Donna Rose Addis | The University of Auckland (original) (raw)
Uploads
Papers by Donna Rose Addis
Abstract Recent neuroimaging work has demonstrated that the hippocampus is engaged when imagining... more Abstract Recent neuroimaging work has demonstrated that the hippocampus is engaged when imagining the future, in some cases more than when remembering the past. It is possible that this hippocampal activation reflects recombining details into coherent scenarios and/or the encoding of these scenarios into memory for later use. However, inconsistent findings have emerged from recent studies of future simulation in patients with memory loss and hippocampal damage.
During the past few years, there has been a dramatic increase in research examining the role of m... more During the past few years, there has been a dramatic increase in research examining the role of memory in imagination and future thinking. This work has revealed striking similarities between remembering the past and imagining or simulating the future, including the finding that a common brain network underlies both memory and imagination.
Previous neuroimaging studies that have examined autobiographical memory specificity have utilize... more Previous neuroimaging studies that have examined autobiographical memory specificity have utilized retrieval cues associated with prior searches of the event, potentially changing the retrieval processes being investigated. In the current study, musical cues were used to naturally elicit memories from multiple levels of specificity (ie, lifetime period, general event, and event-specific). Sixteen young adults participated in a neuroimaging study in which they retrieved autobiographical memories associated with musical cues.
Autobiographical memory (AM) retrieval appears to specifically activate the hippocampus. It is li... more Autobiographical memory (AM) retrieval appears to specifically activate the hippocampus. It is likely that qualities of AMs that contribute to re-experiencing, such as detail, emotionality and personal significance, modulate hippocampal activation. We conducted an event-related fMRI study, in which participants retrieved 40 AMs, and rated each for either level of detail, emotion or personal significance. Two control tasks (sentence completion and size discrimination) were also included.
Methods Participants viewed positive and negative images while undergoing a functional magnetic r... more Methods Participants viewed positive and negative images while undergoing a functional magnetic resonance imaging (fMRI) scan. Structural equation modeling was used to compare young and older adults' connectivity among regions of the emotional memory network while they encoded negative or positive items. Results Aging did not impact the connectivity among regions engaged during the encoding of negative information, but age differences did arise during the encoding of positive information.
Patient and neuroimaging studies report that the ability to remember past personal experiences an... more Patient and neuroimaging studies report that the ability to remember past personal experiences and the ability to envision future personal experiences are interconnected. Loss of episodic memory is typically accompanied by loss of future imagining, and engaging in either activity recruits common brain areas. The relationship between episodic memory and future imagining is also suggested by their co-emergence in ontogenetic development.
Abstract Recent studies have demonstrated that remembering past experiences and imagining future ... more Abstract Recent studies have demonstrated that remembering past experiences and imagining future scenarios recruits a core network including the hippocampus. Even so, constructing future events engages the hippocampus more than remembering past events. This fMRI study examined whether increased hippocampal activity for future events includes both specific and general events. Participants constructed specific and general past and future events during fMRI scanning.
Abstract Mental simulations of future experiences are often concerned with emotionally arousing e... more Abstract Mental simulations of future experiences are often concerned with emotionally arousing events. Although it is widely believed that mental simulations enhance future behavior, virtually nothing is known about how memory for these simulations changes over time or whether simulations of emotional experiences are especially well remembered.
Summary Semantic dementia is a progressive neurodegenerative condition characterized by the profo... more Summary Semantic dementia is a progressive neurodegenerative condition characterized by the profound and amodal loss of semantic memory in the context of relatively preserved episodic memory. In contrast, patients with Alzheimer's disease typically display impairments in episodic memory, but with semantic deficits of a much lesser magnitude than in semantic dementia.
We examined the neural correlates of specific (ie, unique to time and place) and general (ie, ext... more We examined the neural correlates of specific (ie, unique to time and place) and general (ie, extended in or repeated over time) autobiographical memories (AMs) during their initial construction and later elaboration phases. The construction and elaboration of specific and general events engaged a widely distributed set of regions previously associated with AM recall. Specific (vs.
Numerous neuroimaging studies have revealed that in young adults, remembering the past and imagin... more Numerous neuroimaging studies have revealed that in young adults, remembering the past and imagining the future engage a common core network. Although it has been observed that older adults engage a similar network during these tasks, it is unclear whether or not they activate this network in a similar manner to young adults. Young and older participants completed two autobiographical tasks (imagining future events and recalling past events) in addition to a semantic���visuospatial control task.
Models of autobiographical memory propose two routes to retrieval depending on cue specificity. W... more Models of autobiographical memory propose two routes to retrieval depending on cue specificity. When available cues are specific and personally-relevant, a memory can be directly accessed. However, when available cues are generic, one must engage a generative retrieval process to produce more specific cues to successfully access a relevant memory. The current study sought to characterize the neural bases of these retrieval processes.
Abstract Older adults show age-related reductions in memory for neutral items within complex visu... more Abstract Older adults show age-related reductions in memory for neutral items within complex visual scenes, but just like young adults, older adults exhibit a memory advantage for emotional items within scenes compared with the background scene information. The present study examined young and older adults' encoding-stage effective connectivity for selective memory of emotional items versus memory for both the emotional item and its background.
Abstract The role of the hippocampus in imagining the future has been of considerable interest. P... more Abstract The role of the hippocampus in imagining the future has been of considerable interest. Preferential right hippocampal engagement is observed for imagined future events relative to remembered past events, and patients with hippocampal damage are impaired when imagining detailed future events. However, some patients with hippocampal damage are not impaired at imagining, suggesting that there are conditions in which the hippocampus may not be necessary for episodic simulation.
Neuropsychologia, Jan 1, 2007
Journal of …, Jan 1, 2005
Nature Reviews Neuroscience, Jan 1, 2007
Philosophical …, Jan 1, 2007
Annals of the New York …, Jan 1, 2008
Abstract Recent neuroimaging work has demonstrated that the hippocampus is engaged when imagining... more Abstract Recent neuroimaging work has demonstrated that the hippocampus is engaged when imagining the future, in some cases more than when remembering the past. It is possible that this hippocampal activation reflects recombining details into coherent scenarios and/or the encoding of these scenarios into memory for later use. However, inconsistent findings have emerged from recent studies of future simulation in patients with memory loss and hippocampal damage.
During the past few years, there has been a dramatic increase in research examining the role of m... more During the past few years, there has been a dramatic increase in research examining the role of memory in imagination and future thinking. This work has revealed striking similarities between remembering the past and imagining or simulating the future, including the finding that a common brain network underlies both memory and imagination.
Previous neuroimaging studies that have examined autobiographical memory specificity have utilize... more Previous neuroimaging studies that have examined autobiographical memory specificity have utilized retrieval cues associated with prior searches of the event, potentially changing the retrieval processes being investigated. In the current study, musical cues were used to naturally elicit memories from multiple levels of specificity (ie, lifetime period, general event, and event-specific). Sixteen young adults participated in a neuroimaging study in which they retrieved autobiographical memories associated with musical cues.
Autobiographical memory (AM) retrieval appears to specifically activate the hippocampus. It is li... more Autobiographical memory (AM) retrieval appears to specifically activate the hippocampus. It is likely that qualities of AMs that contribute to re-experiencing, such as detail, emotionality and personal significance, modulate hippocampal activation. We conducted an event-related fMRI study, in which participants retrieved 40 AMs, and rated each for either level of detail, emotion or personal significance. Two control tasks (sentence completion and size discrimination) were also included.
Methods Participants viewed positive and negative images while undergoing a functional magnetic r... more Methods Participants viewed positive and negative images while undergoing a functional magnetic resonance imaging (fMRI) scan. Structural equation modeling was used to compare young and older adults' connectivity among regions of the emotional memory network while they encoded negative or positive items. Results Aging did not impact the connectivity among regions engaged during the encoding of negative information, but age differences did arise during the encoding of positive information.
Patient and neuroimaging studies report that the ability to remember past personal experiences an... more Patient and neuroimaging studies report that the ability to remember past personal experiences and the ability to envision future personal experiences are interconnected. Loss of episodic memory is typically accompanied by loss of future imagining, and engaging in either activity recruits common brain areas. The relationship between episodic memory and future imagining is also suggested by their co-emergence in ontogenetic development.
Abstract Recent studies have demonstrated that remembering past experiences and imagining future ... more Abstract Recent studies have demonstrated that remembering past experiences and imagining future scenarios recruits a core network including the hippocampus. Even so, constructing future events engages the hippocampus more than remembering past events. This fMRI study examined whether increased hippocampal activity for future events includes both specific and general events. Participants constructed specific and general past and future events during fMRI scanning.
Abstract Mental simulations of future experiences are often concerned with emotionally arousing e... more Abstract Mental simulations of future experiences are often concerned with emotionally arousing events. Although it is widely believed that mental simulations enhance future behavior, virtually nothing is known about how memory for these simulations changes over time or whether simulations of emotional experiences are especially well remembered.
Summary Semantic dementia is a progressive neurodegenerative condition characterized by the profo... more Summary Semantic dementia is a progressive neurodegenerative condition characterized by the profound and amodal loss of semantic memory in the context of relatively preserved episodic memory. In contrast, patients with Alzheimer's disease typically display impairments in episodic memory, but with semantic deficits of a much lesser magnitude than in semantic dementia.
We examined the neural correlates of specific (ie, unique to time and place) and general (ie, ext... more We examined the neural correlates of specific (ie, unique to time and place) and general (ie, extended in or repeated over time) autobiographical memories (AMs) during their initial construction and later elaboration phases. The construction and elaboration of specific and general events engaged a widely distributed set of regions previously associated with AM recall. Specific (vs.
Numerous neuroimaging studies have revealed that in young adults, remembering the past and imagin... more Numerous neuroimaging studies have revealed that in young adults, remembering the past and imagining the future engage a common core network. Although it has been observed that older adults engage a similar network during these tasks, it is unclear whether or not they activate this network in a similar manner to young adults. Young and older participants completed two autobiographical tasks (imagining future events and recalling past events) in addition to a semantic���visuospatial control task.
Models of autobiographical memory propose two routes to retrieval depending on cue specificity. W... more Models of autobiographical memory propose two routes to retrieval depending on cue specificity. When available cues are specific and personally-relevant, a memory can be directly accessed. However, when available cues are generic, one must engage a generative retrieval process to produce more specific cues to successfully access a relevant memory. The current study sought to characterize the neural bases of these retrieval processes.
Abstract Older adults show age-related reductions in memory for neutral items within complex visu... more Abstract Older adults show age-related reductions in memory for neutral items within complex visual scenes, but just like young adults, older adults exhibit a memory advantage for emotional items within scenes compared with the background scene information. The present study examined young and older adults' encoding-stage effective connectivity for selective memory of emotional items versus memory for both the emotional item and its background.
Abstract The role of the hippocampus in imagining the future has been of considerable interest. P... more Abstract The role of the hippocampus in imagining the future has been of considerable interest. Preferential right hippocampal engagement is observed for imagined future events relative to remembered past events, and patients with hippocampal damage are impaired when imagining detailed future events. However, some patients with hippocampal damage are not impaired at imagining, suggesting that there are conditions in which the hippocampus may not be necessary for episodic simulation.
Neuropsychologia, Jan 1, 2007
Journal of …, Jan 1, 2005
Nature Reviews Neuroscience, Jan 1, 2007
Philosophical …, Jan 1, 2007
Annals of the New York …, Jan 1, 2008