The Clinical Proteomic Technologies for Cancer (original) (raw)

O-6-Methylguanine-DNA Methyltransferase Peptide 1

Background

Catalog Number:

CPTC-MGMT-1

RRID:

AB_2890089

Target Antigen:

O-6-Methylguanine-DNA Methyltransferase Peptide 1

Isotype:

IgG

Species:

Rabbit Monoclonal Antibody

Last Updated:

02/09/2024

Antigen Recognition(s):

Peptide

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Characterization Data [Compare Characterization Data]
Background

NCI Identification Number:

00378

Antigen Name:

O-6-Methylguanine-DNA Methyltransferase Peptide 1

CPTC Name:

CPTC-MGMT Peptide 1

Aliases:

O-6-Methylguanine-DNA Methyltransferase; Methylated-DNA--Protein-Cysteine Methyltransferase; 6-O-Methylguanine-DNA Methyltransferase; O-6-Methylguanine-DNA-Alkyltransferase; EC 2.1.1.63; O6-Methylguanine-DNA Methyltransferase; Methylguanine-DNA Methyltransferase; MGMT

Function:

Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. MGMT (O-6-Methylguanine-DNA Methyltransferase) is a Protein Coding gene. Diseases associated with MGMT include Oligodendroglioma and Gliosarcoma. Among its related pathways are DNA Damage Reversal and Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include calcium ion binding and damaged DNA binding.Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. Protein arginine methyltransferases are enyzmes that catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to the arginine residues on histones and other proteins. The dysregulation of this methylation is critical in the development of certain cancers.

Chromosomal Localization:

10q26.3

Accession Number:

NP_002403.3

UniProt Accession Number:

P16455

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

GNPVPILIPCHR

Native Sequence:

Calculated Isoelectric Point:

Molecular Weight:

1320

Last Updated:

09/02/2020

Characterization Data

SOPs

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