The Clinical Proteomic Technologies for Cancer (original) (raw)

Integrin Subunit Alpha M Peptide 1

Background

Catalog Number:

CPTC-ITGAM-1

Target Antigen:

Integrin Subunit Alpha M Peptide 1

Isotype:

IgG

Species:

Rabbit Monoclonal Antibody

Last Updated:

07/03/2024

Antigen Recognition(s):

Peptide, Endogenous

Characterization Data [Compare Characterization Data]
Background

NCI Identification Number:

00450

Antigen Name:

Integrin Subunit Alpha M Peptide 1

CPTC Name:

CPTC-ITGAM Peptide 1

Aliases:

Integrin Subunit Alpha M; Integrin, Alpha M (Complement Component 3 Receptor 3 Subunit); Cell Surface Glycoprotein MAC-1 Subunit Alpha; Complement Component 3 Receptor 3 Subunit; CD11 Antigen-Like Family Member B; Leukocyte Adhesion Receptor MO1; Integrin Alpha-M; CR-3 Alpha Chain; CD11B; MAC-1; CR3A; Integrin, Alpha M (Complement Component Receptor 3, Alpha; Also Known As CD11b (P170), Macrophage Antigen Alpha Polypeptide); Neutrophil Adherence Receptor Alpha-M Subunit; Macrophage Antigen Alpha Polypeptide; Neutrophil Adherence Receptor; Antigen CD11b (P170); CD11b Antigen; MAC1A; SLEB6; ITGAM; CD11b; MO1A

Function:

This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene.ITGAM (Integrin Subunit Alpha M) is a Protein Coding gene. Diseases associated with ITGAM include Systemic Lupus Erythematosus 6 and Shwartzman Phenomenon. Among its related pathways are Neuroscience and Transcriptional misregulation in cancer. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is ITGAX.Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PubMed:9558116, PubMed:20008295). It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity).

Chromosomal Localization:

16p11.2

Accession Number:

NP_001139280.1

UniProt Accession Number:

P11215

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

LACESASSTEVSGALK

Native Sequence:

Calculated Isoelectric Point:

Molecular Weight:

1760

Last Updated:

09/30/2020

Characterization Data

SOPs

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