Chinnakannu Jayakumar | Anna University (original) (raw)
Papers by Chinnakannu Jayakumar
International Journal of Occupational Safety and Ergonomics, 2021
There is a significant need in the current industrial scenario for methods to be formulated to tr... more There is a significant need in the current industrial scenario for methods to be formulated to treat dangerous chemicals most safely. Accidental release of toxic chemicals will result in emergencies. Hence an Emergency Response Plan (ERP) is inevitable. The most toxic chemicals in the water and wastewater sector are Chlorine & hydrogen sulphide, whereas Methane is a flammable gas. CAMEO software is used in this research to predict the region that toxic gas release impacts. This research deals with a sewage treatment plant ERP and control measures for Methane and chlorine gases. The affected area of hazard will depend upon the weather conditions and the time of the accident. Comparing two different seasons, the impacted distance is more significant in summer than in winter. It is observed that the night and early morning time is more dangerous than the afternoon and evening time as it shows the larger impacted distance.
Bioprocess Engineering, 2000
ABSTRACT
Indian Journal of Pharmaceutical Education and Research, 2021
Objectives: A systematic in-vitro study has been achieved to decide the stability of a selection ... more Objectives: A systematic in-vitro study has been achieved to decide the stability of a selection of three presidential hydrotropes to decorate the obvious aqueous solubility of the sparingly water-soluble drug, mebendazole drug. This study is that the ANN model to be prediction the solubility of the mebendazole drug among the chemical substances. Methodology: These experimental data, together with a selection of recounted and estimate physico-chemical consequences of the hydrotropes are after that utilizing insilico to set up a counterfeit neural system (ANN) to engage for desires mebendazole drug solubilization. These trial information, along with a determination of described and gauge physico-chemical outcomes of the hydrotropes are after that using in-silico to set up a counterfeit neural system (ANN) to engage for desires mebendazole tranquilize solubilization. The readied ANN transformed into once determined to exist particularly correct predictions of mebendazole drug solubilization in the presence of hydrotropes and was once for that purpose validated to provide a precious capacity through which hydrotrope sensibility could in like way be screened computationally. The readied ANN transformed into once resolved to exist especially address forecasts of mebendazole tranquilize solubilization within the sight of hydrotropes and was once for that reason approved to give a valuable limit through which hydrotrope sensibility could in like way be screened computationally. The artificial neural network for predicting the solubility properties of the hydrotropic-ester combination was once developed the utilization of MATLAB 2011. For growing the ANN, solubility records that changed into obtained from the experiments had been used. Results: The interest of the hydrotropic will become set as input to the neural network and thus, the precise solubility turn out to be set as target records. The set of rules used to prepare the community modified into the Levenberg Marquardt algorithm. Conclusion: Two hidden layers were expressed. Randomly chosen 80% of the data became used to train the network, It's far is inferred that in-silico screening of drug/hydrotrope structures the utilization of artificial neural networks presents specifically possible to decrease the want for large laboratory testing of those systems and will thus flexibly an economy in expressions of diminished costs and time in tranquilize framework improvement.
Indian Journal of Pharmaceutical Education and Research, 2021
Objectives: A systematic study is required to enhance the solubility of insoluble fluid drugs tha... more Objectives: A systematic study is required to enhance the solubility of insoluble fluid drugs that are only sparingly soluble. Hydrotropy may be a distinctive development to reinforce the liquid solubility of poorly water-soluble drugs. Materials and Methods: The term hydrotropic has been wont to designate the rise in the solubility of assorted substances in water because of the presence of enormous amounts of additives. Sodium salicylate, sodium benzoate, and resorcinol are utilized to reinforce the liquid solubility of many poorly soluble drugs. Varied organic solvents like methyl alcohol, chloroform, alcohol, dimethylformamide, and benzene are utilized for the solubilization of poorly soluble drugs. Theophylline drug was accessories to numerous hydrotrope concentrations (0-3 mol/L) and also the non-inheritable sample for a solubility determination was analyzed in an exploitation UV spectrophotometer. Results: The solubility of theophylline has been specifically found to improve with an increase in hydrotrope concentration and also with a device temperature likely to be close to that of other organic compounds and drugs. Conclusion: To initiate substantial solubilization of the theophylline compound, a minimum hydrotrope concentration (MHC) in the aqueous phase was needed. As a consequence of the improvement in the solubilization of theophylline, the coefficient of mass transfer was also observed to expand with an increase in the hydrotropic concentration at 303 K. To have a substantial enhancement within the mass transfer coefficient, a threshold value equivalent to MHC is to be maintained. For all sets of experiments, the maximal enhancement factor, which is the value ratio between the presence and absence of a hydrotrope, has been calculated. Thermodynamic parameters such as Gibb's free energy, enthalpy, and entropy of theophylline were calculated to determine the hydrotropic aggregation activity of theophylline. With an increase in system temperature, Gibb's free energy declines. It was found that the aggregation of hydrotropes was exothermic and preferred by a positive entropy value.
Korean Journal of Chemical Engineering, Feb 12, 2013
Teaching Documents by Chinnakannu Jayakumar
Books by Chinnakannu Jayakumar
COURSE OBJECTIVES: To impart knowledge and skills required for research and IPR: Problem formul... more COURSE OBJECTIVES:
To impart knowledge and skills required for research and IPR:
Problem formulation, analysis and solutions.
Technical paper writing / presentation without violating professional ethics
Patent drafting and filing patents.
International Journal of Occupational Safety and Ergonomics, 2021
There is a significant need in the current industrial scenario for methods to be formulated to tr... more There is a significant need in the current industrial scenario for methods to be formulated to treat dangerous chemicals most safely. Accidental release of toxic chemicals will result in emergencies. Hence an Emergency Response Plan (ERP) is inevitable. The most toxic chemicals in the water and wastewater sector are Chlorine & hydrogen sulphide, whereas Methane is a flammable gas. CAMEO software is used in this research to predict the region that toxic gas release impacts. This research deals with a sewage treatment plant ERP and control measures for Methane and chlorine gases. The affected area of hazard will depend upon the weather conditions and the time of the accident. Comparing two different seasons, the impacted distance is more significant in summer than in winter. It is observed that the night and early morning time is more dangerous than the afternoon and evening time as it shows the larger impacted distance.
Bioprocess Engineering, 2000
ABSTRACT
Indian Journal of Pharmaceutical Education and Research, 2021
Objectives: A systematic in-vitro study has been achieved to decide the stability of a selection ... more Objectives: A systematic in-vitro study has been achieved to decide the stability of a selection of three presidential hydrotropes to decorate the obvious aqueous solubility of the sparingly water-soluble drug, mebendazole drug. This study is that the ANN model to be prediction the solubility of the mebendazole drug among the chemical substances. Methodology: These experimental data, together with a selection of recounted and estimate physico-chemical consequences of the hydrotropes are after that utilizing insilico to set up a counterfeit neural system (ANN) to engage for desires mebendazole drug solubilization. These trial information, along with a determination of described and gauge physico-chemical outcomes of the hydrotropes are after that using in-silico to set up a counterfeit neural system (ANN) to engage for desires mebendazole tranquilize solubilization. The readied ANN transformed into once determined to exist particularly correct predictions of mebendazole drug solubilization in the presence of hydrotropes and was once for that purpose validated to provide a precious capacity through which hydrotrope sensibility could in like way be screened computationally. The readied ANN transformed into once resolved to exist especially address forecasts of mebendazole tranquilize solubilization within the sight of hydrotropes and was once for that reason approved to give a valuable limit through which hydrotrope sensibility could in like way be screened computationally. The artificial neural network for predicting the solubility properties of the hydrotropic-ester combination was once developed the utilization of MATLAB 2011. For growing the ANN, solubility records that changed into obtained from the experiments had been used. Results: The interest of the hydrotropic will become set as input to the neural network and thus, the precise solubility turn out to be set as target records. The set of rules used to prepare the community modified into the Levenberg Marquardt algorithm. Conclusion: Two hidden layers were expressed. Randomly chosen 80% of the data became used to train the network, It's far is inferred that in-silico screening of drug/hydrotrope structures the utilization of artificial neural networks presents specifically possible to decrease the want for large laboratory testing of those systems and will thus flexibly an economy in expressions of diminished costs and time in tranquilize framework improvement.
Indian Journal of Pharmaceutical Education and Research, 2021
Objectives: A systematic study is required to enhance the solubility of insoluble fluid drugs tha... more Objectives: A systematic study is required to enhance the solubility of insoluble fluid drugs that are only sparingly soluble. Hydrotropy may be a distinctive development to reinforce the liquid solubility of poorly water-soluble drugs. Materials and Methods: The term hydrotropic has been wont to designate the rise in the solubility of assorted substances in water because of the presence of enormous amounts of additives. Sodium salicylate, sodium benzoate, and resorcinol are utilized to reinforce the liquid solubility of many poorly soluble drugs. Varied organic solvents like methyl alcohol, chloroform, alcohol, dimethylformamide, and benzene are utilized for the solubilization of poorly soluble drugs. Theophylline drug was accessories to numerous hydrotrope concentrations (0-3 mol/L) and also the non-inheritable sample for a solubility determination was analyzed in an exploitation UV spectrophotometer. Results: The solubility of theophylline has been specifically found to improve with an increase in hydrotrope concentration and also with a device temperature likely to be close to that of other organic compounds and drugs. Conclusion: To initiate substantial solubilization of the theophylline compound, a minimum hydrotrope concentration (MHC) in the aqueous phase was needed. As a consequence of the improvement in the solubilization of theophylline, the coefficient of mass transfer was also observed to expand with an increase in the hydrotropic concentration at 303 K. To have a substantial enhancement within the mass transfer coefficient, a threshold value equivalent to MHC is to be maintained. For all sets of experiments, the maximal enhancement factor, which is the value ratio between the presence and absence of a hydrotrope, has been calculated. Thermodynamic parameters such as Gibb's free energy, enthalpy, and entropy of theophylline were calculated to determine the hydrotropic aggregation activity of theophylline. With an increase in system temperature, Gibb's free energy declines. It was found that the aggregation of hydrotropes was exothermic and preferred by a positive entropy value.
Korean Journal of Chemical Engineering, Feb 12, 2013
COURSE OBJECTIVES: To impart knowledge and skills required for research and IPR: Problem formul... more COURSE OBJECTIVES:
To impart knowledge and skills required for research and IPR:
Problem formulation, analysis and solutions.
Technical paper writing / presentation without violating professional ethics
Patent drafting and filing patents.