The Clinical Proteomic Technologies for Cancer (original) (raw)

Beta-2-Microglobulin Peptide 1

Background

Catalog Number:

CPTC-B2M-1

RRID:

AB_2890076

Target Antigen:

Beta-2-Microglobulin Peptide 1

Isotype:

IgG

Species:

Rabbit Monoclonal Antibody

Last Updated:

07/03/2024

Antigen Recognition(s):

Peptide, Endogenous

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Characterization Data [Compare Characterization Data]
Background

NCI Identification Number:

00346

Antigen Name:

Beta-2-Microglobulin Peptide 1

CPTC Name:

CPTC-B2M Peptide 1

Aliases:

Beta-2-Microglobulin; Beta Chain Of MHC Class I Molecules; Beta-2-Microglobin; IMD43; B2M

Function:

This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.B2M (Beta-2-Microglobulin) is a Protein Coding gene. Diseases associated with B2M include Immunodeficiency 43 and Amyloidosis, Familial Visceral. Among its related pathways are Antigen processing-Cross presentation and Interferon gamma signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is HLA-DPA1.Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553).

Chromosomal Localization:

15q21.1

Accession Number:

NP_004039.1

UniProt Accession Number:

P61769

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

VNHVTLSQPK

Native Sequence:

Calculated Isoelectric Point:

Molecular Weight:

1100

Last Updated:

09/02/2020

Characterization Data

SOPs

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