Miltos Balidis | Aristotle University of Thessaloniki (original) (raw)

Papers by Miltos Balidis

Journal of Cataract and Refractive Surgery

Purpose: To validate the Democritus Digital Acuity and Reading Test (DDART) as a distance VA (dVA... more Purpose: To validate the Democritus Digital Acuity and Reading Test (DDART) as a distance VA (dVA) test against a series of prevalent conventional distance vision charts. Setting: Ophthalmology Department, University Hospital of Alexandroupolis, Alexandroupolis, Greece; Ophthalmology Department, AHEPA University Hospital, Thessaloniki, Greece; and Ophthalmica Institute of Ophthalmology & Microsurgery, Thessaloniki, Greece. Design: Prospective multicenter validation study. Methods: The distance best spectacle-corrected visual acuity (dBSCVA) was compared in normal (NVG) and low (LVG) vision participants against 4 prevalent conventional distance vision charts (ETDRS, Snellen, Landolt C, and Tumbling E) by a predefined 2.5-symbol noninferiority margin and intraclass correlation coefficients (ICCs). DDART's test–retest (TRT) reliability was assessed with ICCs. Results: 534 participants (471 and 63 with normal and low vision, respectively) were included in the study. The mean differe...

Acta Ophthalmologica

Purpose: The purpose of this study was to exhibit the advantages of preservative‐free hydrocortis... more Purpose: The purpose of this study was to exhibit the advantages of preservative‐free hydrocortisone in the postoperative treatment regimen of transepithelial photorefractive keratectomy (Trans‐PRK) for the promotion of epithelization and minimalization of early haze appearance.Methods: In this prospective, randomized controlled study, 40 patients who had undergone trans‐PRK were divided into two equal groups, the first group received hydrocortisone (Softacort®, Laboratoires Thea) 2 drops 4 times daily for 7 days and the control group received no complementary medication. Both groups were given: artificial tears 2 drops hourly for 7 days, then administered every 2 h for 21 days and tapered till 3 months post‐operation, antibiotic drops (quinolone) 4 times daily and autologous serum hourly for 7 days, and a bandage contact lens till complete epithelization of the surgical wound. Patients were monitored daily to determine the time of a complete epithelization and then on day 15 and 30...

Trends in ophthalmology, Apr 1, 2019

Background: Advances in genomics continue to enable the discovery of gene variants which cause va... more Background: Advances in genomics continue to enable the discovery of gene variants which cause various inherited ophthalmic disorders. Several case reports have shown an association between keratoconus and retinal disease but whether there is a genetic basis for this is still not known. Methods: Clinical case study with Pentacam imaging, fundus autofluorescence (FAF), macular optical coherence tomography (OCT), electrophysiology studies, and genetic analysis. Results: We report three brothers, two of whom have keratoconus and one who was found to have bilateral cone-rod dystrophy. This was supported by color vision and electrophysiology testing, fundus autofluorescence, and macular OCT findings. Genomic data analysis revealed three rare gene variants (MAP3K19, ADGRV1, and PIK3CG) common to the brother with cone-rod dystrophy and one brother with keratoconus. There was also a very significant variant in the CHST6 gene in the latter. Whole exome sequencing data revealed a rare missense variant for IMPG2 gene in both brothers. Conclusion: Among the four genes with shared mutations in two of the brothers, IMPG2 has been linked to retinal disease while MAP3K19 and PIK3CG carry high risk scores for keratoconus pathogenesis. A highly damaging CHST6 variant detected in the brother with keratoconus is known to cause macular corneal dystrophy and corneal thinning. This study offers the first familial genetic analysis for keratoconus and cone-rod dystrophy. More studies with genomic investigations are needed in order to further elucidate the possible relationship between these two diseases.

Graefe's Archive for Clinical and Experimental Ophthalmology, 2020

Purpose: To compare the refractive outcomes in patients following either combined or sequential t... more Purpose: To compare the refractive outcomes in patients following either combined or sequential trabeculectomy and phacoemulsification. Methods: Evaluation of the medical records of patients who underwent one of three treatment combinations on their eyes including combined phaco-trabeculectomy (47 eyes), a sequential phacoemulsification procedure, at least 3 months following trabeculectomy (33 eyes), and phacoemulsification alone (48 eyes). Results: There were no significant differences among the three groups in characteristics such as age, sex, axial length, the postoperative spherical equivalent (SE) and refractive prediction error (RPE) at 1 week and 2 months post procedure. Significant differences existed between the three groups in terms of preoperative intraocular pressure, predicted SE, and the mean absolute error (MAE) at 1 week and 2 months post procedure. The proportions of cases with a RPE > 1.0 diopter (D) or <-1.0 D were significantly different between the three groups. Conclusions: There were significant differences between the three groups in terms of the MAE at 1 week and 2 months after surgery. With respect to the predicted SE, phacotrabeculectomy seems to be less accurate than the phacoemulsification alone. Therefore, careful consideration should be given to the selection of the intraocular lens power.

Klinische Monatsblätter für Augenheilkunde, 2021

Journal of Ophthalmology, 2022

Journal of Ophthalmology

Purpose. To evaluate the clinical outcome and safety profile of a new sutureless scleral fixation... more Purpose. To evaluate the clinical outcome and safety profile of a new sutureless scleral fixation (SSF) technique using a single-piece foldable acrylic Carlevale intraocular lens. Methods. In this case study, 27 eyes of 27 patients were implanted with an SSF single-piece IOL because of inadequate or absent capsular support. The hand-shake technique used during surgery was combined with the creation of scleral pockets in order to secure the IOL haptics. The BCVA was evaluated in the 1st and 6th month in every patient and in the 12th and 24th months, when possible. Also, we evaluated the improvement achieved in spherical equivalent values from baseline to the 6th month after the procedure. Intraoperative and postoperative complications were assessed. Results. The mean age was 69.1 ± 14.9 years, and the mean follow-up was 13.6 ± 4.8 months. Indications of scleral-fixated IOL included dislocated posterior chamber IOL (40.7%), dislocated anterior chamber IOL (11.1%), subluxated traumatic...

Background: Refractive surgery (RS) for myopia has made a very big progress regarding its safety ... more Background: Refractive surgery (RS) for myopia has made a very big progress regarding its safety and predictability of the outcome. Still, a small percentage of operations require retreatment. Therefore, both legally and ethically, patients should be informed that sometimes a corrective RS may be required. We addressed this issue using Neural Networks (NN) in RS for myopia. This was a recently developed validation study of a NN. Methods: We anonymously searched the Ophthalmica Institute of Ophthalmology and Microsurgery database for patients who underwent RS with PRK, LASEK, Epi-LASIK or LASIK between 2010 and 2018. We used a total of 13 factors related to RS. Data was divided into four sets of successful RS outcomes used for training the NN, successful RS outcomes used for testing the NN performance, RS outcomes that required retreatment used for training the NN and RS outcomes that required retreatment used for testing the NN performance. We created eight independent Learning Vec...

Background: Retinitis pigmentosa (RP), an inherited degenerative ocular disease, is considered th... more Background: Retinitis pigmentosa (RP), an inherited degenerative ocular disease, is considered the most common type of retinal dystrophy. Abnormalities of the photoreceptors, particularly the rods, and of the retinal pigment epithelium, characterizes this disease. The abnormalities progress from the midperiphery to the central retina. We here reviewed the developments in RP genetics in the last decade, along with its clinical features and natural course. Methods: The present review focused on articles in English language published between January 2008 and February 2020, and deposited in PubMed and Google Scholar databases. We searched for articles reporting on the clinical manifestations and genes related to both syndromic and non-syndromic RP. We screened and analyzed 139 articles, published in the last decade, referring to RP pathogenesis and identified, summarized, and highlighted the most significant genes implicated in either syndromic or non-syndromic RP pathogenesis, causing ...

Purpose: To test the hypothesis that neodymium:yttrium–aluminum–garnet (Nd:YAG) laser peripheral ... more Purpose: To test the hypothesis that neodymium:yttrium–aluminum–garnet (Nd:YAG) laser peripheral iridotomy (LPI) significantly reduces the incidence of conversion from pigment dispersion syndrome (PDS) with ocular hypertension (OHT) to pigmentary glaucoma (PG). Design: Prospective, randomized, controlled 3-year trial. Participants: One hundred sixteen eyes of 116 patients with PDS and OHT. Intervention: Patients were assigned randomly either to Nd:YAG LPI or to a control group (no laser). Main Outcome Measures: The primary outcome measure was conversion to PG within 3 years, based on full-threshold visual field (VF) analysis using the Ocular Hypertension Treatment Study criteria. Secondary outcome measures were whether eyes required topical antiglaucoma medications during the study period and the time to conversion or medication. Results: Fifty-seven patients were randomized to undergo laser treatment and 59 were randomized to no laser (controls). Age, gender, spherical equivalent r...

Graefe's Archive for Clinical and Experimental Ophthalmology

The Open Ophthalmology Journal, Jul 31, 2017

Background: Since the late 1990s corneal crosslinking (CXL) has been proposed as a new treatment ... more Background: Since the late 1990s corneal crosslinking (CXL) has been proposed as a new treatment option which can stop progression of keratoconus with promising results in adults. Objective: Keratoconus presents a higher rate and faster progression in paediatric patients and for this reason prompt and effective treatment is essential. Due to its success in adult keratoconus patients, CXL has been recently applied to children in order to stop or slow progression of keratoconus in paediatric patients. Conclusions: This article will present an update of the literature on the topic of CXL in this age group.

Drug Design, Development and Therapy, Feb 1, 2019

Macular edema (ME) represents the most common cause for visual loss among uveitis patients. The m... more Macular edema (ME) represents the most common cause for visual loss among uveitis patients. The management of uveitic macular edema (UME) may be challenging, due to its often recalcitrant nature. Corticosteroids remain the mainstay of treatment, through their capability of effectively controlling inflammation and the associated ME. Topical steroids may be effective in milder cases of UME, particularly in edema associated with anterior uveitis. Posterior sub-Tenon and orbital floor steroids, as well as intravitreal steroids often induce rapid regression of UME, although this may be followed by recurrence of the pathology. Intravitreal corticosteroid implants provide sustained release of steroids facilitating regression of ME with less frequent injections. Topical nonsteroidal anti-inflammatory drugs may provide a safe alternative or adjuvant therapy to topical steroids in mild UME, predominantly in cases with underlying anterior uveitis. Immunomodulators including methotrexate, mycophenolate mofetil, tacrolimus, azathioprine, and cyclosporine, as well as biologic agents, notably the antitumor necrosis factor-α monoclonal antibodies adalimumab and infliximab, may accomplish the control of inflammation and associated ME in refractory cases, or enable the tapering of steroids. Newer biotherapies have demonstrated promising outcomes and may be considered in persisting cases of UME.

Journal of refractive surgery (Thorofare, N.J. : 1995), 2010

To present a case of advancing keratoconus treated with corneal collagen cross-linking (CXL) with... more To present a case of advancing keratoconus treated with corneal collagen cross-linking (CXL) with ultraviolet A (UVA) light and riboflavin complicated with sterile infiltrates. The patient's cornea was de-epithelialized and CXL was performed with application of riboflavin and exposure to UVA light (370 nm, 3 mW/cm2) for 30 minutes. Early in the postoperative period, the patient presented with 11 deep stromal infiltrates of 1 to 2 mm with clear demarked edges in a circle near the limbus with some clear cornea. Corneal cultures were negative. Treatment consisted of antibiotic ofloxacin and tobramycin four times daily, and dexamethasone drops six times daily. After 2 months, scars remained evident. This complication has not been reported previously and may be an individual hypersensitivity reaction to the riboflavin or UVA light in the anterior stroma.

Eye and Vision

Purpose To report preliminary 6-month results on the use of the Preserflo Microshunt implant with... more Purpose To report preliminary 6-month results on the use of the Preserflo Microshunt implant with and without Ologen in 50 pseudophakic eyes with moderate to advanced primary open-angle glaucoma (POAG). Methods Fifty pseudophakic eyes underwent ab externo Preserflo Microshunt implantation. Data was gathered retrospectively and two groups were then created, group A with application of MMC 0.2 mg/ml and group B with MMC 0.2 mg/ml and Ologen collagen matrix (OCM) implantation. Absolute success was regarded as the percentage of eyes achieving: a) 5 ≤ intraocular pressure (IOP) ≤ 13 mmHg, b) 5 ≤ IOP ≤ 16 mmHg, and c) 5 ≤ IOP ≤ 21 mmHg without additional medication or surgery and qualified success was regarded as the percentage of eyes achieving a) IOP ≤ 13 mmHg, b) IOP ≤ 16 mmHg, and c) IOP ≤ 21 mmHg with or without medication. Evaluation was performed using a log-rank Kaplan-Meier test. A scatterplot analysis presented the treatment effect data of all eyes with a minimum of 20% IOP redu...

Klinische Monatsblätter für Augenheilkunde

Medical Principles and Practice

Significance of the Study • Corneal stroma demarcation line depth did not differ significantly be... more Significance of the Study • Corneal stroma demarcation line depth did not differ significantly between the eyes treated with the pulsed, accelerated collagen cross-linking (CXL) protocol and the Dresden protocol. This supports the suggestion that the two techniques may have similar efficacies in the treatment of keratoconus. • The use of pulsed light compared to continuous light may improve the availability of oxygen during CXL treatment, resulting in better postoperative outcomes.

Klinische Monatsblätter für Augenheilkunde

Journal of Cataract and Refractive Surgery

Purpose: To validate the Democritus Digital Acuity and Reading Test (DDART) as a distance VA (dVA... more Purpose: To validate the Democritus Digital Acuity and Reading Test (DDART) as a distance VA (dVA) test against a series of prevalent conventional distance vision charts. Setting: Ophthalmology Department, University Hospital of Alexandroupolis, Alexandroupolis, Greece; Ophthalmology Department, AHEPA University Hospital, Thessaloniki, Greece; and Ophthalmica Institute of Ophthalmology & Microsurgery, Thessaloniki, Greece. Design: Prospective multicenter validation study. Methods: The distance best spectacle-corrected visual acuity (dBSCVA) was compared in normal (NVG) and low (LVG) vision participants against 4 prevalent conventional distance vision charts (ETDRS, Snellen, Landolt C, and Tumbling E) by a predefined 2.5-symbol noninferiority margin and intraclass correlation coefficients (ICCs). DDART's test–retest (TRT) reliability was assessed with ICCs. Results: 534 participants (471 and 63 with normal and low vision, respectively) were included in the study. The mean differe...

Acta Ophthalmologica

Purpose: The purpose of this study was to exhibit the advantages of preservative‐free hydrocortis... more Purpose: The purpose of this study was to exhibit the advantages of preservative‐free hydrocortisone in the postoperative treatment regimen of transepithelial photorefractive keratectomy (Trans‐PRK) for the promotion of epithelization and minimalization of early haze appearance.Methods: In this prospective, randomized controlled study, 40 patients who had undergone trans‐PRK were divided into two equal groups, the first group received hydrocortisone (Softacort®, Laboratoires Thea) 2 drops 4 times daily for 7 days and the control group received no complementary medication. Both groups were given: artificial tears 2 drops hourly for 7 days, then administered every 2 h for 21 days and tapered till 3 months post‐operation, antibiotic drops (quinolone) 4 times daily and autologous serum hourly for 7 days, and a bandage contact lens till complete epithelization of the surgical wound. Patients were monitored daily to determine the time of a complete epithelization and then on day 15 and 30...

Trends in ophthalmology, Apr 1, 2019

Background: Advances in genomics continue to enable the discovery of gene variants which cause va... more Background: Advances in genomics continue to enable the discovery of gene variants which cause various inherited ophthalmic disorders. Several case reports have shown an association between keratoconus and retinal disease but whether there is a genetic basis for this is still not known. Methods: Clinical case study with Pentacam imaging, fundus autofluorescence (FAF), macular optical coherence tomography (OCT), electrophysiology studies, and genetic analysis. Results: We report three brothers, two of whom have keratoconus and one who was found to have bilateral cone-rod dystrophy. This was supported by color vision and electrophysiology testing, fundus autofluorescence, and macular OCT findings. Genomic data analysis revealed three rare gene variants (MAP3K19, ADGRV1, and PIK3CG) common to the brother with cone-rod dystrophy and one brother with keratoconus. There was also a very significant variant in the CHST6 gene in the latter. Whole exome sequencing data revealed a rare missense variant for IMPG2 gene in both brothers. Conclusion: Among the four genes with shared mutations in two of the brothers, IMPG2 has been linked to retinal disease while MAP3K19 and PIK3CG carry high risk scores for keratoconus pathogenesis. A highly damaging CHST6 variant detected in the brother with keratoconus is known to cause macular corneal dystrophy and corneal thinning. This study offers the first familial genetic analysis for keratoconus and cone-rod dystrophy. More studies with genomic investigations are needed in order to further elucidate the possible relationship between these two diseases.

Graefe's Archive for Clinical and Experimental Ophthalmology, 2020

Purpose: To compare the refractive outcomes in patients following either combined or sequential t... more Purpose: To compare the refractive outcomes in patients following either combined or sequential trabeculectomy and phacoemulsification. Methods: Evaluation of the medical records of patients who underwent one of three treatment combinations on their eyes including combined phaco-trabeculectomy (47 eyes), a sequential phacoemulsification procedure, at least 3 months following trabeculectomy (33 eyes), and phacoemulsification alone (48 eyes). Results: There were no significant differences among the three groups in characteristics such as age, sex, axial length, the postoperative spherical equivalent (SE) and refractive prediction error (RPE) at 1 week and 2 months post procedure. Significant differences existed between the three groups in terms of preoperative intraocular pressure, predicted SE, and the mean absolute error (MAE) at 1 week and 2 months post procedure. The proportions of cases with a RPE > 1.0 diopter (D) or <-1.0 D were significantly different between the three groups. Conclusions: There were significant differences between the three groups in terms of the MAE at 1 week and 2 months after surgery. With respect to the predicted SE, phacotrabeculectomy seems to be less accurate than the phacoemulsification alone. Therefore, careful consideration should be given to the selection of the intraocular lens power.

Klinische Monatsblätter für Augenheilkunde, 2021

Journal of Ophthalmology, 2022

Journal of Ophthalmology

Purpose. To evaluate the clinical outcome and safety profile of a new sutureless scleral fixation... more Purpose. To evaluate the clinical outcome and safety profile of a new sutureless scleral fixation (SSF) technique using a single-piece foldable acrylic Carlevale intraocular lens. Methods. In this case study, 27 eyes of 27 patients were implanted with an SSF single-piece IOL because of inadequate or absent capsular support. The hand-shake technique used during surgery was combined with the creation of scleral pockets in order to secure the IOL haptics. The BCVA was evaluated in the 1st and 6th month in every patient and in the 12th and 24th months, when possible. Also, we evaluated the improvement achieved in spherical equivalent values from baseline to the 6th month after the procedure. Intraoperative and postoperative complications were assessed. Results. The mean age was 69.1 ± 14.9 years, and the mean follow-up was 13.6 ± 4.8 months. Indications of scleral-fixated IOL included dislocated posterior chamber IOL (40.7%), dislocated anterior chamber IOL (11.1%), subluxated traumatic...

Background: Refractive surgery (RS) for myopia has made a very big progress regarding its safety ... more Background: Refractive surgery (RS) for myopia has made a very big progress regarding its safety and predictability of the outcome. Still, a small percentage of operations require retreatment. Therefore, both legally and ethically, patients should be informed that sometimes a corrective RS may be required. We addressed this issue using Neural Networks (NN) in RS for myopia. This was a recently developed validation study of a NN. Methods: We anonymously searched the Ophthalmica Institute of Ophthalmology and Microsurgery database for patients who underwent RS with PRK, LASEK, Epi-LASIK or LASIK between 2010 and 2018. We used a total of 13 factors related to RS. Data was divided into four sets of successful RS outcomes used for training the NN, successful RS outcomes used for testing the NN performance, RS outcomes that required retreatment used for training the NN and RS outcomes that required retreatment used for testing the NN performance. We created eight independent Learning Vec...

Background: Retinitis pigmentosa (RP), an inherited degenerative ocular disease, is considered th... more Background: Retinitis pigmentosa (RP), an inherited degenerative ocular disease, is considered the most common type of retinal dystrophy. Abnormalities of the photoreceptors, particularly the rods, and of the retinal pigment epithelium, characterizes this disease. The abnormalities progress from the midperiphery to the central retina. We here reviewed the developments in RP genetics in the last decade, along with its clinical features and natural course. Methods: The present review focused on articles in English language published between January 2008 and February 2020, and deposited in PubMed and Google Scholar databases. We searched for articles reporting on the clinical manifestations and genes related to both syndromic and non-syndromic RP. We screened and analyzed 139 articles, published in the last decade, referring to RP pathogenesis and identified, summarized, and highlighted the most significant genes implicated in either syndromic or non-syndromic RP pathogenesis, causing ...

Purpose: To test the hypothesis that neodymium:yttrium–aluminum–garnet (Nd:YAG) laser peripheral ... more Purpose: To test the hypothesis that neodymium:yttrium–aluminum–garnet (Nd:YAG) laser peripheral iridotomy (LPI) significantly reduces the incidence of conversion from pigment dispersion syndrome (PDS) with ocular hypertension (OHT) to pigmentary glaucoma (PG). Design: Prospective, randomized, controlled 3-year trial. Participants: One hundred sixteen eyes of 116 patients with PDS and OHT. Intervention: Patients were assigned randomly either to Nd:YAG LPI or to a control group (no laser). Main Outcome Measures: The primary outcome measure was conversion to PG within 3 years, based on full-threshold visual field (VF) analysis using the Ocular Hypertension Treatment Study criteria. Secondary outcome measures were whether eyes required topical antiglaucoma medications during the study period and the time to conversion or medication. Results: Fifty-seven patients were randomized to undergo laser treatment and 59 were randomized to no laser (controls). Age, gender, spherical equivalent r...

Graefe's Archive for Clinical and Experimental Ophthalmology

The Open Ophthalmology Journal, Jul 31, 2017

Background: Since the late 1990s corneal crosslinking (CXL) has been proposed as a new treatment ... more Background: Since the late 1990s corneal crosslinking (CXL) has been proposed as a new treatment option which can stop progression of keratoconus with promising results in adults. Objective: Keratoconus presents a higher rate and faster progression in paediatric patients and for this reason prompt and effective treatment is essential. Due to its success in adult keratoconus patients, CXL has been recently applied to children in order to stop or slow progression of keratoconus in paediatric patients. Conclusions: This article will present an update of the literature on the topic of CXL in this age group.

Drug Design, Development and Therapy, Feb 1, 2019

Macular edema (ME) represents the most common cause for visual loss among uveitis patients. The m... more Macular edema (ME) represents the most common cause for visual loss among uveitis patients. The management of uveitic macular edema (UME) may be challenging, due to its often recalcitrant nature. Corticosteroids remain the mainstay of treatment, through their capability of effectively controlling inflammation and the associated ME. Topical steroids may be effective in milder cases of UME, particularly in edema associated with anterior uveitis. Posterior sub-Tenon and orbital floor steroids, as well as intravitreal steroids often induce rapid regression of UME, although this may be followed by recurrence of the pathology. Intravitreal corticosteroid implants provide sustained release of steroids facilitating regression of ME with less frequent injections. Topical nonsteroidal anti-inflammatory drugs may provide a safe alternative or adjuvant therapy to topical steroids in mild UME, predominantly in cases with underlying anterior uveitis. Immunomodulators including methotrexate, mycophenolate mofetil, tacrolimus, azathioprine, and cyclosporine, as well as biologic agents, notably the antitumor necrosis factor-α monoclonal antibodies adalimumab and infliximab, may accomplish the control of inflammation and associated ME in refractory cases, or enable the tapering of steroids. Newer biotherapies have demonstrated promising outcomes and may be considered in persisting cases of UME.

Journal of refractive surgery (Thorofare, N.J. : 1995), 2010

To present a case of advancing keratoconus treated with corneal collagen cross-linking (CXL) with... more To present a case of advancing keratoconus treated with corneal collagen cross-linking (CXL) with ultraviolet A (UVA) light and riboflavin complicated with sterile infiltrates. The patient's cornea was de-epithelialized and CXL was performed with application of riboflavin and exposure to UVA light (370 nm, 3 mW/cm2) for 30 minutes. Early in the postoperative period, the patient presented with 11 deep stromal infiltrates of 1 to 2 mm with clear demarked edges in a circle near the limbus with some clear cornea. Corneal cultures were negative. Treatment consisted of antibiotic ofloxacin and tobramycin four times daily, and dexamethasone drops six times daily. After 2 months, scars remained evident. This complication has not been reported previously and may be an individual hypersensitivity reaction to the riboflavin or UVA light in the anterior stroma.

Eye and Vision

Purpose To report preliminary 6-month results on the use of the Preserflo Microshunt implant with... more Purpose To report preliminary 6-month results on the use of the Preserflo Microshunt implant with and without Ologen in 50 pseudophakic eyes with moderate to advanced primary open-angle glaucoma (POAG). Methods Fifty pseudophakic eyes underwent ab externo Preserflo Microshunt implantation. Data was gathered retrospectively and two groups were then created, group A with application of MMC 0.2 mg/ml and group B with MMC 0.2 mg/ml and Ologen collagen matrix (OCM) implantation. Absolute success was regarded as the percentage of eyes achieving: a) 5 ≤ intraocular pressure (IOP) ≤ 13 mmHg, b) 5 ≤ IOP ≤ 16 mmHg, and c) 5 ≤ IOP ≤ 21 mmHg without additional medication or surgery and qualified success was regarded as the percentage of eyes achieving a) IOP ≤ 13 mmHg, b) IOP ≤ 16 mmHg, and c) IOP ≤ 21 mmHg with or without medication. Evaluation was performed using a log-rank Kaplan-Meier test. A scatterplot analysis presented the treatment effect data of all eyes with a minimum of 20% IOP redu...

Klinische Monatsblätter für Augenheilkunde

Medical Principles and Practice

Significance of the Study • Corneal stroma demarcation line depth did not differ significantly be... more Significance of the Study • Corneal stroma demarcation line depth did not differ significantly between the eyes treated with the pulsed, accelerated collagen cross-linking (CXL) protocol and the Dresden protocol. This supports the suggestion that the two techniques may have similar efficacies in the treatment of keratoconus. • The use of pulsed light compared to continuous light may improve the availability of oxygen during CXL treatment, resulting in better postoperative outcomes.

Klinische Monatsblätter für Augenheilkunde