmektedir. Tekerlekli sandalye, ambulasyonun temel şeklidir ve omurilik yaralanmalı hastalar tarafından düzenli olarak kullanılmaktadır.
Spine, 2010
Study Design. Case report. Objectives. To report a case with paraplegia caused by spinal hydatid ... more Study Design. Case report. Objectives. To report a case with paraplegia caused by spinal hydatid cyst. Summary of Background Data. Hydatid cyst is a disease caused by larval Echinococcus granulosus tapeworm. Spinal hydatid cyst rarely leads to severe neurologic problems. Methods. A 34-year-old male patient was referred to our outpatient clinic due to back and low back pain, progressive weakness and numbness in both lower extremities, and a prediagnosis of lumbar disc hernia. He had spastic paraplegia, and thorax magnetic resonance imaging revealed a lobulated cystic lesion with extradural intraspinal localization. Results. After surgery and following 2 months of rehabilitation program, the patient showed a dramatic clinical improvement. Conclusion. By this case, it is emphasized that spinal hydatid cyst should come to mind in the differential diagnosis of spinal cord compression, and the importance of prevention, early diagnosis, and treatment is highlighted because of high mortality and morbidity.
Rheumatology International, 2005
The pathogenesis of reflex sympathetic dystrophy (RSD) is not completely understood. However, an ... more The pathogenesis of reflex sympathetic dystrophy (RSD) is not completely understood. However, an excessive regional inflammation, sensitization of primary somatosensory afferents, and sensitization of spinal neurons are considered to have a role in the pathogenesis of RSD. The underlying pathophysiology relating the clinical picture may help to determine the pharmacotherapeutic approach for an individual patient. Scintigraphy using radiolabelled human polyclonal non-specific immunoglobulin (HIG) has been recognized as a useful tool for the localization of inflammatory disorders. Thirty-six consecutive RSD patients associated with hemiplegia were included in this study. All the patients in this study had three phases bone scan and Tc-99m HIG scintigraphy. On admission, of 36 patients with positive bone scan, 30 had positive Tc-99m HIG scan. All the patients were symptomatic at the time of bone scanning. On the contrary, 24 out of 36 patients subsequently became asymptomatic at an 8-month re-evaluation period. Tc-99m HIG scintigraphy is a non-invasive complementary method for the determination of ongoing inflammatory reactions which also aids the clinicians to predict the response to anti-inflammatory therapy at the very early phase of RSD associated with hemiplegia. This preliminary study may be a source of inspiration for further studies with larger series and longer follow-up .