The Clinical Proteomic Technologies for Cancer (original) (raw)

Macrophage Stimulating 1 Peptide 1

Background

Catalog Number:

CPTC-MST1-1

Target Antigen:

Macrophage Stimulating 1 Peptide 1

Isotype:

IgG

Species:

Rabbit Monoclonal Antibody

Last Updated:

02/09/2024

Antigen Recognition(s):

Peptide, Recombinant Full-length, Endogenous

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Characterization Data [Compare Characterization Data]

Western Blot - Tissue or Cell Lysate

Click to enlarge image Western blot using CPTC-MST1-1 as primary antibody against PBMC (lane 2), HeLa (lane 3), Jurkat (lane 4), A549 (lane 5), MCF7 (lane 6), and NCI-H226 (lane 7) whole cell lysates. Expected molecular weight - 80.3 kDa. Molecular weight standards are also included (lane 1). PBMC is presumed positive. All other cell lines are negative. Click image to enlarge

Result: Presumed Positive (with additional bands)

Western blot using CPTC-MST1-1 as primary antibody against PBMC (lane 2), HeLa (lane 3), Jurkat (lane 4), A549 (lane 5), MCF7 (lane 6), and NCI-H226 (lane 7) whole cell lysates. Expected molecular weight - 80.3 kDa. Molecular weight standards are also included (lane 1). PBMC is presumed positive. All other cell lines are negative.

Background

NCI Identification Number:

00435

Antigen Name:

Macrophage Stimulating 1 Peptide 1

CPTC Name:

CPTC-MST1 Peptide 1

Aliases:

Macrophage Stimulating 1; MSP; Hepatocyte Growth Factor-Like Protein; Macrophage-Stimulating Protein; D3F15S2; DNF15S2; NF15S2; HGFL; Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like); Hepatocyte Growth Factor-Like Protein Homolog; Macrophage Stimulatory Protein; Hepatocyte Growth Factor-Like; EC 3.4.21; MST1

Function:

The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds.MST1 (Macrophage Stimulating 1) is a Protein Coding gene. Diseases associated with MST1 include Cholangitis, Primary Sclerosing and Inflammatory Bowel Disease 12. Among its related pathways are Signaling by GPCR and amb2 Integrin signaling. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is HGF.

Chromosomal Localization:

3p21.31

Accession Number:

NP_066278.3

UniProt Accession Number:

P26927

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

VVGGHPGNSPWTVSLR

Native Sequence:

Calculated Isoelectric Point:

Molecular Weight:

1760

Last Updated:

09/28/2020

Characterization Data

SOPs

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