The Clinical Proteomic Technologies for Cancer (original) (raw)

5'-Nucleotidase Ecto Peptide 1

Background

NCI Identification Number:

00454

Antigen Name:

5'-Nucleotidase Ecto Peptide 1

CPTC Name:

CPTC-NT5E Peptide 1

Aliases:

5'-Nucleotidase Ecto; Ecto-5'-Nucleotidase; 5'-Nucleotidase; EC 3.1.3.5; CALJA; 5'-NT; CD73; NT5; NTE; ENT; EN; 5'-Nucleotidase, Ecto (CD73); Purine 5-Prime-Nucleotidase; 5' Nucleotidase (CD73); CD73 Antigen; E5NT; NT5E; NT

Function:

The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.NT5E (5'-Nucleotidase Ecto) is a Protein Coding gene. Diseases associated with NT5E include Calcification Of Joints And Arteries and Intestinal Tuberculosis. Among its related pathways are Neuroscience and ATP/ITP metabolism. Gene Ontology (GO) annotations related to this gene include nucleotide binding and hydrolase activity, acting on ester bonds.Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities.

Chromosomal Localization:

6q14.3

Accession Number:

NP_002517.1

UniProt Accession Number:

P21589

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

VIYPAVEGR

Native Sequence:

Calculated Isoelectric Point:

Molecular Weight:

990

Last Updated:

10/01/2020

Characterization Data

SOPs

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