The Clinical Proteomic Technologies for Cancer (original) (raw)

TNF Receptor Superfamily Member 17 Peptide 1

Background

NCI Identification Number:

00298

Antigen Name:

TNF Receptor Superfamily Member 17 Peptide 1

CPTC Name:

CPTC-TNFRSF17 Peptide 1

Aliases:

TNF Receptor Superfamily Member 17; Tumor Necrosis Factor Receptor Superfamily Member 17; B-Cell Maturation Protein; BCMA; BCM; Tumor Necrosis Factor Receptor Superfamily, Member 17; B Cell Maturation Antigen; B-Cell Maturation Factor; CD269 Antigen; TNFRSF13A; CD269

Function:

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. TNFRSF17 (TNF Receptor Superfamily Member 17) is a Protein Coding gene. Diseases associated with TNFRSF17 include Autoimmune Disease and Common Variable Immunodeficiency. Among its related pathways are PEDF Induced Signaling and Innate Immune System. An important paralog of this gene is TNFRSF13C.Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.

Chromosomal Localization:

16p13.13

Accession Number:

NP_001183.2

UniProt Accession Number:

Q02223

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

CSLPAALS(ph)ATEIEK

Native Sequence:

Calculated Isoelectric Point:

Molecular Weight:

1540

Last Updated:

08/21/2020

Characterization Data

SOPs

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