Elpis Hatziagorou | Aristotle University of Thessaloniki (original) (raw)

Papers by Elpis Hatziagorou

Research paper thumbnail of 733 Physical activity, six-minute-walk test, and quality of life in people with cystic fibrosis

Journal of Cystic Fibrosis, Sep 30, 2023

Research paper thumbnail of Inhaler technique in a pediatric emergency department: Impact of an educational intervention among healthcare professionals in Greece

Medical education, web and internet

Research paper thumbnail of Long term outcome of parapneumonic effusions in children

European Respiratory Journal, Sep 1, 2013

Body: Aim: The objective of this study was the evaluation of the long term outcome of the parapne... more Body: Aim: The objective of this study was the evaluation of the long term outcome of the parapneumonic effusion (PPE) in children regarding lung function and exercise tolerance. Method: The design of the study included children with PPE 2 years after the initial infection (group A), hospitalized in 3rd Pulmonary Pediatric Department of Aristotle University of Thessaloniki in Greece between January 1994 and December 2009. A second group of healthy children was used as the control group (group B). All children performed spirometry and a symptom-limited cardiopulmonary exercise test on cycle ergometer. Exclusion criteria for both groups were asthma prior to initial infection using the stringent indexes for the predication of asthma. Results: A total of 38 children of group A and 36 of group B were included in the study. Children of group A showed statistically significantly lower values in FVC, FEV1 and FEV1/FVC with no difference in FEF25-75 compared to group B. All children in both groups had no differences in maximal exercise capacity (VO2max). Although VO2peak was similar in both groups, slight differences were observed in ventilatory response to exercise between the two groups. Children with PPE had lower breathing reserve values and higher respiratory equivalent to oxygen (VE/VO2) during exercise compared to healthy subjects. Conclusions: This study showed that there are no clinically significant long term effects on lung function among children with PPE compared to normal.

Research paper thumbnail of Does Pseudomonas status affect exercise capacity in CF?

Introduction: Cardio-Pulmonary Exercise Testing (CPET) has been recognized as a valuable method i... more Introduction: Cardio-Pulmonary Exercise Testing (CPET) has been recognized as a valuable method in assessing disease burden and exercise capacity among CF patients. Aim: To evaluate differences in CPET, LCI and High Resolution Computed Tomography (HRCT) indices among patients colonized or not with Pseudomonas Aeruginosa; to examine whether exercise testing indices correlate with lung structural damages as reflected by Bhalla score and to check if pseudomonas colonization can predict exercise intolerance. Subjects: Seventy eight (78) children and adults with CF (31 males) mean (range) age 17.08 (6.75; 24.25) performed spirometry, Multiple Breath Washout (MBW) and CPET along with HRCT on the same day during their admission or follow up visit. Results: 78 CF patients (mean FEV1: 83.3% mean LCI: 10.9 and mean VO2peak: 79.1%) were evaluated. 33 were chronically colonized with Pseudomonas Aeruginosa, 24 were intermittently colonized whereas 21 were Pseudomonas free. Statistically significant differences were observed among the three groups in: peak oxygen uptake % predicted (VO2peak%) (p Conclusion: Exercise capacity as reflected by peak oxygen uptake is reduced in pseudomonas colonized patients and reflects lung structural damages as shown on HRCT. Pseudomonas colonization could predict exercise limitation among CF patients.

Research paper thumbnail of Efficacy and safety of inhaled corticosteroids in combination with a long-acting beta2-agonist in asthmatic children under age 5

The incidence of asthma in children under age 5 is higher than in any other segment of the popula... more The incidence of asthma in children under age 5 is higher than in any other segment of the population. Current NAEPP guidelines recommend treatment of some asthmatics in this age group with the combination of an inhaled corticosteroid and a long-acting beta 2-agonist even though this practice has never been studied with children younger than 4. This retrospective study analyzes the efficacy and safety of a combination of fluticasone propionate (FP) and salmeterol (SA) in children under 5. Fifty patients who started using FP/SA before the age of 60 months were included in the analysis. To determine efficacy, we tracked the change in emergency room visits, hospitalizations, and the frequency of wheezing as a result of treatment. Emergency room visits were reduced from 78 to 5 (p < 0.001), hospitalizations were reduced from 43 to 2 (p < 0.001) and frequency of wheezing, daily, weekly, or monthly, was also reduced significantly (p < 0.003). In terms of safety, there was only a 3.4% reduction in height percentile (p = 0.37). Combination therapy is highly efficacious and safe for asthmatics under the age of 5. A well-designed prospective study is necessary to further evaluate the benefits and risks of this treatment method.

Research paper thumbnail of Leptin levels can reflect exercise capacity in overweight children

INTRODUCTION: Leptin has been identified as a key hormone in weight and energy homeostasis both i... more INTRODUCTION: Leptin has been identified as a key hormone in weight and energy homeostasis both in children and adults. AIM: To examine whether adipokines (leptin, adiponektin) along with resistance to insulin index (Homa-IR) can be related independently to Cardiopulmonary Exercise Testing (CPET) and spirometry indices in obese, overweight and normal-weight children. METHODS: Obese (n=32), overweight (n= 21) and normal-weight (n= 30) children aged 8-16 years old participated. Peak oxygen uptake (VO2peak, VO2peak%), oxygen consumption at anaerobic threshold (VO2AT,VO2AT%), pulmonary ventilation at peak exercise (VE), respiratory equivalent ratios for oxygen and carbon dioxide at peak exercise (VE/VO2, VE/VCO2), end tidal CO2 (PetCO2) and end tidal oxygen at peak exercise (PetO2) along with spirometry indices FEV1, FEV1%, FVC, FVC%, FEF 25-75, FEF25-75% and leptin, adiponektin, and Homa –IR were evaluated. RESULTS: In overweight children adiponektin correlated to FEV1% (r=0.46, p=0.052) and in obese Homa-ir correlated with FEV1/FVC (r=0.429, p=0.029). Regression analysis revealed that leptin was independently related to peak oxygen uptake, VOpeak% (β= -0,455, p= 0.05) in overweight children but not in obese and normal-weight. No such relationship was found between adiponektin, and Homa-IR with the rest CPET and spirometry indices. CONCLUSION: In overweight children leptin levels seem to reflect exercise capacity. This finding indicates that higher leptin levels in overweight children may commence mechanisms that lead to exercise intolerance. However, more studies with larger cohorts are needed to confirm these findings.

Research paper thumbnail of P239 Pulmonary medication adherence among children and adults with cystic fibrosis

Journal of Cystic Fibrosis

Research paper thumbnail of The Exeter Activity Unlimited statement on physical activity and exercise for cystic fibrosis: methodology and results of an international, multidisciplinary, evidence-driven expert consensus

Chronic Respiratory Disease, Sep 7, 2022

Research paper thumbnail of Comparative in vitro activity of fluoroquinolones against P. aeruginosa isolated from Greek CF patients

European Respiratory Journal, 2020

Research paper thumbnail of EPS1.03 Recommended shielding against COVID-19 impacts physical activity levels and adherence to airway clearance therapy in patients with cystic fibrosis

Journal of Cystic Fibrosis, 2021

Research paper thumbnail of P338 Is pulmonary medication adherence affected by disease severity among adult patients with cystic fibrosis?

Journal of Cystic Fibrosis, 2020

• Maternal supervision, but not paternal supervision, is highly predictive of improved adherence.... more • Maternal supervision, but not paternal supervision, is highly predictive of improved adherence. • Adolescents reported that they utilised intentional non-adherence as a strategy to rebel against over-protective parenting and their parents' mandated adherence. Anxiety and Depression • The presence of an anxiety disorder was significantly related to better adherence to NA. • Adherence to NA was lower among adolescents with a depressive disorder and those whose mothers exhibited depressive symptoms. Conclusion: The barriers and facilitators reported in this review identify areas for intervention by children's community nursing teams seeking to ameliorate adherence and self-management strategies among adolescents with CF.

Research paper thumbnail of WS06.6 Effect of lumacaftor/ivacaftor on lung clearance index and exercise capacity among patients aged over 12 years with cystic fibrosis homozygous for F508del-CFTR

Journal of Cystic Fibrosis, 2018

Research paper thumbnail of P121 Short-term effect of physiotherapy on Lung Clearance Index among patients with cystic fibrosis

Journal of Cystic Fibrosis, 2018

Research paper thumbnail of The Beneficial Effect of the Mobile Application Euglyca in Children and Adolescents with Type 1 Diabetes Mellitus: A Randomized Controlled Trial

Diabetes Technology & Therapeutics, 2019

BACKGROUND Euglyca® is a mobile application which we developed for children and adolescents suffe... more BACKGROUND Euglyca® is a mobile application which we developed for children and adolescents suffering diabetes mellitus type 1 (T1DM) for calculation of the appropriate insulin bolus dose by importing in the equation carbohydrates, lipids, glucose levels and personalized parameters. Aim of this study is to evaluate the efficacy of this application on patients' glycemic control and satisfaction. METHODS Eighty children and adolescents (aged 13.5 ± 2.8 years old, mean ± SD) with T1DM were included in the study and were randomly and equally assigned in two groups. Patients were asked to use Euglyca® for the calculation of the bolus insulin dose in the E group and to pursue their routine calculations in the C group (controls). At baseline and at 3, 6 and 12 months following the initial visit, glycated hemoglobin (HbA1c) values, percentages of hypoglycemias, hyperglycemias and normoglycemias were determined for each patient while Diabetes Treatment Satisfaction questionnaire (DTSQ) was used to assess patients' treatment satisfaction at baseline and at 6 and 12 months. RESULTS Children and adolescents in the E group had a statistically significant decrease in HbA1c values and increase in percentages of normoglycemias and DTSQ scores, in comparison to children and adolescents in the C group. In the E group, a statistically significant positive linear correlation was found between DTSQs score and percentages of normoglycemias and a statistically significant negative correlation between changes in percentages of normoglycemias (Δnormoglycemias) and changes in HbA1c (ΔHbA1c). CONCLUSIONS The use of the mobile application Euglyca® contributes to the improvement of glycemic control and treatment satisfaction of children and adolescents with T1DM.

Research paper thumbnail of WS09.2 Physical activity and quality of life among patients with cystic fibrosis

Journal of Cystic Fibrosis, 2016

Research paper thumbnail of WS10.4 Disease-related pain in children and adolescents with cystic fibrosis (CF): effect on the health-related quality of life

Journal of Cystic Fibrosis, 2016

Conclusion: Detection of lung damage, expressed as LCI, when associated to an abnormal exercise r... more Conclusion: Detection of lung damage, expressed as LCI, when associated to an abnormal exercise response, seems to be linked to functional impairment even in those patient with normal FEV 1. Godfrey and LCI together might help monitoring disease progression earlier and tailoring exercise programs.

Research paper thumbnail of EPS6.4 Home visits vs. telephone monitoring among patients with cystic fibrosis: which is superior?

Journal of Cystic Fibrosis, 2017

Conclusion: Analyses using 2015 US and UK CF registry data demonstrate clinical benefits in pts t... more Conclusion: Analyses using 2015 US and UK CF registry data demonstrate clinical benefits in pts treated with IVA in real-world settings, including lower risks of death relative to untreated comparator pts. These findings support disease modification by CFTR modulator therapy.

Research paper thumbnail of 243 Chronic rhino-sinusitis and nasal polyposis among patients with cystic fibrosis

Journal of Cystic Fibrosis, 2017

Objective: To evaluate sinonasal disease and nasal polyposis among patients with CF. Method: CF p... more Objective: To evaluate sinonasal disease and nasal polyposis among patients with CF. Method: CF patients attending a CF clinic underwent prospective evaluation of chronic rhinosinusitis. They completed a questionnaire on sinonasal symptoms, SNOT-2-(Sino-Nasal-Outcome-Test) and subsequently underwent nasoendoscopy. Abnormalities identified were quantified using endoscopic (Lund-Kennedy) scoring system. The relationship between symptoms of chronic rhino-sinusitis (CRS) and endoscopic findings was assessed. Results: One hundred and ten CF patients (n = 110, mean age 11 ± 5 years) were studied. Main symptoms were nasal congestion (68.75%), thick nasal discharge/post-nasal discharge (56.25%), facial pain/pressure (12.5%) and hyposmia/anosmia (12.5%). Fourty-seven CF patients (42.7%) complained for symptoms of CRS. Seventy-seven CF patients (70%) had evidence of CRS on naso-endoscopy including 14 patients (12.7%) with nasal polyps. Mean age of presentation of polyps was 12.2 (±6) years. There was a significant correlation between sinonasal symptoms (SNOT-2) and the Lund-Kennedy endoscopic score. All patients with nasal polyps received nasal steroids for a mean period of 5.5 months with good response. Eight (57.1%) received oral steroids for 12 days and 4 patients underwent polypectomy. One patient relapsed 1.5 years later. Conclusions: Nasal polyposis is a common clinical feature among patients with CF. ENT evaluation should be performed as part of annual review. Conservative management of chronic rhino-sinusitis is the most common practice. 244 Otorhinolaryngological manifestations in patients with cystic fibrosis. Review of cases in a third level hospital

Research paper thumbnail of Home care and benefit in days of hospitalization, cost and quality of life for children with cystic fibrosis

European Respiratory Journal, 2016

Background: Days of hospitalization are emerging as an important indicator of quality of life (QO... more Background: Days of hospitalization are emerging as an important indicator of quality of life (QOL) among children with chronic diseases. Aim: To evaluate the QOL of children with cystic fibrosis in relation to days of hospitalization in a home care project. Patients- Method: Sixty children (mean age 10.5 years, 58.3% males, mean FEV1 98.1 ± 24.8%) with cystic fibrosis and their parents were entered prospectively in a home care project. The program was covered by two nurses and two physiotherapists who visited homes on a regular weekly basis and were referred to the CF centre. QOL DISABKIDS questionnaire for children with cystic fibrosis was completed before and one year after implementation of the home care project. We counted the days of hospitalization and cost of hospitalization before and one year after the entry of these patients in the home care project. Results: Mean days of hospitalization decreased significantly (11.1±8.9 days before, to 4.9 ±5.9, p Conclusion: Home Care contributes to significant reduction of days of hospitalization and the associated costs. It also improves quality of life of CF children.

Research paper thumbnail of 132 Multiple breath washout and forced oscillation technique to assess lung disease in cystic fibrosis

Journal of Cystic Fibrosis, 2016

Research paper thumbnail of 733 Physical activity, six-minute-walk test, and quality of life in people with cystic fibrosis

Journal of Cystic Fibrosis, Sep 30, 2023

Research paper thumbnail of Inhaler technique in a pediatric emergency department: Impact of an educational intervention among healthcare professionals in Greece

Medical education, web and internet

Research paper thumbnail of Long term outcome of parapneumonic effusions in children

European Respiratory Journal, Sep 1, 2013

Body: Aim: The objective of this study was the evaluation of the long term outcome of the parapne... more Body: Aim: The objective of this study was the evaluation of the long term outcome of the parapneumonic effusion (PPE) in children regarding lung function and exercise tolerance. Method: The design of the study included children with PPE 2 years after the initial infection (group A), hospitalized in 3rd Pulmonary Pediatric Department of Aristotle University of Thessaloniki in Greece between January 1994 and December 2009. A second group of healthy children was used as the control group (group B). All children performed spirometry and a symptom-limited cardiopulmonary exercise test on cycle ergometer. Exclusion criteria for both groups were asthma prior to initial infection using the stringent indexes for the predication of asthma. Results: A total of 38 children of group A and 36 of group B were included in the study. Children of group A showed statistically significantly lower values in FVC, FEV1 and FEV1/FVC with no difference in FEF25-75 compared to group B. All children in both groups had no differences in maximal exercise capacity (VO2max). Although VO2peak was similar in both groups, slight differences were observed in ventilatory response to exercise between the two groups. Children with PPE had lower breathing reserve values and higher respiratory equivalent to oxygen (VE/VO2) during exercise compared to healthy subjects. Conclusions: This study showed that there are no clinically significant long term effects on lung function among children with PPE compared to normal.

Research paper thumbnail of Does Pseudomonas status affect exercise capacity in CF?

Introduction: Cardio-Pulmonary Exercise Testing (CPET) has been recognized as a valuable method i... more Introduction: Cardio-Pulmonary Exercise Testing (CPET) has been recognized as a valuable method in assessing disease burden and exercise capacity among CF patients. Aim: To evaluate differences in CPET, LCI and High Resolution Computed Tomography (HRCT) indices among patients colonized or not with Pseudomonas Aeruginosa; to examine whether exercise testing indices correlate with lung structural damages as reflected by Bhalla score and to check if pseudomonas colonization can predict exercise intolerance. Subjects: Seventy eight (78) children and adults with CF (31 males) mean (range) age 17.08 (6.75; 24.25) performed spirometry, Multiple Breath Washout (MBW) and CPET along with HRCT on the same day during their admission or follow up visit. Results: 78 CF patients (mean FEV1: 83.3% mean LCI: 10.9 and mean VO2peak: 79.1%) were evaluated. 33 were chronically colonized with Pseudomonas Aeruginosa, 24 were intermittently colonized whereas 21 were Pseudomonas free. Statistically significant differences were observed among the three groups in: peak oxygen uptake % predicted (VO2peak%) (p Conclusion: Exercise capacity as reflected by peak oxygen uptake is reduced in pseudomonas colonized patients and reflects lung structural damages as shown on HRCT. Pseudomonas colonization could predict exercise limitation among CF patients.

Research paper thumbnail of Efficacy and safety of inhaled corticosteroids in combination with a long-acting beta2-agonist in asthmatic children under age 5

The incidence of asthma in children under age 5 is higher than in any other segment of the popula... more The incidence of asthma in children under age 5 is higher than in any other segment of the population. Current NAEPP guidelines recommend treatment of some asthmatics in this age group with the combination of an inhaled corticosteroid and a long-acting beta 2-agonist even though this practice has never been studied with children younger than 4. This retrospective study analyzes the efficacy and safety of a combination of fluticasone propionate (FP) and salmeterol (SA) in children under 5. Fifty patients who started using FP/SA before the age of 60 months were included in the analysis. To determine efficacy, we tracked the change in emergency room visits, hospitalizations, and the frequency of wheezing as a result of treatment. Emergency room visits were reduced from 78 to 5 (p < 0.001), hospitalizations were reduced from 43 to 2 (p < 0.001) and frequency of wheezing, daily, weekly, or monthly, was also reduced significantly (p < 0.003). In terms of safety, there was only a 3.4% reduction in height percentile (p = 0.37). Combination therapy is highly efficacious and safe for asthmatics under the age of 5. A well-designed prospective study is necessary to further evaluate the benefits and risks of this treatment method.

Research paper thumbnail of Leptin levels can reflect exercise capacity in overweight children

INTRODUCTION: Leptin has been identified as a key hormone in weight and energy homeostasis both i... more INTRODUCTION: Leptin has been identified as a key hormone in weight and energy homeostasis both in children and adults. AIM: To examine whether adipokines (leptin, adiponektin) along with resistance to insulin index (Homa-IR) can be related independently to Cardiopulmonary Exercise Testing (CPET) and spirometry indices in obese, overweight and normal-weight children. METHODS: Obese (n=32), overweight (n= 21) and normal-weight (n= 30) children aged 8-16 years old participated. Peak oxygen uptake (VO2peak, VO2peak%), oxygen consumption at anaerobic threshold (VO2AT,VO2AT%), pulmonary ventilation at peak exercise (VE), respiratory equivalent ratios for oxygen and carbon dioxide at peak exercise (VE/VO2, VE/VCO2), end tidal CO2 (PetCO2) and end tidal oxygen at peak exercise (PetO2) along with spirometry indices FEV1, FEV1%, FVC, FVC%, FEF 25-75, FEF25-75% and leptin, adiponektin, and Homa –IR were evaluated. RESULTS: In overweight children adiponektin correlated to FEV1% (r=0.46, p=0.052) and in obese Homa-ir correlated with FEV1/FVC (r=0.429, p=0.029). Regression analysis revealed that leptin was independently related to peak oxygen uptake, VOpeak% (β= -0,455, p= 0.05) in overweight children but not in obese and normal-weight. No such relationship was found between adiponektin, and Homa-IR with the rest CPET and spirometry indices. CONCLUSION: In overweight children leptin levels seem to reflect exercise capacity. This finding indicates that higher leptin levels in overweight children may commence mechanisms that lead to exercise intolerance. However, more studies with larger cohorts are needed to confirm these findings.

Research paper thumbnail of P239 Pulmonary medication adherence among children and adults with cystic fibrosis

Journal of Cystic Fibrosis

Research paper thumbnail of The Exeter Activity Unlimited statement on physical activity and exercise for cystic fibrosis: methodology and results of an international, multidisciplinary, evidence-driven expert consensus

Chronic Respiratory Disease, Sep 7, 2022

Research paper thumbnail of Comparative in vitro activity of fluoroquinolones against P. aeruginosa isolated from Greek CF patients

European Respiratory Journal, 2020

Research paper thumbnail of EPS1.03 Recommended shielding against COVID-19 impacts physical activity levels and adherence to airway clearance therapy in patients with cystic fibrosis

Journal of Cystic Fibrosis, 2021

Research paper thumbnail of P338 Is pulmonary medication adherence affected by disease severity among adult patients with cystic fibrosis?

Journal of Cystic Fibrosis, 2020

• Maternal supervision, but not paternal supervision, is highly predictive of improved adherence.... more • Maternal supervision, but not paternal supervision, is highly predictive of improved adherence. • Adolescents reported that they utilised intentional non-adherence as a strategy to rebel against over-protective parenting and their parents' mandated adherence. Anxiety and Depression • The presence of an anxiety disorder was significantly related to better adherence to NA. • Adherence to NA was lower among adolescents with a depressive disorder and those whose mothers exhibited depressive symptoms. Conclusion: The barriers and facilitators reported in this review identify areas for intervention by children's community nursing teams seeking to ameliorate adherence and self-management strategies among adolescents with CF.

Research paper thumbnail of WS06.6 Effect of lumacaftor/ivacaftor on lung clearance index and exercise capacity among patients aged over 12 years with cystic fibrosis homozygous for F508del-CFTR

Journal of Cystic Fibrosis, 2018

Research paper thumbnail of P121 Short-term effect of physiotherapy on Lung Clearance Index among patients with cystic fibrosis

Journal of Cystic Fibrosis, 2018

Research paper thumbnail of The Beneficial Effect of the Mobile Application Euglyca in Children and Adolescents with Type 1 Diabetes Mellitus: A Randomized Controlled Trial

Diabetes Technology & Therapeutics, 2019

BACKGROUND Euglyca® is a mobile application which we developed for children and adolescents suffe... more BACKGROUND Euglyca® is a mobile application which we developed for children and adolescents suffering diabetes mellitus type 1 (T1DM) for calculation of the appropriate insulin bolus dose by importing in the equation carbohydrates, lipids, glucose levels and personalized parameters. Aim of this study is to evaluate the efficacy of this application on patients' glycemic control and satisfaction. METHODS Eighty children and adolescents (aged 13.5 ± 2.8 years old, mean ± SD) with T1DM were included in the study and were randomly and equally assigned in two groups. Patients were asked to use Euglyca® for the calculation of the bolus insulin dose in the E group and to pursue their routine calculations in the C group (controls). At baseline and at 3, 6 and 12 months following the initial visit, glycated hemoglobin (HbA1c) values, percentages of hypoglycemias, hyperglycemias and normoglycemias were determined for each patient while Diabetes Treatment Satisfaction questionnaire (DTSQ) was used to assess patients' treatment satisfaction at baseline and at 6 and 12 months. RESULTS Children and adolescents in the E group had a statistically significant decrease in HbA1c values and increase in percentages of normoglycemias and DTSQ scores, in comparison to children and adolescents in the C group. In the E group, a statistically significant positive linear correlation was found between DTSQs score and percentages of normoglycemias and a statistically significant negative correlation between changes in percentages of normoglycemias (Δnormoglycemias) and changes in HbA1c (ΔHbA1c). CONCLUSIONS The use of the mobile application Euglyca® contributes to the improvement of glycemic control and treatment satisfaction of children and adolescents with T1DM.

Research paper thumbnail of WS09.2 Physical activity and quality of life among patients with cystic fibrosis

Journal of Cystic Fibrosis, 2016

Research paper thumbnail of WS10.4 Disease-related pain in children and adolescents with cystic fibrosis (CF): effect on the health-related quality of life

Journal of Cystic Fibrosis, 2016

Conclusion: Detection of lung damage, expressed as LCI, when associated to an abnormal exercise r... more Conclusion: Detection of lung damage, expressed as LCI, when associated to an abnormal exercise response, seems to be linked to functional impairment even in those patient with normal FEV 1. Godfrey and LCI together might help monitoring disease progression earlier and tailoring exercise programs.

Research paper thumbnail of EPS6.4 Home visits vs. telephone monitoring among patients with cystic fibrosis: which is superior?

Journal of Cystic Fibrosis, 2017

Conclusion: Analyses using 2015 US and UK CF registry data demonstrate clinical benefits in pts t... more Conclusion: Analyses using 2015 US and UK CF registry data demonstrate clinical benefits in pts treated with IVA in real-world settings, including lower risks of death relative to untreated comparator pts. These findings support disease modification by CFTR modulator therapy.

Research paper thumbnail of 243 Chronic rhino-sinusitis and nasal polyposis among patients with cystic fibrosis

Journal of Cystic Fibrosis, 2017

Objective: To evaluate sinonasal disease and nasal polyposis among patients with CF. Method: CF p... more Objective: To evaluate sinonasal disease and nasal polyposis among patients with CF. Method: CF patients attending a CF clinic underwent prospective evaluation of chronic rhinosinusitis. They completed a questionnaire on sinonasal symptoms, SNOT-2-(Sino-Nasal-Outcome-Test) and subsequently underwent nasoendoscopy. Abnormalities identified were quantified using endoscopic (Lund-Kennedy) scoring system. The relationship between symptoms of chronic rhino-sinusitis (CRS) and endoscopic findings was assessed. Results: One hundred and ten CF patients (n = 110, mean age 11 ± 5 years) were studied. Main symptoms were nasal congestion (68.75%), thick nasal discharge/post-nasal discharge (56.25%), facial pain/pressure (12.5%) and hyposmia/anosmia (12.5%). Fourty-seven CF patients (42.7%) complained for symptoms of CRS. Seventy-seven CF patients (70%) had evidence of CRS on naso-endoscopy including 14 patients (12.7%) with nasal polyps. Mean age of presentation of polyps was 12.2 (±6) years. There was a significant correlation between sinonasal symptoms (SNOT-2) and the Lund-Kennedy endoscopic score. All patients with nasal polyps received nasal steroids for a mean period of 5.5 months with good response. Eight (57.1%) received oral steroids for 12 days and 4 patients underwent polypectomy. One patient relapsed 1.5 years later. Conclusions: Nasal polyposis is a common clinical feature among patients with CF. ENT evaluation should be performed as part of annual review. Conservative management of chronic rhino-sinusitis is the most common practice. 244 Otorhinolaryngological manifestations in patients with cystic fibrosis. Review of cases in a third level hospital

Research paper thumbnail of Home care and benefit in days of hospitalization, cost and quality of life for children with cystic fibrosis

European Respiratory Journal, 2016

Background: Days of hospitalization are emerging as an important indicator of quality of life (QO... more Background: Days of hospitalization are emerging as an important indicator of quality of life (QOL) among children with chronic diseases. Aim: To evaluate the QOL of children with cystic fibrosis in relation to days of hospitalization in a home care project. Patients- Method: Sixty children (mean age 10.5 years, 58.3% males, mean FEV1 98.1 ± 24.8%) with cystic fibrosis and their parents were entered prospectively in a home care project. The program was covered by two nurses and two physiotherapists who visited homes on a regular weekly basis and were referred to the CF centre. QOL DISABKIDS questionnaire for children with cystic fibrosis was completed before and one year after implementation of the home care project. We counted the days of hospitalization and cost of hospitalization before and one year after the entry of these patients in the home care project. Results: Mean days of hospitalization decreased significantly (11.1±8.9 days before, to 4.9 ±5.9, p Conclusion: Home Care contributes to significant reduction of days of hospitalization and the associated costs. It also improves quality of life of CF children.

Research paper thumbnail of 132 Multiple breath washout and forced oscillation technique to assess lung disease in cystic fibrosis

Journal of Cystic Fibrosis, 2016