The Clinical Proteomic Technologies for Cancer (original) (raw)
Arginase 2 Peptide 1
Background
NCI Identification Number:
00345
Antigen Name:
Arginase 2 Peptide 1
CPTC Name:
CPTC-ARG2 Peptide 1
Aliases:
Arginase 2; Arginase-2, Mitochondrial; Kidney-Type Arginase; Non-Hepatic Arginase; Arginase, Type II; Type II Arginase; Arginase II; EC 3.5.3.1; L-Arginine Amidinohydrolase; L-Arginine Ureahydrolase; Nonhepatic Arginase; Kidney Arginase; EC 3.5.3; ARG2
Function:
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described.ARG2 (Arginase 2) is a Protein Coding gene. Diseases associated with ARG2 include Argininemia and Impotence. Among its related pathways are Arginine biosynthesis and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include arginase activity. An important paralog of this gene is ARG1.May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells (PubMed:27745970). May suppress inflammation-related signaling in asthmatic airway epithelium (PubMed:27214549). May contribute to the immune evasion of H.pylori by restricting M1 macrophage activation and polyamine metabolism (By similarity). In fetal dendritic cells may play a role in promoting immune suppression and T cell TNF-alpha production during gestation (PubMed:28614294). Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction (PubMed:22928666). Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling (PubMed:25484082). Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity (PubMed:23832324). Since NOS is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase-2 plays a role in both male and female sexual arousal (PubMed:12859189).
Chromosomal Localization:
14q24.1
Accession Number:
NP_001163.1
UniProt Accession Number:
P78540
DNA Source:
N/A
Immunogen:
Synthetic Peptide
Vector Name:
N/A
Extinction Coefficient:
Buffers:
Expressed Sequence:
TFDLLIGK
Native Sequence:
Calculated Isoelectric Point:
Molecular Weight:
880
Last Updated:
09/02/2020
Links
- EnsEMBL - EnsEMBL ARG2
- Entrez - Entrez ARG2
- Uniprot - Uniprot P78540
Characterization Data
SOPs
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