The Clinical Proteomic Technologies for Cancer (original) (raw)

Troponin T2, Cardiac Type Peptide 1

Background

Catalog Number:

CPTC-TNNT2-1

Target Antigen:

Troponin T2, Cardiac Type Peptide 1

Isotype:

IgG

Species:

Rabbit Recombinant Cloned Antibody

Last Updated:

08/24/2022

Antigen Recognition(s):

Peptide

Characterization Data [Compare Characterization Data]
Background

NCI Identification Number:

00335

Antigen Name:

Troponin T2, Cardiac Type Peptide 1

CPTC Name:

CPTC-TNNT2 Peptide 1

Aliases:

Troponin T2, Cardiac Type; Cardiomyopathy, Dilated 1D (Autosomal Dominant); Cardiomyopathy, Hypertrophic 2; Troponin T Type 2 (Cardiac); Troponin T, Cardiac Muscle; CMPD2; CTnT; Truncated Cardiac Troponin T; Cardiac Muscle Troponin T; CMD1D; LVNC6; TNNT2; CMH2; RCM3; TnTC; TnTc

Function:

The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined.TNNT2 (Troponin T2, Cardiac Type) is a Protein Coding gene. Diseases associated with TNNT2 include Cardiomyopathy, Dilated, 1D and Cardiomyopathy, Familial Hypertrophic, 2. Among its related pathways are Dilated cardiomyopathy (DCM) and Mesenchymal Stem Cells and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include actin binding and structural constituent of cytoskeleton. An important paralog of this gene is TNNT1.Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. TNNT2_HUMAN,P45379

Chromosomal Localization:

1q32.1

Accession Number:

XP_024305218.1

UniProt Accession Number:

P45379

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

VLAIDHLNEDQLR

Native Sequence:

Calculated Isoelectric Point:

Molecular Weight:

1430

Last Updated:

08/23/2020

Characterization Data

SOPs

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