The Clinical Proteomic Technologies for Cancer (original) (raw)

SLAM Family Member 8 Peptide 1

Background

Catalog Number:

CPTC-SLAMF8-1

Target Antigen:

SLAM Family Member 8 Peptide 1

Isotype:

IgG

Species:

Rabbit Monoclonal Antibody

Last Updated:

07/03/2024

Antigen Recognition(s):

Peptide, Recombinant Full-length, Endogenous

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Characterization Data [Compare Characterization Data]

NCI 60 Protein Array

Click to enlarge image Protein Array in which CPTC-SLAMF8-1 is screened against the NCI60 cell line panel for expression. Data is normalized to a mean signal of 1.0 and standard deviation of 0.5. Color conveys over-expression level (green), basal level (blue), under-expression level (red). Click image to enlarge

Result: Presumed Positive

Protein Array in which CPTC-SLAMF8-1 is screened against the NCI60 cell line panel for expression. Data is normalized to a mean signal of 1.0 and standard deviation of 0.5. Color conveys over-expression level (green), basal level (blue), under-expression level (red).

Western Blot - Tissue or Cell Lysate

Click to enlarge image Western blot using CPTC-SLAMF8-1 as primary antibody against human PBMC (2), HeLa (3), Jurkat (4), A549 (5), MCF7 (6) and H226 (7) whole cell lysates. The expected molecular weight is 31.7 kDa. Cytochrome C was used as a loading control. Target is glycosylated. A549 is positive. All other cell lines are negative. Click image to enlarge

Result: Positive

Western blot using CPTC-SLAMF8-1 as primary antibody against human PBMC (2), HeLa (3), Jurkat (4), A549 (5), MCF7 (6) and H226 (7) whole cell lysates. The expected molecular weight is 31.7 kDa. Cytochrome C was used as a loading control. Target is glycosylated. A549 is positive. All other cell lines are negative.

Background

NCI Identification Number:

00393

Antigen Name:

SLAM Family Member 8 Peptide 1

CPTC Name:

CPTC-SLAMF8 Peptide 1

Aliases:

SLAM Family Member 8; BLAME; BCM-Like Membrane Protein; SBBI42; CD353; B Lymphocyte Activator Macrophage Expressed; B-Lymphocyte Activator Macrophage Expressed; CD353 Antigen; SLAMF8

Function:

This gene encodes a member of the CD2 family of cell surface proteins involved in lymphocyte activation. These proteins are characterized by Ig domains. This protein is expressed in lymphoid tissues, and studies of a similar protein in mouse suggest that it may function during B cell lineage commitment. The gene is found in a region of chromosome 1 containing many CD2 genes.SLAMF8 (SLAM Family Member 8) is a Protein Coding gene. Diseases associated with SLAMF8 include Familial Cold Autoinflammatory Syndrome 3. An important paralog of this gene is LY9.May play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor.

Chromosomal Localization:

1q23.2

Accession Number:

NP_064510.1

UniProt Accession Number:

Q9P0V8

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

VGGSVLLVAARPPGFQVR

Native Sequence:

Calculated Isoelectric Point:

Molecular Weight:

1980

Last Updated:

09/02/2020

Characterization Data

SOPs

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