Dimitrios Michmizos | Aristotle University of Thessaloniki (original) (raw)

Papers by Dimitrios Michmizos

Research paper thumbnail of Remyelination in the subcortical areas of the rat’s brain following mild heat lesions

Multiple Sclerosis Journal, 1999

Research paper thumbnail of Cardiovascular diseases and Alzheimer's disease: A potential relationship

Journal of Systems and Integrative Neuroscience, 2019

The study of the relationship between cardiovascular diseases (CVDs) and Alzheimer's disease (AD)... more The study of the relationship between cardiovascular diseases (CVDs) and Alzheimer's disease (AD) can be complicated. The diagnostic criteria of AD usually exclude patients with any clinical CVD (the combination of CVD and dementia leading more strongly towards a diagnosis of multi-infarction dementia rather than in AD). Nevertheless, there is strong evidence supporting the notion that CVDs contributes at least to the onset of AD, as demonstrated by numerous autopsy studies. The incidence of microvascular ischemic episodes has been found to strongly correlate with Dementia. Nevertheless, it is not clear whether this association is due to the fact that they share common risk factors or if the CVDs are directly or indirectly involved in the pathogenesis leading to AD. Understanding the etiology of one of these diseases can lead to understanding the onset, progression and treatment of the other.

Research paper thumbnail of The morphology of brain capillaries and the blood brain barrier in vascular dementia and in Alzheimer's disease

Research paper thumbnail of Individual Supportive Psychotherapy in Multiple Sclerosis: A Single-Case Study

This individual case study follows a 47-yearold woman who was directed by her treating physicians... more This individual case study follows a 47-yearold woman who was directed by her treating physicians to individual psychotherapy after being diagnosed with Multiple Sclerosis (MS). The main methods our study was based on were clinical observations and neuropsychological assessments. The patient’s concerns revolved around her self-care and her inability to set boundaries in her interpersonal relationships. During her first sessions, she demonstrated symptoms of anxiety, depression, and self-destructive behavior. Due to these facts, psycho-supportive medication was deemed essential. The main purpose of this case study was to investigate whether supportive psychotherapy may be of additional help to patients with MS. In this individual case, we will present how effective supportive psychotherapy can be for the patient, which is part of the treatment for a personalized holistic intervention programme. Given the lack of relevant research in Greece, this study can help expand the knowledge an...

Research paper thumbnail of The probable auto-antigenic role of lipids (anti-ganglioside antibodies) in the pathogenesis of Alzheimer's disease

Journal of Alzheimer's disease : JAD, 2014

We examined the sera of 103 demented patients of a mean age of 75 years and 60 age-matched health... more We examined the sera of 103 demented patients of a mean age of 75 years and 60 age-matched healthy individuals, using ELISA, to investigate the levels of IgM antibodies against GM1, GD1b, and GQ1b gangliosides and their possible correlation with clinical parameters (age, severity, and type of dementia). All the individuals that demonstrated positive titers of anti-ganglioside antibodies were demented patients whereas normal controls showed borderline or negative values. Significant correlation was revealed between IgM anti-GM1 and both the age of the patients and the severity of dementia. Most of the patients with increased IgM anti-GD1b titers suffered from AD.

Research paper thumbnail of Increase of interleukin-6 levels is related with depressive phenomena in the acute (relapsing) phase of multiple sclerosis

Multiple Sclerosis Journal, 2012

Research paper thumbnail of Anti-MAG antibodies during clinical exacerbation of multiple sclerosis

Multiple Sclerosis Journal, 1999

Research paper thumbnail of Cognitive decline in Multiple Sclerosis patients

Hellenic journal of nuclear medicine, 2019

Cognitive impairment is a common phenomenon in multiple sclerosis (MS), occurring at all stages o... more Cognitive impairment is a common phenomenon in multiple sclerosis (MS), occurring at all stages of the disease, even at the earliest, and can be a major source of disability, social impairment, and impoverished quality of life. Cognitive dysfunction is mainly focused on working memory, conceptual reasoning, verbal fluency, speed of information processing, attention and executive function. Additional clinical factors, including disease course, fatigue and affective disturbance, can impact the degree of MS-related cognitive impairment. We present the results from the two-phases of our prospective study on cognitive decline in MS patients using the data collected from the A' Neurologic clinic at AHEPA hospital, Thessaloniki, Greece. Most of the patients of the present study revealed mild cognitive impairment with mild influence on the everyday function. We found weak correlation between cognitive deficit and the duration of MS, as well as the physical disability status and moderate...

Research paper thumbnail of Remyelination in the subcortical areas of the rat’s brain following mild heat lesions

Multiple Sclerosis Journal, 1999

Research paper thumbnail of Preliminary Results on Cognitive Impairment in A Cohort of Greek Multiple Sclerosis Patients

Open Access Journal of Neurology & Neurosurgery

Research paper thumbnail of Individual Supportive Psychotherapy in Multiple Sclerosis: A Single-Case Study

This individual case study follows a 47-yearold woman who was directed by her treating physicians... more This individual case study follows a 47-yearold woman who was directed by her treating physicians to individual psychotherapy after being diagnosed with Multiple Sclerosis (MS). The main methods our study was based on were clinical observations and neuropsychological assessments. The patient's concerns revolved around her self-care and her inability to set boundaries in her interpersonal relationships. During her first sessions, she demonstrated symptoms of anxiety, depression, and self-destructive behavior. Due to these facts, psycho-supportive medication was deemed essential. The main purpose of this case study was to investigate whether supportive psychotherapy may be of additional help to patients with MS. In this individual case, we will present how effective supportive psychotherapy can be for the patient, which is part of the treatment for a personalized holistic intervention programme. Given the lack of relevant research in Greece, this study can help expand the knowledge and deepen the understanding in this field. Moreover, this study may reinforce the importance the care of MS patients to be carried out in a holistic intervention program. After one year of individual psychotherapy, the patient demonstrated significant improvement. Psychotherapeutic and supportive interventions, combined with MS medication, have been proved to be a more appropriate treatment for coping with and managing this chronic disease.

Research paper thumbnail of A probable role of copper in the comorbidity in Wilson’s and Creutzfeldt-Jakob’s Diseases: a case report

Virology Journal

Background To the best of our knowledgedd, there is currently no case in the literature reporting... more Background To the best of our knowledgedd, there is currently no case in the literature reporting the comorbidity of Wilson’s and Creutzfeldt-Jakob disease (CJD), linked through copper. Case presentation A 44-year-old male with a history of inherited Wilson’s disease (hepatolenticular degeneration), which manifested as mild liver injury and psychiatric symptoms, was admitted to our department due to speech and cognitive disturbances. Upon his admission, he had motor aphasia as well as psychomotor retardation with an otherwise normal neurological examination. Laboratory tests, including liver enzymes, copper and serum ammonia were all within normal range. The brain MRI showed increased T2 signal in the caudate nuclei, attributed to copper deposition in the context of Wilson’s disease. In the electroencephalogram, periodic sharp discharges were eminent, initially unilateral and then generalized. The positive 14–3-3 protein in the cerebrospinal fluid (CSF) and the new brain MRI, that d...

Research paper thumbnail of Ultrastructural study of the human cerebellar cortex

Journal of Neurology & Stroke

There are four kinds of inhibitory neurons in the cerebellar cortex. The basket cells, the stella... more There are four kinds of inhibitory neurons in the cerebellar cortex. The basket cells, the stellate neurons and the Golgi II neurons that produce inhibitory synapses with Purkinje cells using mainly GABA. GABAenergic vesicles are ellipsoid in contrast to the cholinergic which are spheroid. This why Gray named the cholinergic, vesicles S J Neurol Stroke. 2019;9(2):57-59.

Research paper thumbnail of A Roadmap Towards A Functional Paradigm For Learning & Memory In Plants

Journal of Plant Physiology

Research paper thumbnail of Late-life depression and Alzheimer disease: a potential synergy of the underlying mechanisms

Current medicinal chemistry, Sep 2, 2016

A number of biological and clinical characteristics typical of late life depression (LLD) has bee... more A number of biological and clinical characteristics typical of late life depression (LLD) has been suggested by recent research findings. The close association of LLD with cognitive impairment is now well documented and evidenced. However, it is still not clear whether it is depression that leads to cognitive decline, and in more severe cases, to dementia. The work presented in this review article suggests that depression and dementia frequently and strongly copresent, even if the causality remains largely opaque.

Research paper thumbnail of Kimmerle's Anomaly as a Possible Causative Factor of Chronic Tension-Type Headaches and Neurosensory Hearing Loss: Case Report and Literature Review

The International Journal of Neuroscience, Mar 1, 2010

Kimmerle&... more Kimmerle's anomaly also known as ponticulus posticus is a common anatomical variation of the atlas, the first cervical vertebra. It is the product of the complete or incomplete ossification of the posterior atlanto-occipital membrane over the vertebral artery groove resulting in the formation of a foramen (arcuate foramen) containing the vertebral artery and the posterior branch of the C-1 spinal nerve. This variation has been associated with vertebro-basilar insufficiency symptoms, various types of headaches, and acute hearing loss. The aim of the present study is to substantiate whether Kimmerle's anomaly is the possible cause of chronic tension-type headaches and neurosensory-type hearing loss in a patient with a known history of headaches and accompanied unilateral hearing loss. The headaches demonstrated the characteristics of the chronic tension-type; the audiometric investigation concluded the hearing loss to be of the neurosensory type; whereas, the imaging examinations revealed the existence of a partial osseous bridge, that is an incomplete arcuate foramen (ponticulus posticus or Kimmerle's anomaly) on the upper surface of atlas. Both the clinical and the radiological findings of this case are indicative of a possible connection between Kimmerle's anomaly and the manifestation of chronic tension-type headaches and neurosensory-type hearing loss.

Research paper thumbnail of Increase of IL-6 levels in the acute phase of multiple sclerosis is possibly related with the presence of depression

European Journal of Neurology

Research paper thumbnail of Increase in Interleukin-6 Levels Is Related to Depressive Phenomena in the Acute (Relapsing) Phase of Multiple Sclerosis

Journal of Neuropsychiatry, 2011

Research paper thumbnail of Living with Multiple Sclerosis

AJN, American Journal of Nursing, 1955

Research paper thumbnail of Kimmerle's Anomaly as a Possible Causative Factor of Chronic Tension-Type Headaches and Neurosensory Hearing Loss: Case Report and Literature Review

The International Journal of Neuroscience, Mar 1, 2010

Kimmerle&... more Kimmerle's anomaly also known as ponticulus posticus is a common anatomical variation of the atlas, the first cervical vertebra. It is the product of the complete or incomplete ossification of the posterior atlanto-occipital membrane over the vertebral artery groove resulting in the formation of a foramen (arcuate foramen) containing the vertebral artery and the posterior branch of the C-1 spinal nerve. This variation has been associated with vertebro-basilar insufficiency symptoms, various types of headaches, and acute hearing loss. The aim of the present study is to substantiate whether Kimmerle's anomaly is the possible cause of chronic tension-type headaches and neurosensory-type hearing loss in a patient with a known history of headaches and accompanied unilateral hearing loss. The headaches demonstrated the characteristics of the chronic tension-type; the audiometric investigation concluded the hearing loss to be of the neurosensory type; whereas, the imaging examinations revealed the existence of a partial osseous bridge, that is an incomplete arcuate foramen (ponticulus posticus or Kimmerle's anomaly) on the upper surface of atlas. Both the clinical and the radiological findings of this case are indicative of a possible connection between Kimmerle's anomaly and the manifestation of chronic tension-type headaches and neurosensory-type hearing loss.

Research paper thumbnail of Remyelination in the subcortical areas of the rat’s brain following mild heat lesions

Multiple Sclerosis Journal, 1999

Research paper thumbnail of Cardiovascular diseases and Alzheimer's disease: A potential relationship

Journal of Systems and Integrative Neuroscience, 2019

The study of the relationship between cardiovascular diseases (CVDs) and Alzheimer's disease (AD)... more The study of the relationship between cardiovascular diseases (CVDs) and Alzheimer's disease (AD) can be complicated. The diagnostic criteria of AD usually exclude patients with any clinical CVD (the combination of CVD and dementia leading more strongly towards a diagnosis of multi-infarction dementia rather than in AD). Nevertheless, there is strong evidence supporting the notion that CVDs contributes at least to the onset of AD, as demonstrated by numerous autopsy studies. The incidence of microvascular ischemic episodes has been found to strongly correlate with Dementia. Nevertheless, it is not clear whether this association is due to the fact that they share common risk factors or if the CVDs are directly or indirectly involved in the pathogenesis leading to AD. Understanding the etiology of one of these diseases can lead to understanding the onset, progression and treatment of the other.

Research paper thumbnail of The morphology of brain capillaries and the blood brain barrier in vascular dementia and in Alzheimer's disease

Research paper thumbnail of Individual Supportive Psychotherapy in Multiple Sclerosis: A Single-Case Study

This individual case study follows a 47-yearold woman who was directed by her treating physicians... more This individual case study follows a 47-yearold woman who was directed by her treating physicians to individual psychotherapy after being diagnosed with Multiple Sclerosis (MS). The main methods our study was based on were clinical observations and neuropsychological assessments. The patient’s concerns revolved around her self-care and her inability to set boundaries in her interpersonal relationships. During her first sessions, she demonstrated symptoms of anxiety, depression, and self-destructive behavior. Due to these facts, psycho-supportive medication was deemed essential. The main purpose of this case study was to investigate whether supportive psychotherapy may be of additional help to patients with MS. In this individual case, we will present how effective supportive psychotherapy can be for the patient, which is part of the treatment for a personalized holistic intervention programme. Given the lack of relevant research in Greece, this study can help expand the knowledge an...

Research paper thumbnail of The probable auto-antigenic role of lipids (anti-ganglioside antibodies) in the pathogenesis of Alzheimer's disease

Journal of Alzheimer's disease : JAD, 2014

We examined the sera of 103 demented patients of a mean age of 75 years and 60 age-matched health... more We examined the sera of 103 demented patients of a mean age of 75 years and 60 age-matched healthy individuals, using ELISA, to investigate the levels of IgM antibodies against GM1, GD1b, and GQ1b gangliosides and their possible correlation with clinical parameters (age, severity, and type of dementia). All the individuals that demonstrated positive titers of anti-ganglioside antibodies were demented patients whereas normal controls showed borderline or negative values. Significant correlation was revealed between IgM anti-GM1 and both the age of the patients and the severity of dementia. Most of the patients with increased IgM anti-GD1b titers suffered from AD.

Research paper thumbnail of Increase of interleukin-6 levels is related with depressive phenomena in the acute (relapsing) phase of multiple sclerosis

Multiple Sclerosis Journal, 2012

Research paper thumbnail of Anti-MAG antibodies during clinical exacerbation of multiple sclerosis

Multiple Sclerosis Journal, 1999

Research paper thumbnail of Cognitive decline in Multiple Sclerosis patients

Hellenic journal of nuclear medicine, 2019

Cognitive impairment is a common phenomenon in multiple sclerosis (MS), occurring at all stages o... more Cognitive impairment is a common phenomenon in multiple sclerosis (MS), occurring at all stages of the disease, even at the earliest, and can be a major source of disability, social impairment, and impoverished quality of life. Cognitive dysfunction is mainly focused on working memory, conceptual reasoning, verbal fluency, speed of information processing, attention and executive function. Additional clinical factors, including disease course, fatigue and affective disturbance, can impact the degree of MS-related cognitive impairment. We present the results from the two-phases of our prospective study on cognitive decline in MS patients using the data collected from the A' Neurologic clinic at AHEPA hospital, Thessaloniki, Greece. Most of the patients of the present study revealed mild cognitive impairment with mild influence on the everyday function. We found weak correlation between cognitive deficit and the duration of MS, as well as the physical disability status and moderate...

Research paper thumbnail of Remyelination in the subcortical areas of the rat’s brain following mild heat lesions

Multiple Sclerosis Journal, 1999

Research paper thumbnail of Preliminary Results on Cognitive Impairment in A Cohort of Greek Multiple Sclerosis Patients

Open Access Journal of Neurology & Neurosurgery

Research paper thumbnail of Individual Supportive Psychotherapy in Multiple Sclerosis: A Single-Case Study

This individual case study follows a 47-yearold woman who was directed by her treating physicians... more This individual case study follows a 47-yearold woman who was directed by her treating physicians to individual psychotherapy after being diagnosed with Multiple Sclerosis (MS). The main methods our study was based on were clinical observations and neuropsychological assessments. The patient's concerns revolved around her self-care and her inability to set boundaries in her interpersonal relationships. During her first sessions, she demonstrated symptoms of anxiety, depression, and self-destructive behavior. Due to these facts, psycho-supportive medication was deemed essential. The main purpose of this case study was to investigate whether supportive psychotherapy may be of additional help to patients with MS. In this individual case, we will present how effective supportive psychotherapy can be for the patient, which is part of the treatment for a personalized holistic intervention programme. Given the lack of relevant research in Greece, this study can help expand the knowledge and deepen the understanding in this field. Moreover, this study may reinforce the importance the care of MS patients to be carried out in a holistic intervention program. After one year of individual psychotherapy, the patient demonstrated significant improvement. Psychotherapeutic and supportive interventions, combined with MS medication, have been proved to be a more appropriate treatment for coping with and managing this chronic disease.

Research paper thumbnail of A probable role of copper in the comorbidity in Wilson’s and Creutzfeldt-Jakob’s Diseases: a case report

Virology Journal

Background To the best of our knowledgedd, there is currently no case in the literature reporting... more Background To the best of our knowledgedd, there is currently no case in the literature reporting the comorbidity of Wilson’s and Creutzfeldt-Jakob disease (CJD), linked through copper. Case presentation A 44-year-old male with a history of inherited Wilson’s disease (hepatolenticular degeneration), which manifested as mild liver injury and psychiatric symptoms, was admitted to our department due to speech and cognitive disturbances. Upon his admission, he had motor aphasia as well as psychomotor retardation with an otherwise normal neurological examination. Laboratory tests, including liver enzymes, copper and serum ammonia were all within normal range. The brain MRI showed increased T2 signal in the caudate nuclei, attributed to copper deposition in the context of Wilson’s disease. In the electroencephalogram, periodic sharp discharges were eminent, initially unilateral and then generalized. The positive 14–3-3 protein in the cerebrospinal fluid (CSF) and the new brain MRI, that d...

Research paper thumbnail of Ultrastructural study of the human cerebellar cortex

Journal of Neurology & Stroke

There are four kinds of inhibitory neurons in the cerebellar cortex. The basket cells, the stella... more There are four kinds of inhibitory neurons in the cerebellar cortex. The basket cells, the stellate neurons and the Golgi II neurons that produce inhibitory synapses with Purkinje cells using mainly GABA. GABAenergic vesicles are ellipsoid in contrast to the cholinergic which are spheroid. This why Gray named the cholinergic, vesicles S J Neurol Stroke. 2019;9(2):57-59.

Research paper thumbnail of A Roadmap Towards A Functional Paradigm For Learning & Memory In Plants

Journal of Plant Physiology

Research paper thumbnail of Late-life depression and Alzheimer disease: a potential synergy of the underlying mechanisms

Current medicinal chemistry, Sep 2, 2016

A number of biological and clinical characteristics typical of late life depression (LLD) has bee... more A number of biological and clinical characteristics typical of late life depression (LLD) has been suggested by recent research findings. The close association of LLD with cognitive impairment is now well documented and evidenced. However, it is still not clear whether it is depression that leads to cognitive decline, and in more severe cases, to dementia. The work presented in this review article suggests that depression and dementia frequently and strongly copresent, even if the causality remains largely opaque.

Research paper thumbnail of Kimmerle's Anomaly as a Possible Causative Factor of Chronic Tension-Type Headaches and Neurosensory Hearing Loss: Case Report and Literature Review

The International Journal of Neuroscience, Mar 1, 2010

Kimmerle&... more Kimmerle's anomaly also known as ponticulus posticus is a common anatomical variation of the atlas, the first cervical vertebra. It is the product of the complete or incomplete ossification of the posterior atlanto-occipital membrane over the vertebral artery groove resulting in the formation of a foramen (arcuate foramen) containing the vertebral artery and the posterior branch of the C-1 spinal nerve. This variation has been associated with vertebro-basilar insufficiency symptoms, various types of headaches, and acute hearing loss. The aim of the present study is to substantiate whether Kimmerle's anomaly is the possible cause of chronic tension-type headaches and neurosensory-type hearing loss in a patient with a known history of headaches and accompanied unilateral hearing loss. The headaches demonstrated the characteristics of the chronic tension-type; the audiometric investigation concluded the hearing loss to be of the neurosensory type; whereas, the imaging examinations revealed the existence of a partial osseous bridge, that is an incomplete arcuate foramen (ponticulus posticus or Kimmerle's anomaly) on the upper surface of atlas. Both the clinical and the radiological findings of this case are indicative of a possible connection between Kimmerle's anomaly and the manifestation of chronic tension-type headaches and neurosensory-type hearing loss.

Research paper thumbnail of Increase of IL-6 levels in the acute phase of multiple sclerosis is possibly related with the presence of depression

European Journal of Neurology

Research paper thumbnail of Increase in Interleukin-6 Levels Is Related to Depressive Phenomena in the Acute (Relapsing) Phase of Multiple Sclerosis

Journal of Neuropsychiatry, 2011

Research paper thumbnail of Living with Multiple Sclerosis

AJN, American Journal of Nursing, 1955

Research paper thumbnail of Kimmerle's Anomaly as a Possible Causative Factor of Chronic Tension-Type Headaches and Neurosensory Hearing Loss: Case Report and Literature Review

The International Journal of Neuroscience, Mar 1, 2010

Kimmerle&... more Kimmerle's anomaly also known as ponticulus posticus is a common anatomical variation of the atlas, the first cervical vertebra. It is the product of the complete or incomplete ossification of the posterior atlanto-occipital membrane over the vertebral artery groove resulting in the formation of a foramen (arcuate foramen) containing the vertebral artery and the posterior branch of the C-1 spinal nerve. This variation has been associated with vertebro-basilar insufficiency symptoms, various types of headaches, and acute hearing loss. The aim of the present study is to substantiate whether Kimmerle's anomaly is the possible cause of chronic tension-type headaches and neurosensory-type hearing loss in a patient with a known history of headaches and accompanied unilateral hearing loss. The headaches demonstrated the characteristics of the chronic tension-type; the audiometric investigation concluded the hearing loss to be of the neurosensory type; whereas, the imaging examinations revealed the existence of a partial osseous bridge, that is an incomplete arcuate foramen (ponticulus posticus or Kimmerle's anomaly) on the upper surface of atlas. Both the clinical and the radiological findings of this case are indicative of a possible connection between Kimmerle's anomaly and the manifestation of chronic tension-type headaches and neurosensory-type hearing loss.