The Clinical Proteomic Technologies for Cancer (original) (raw)

Keratin Group B Peptide 1

Background

Catalog Number:

CPTC-KRT Group B-1

Target Antigen:

Keratin Group B Peptide 1

Isotype:

IgG

Species:

Rabbit Recombinant Cloned Antibody

Last Updated:

10/22/2021

Antigen Recognition(s):

Peptide, Recombinant Full-length, Endogenous

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Characterization Data [Compare Characterization Data]
Background

NCI Identification Number:

00457

Antigen Name:

Keratin Group B Peptide 1

CPTC Name:

CPTC-KRT Group B Peptide 1

Aliases:

Keratin 7; Keratin, Type II Cytoskeletal 7; Sarcolectin; SCL; K7; Keratin, 55K Type II Cytoskeletal; Type-II Keratin Kb7; Keratin 7, Type II; Cytokeratin 7; K2C7; CK-7; CK7; Keratin, Simple Epithelial Type I, K7; Type II Mesothelial Keratin K7; Keratin-7; KRT7; Keratin 8; CYK8; K8; Keratin, Type II Cytoskeletal 8; Type-II Keratin Kb8; Keratin 8, Type II; Cytokeratin-8; CARD2; CK-8; K2C8; CK8; KO; Keratin-8; KRT8

Function:

A peptide homologous to a group of Keratin Group B proteins (Keratin Group B: KRT7 KRT8 hCG_1988300) was used for antibody generation. KRT7: The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described. KRT7 (Keratin 7) is a Protein Coding gene. Diseases associated with KRT7 include Pseudomyxoma Peritonei and Signet Ring Cell Adenocarcinoma. Among its related pathways are Cytoskeleton remodeling Neurofilaments and Developmental Biology. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT5. Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).KRT8: This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. KRT8 (Keratin 8) is a Protein Coding gene. Diseases associated with KRT8 include Liver Cirrhosis and Cryptogenic Cirrhosis. Among its related pathways are Cytoskeleton remodeling Neurofilaments and Signaling mediated by p38-alpha and p38-beta. Gene Ontology (GO) annotations related to this gene include structural molecule activity and scaffold protein binding. An important paralog of this gene is KRT5. Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.

Chromosomal Localization:

KRT7: 12q13.13; KRT8: 12q13.13;

Accession Number:

N/A

UniProt Accession Number:

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

CELQSQISDTSVVLSMDNSR

Native Sequence:

Calculated Isoelectric Point:

Molecular Weight:

2200

Last Updated:

10/02/2020

Characterization Data

SOPs

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