Ozgur Omer Yildiz | Ankara Yildirim Beyazit University (original) (raw)

Papers by Ozgur Omer Yildiz

Current thoracic surgery, 2018

Pulmonary alveolar proteinosis (PAP) is a rare disease characterized by accumulation of material ... more Pulmonary alveolar proteinosis (PAP) is a rare disease characterized by accumulation of material in the alveoli of the lungs. It is generally diagnosed in middle-aged men. The most common complaints are cough and dyspnea. Characteristic radiological findings of PAP include nodular infiltration with a tendency to merge and ground glass density, septal thickening and resemblance to paving stone. Typical findings include periodic acid-Schiff (PAS) stain positive materials in the alveolar proteinosis, milky appearance of bronchoalveolar lavage (BAL), interstitial opacities, thickened interlobular septa, and patchy central or peripheral ground-glass opacities in the lung parenchyma in the chest CT. The most effective proved treatment is whole lung lavage. The aim of the treatment in PAP cases is to restore the alveolar gas exchange by removing excess surfactant accumulated in the alveoli.

Research Square (Research Square), Mar 21, 2023

Aim of study: The aim of this study is to evaluate the surgical perspective on the coexistence of... more Aim of study: The aim of this study is to evaluate the surgical perspective on the coexistence of chronic obstructive pulmonary disease (COPD) and lung cancer. Materials and Methods: Lung cancer and COPD are two diseases with high morbidity and mortality rates worldwide. In the present study, we present our experience with a total of 63 patients with both COPD and lung cancer who underwent surgical treatment in our center. This retrospective study included 63 patients with COPD and lung cancer who underwent preoperative pulmonary rehabilitation between March 2019 and June 2020 in our center. Statistical analyses were performed with SPSS version 15 package program. Results: This study included a total of 63 patients. The disease duration for patients diagnosed with COPD was 2-9 years. Positive correlations were noted between time since COPD diagnosis and intensive and nonintensive care hospitalization durations (p<0.05). A positive correlation was noted between preoperative pulmonary rehabilitation period and clinic stay (p=0.05). Conclusion: Meticulous preoperative evaluation in patients with both COPD and lung cancer is crucial to avoid negative outcomes. Furthermore, preoperative pulmonary rehabilitation increases the chance of resection for patients with COPD and should be considered.

Medical Science and Discovery, 2022

Objective: In our study, we aimed to evaluate the effects of EGFR gene mutation on the clinical c... more Objective: In our study, we aimed to evaluate the effects of EGFR gene mutation on the clinical course of Non-Small Cell Lung carcinoma. Material and Methods: Our study was conducted retrospectively on patients who were operated on for NSCLC diagnosed as adenocarcinoma. The International Cancer Control Association and the American Cancer Committee eighth TNM classification system were evaluated in our study. Case groups at this stage were divided into two main groups as EGFR gene mutation (+/-) and data between the clinical behaviours of these two main groups were investigated. Results: There was no statistically significant difference between the two groups in terms of age, gender, smoking, and type of surgery (p = 0.727, p = 0.936, p = 0.463). The relationship between EGFR and surgery type was also not significant (2 = 0.268; p = 0.992). There were no statistically significant difference between the medians of Suv-Max value (z = 1.083; p = 0.279). Among 653 cases in all NSCLC aden...

The World Clinics Journal of Medical Sciences, 2017

hinner is a chemical substance composed of organic solvents such as toluene, benzene and xylene u... more hinner is a chemical substance composed of organic solvents such as toluene, benzene and xylene used to lower viscosity of paints. Toluene used in paint thinners affects the lipids of cell membrane and myelin sheath due to its lipophilicity. Intake of the aromatic hydrocarbons through inhalation or oral ingestion affects lipid of cell membrane and myelin sheath and increases growth of free radicals; and this leads to their absorption in brain, kidney and lungs and tissues of the body that contain fat. 1 Injection of the thinner causes cellulite and necrosis of the hydrocarbons in the injection site. 2 CASE REPORT A 23 age-old woman was admitted to a health institution after injecting thinner into her left cervical region in a suicide attempt. While the patient was conscious when she was admitted, she was intubated due to her deteriorating condition in 24 hours. In the cervical and thoracic CT scans, bilateral air artefacts from left cervical region to paracardial region, growth of the tissues under the skin in the left cervical region, mediastinal enlargement, loculated collections and bilateral pleural effusion were identified. Urgent surgical intervention was decided and bilateral tube thoracotomy

Journal of contemporary medicine, Jul 31, 2022

During the COVID-19 pandemic, all elective surgeries, except emergency surgeries and surgeries fo... more During the COVID-19 pandemic, all elective surgeries, except emergency surgeries and surgeries for patients with malignancy, were postponed. In this study, patients who presented to the thoracic surgery clinic of our hospital during and those who presented before the COVID-19 pandemic were compared, and changes in characteristics of the patients presenting to the thoracic surgery clinic during the COVID-19 pandemic were investigated. Material and Method: Age, gender, and reason for admission to the hospital were documented for all patients who presented to the thoracic surgery clinic of our hospital during March 2019-March 2020 and March 2020-March 2021. Patients presenting to the clinic were categorized into malignancy, trauma, chest pain, pneumothorax, and other disease groups. Results: In total, 947 patients presented to the clinic in the prepandemic period. Conversely, 756 patients presented to the clinic during the pandemic. In the pre-pandemic period, 353 patients presented with trauma; this number decreased to 154 during the pandemic. Additionally, during the pandemic, a decrease was observed in all patient admissions other than those due to malignancies. Conclusion: During the pandemic, there has been a decrease in patient admissions due to trauma, mostly as a result of curfews and restrictions. However, there has been a significant increase in the number of patients presenting with lung malignancies during the pandemic. This may be due to findings of incidental lung masses in the thoracic computed tomography performed after COVID-19 prediagnosis.

Journal of Health Sciences and Medicine

Aim: The study-cohort aims to assess PET-CT's correlation with adenocarcinomas' subtypes ... more Aim: The study-cohort aims to assess PET-CT's correlation with adenocarcinomas' subtypes and propose a scoring system for mediastinal lymph nodes staging. Material and Method: The patient cohort is a multicenter, retrospective analysis of 268 patient that underwent surgery for NSCLC adenocarcinoma. Preoperative PET-CT results for mediastinal lymph node staging was pathologically confirmed on tissue specimens obtained at anatomical resection. Statistical evaluation of PET CT, radiological and pathological outcomes were performed on all subgroups. Results: The low FDG affinity in the lepidic pattern was statistically significant in the study (p

Medicine Science | International Medical Journal, 2021

Lymph node involvement is an important prognostic factor for non-small cell lung cancer. This stu... more Lymph node involvement is an important prognostic factor for non-small cell lung cancer. This study aims to investigate the relationship between lymph node involvement and the depth of chest wall invasion. Thirty-three patients who were operated on between 2015 and 2019 for radiologically and pathologically diagnosed chest wall invasion were retrospectively reviewed. Thirtytwo of the patients were male (97.3%) and 1 was female (2.7%) with an average age of 59.4 years. The tumor had a mean diameter of 5.81cm. The invasion was in the posterior part of the chest wall in 17 patients (51.5%), lateral in 11 (33.3%) and anterior chest wall in 5 patients (15.2%). Pleural, soft tissue and costal involvement was present in 32, 19 and 9 cases, respectively. A statistically negative correlation was observed between the depth of chest wall invasion and metastasis of lymph nodes no. 2, 4, 7, 10 and 11 (p:0.041, p:0.006, p:0.011, p:0.025, and p:0.009, respectively). As the invasion progresses towards the periphery, the result of the histopathological evaluation of the lymph nodes number 2, 4, 7, 10 and 11 was found to be benign in 73.1%, 64.6%, 91.4%, 87.5% and 64.9%, respectively. The correlation between the depth of invasion and lymph node metastasis, a subject of negligence up to now was evaluated. The findings presented herein have shown that in chest wall resections, the possibility of complete resection and the presence of lymphatic involvement which is an important prognostic marker are more important in terms of survival compared to the depth of invasion.

Eurasian Journal of Emergency Medicine, 2021

Aim: Traumatic rib fractures are a common injury in the trauma population and may cause severe pa... more Aim: Traumatic rib fractures are a common injury in the trauma population and may cause severe pain in cases of both isolated rib fractures and chest injuries. The aim of our study was to compare the early pain control of intercostal block with that of intravenous analgesia + intercostal nerve block in patients with rib fractures admitted to the emergency department due to blunt thoracic trauma. Materials and Methods: Patients admitted to the emergency department due to blunt thoracic trauma in a tertiary medical facility were evaluated retrospectively. Forty-eight patients were included in the study. The patients were divided into two groups: on in which only intercostal nerve block was performed and another in which intravenous analgesia + intercostal block were performed concurrently. Results: Nine patients (18.7%) were given only intercostal block, while 39 patients (81.3%) were given intravenous analgesia + intercostal nerve block. Considering the early pain results of group A (intercostal nerve block) and group B (intravenous analgesia + intercostal nerve block), significant improvement was observed in group B in terms of pain results after the first 15 minutes. Conclusion: We conclude that the combination of intravenous nonsteroidal anti-inflammatory drugs or opioid derivatives and intercostal nerve block would be an effective combination in pain control in patients with rib fractures. In addition, intercostal nerve block would be beneficial in pain control and increase respiratory efficiency in patients with rib fractures, since it is both easy to apply and accelerates healing by providing effective analgesia. Due to these positive effects, we believe that it reduces the duration of hospital stay and would offer great advantages in terms of efficiency and cost.

Current Medical Research, 2022

Background: Surgery is required in 10-15% of patients with thoracic injuries. Surgery performed w... more Background: Surgery is required in 10-15% of patients with thoracic injuries. Surgery performed within the first few hours of the injury is considered as an emergency surgery. The aim of study is to share our experiences with emergency surgical approaches in thoracic trauma. Methods: Our study was carried out between June 2012-June 2020, by retrospective analysis of cases who were evaluated for thoracic trauma in the emergency department and who underwent emergency surgery. Results: There were 5784 patients who requested for thoracic surgery consultation due to thoracic trauma. Of these cases, 1317 (22.8%) were patients who were evaluated in the emergency service due to isolated thoracic trauma. There were 18 patients (1.3%) who underwent emergency surgery for isolated thoracic trauma. Glasgow score was higher in the group that was discharged after recovery among all groups; and this was statistically significant (p= 0.045). It was statistically significant that intubation and low modified trauma scores were a poor prognostic factor (respectively p= 0.035, p=0,025). Conclusions: Tube thoracostomy is sufficient for most of the thoracic traumas. After emergency evaluation, fast and correct decision in the appropriate surgical indication significantly reduces mortality.

The Turkish Journal of Thoracic and Cardiovascular Surgery, 2020

Background: This study aims to compare the results of the open surgical approach versus endobronc... more Background: This study aims to compare the results of the open surgical approach versus endobronchial conical stent application in the treatment of extensive fistulas. Methods: Between December 2004 and April 2016, a total of 36 patients (34 males, 2 females; mean age 59.6±8.1 years; range, 40 to 72 years) with a bronchopleural fistula of ≥8 mm in diameter and underwent either conventional open surgery with stump-supported intercostal muscle flap or endobronchial ultra-flex expandable stenting were retrospectively analyzed. The demographic and clinical characteristics of the patients, operative data including the length of hospital stay, thoracic drainage time, and early mortality, and survival data were recorded. Results: The mean hospitalization time was 17.4±4.5 days for the bronchoscopic group and 22.5±6.7 days for the invasive surgery group (p=0.026). The median time to removal of thoracic drains was 15 (range, 10 to 30) days for the bronchoscopic group and 26 (range, 14 to 55)...

Journal of Surgery and Medicine, 2019

Mucoepidermoid carcinoma of the thymus is a rare malignant neoplasm of the anterior mediastinum. ... more Mucoepidermoid carcinoma of the thymus is a rare malignant neoplasm of the anterior mediastinum. There are less than 30 cases described in the English literature. We report a case of a 77-year-old man with right chest pain. Thorax CT scan showed a lobulated cystic mass having a focal solid portion with direct invasion of the adjacent pericardium in the anterior mediastinum. He underwent surgical resection for his anterior mediastinal mass via right thoracoscopic surgery without any complication. He had an uneventful recovery and was discharged on the sixth postoperative day.

Current Thoracic Surgery, 2017

Background: Hydatid cyst disease, which is mostly caused by Echinococcus granulosus, may result i... more Background: Hydatid cyst disease, which is mostly caused by Echinococcus granulosus, may result in high morbidity rates particularly in endemic regions, and mortality depending on its size and on the organs where it is located. While the disease can be diagnosed radiologically because of typical symptoms, it becomes more difficult to distinguish it from lung malignancies as the cysts get complicated. Materials and Methods: 15 cases of pulmonary hydatid cyst that underwent clinical and radiological examinations and surgery after being diagnosed as lung abscess and lung cancer between 2008 and 2014 were retrospectively reviewed. Results: Radiological features of the 80% of the cases in thoracic CT were mimicking tumour in the form of thick walled cavitary lesion, hilar mass, cystic necrotic solid mass or solid mass; and 20% of them had radiological features mimicking abscess in the form of thin walled cavitary lesion. Lobectomy was performed for one case, wedge resection was performed for two cases and cystotomy-capitonnage was performed for 12 cases. Conclusions: It should be kept in mind that pulmonary hydatid cyst clinically and radiologically may mimic lung cancer and lung abscess.

Respiratory Medicine Case Reports, 2017

Pneumorrhachis is a rare phenomenon which may be caused by trauma, intracraneal infection, pneumo... more Pneumorrhachis is a rare phenomenon which may be caused by trauma, intracraneal infection, pneumomediastinum or iatrogenic factors. Presence of air in the spinal canal is reported in most cases. In this article, we report a case with PR in the spinal canal without any neurological deficit, which developed secondary to subcutaneous emphysema.

Current Thoracic Surgery, 2018

Background: Mediastinal lymph node involvement is the most important factor determining the treat... more Background: Mediastinal lymph node involvement is the most important factor determining the treatment and the prognosis with non-small cell lung cancer (NSCLC). In our study, the role of PET-CT was assessed in the evaluation of intrathoracic lymph node involvement in patients with preoperative NSCLC. Materials and Methods: The study included 510 cases selected according to the criteria identified between January 2009 and July 2011. PET-CT staging and thorax-CT, size of lymph nodes, histological type of tumor, mediastinal lymph nodes taken and the pathological results were assessed. Results: SUVmax cutoff value was taken as 2.5 for the metastatic analysis of lymph nodes in PET-CT and N1 and N2 lymph node stations were evaluated. Sensitivity for the N2 lymph node stations, was 74.7%, specificity 49.4%, Positive Predictive Value 25.4%, Negative Predictive Value 89,.5% and accuracy 54.1% (p < 0.001). Following the statistical analysis, the new SUVmax cutoff value for the N1 lymph node groups was calculated as 3.34, and for N2 lymph node groups 5.6. Based on the new SUVmax cutoff value for N2 lymph node groups, the sensitivity of PET-CT was calculated as 43.2%, specificity 94.4%, PPV 64.1%, NPV 87.8% and accuracy 84.9% (p < 0.001). Conclusions: Calculating a new cut off value of SUVmax all around the world would increase the NPV of PET-CT and so it would reduce to use of invasive methods. PPV of PET-CT is still not at an acceptable level, so positive results of PET-CT for mediastinal lymph node staging should be confirmed with invasive diagnostic techniques.

In this study, the metaphoric perceptions of the students studying in medical faculties regarding... more In this study, the metaphoric perceptions of the students studying in medical faculties regarding the concept of ethics were determined. In the study, which used a phenomenology research design, the metaphor form , which is both printed and online format, containing the expression “Ethics is like …, because …” was used as a data collection tool. A total of 1040 medical faculty students from 29 different medical faculties participated in the study and 907 of these forms were evaluated. The study was conducted with 514 (56.67%) female and 393 (43.33%) male medical students. The data obtained were analyzed by content analysis technique. It was determined that medical students formed 375 different metaphors regarding the concept of ethics and the metaphors of moral, conscience, water, constitution, life, human, mirror and scales were used the most. It was seen that the metaphors formed by the medical students were gathered under 8 different conceptual categories as the source of life,...

International Journal of Scientific and Technological Research, 2020

Objective: Lung cancer which is one of the most serious health issues, is the deadliest type of c... more Objective: Lung cancer which is one of the most serious health issues, is the deadliest type of cancer. Non-small cell lung cancer accounts for 85% of lung cancers. Epidemiological and demographic features of non-small cell lung cancer vary between countries. This study aims to retrospectively examine demographic, epidemiological and clinical features of female patients with NSCLC. Materials and methods: 42 female patients, who were diagnosed with NSCLC following the laboratory and imaging tests and operational methods and underwent operation and staging between 2016-2018, have been retrospectively examined. Findings: The average age of 42 female patients with NSCLC is 56,8 (30-74). 7 of the patients (%16,7) smoke cigarettes and 4 patients (%9,5) lost more than 10 kg in the last six months. According to the analysis of tumor locations, the tumor lesions were left sided in 12 cases (%28,5), and right-sided in 30 cases (%71,5). 32 patients (%76,2) were diagnosed with preoperative NSCLC following transthoracic fine needle aspiration biopsy and 10 patients (%23,8) were diagnosed following broncoscopic biopsy. Adenocarcinoma, which is the most common tumor cell types, was found in 37 patients (%88,1). Squamus cell carcinoma which is the second most common type, was found in 4 patients (%9,5) and 1 patient (%2,4) had mucoepidermoid carcinoma. The median tumor size was 4,19 cm (1-13 cm), and average PET-CT SUVmax value was 11,02 (2,89-33). The mean SUVmax value in adenocarcinoma cases was 10,06 (2,89-21,36), and 21,03 (14,47-33) in squamus cell carcinoma. While 35 of the patients (%83,3) underwent resection and 7 patients (%16,6) underwent only mediastinoscopy. According to the pathology results 7 patients (%16,7) were grouped as Stage 1A, 3 patients (%7,1) Stage 1B, 3 patients (%7,1) Stage 2A, 2 patients (%4,8) Stage 2B, 21 patients (%50) Stage 3A and 1 patient (%2,4) Stage 3B. Results: In this study, we found that adenocarcinoma is more common in female patients, and according to the pathological examination, %57,1 of the patients were in Stage 3. Lung cancer awareness needs to be raised among women, who are more likely to be affected by it. They need to be made aware of the symptoms for early diagnosis and routine screenings should be provided.

Kafkas Journal of Medical Sciences, 2021

Aim: Thoracic surgeons frequently encounter blunt thoracic traumas at the emergency ward. The cli... more Aim: Thoracic surgeons frequently encounter blunt thoracic traumas at the emergency ward. The clinical findings of such cases may require immediate action. The aim of the study is to discuss the efficiency of trauma scoring in the clinical course of blunt thoracic trauma. Material and Method: Inpatients with blunt thoracic trauma who received care at the department of thoracic surgery between January 2017-2019 were analyzed. The cases were assessed based on gender, trauma type, surgical intervention, length of stay, and chest trauma scoring (CTS) (contusion, rib fracture, age) parameters. Results: 111 (79.3%) of the 140 patients assessed were male, and 29 (20.7%) were female, and the average age was 49.3 (12-93). The patients were analyzed based on the chest trauma scoring calculated using the age, contusion, and rib fracture parameters. It was concluded that the trauma scoring varied between 2 and 7 (mean score 3.49+1.49). There was a statistically significant relationship between the increasing age and the number of rib fractures (p=0.004). An increased possibility of hemothorax and pneumothorax as the age increases was also observed (p=0.016, p=0.016, respectively). It was determined that the higher the contusion rate was, the higher was the possibility of hemothorax (p=0.03). It was observed that as the number of rib fractures increased, the possibility of hemothorax and pneumothorax increased and the relationship was statistically significant (p=0.009, p=0.018, respectively). A statistically significant relationship between CTS score and pathologies of hemothorax and pneumothorax was identified (p=0.001, p=0.008, respectively). However, no relationship between the CTS score and length of stay (p=0.612, p=0.612, respectively) was observed. Conclusion: The trauma scoring systems indeed act as an early warning system for the clinicians. However, the changing and developing health systems and many clinical parameters require modification in CTS, which is used to predict the clinical course of patients with isolated thoracic trauma, as in all trauma scores.

Annals of Medical Research, 2020

Aim: T1 patients who were operated due to non-small cell lung cancer (NSCLC)were evaluated retros... more Aim: T1 patients who were operated due to non-small cell lung cancer (NSCLC)were evaluated retrospectively. The objective of this study was to evaluate metastatic lymph node status in T1 tumors and to discuss staging approaches in these tumors. Material and Methods: A total of 217 patients who met specified criteria between May 2012 and May 2019 were included in the study. Patients operated due to NSCLC who have a tumor size < 3 cm were evaluated in terms of age, gender, preoperative diagnostic methods, thorax CT and PET-CT examinations, size, anatomic localization and histopathologic type of tumors, excised mediastinal lymph nodes and pathology results. Results: Of total 292 lymph node stations sampled in patients with adenocarcinoma, 257 (89.73%) were reported as benign and 30 (10.27) as malignant according to pathologic results. Of total 316 lymph node stations sampled in patients with squamous cell carcinoma, 298 (94.3%) were benign and 18 (5.7%) were malignant.N2 positivity was found in 40 (18.43%) of the 217 patients. Conclusion: Mediastinoscopy should be performed for staging in the presence of a tumor size above 2 cm, histopathological type of adenocarcinoma, high mass SUVmax values, lymph node with radiological growth and pathological involvement.