The Clinical Proteomic Technologies for Cancer (original) (raw)

CD48 Molecule Peptide 1

Background

Catalog Number:

CPTC-CD48-1

Target Antigen:

CD48 Molecule Peptide 1

Isotype:

IgG

Species:

Rabbit Recombinant Cloned Antibody

Last Updated:

03/19/2025

Antigen Recognition(s):

Peptide, Recombinant Full-length

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Characterization Data [Compare Characterization Data]

Western Blot - Tissue or Cell Lysate

Click to enlarge image Western blot using CPTC-CD48-1 as primary antibody against PBMC (lane 2), HeLa (lane 3), Jurkat (lane 4), A549 (lane 5), MCF7 (lane 6), and NCI-H226 (lane 7) whole cell lysates. Expected molecular weight - 27.7 kDa and 19.4 kDa. Molecular weight standards are also included (lane 1). Target protein is subject to glycosylation which can affect the migration in electrophoresis. This can make the target appear as a higher molecular weight protein. Click image to enlarge

Result: Negative

Western blot using CPTC-CD48-1 as primary antibody against PBMC (lane 2), HeLa (lane 3), Jurkat (lane 4), A549 (lane 5), MCF7 (lane 6), and NCI-H226 (lane 7) whole cell lysates. Expected molecular weight - 27.7 kDa and 19.4 kDa. Molecular weight standards are also included (lane 1). Target protein is subject to glycosylation which can affect the migration in electrophoresis. This can make the target appear as a higher molecular weight protein.

Background

NCI Identification Number:

00427

Antigen Name:

CD48 Molecule Peptide 1

CPTC Name:

CPTC-CD48 Peptide 1

Aliases:

CD48 Molecule; SLAMF2; Signaling Lymphocytic Activation Molecule 2; CD48 Antigen (B-Cell Membrane Protein); B-Lymphocyte Activation Marker BLAST-1; Leukocyte Antigen MEM-102; BCM1 Surface Antigen; SLAM Family Member 2; CD48 Antigen; BLAST1; BLAST; HCD48; MCD48; TCT.1; BCM1; MEM-102; CD48

Function:

This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. The encoded protein is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells. The encoded protein does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.CD48 (CD48 Molecule) is a Protein Coding gene. Diseases associated with CD48 include Lymphoproliferative Syndrome, X-Linked, 1 and Cone-Rod Dystrophy 6. Among its related pathways are Gastric Cancer Network 2 and Cell surface interactions at the vascular wall. Gene Ontology (GO) annotations related to this gene include antigen binding. An important paralog of this gene is SLAMF1.Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation.

Chromosomal Localization:

1q23.3

Accession Number:

NP_001769.2

UniProt Accession Number:

P09326

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

LQVLDPVPKPVIK

Native Sequence:

Calculated Isoelectric Point:

Molecular Weight:

1430

Last Updated:

09/21/2020

Characterization Data

SOPs

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