The Clinical Proteomic Technologies for Cancer (original) (raw)

Signal Transducer And Activator Of Transcription 6 Peptide 1

Background

NCI Identification Number:

00456

Antigen Name:

Signal Transducer And Activator Of Transcription 6 Peptide 1

CPTC Name:

CPTC-STAT6 Peptide 1

Aliases:

Signal Transducer And Activator Of Transcription 6; Signal Transducer And Activator Of Transcription 6, Interleukin-4 Induced; IL-4-STAT; D12S1644; Transcription Factor IL-4 STAT; STAT, Interleukin4-Induced; EC 2.4.1.227; EC 2.7.7.6; IL-4 Stat; STAT6B; STAT6C; STAT6

Function:

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.STAT6 (Signal Transducer And Activator Of Transcription 6) is a Protein Coding gene. Diseases associated with STAT6 include Hemangiopericytoma, Malignant and Nut Allergy. Among its related pathways are Signaling by GPCR and GPCR Pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is STAT5B.Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.

Chromosomal Localization:

12q13.3

Accession Number:

NP_001171549.1

UniProt Accession Number:

P42226

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

GYVPATIK

Native Sequence:

Calculated Isoelectric Point:

Molecular Weight:

880

Last Updated:

10/01/2020

Characterization Data

SOPs

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