The Clinical Proteomic Technologies for Cancer (original) (raw)

Keratin 7 Peptide 1

Background

NCI Identification Number:

00243

Antigen Name:

Keratin 7 Peptide 1

CPTC Name:

CPTC-KRT7 Peptide 1

Aliases:

Keratin 7; Sarcolectin; Keratin, 55K Type II Cytoskeletal; Keratin, Type II Cytoskeletal 7; Type-II Keratin Kb7; Keratin 7, Type II; Cytokeratin 7; CK-7; SCL; K7; Keratin, Simple Epithelial Type I, K7; Type II Mesothelial Keratin K7; Cytokeratin-7; Keratin-7; K2C7; CK7

Function:

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described.

KRT7 (Keratin 7) is a Protein Coding gene. Diseases associated with KRT7 include Pseudomyxoma Peritonei and Mucinous Cystadenocarcinoma. Among its related pathways are Cytoskeleton remodeling Neurofilaments and Keratinization. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT5.

Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).

Chromosomal Localization:

12q13.13

Accession Number:

NP_005547.3

UniProt Accession Number:

P08729

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

SAYGGPVGAGIR

Native Sequence:

Calculated Isoelectric Point:

0

Molecular Weight:

1320

Last Updated:

02/26/2018

Characterization Data

SOPs

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