The Clinical Proteomic Technologies for Cancer (original) (raw)

WAP Four-Disulfide Core Domain 2 Peptide 2

Background

Catalog Number:

CPTC-WFDC2-2

Target Antigen:

WAP Four-Disulfide Core Domain 2 Peptide 2

Isotype:

IgG

Species:

Rabbit Recombinant Cloned Antibody

Last Updated:

02/09/2024

Antigen Recognition(s):

Peptide, Recombinant Full-length, Endogenous

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Characterization Data [Compare Characterization Data]

IP

Result: Negative

Antibody CPTC-WFDC2-2 was tested in IP-WB in Cell lines OVCAR-8 and OVCAR-3. The antibody is not suitable for this application.

Background

NCI Identification Number:

00326

Antigen Name:

WAP Four-Disulfide Core Domain 2 Peptide 2

CPTC Name:

CPTC-WFDC2 Peptide 2

Aliases:

WAP Four-Disulfide Core Domain 2; WAP5; HE4; WAP Four-Disulfide Core Domain Protein 2; Major Epididymis-Specific Protein E4; Putative Protease Inhibitor WAP5; Epididymal Secretory Protein E4; Epididymal Protein 4; DJ461P17.6; EDDM4; Epididymis-Specific, Whey-Acidic Protein Type, Four-Disulfide Core; Epididymis Secretory Sperm Binding Protein; WAP Domain Containing Protein HE4-V4; WFDC2

Function:

This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. WFDC2 (WAP Four-Disulfide Core Domain 2) is a Protein Coding gene. Diseases associated with WFDC2 include Fallopian Tube Carcinoma and Ovarian Cancer. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity and cysteine-type endopeptidase inhibitor activity.Broad range protease inhibitor.

Chromosomal Localization:

20q13.12

Accession Number:

NP_006094.3

UniProt Accession Number:

Q14508

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

DQCQVDSQCPGQMK

Native Sequence:

Calculated Isoelectric Point:

Molecular Weight:

1540

Last Updated:

08/21/2020

Characterization Data

SOPs

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