The Clinical Proteomic Technologies for Cancer (original) (raw)

Transporter 2, ATP Binding Cassette Subfamily B Member Peptide 1

Background

NCI Identification Number:

00399

Antigen Name:

Transporter 2, ATP Binding Cassette Subfamily B Member Peptide 1

CPTC Name:

CPTC-TAP2 Peptide 1

Aliases:

Transporter 2, ATP Binding Cassette Subfamily B Member; RING11; PSF2; Transporter 2, ATP-Binding Cassette, Sub-Family B (MDR/TAP); Peptide Transporter Involved In Antigen Processing 2; Really Interesting New Gene 11 Protein; Antigen Peptide Transporter 2; Peptide Transporter PSF2; Peptide Supply Factor 2; D6S217E; ABCB3; PSF-2; APT2; ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 3; ATP-Binding Cassette Sub-Family B Member 3; Transporter 2, ABC (ATP Binding Cassette); Peptide Transporter TAP2; ABC Transporter, MHC 2; ABC18; TAP2; Y1

Function:

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.TAP2 (Transporter 2, ATP Binding Cassette Subfamily B Member) is a Protein Coding gene. Diseases associated with TAP2 include Immunodeficiency By Defective Expression Of Mhc Class I and Bare Lymphocyte Syndrome, Type I. Among its related pathways are Antigen processing-Cross presentation and Regulation of activated PAK-2p34 by proteasome mediated degradation. Gene Ontology (GO) annotations related to this gene include transporter activity and ATPase activity, coupled to transmembrane movement of substances. An important paralog of this gene is ENSG00000250264.Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.

Chromosomal Localization:

6p21.32

Accession Number:

NP_000535.3

UniProt Accession Number:

Q03519

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

EAVGGLQTVR

Native Sequence:

Calculated Isoelectric Point:

Molecular Weight:

1100

Last Updated:

09/02/2020

Characterization Data

SOPs

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