Karim S Abdallah | Assiut University (original) (raw)

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Papers by Karim S Abdallah

Research paper thumbnail of Biosimilar Recombinant Human FSH (Follitropin Alpha) for Controlled Ovarian Stimulation in Ovulatory Women Undergone Ivf/Icsi Cycles? A Systematic Review and Meta-Analysis

Research paper thumbnail of Misdiagnosed Septate Uterus in Women Scheduled for In-Vitro-Fertilization (Ivf): A 5-YEAR Cohort Study

Fertility and Sterility, 2020

Research paper thumbnail of Predictability of Ovarian Sensitivity Index for Antagonist-Protocol Icsi Cycle Outcomes

Fertility and Sterility, 2021

Research paper thumbnail of Impairment of Uterine Contractility Is Associated with Unexplained Infertility

Seminars in Reproductive Medicine, 2020

The uterine junctional zone represents the juncture between endometrium and myometrium. The junct... more The uterine junctional zone represents the juncture between endometrium and myometrium. The junctional zone is hormonally dependent and displays continuous peristaltic activity throughout the menstrual cycle in the nonpregnant state which is concerned with sperm transport and embryo implantation. Peristalsis may be observed using various invasive and noninvasive modalities, of which ultrasound is the most readily applied in the clinical setting. Women with pelvic pathology display alterations in uterine peristalsis which may contribute to infertility. Characterization of peristalsis in infertility subgroups, the development of a subjective peristalsis tool, and the application of potential therapeutics to an assisted reproductive treatment setting are the subject of ongoing investigation. Meta-analysis indicates a potential role for oxytocin antagonist in the improvement of fertility treatments.

Research paper thumbnail of How and Why to Define Unexplained Infertility?

Seminars in Reproductive Medicine, 2020

Unexplained infertility represents up to 30% of all cases of infertility. It is a diagnosis of ex... more Unexplained infertility represents up to 30% of all cases of infertility. It is a diagnosis of exclusion, where no cause for infertility may be identified in the investigation of the couple, be it anovulation, fallopian tube blockage, or severe male factor. Unexplained infertility therefore cannot be considered a diagnosis to which a specific treatment is directed, rather that it indicates a failure to reach a diagnosis of the true cause of infertility. In this review, we explore the evidence base and potential limitations of the current routine infertility assessment. We also aim to highlight the importance of considering the prognosis of each individual couple through the process of assessment and propose a reconsidered approach to treatment, targeted to the prognosis rather than the diagnosis. Ultimately, a better understanding of the mechanisms of infertility will reduce the number of couples diagnosed with “unexplained” infertility.

Research paper thumbnail of Uterine distension media for outpatient hysteroscopy

Research paper thumbnail of Evaluation of Endometrial and Subendometrial Vascularization and Endometrial Volume by 3-D Power Doppler Ultrasound and Its Relationship with Age and Pregnancy in Intrauterine Insemination Cycles

Gynecologic and Obstetric Investigation, 2011

Aims: To measure endometrial volume and endometrial-subendometrial vascularization by 3-D power D... more Aims: To measure endometrial volume and endometrial-subendometrial vascularization by 3-D power Doppler ultrasound in patients undergoing cycles of artificial insemination with ovarian stimulation, to evaluate their relationship with patients’ age and pregnancy development. Methods: We included patients with primary and secondary infertility of one year of evolution. We measured vascular indexes and endometrial volume by 3-D power Doppler ultrasound. Results: Seventy-nine consecutive cycles were studied. Endometrial volume average was 4.7 ± 2.66 ml. We did not find any difference between the endometrial volumes in women who did versus did not become pregnant (9 vs. 70 women, respectively). The endometrial vascular index was significantly higher in patients aged between 31 and 33 years old. In patients between the ages of 31 and 33, both the endometrial flow index (FI; p = 0.017) and the endometrial vascular FI (p = 0.013) were higher. At the subendometrial area, the vascular FI was ...

Research paper thumbnail of Intrauterine injection of human chorionic gonadotropin before embryo transfer may improve clinical pregnancy and implantation rates in blastocysts transfers

Fertility and Sterility, 2013

Objective: To evaluate whether intrauterine injection of hCG before embryo transfer can improve I... more Objective: To evaluate whether intrauterine injection of hCG before embryo transfer can improve IVF-ET outcomes. Design: Meta-analysis. Setting: Not applicable. Patient(s): Infertile women who underwent IVF-ET and received an intrauterine injection of hCG before ET. Intervention(s): Infertile women treated with or without intrauterine hCG injection before ET. Main Outcome Measure(s): The primary outcomes were live birth rate (LBR), ongoing pregnancy rate (OPR), and clinical pregnancy rate (CPR), and the secondary outcomes were implantation rate (IR) and miscarriage rate (MR). Odds ratios with 95% confidence intervals (CIs) and successful ET rates were pooled to determine the effects of hCG on IVF-ET outcomes. Result(s): Fifteen randomized controlled trials (RCTs) with a total of 2,763 participants were included. Infertile women in the experimental group (treated with intrauterine hCG injection before ET) exhibited significantly higher LBR (44.89% vs. 29.76%), OPR (48.09% vs. 33.42%), CPR (47.80% vs. 32.78%), and IR (31.64% vs. 22.52%) than those in the control group (intrauterine injection of placebo or no injection). Furthermore, MR was significantly lower (12.45% vs. 18.56%) in the experimental group than in the control group. Conclusion(s): The findings of this meta-analysis indicate that intrauterine injection of hCG can improve LBR, OPR, CPR, and IR after IVF-ET cycles. In addition, different timing and dosages of hCG administration may exert different effects on IVT-ET outcomes. Notably, infertile women treated with 500 IU hCG within 15 minutes before ET can achieve optimal IVF-ET outcomes. (Fertil Steril Ò 2019;112:89-97. Ó2019 by American Society for Reproductive Medicine.) El resumen está disponible en Español al final del artículo.

Research paper thumbnail of Biosimilar Recombinant Human FSH (Follitropin Alpha) for Controlled Ovarian Stimulation in Ovulatory Women Undergone Ivf/Icsi Cycles? A Systematic Review and Meta-Analysis

Research paper thumbnail of Misdiagnosed Septate Uterus in Women Scheduled for In-Vitro-Fertilization (Ivf): A 5-YEAR Cohort Study

Fertility and Sterility, 2020

Research paper thumbnail of Predictability of Ovarian Sensitivity Index for Antagonist-Protocol Icsi Cycle Outcomes

Fertility and Sterility, 2021

Research paper thumbnail of Impairment of Uterine Contractility Is Associated with Unexplained Infertility

Seminars in Reproductive Medicine, 2020

The uterine junctional zone represents the juncture between endometrium and myometrium. The junct... more The uterine junctional zone represents the juncture between endometrium and myometrium. The junctional zone is hormonally dependent and displays continuous peristaltic activity throughout the menstrual cycle in the nonpregnant state which is concerned with sperm transport and embryo implantation. Peristalsis may be observed using various invasive and noninvasive modalities, of which ultrasound is the most readily applied in the clinical setting. Women with pelvic pathology display alterations in uterine peristalsis which may contribute to infertility. Characterization of peristalsis in infertility subgroups, the development of a subjective peristalsis tool, and the application of potential therapeutics to an assisted reproductive treatment setting are the subject of ongoing investigation. Meta-analysis indicates a potential role for oxytocin antagonist in the improvement of fertility treatments.

Research paper thumbnail of How and Why to Define Unexplained Infertility?

Seminars in Reproductive Medicine, 2020

Unexplained infertility represents up to 30% of all cases of infertility. It is a diagnosis of ex... more Unexplained infertility represents up to 30% of all cases of infertility. It is a diagnosis of exclusion, where no cause for infertility may be identified in the investigation of the couple, be it anovulation, fallopian tube blockage, or severe male factor. Unexplained infertility therefore cannot be considered a diagnosis to which a specific treatment is directed, rather that it indicates a failure to reach a diagnosis of the true cause of infertility. In this review, we explore the evidence base and potential limitations of the current routine infertility assessment. We also aim to highlight the importance of considering the prognosis of each individual couple through the process of assessment and propose a reconsidered approach to treatment, targeted to the prognosis rather than the diagnosis. Ultimately, a better understanding of the mechanisms of infertility will reduce the number of couples diagnosed with “unexplained” infertility.

Research paper thumbnail of Uterine distension media for outpatient hysteroscopy

Research paper thumbnail of Evaluation of Endometrial and Subendometrial Vascularization and Endometrial Volume by 3-D Power Doppler Ultrasound and Its Relationship with Age and Pregnancy in Intrauterine Insemination Cycles

Gynecologic and Obstetric Investigation, 2011

Aims: To measure endometrial volume and endometrial-subendometrial vascularization by 3-D power D... more Aims: To measure endometrial volume and endometrial-subendometrial vascularization by 3-D power Doppler ultrasound in patients undergoing cycles of artificial insemination with ovarian stimulation, to evaluate their relationship with patients’ age and pregnancy development. Methods: We included patients with primary and secondary infertility of one year of evolution. We measured vascular indexes and endometrial volume by 3-D power Doppler ultrasound. Results: Seventy-nine consecutive cycles were studied. Endometrial volume average was 4.7 ± 2.66 ml. We did not find any difference between the endometrial volumes in women who did versus did not become pregnant (9 vs. 70 women, respectively). The endometrial vascular index was significantly higher in patients aged between 31 and 33 years old. In patients between the ages of 31 and 33, both the endometrial flow index (FI; p = 0.017) and the endometrial vascular FI (p = 0.013) were higher. At the subendometrial area, the vascular FI was ...

Research paper thumbnail of Intrauterine injection of human chorionic gonadotropin before embryo transfer may improve clinical pregnancy and implantation rates in blastocysts transfers

Fertility and Sterility, 2013

Objective: To evaluate whether intrauterine injection of hCG before embryo transfer can improve I... more Objective: To evaluate whether intrauterine injection of hCG before embryo transfer can improve IVF-ET outcomes. Design: Meta-analysis. Setting: Not applicable. Patient(s): Infertile women who underwent IVF-ET and received an intrauterine injection of hCG before ET. Intervention(s): Infertile women treated with or without intrauterine hCG injection before ET. Main Outcome Measure(s): The primary outcomes were live birth rate (LBR), ongoing pregnancy rate (OPR), and clinical pregnancy rate (CPR), and the secondary outcomes were implantation rate (IR) and miscarriage rate (MR). Odds ratios with 95% confidence intervals (CIs) and successful ET rates were pooled to determine the effects of hCG on IVF-ET outcomes. Result(s): Fifteen randomized controlled trials (RCTs) with a total of 2,763 participants were included. Infertile women in the experimental group (treated with intrauterine hCG injection before ET) exhibited significantly higher LBR (44.89% vs. 29.76%), OPR (48.09% vs. 33.42%), CPR (47.80% vs. 32.78%), and IR (31.64% vs. 22.52%) than those in the control group (intrauterine injection of placebo or no injection). Furthermore, MR was significantly lower (12.45% vs. 18.56%) in the experimental group than in the control group. Conclusion(s): The findings of this meta-analysis indicate that intrauterine injection of hCG can improve LBR, OPR, CPR, and IR after IVF-ET cycles. In addition, different timing and dosages of hCG administration may exert different effects on IVT-ET outcomes. Notably, infertile women treated with 500 IU hCG within 15 minutes before ET can achieve optimal IVF-ET outcomes. (Fertil Steril Ò 2019;112:89-97. Ó2019 by American Society for Reproductive Medicine.) El resumen está disponible en Español al final del artículo.