The Clinical Proteomic Technologies for Cancer (original) (raw)

S100 Calcium Binding Protein A12 Peptide 1

Background

Catalog Number:

CPTC-S100A12-1

Target Antigen:

S100 Calcium Binding Protein A12 Peptide 1

Isotype:

IgG

Species:

Rabbit Recombinant Cloned Antibody

Last Updated:

08/23/2022

Antigen Recognition(s):

Peptide

Characterization Data [Compare Characterization Data]
Background

NCI Identification Number:

00332

Antigen Name:

S100 Calcium Binding Protein A12 Peptide 1

CPTC Name:

CPTC-S100A12 Peptide 1

Aliases:

S100 Calcium Binding Protein A12; Extracellular Newly Identified RAGE-Binding Protein; Migration Inhibitory Factor-Related Protein 6; Calcium-Binding Protein In Amniotic Fluid 1; Neutrophil S100 Protein; CAAF1; CAGC; CGRP; P6; Protein S100-A12; Calgranulin C; EN-RAGE; ENRAGE; MRP-6; MRP6; S100 Calcium-Binding Protein A12 (Calgranulin C); S100 Calcium-Binding Protein A12; Calgranulin-C; Calcitermin; S100A12

Function:

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. The protein includes an antimicrobial peptide which has antibacterial activity.S100A12 (S100 Calcium Binding Protein A12) is a Protein Coding gene. Diseases associated with S100A12 include Kawasaki Disease and Mooren's Ulcer. Among its related pathways are Activated TLR4 signalling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include calcium ion binding and RAGE receptor binding. An important paralog of this gene is S100A9.S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus.

Chromosomal Localization:

1q21.3

Accession Number:

NP_005612.1

UniProt Accession Number:

P80511

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

GHFDTLSK

Native Sequence:

Calculated Isoelectric Point:

Molecular Weight:

880

Last Updated:

08/23/2020

Characterization Data

SOPs

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