The Clinical Proteomic Technologies for Cancer (original) (raw)

Proteasome 20S Subunit Alpha 1 Peptide 1

Background

NCI Identification Number:

00388

Antigen Name:

Proteasome 20S Subunit Alpha 1 Peptide 1

CPTC Name:

CPTC-PSMA1 Peptide 1

Aliases:

Proteasome 20S Subunit Alpha 1; PROS30; HC2; NU; Proteasome (Prosome, Macropain) Subunit, Alpha Type, 1; Multicatalytic Endopeptidase Complex Subunit C2; Proteasome Subunit Alpha Type-1; Proteasome Subunit Alpha 1; 30 KDa Prosomal Protein; Proteasome Component C2; Macropain Subunit C2; Proteasome Nu Chain; EC 3.4.25.1; PROS-30; Epididymis Secretory Protein Li 275; Proteasome Subunit, Alpha-Type, 1; Testicular Tissue Protein Li 150; Proteasome Subunit Alpha 6; Proteasome Subunit A6; Proteasome Subunit Nu; Macropain Subunit Nu; Protein P30-33K; HEL-S-275; MGC14542; MGC14575; MGC14751; MGC21459; MGC22853; MGC23915; MGC1667; PSMA1; PSC2

Function:

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms.PSMA1 (Proteasome 20S Subunit Alpha 1) is a Protein Coding gene. Diseases associated with PSMA1 include Cystic Fibrosis and Alzheimer Disease. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Antigen processing-Cross presentation. Gene Ontology (GO) annotations related to this gene include RNA binding and threonine-type endopeptidase activity. An important paralog of this gene is ENSG00000256206.Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).

Chromosomal Localization:

11p15.2

Accession Number:

NP_683877.1

UniProt Accession Number:

P25786

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

ETLPAEQDLTTK

Native Sequence:

Calculated Isoelectric Point:

Molecular Weight:

1320

Last Updated:

09/02/2020

Characterization Data

SOPs

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