The Clinical Proteomic Technologies for Cancer (original) (raw)
Metastasin 100 Calcium-Binding Protein A4 (Calvasculin)
Background
NCI Identification Number:
10337
Antigen Name:
Metastasin 100 Calcium-Binding Protein A4 (Calvasculin)
CPTC Name:
CPTC-S100A4
Aliases:
S100A4; 18A2; 42A; CAPL; Calvasculin; FSP1; MTS1; Metastasin; OTTHUMP00000015467; OTTHUMP00000015468; OTTHUMP00000015469; OTTHUMP00000032895; P9KA; PEL98
Function:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Chromosomal Localization:
1q21
Expression System:
E. Coli
Accession Number:
M80563
UniProt Accession Number:
P26447
DNA Source:
HIP:HsCD00004965
Immunogen:
Recombinant Full Length Protein
Vector Name:
pMCSG7
Extinction Coefficient:
3105
Buffers:
50mM NH4HC03
Expressed Sequence:
SNAMACPLEKALDVMVSTFHKYSGKEGDKFKLNKSELKELLTRELPSFLG
KRTDEAAFQKLMSNLDSNRDNEVDFQEYCVFLSCIAMMCNEFFEGFPDKQ
PRKK
Native Sequence:
MACPLEKALDVMVSTFHKYSGKEGDKFKLNKSELKELLTRELPSFLGKRT
DEAAFQKLMSNLDSNRDNEVDFQEYCVFLSCIAMMCNEFFEGFPDKQPRK
K
Calculated Isoelectric Point:
5.84
Molecular Weight:
12001
Last Updated:
08/22/2020
Links
- Entrez - Entrez S100A4
- Uniprot - Uniprot P26447
Characterization Data
Gel
Click image to enlarge
Ag 10337
PAGE of Ag 10337 with molecular weight standards
SOPs
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