Tea Kakuchaya | Bakoulev Center for Cardiovascular Surgery RAMS (original) (raw)
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Conference Presentations by Tea Kakuchaya
STEM CELLS ® , a peer-reviewed journal published monthly, provides a forum for prompt publication... more STEM CELLS ® , a peer-reviewed journal published monthly, provides a forum for prompt publication of original investigative papers and concise reviews. STEM CELLS is written and read by clinical and basic scientists whose expertise encompasses the rapidly expanding fields of stem and progenitor cell biology. Beginning in January 2009, Stem Cells will be co-published by AlphaMed Press and Wiley-Blackwell. EDITORIAL POLICY STEM CELLS welcomes original articles and concise reviews describing basic laboratory investigations of stem cells and the translation of their clinical aspects of characterization and manipulation from the bench to patient care. The Journal covers all aspects of stem cells. The following sections include, but are not limited to, the topics listed: Embryonic Stem Cells/Induced Pluripotent Stem Cells • Culture of embryonic stem cells (ESCs) • Derivation and organization of primitive, early structures, with or without tissue specificity • Factors regulating and/or initiating ESC differentiation • Signaling pathways for pluripotency and differentiation of ESCs • Factors that modulate the pluripotency and differentiation of ESCs, both epigenetic and environmental Tissue-Specific Stem Cells • Regulation of and pathways that govern stem cell self-renewal and/or differentiation • Cellular interactions and signaling pathways necessary for tissue specificity • Genetic and epigenetic changes associated with tissue-specific stem cell differentiation • Molecules and signaling pathways that modulate homing or mobilization of tissue-specific stem/progenitor cells • Characterization of cell markers that delineate tissue-specific stem cells and/or their hierarchy of cellular differentiation • Functional properties of tissue-specific stem and progenitor cells Cancer Stem Cells • Molecular basis of neoplasia as originating from stem cells • Cellular origin of cancer stem cells that drive tumor growth • Processes of self-renewal associated with the growth and spread of tumors • Genetic constraints of the growth process • The cancer stem cell niche, and cancer stem cells as therapeutic targets • Neoplasia-associated mutations as studied by genetic or transcriptional analysis • Mechanisms of cancer stem cell dissemination • Surface markers that define cancer stem cells • Epigenetic influences that alter the regulatory balance of cell proliferation • Mathematical models of cancer cell evolution and mechanisms of survival The Stem Cell Niche • Investigations of stem cell populations within specific anatomic locations • Regulation of tissue generation, maintenance, and repair • How stem cells are prevented from being depleted while protecting the host from overproliferation • How integrated signals function to maintain the balance of stem cells in the host for sustaining tissues • Studies of aberrant functions within the stem cell niche that result in pathology or disease
Papers by Tea Kakuchaya
Diagnostics
The developed near-field microwave diagnostics of dynamical lung tomography provide information a... more The developed near-field microwave diagnostics of dynamical lung tomography provide information about variations of air and blood content depth structure in the processes of breathing and heart beating that are unattainable for other available methods. The method of dynamical pulse 1D tomography (profiling) is based on solving the corresponding nonlinear ill-posed inverse problem in the extremely complicated case of the strongly absorbing frequency-dispersive layered medium with the dual regularization method—a new Lagrange approach in the theory of ill-posed problems. This method has been realized experimentally by data of bistatic measurements with two electrically small bow-tie antennas that provide a subwavelength resolution. The proposed methods of 3D lung tomography based on the multisensory pulse, multifrequency, or multi-base measurements are based on solving the corresponding integral equations in the Born approximation. The experimental 3D tomography of lung air content wa...
CardioSomatics, 2021
Aim. The aim of our study was to conduct a comparative analysis of aerobic high-intensity interva... more Aim. The aim of our study was to conduct a comparative analysis of aerobic high-intensity interval training and constant moderate intensity training in cardiac rehabilitation of adult patients after open-heart surgery, namely after coronary artery bypass grafting (CABG). Material and methods. 137 patients after CABG were included in the study. 90.4% of patients were consider as class I of chronic heart failure after surgery. Cardiorespiratory trainings were initiate in 4 weeks after surgery, using cycling by veloergometers. Two groups were compare according to rehabilitation programs: one carried out constant aerobic trainings of moderate and medium intensity, and the other, aerobic high-intensity interval trainings. Supervised trainings were carry out for 150 minutes per week. Total length of trainings was 47 weeks. Long-term trainings were distantly monitore. Results. Ergospirometric results as well as results of echocardiography were significantly improve after training course. T...
By now, various methods of near-field diagnostics of subsurface inhomogeneities based on the solu... more By now, various methods of near-field diagnostics of subsurface inhomogeneities based on the solution of inverse scattering problems have been developed and demonstrated in experiments. These near-field methods provide a subwavelength (beyond the Rayleigh limit) resolution in tomography and holography of 3D distributed inhomogeneities – as well as in the profiling (retrieval of depth profiles) of one-dimensional subsurface inhomogeneities. Here we present last achievements of these studies: developing the inverse problem theory for frequency dispersive inhomogeneities in multilayer media and its application to monitoring of tissues variations related to breathing and pulse; experimental study of subsurface tomography by measurements with variable source-receiver base, and the statement of inverse scattering problem for targets with nonlinear susceptibility.
European Journal of Heart Failure Supplements, 2008
Objectives To determine the incidence of atrial fibrillation (AF) after conventional and off-pump... more Objectives To determine the incidence of atrial fibrillation (AF) after conventional and off-pump coronary artery bypass grafting (CABG), and identify its predictors. Methods 70 patients, all male, underwent isolated CABG. Patients with history of AF, concomitant valve pathology, severe heart failure, thyroid dysfunction were excluded. Pre- and postoperative examination included all conventional noninvasive and invasive diagnostic procedures, among them measurement of signal-averaged P-wave duration. Results Overall occurrence of AF was 20%, following on-pump CABG 21%, off-pump CABG 19% (p=0.45). Multivariate logistic regression analysis identified following independent predictors of postoperative AF: increasing age (β=1.9), longer history of coronary artery disease (CAD) (β=1.7), longer signal-averaged P-wave duration (SAPD) (β=1.8), left atrium enlargement (β=1.4), longer cardiopulmonary bypass (CPB) and aortic cross-clamping times (β=1.6), need for intraoperative intra-aortic bal...
CardioSomatics
Aim. To develop novel strategies of patients selection and risk stratification after coronary art... more Aim. To develop novel strategies of patients selection and risk stratification after coronary artery bypass surgery before starting aerobic cardiorespiratory training programs. Material and methods. One hundred thirty seven patients 4 weeks after coronary artery bypass surgery were included in our study. RARE scale (risk of activity related events), ergospirometric test, FIT treadmill score and certain laboratory parameters like hemoglobin and alaninaminotransferase were used. Results. Logical interdependence is revealed between certain indicators of cardiorespiratory capacity and risk of developing unfavorable events due to aerobic training activities. Comprehensive protocol is developed based on multifactorial regression analysis, which allows to differentiate patients into low and high class of readiness to physical activities, including aerobic cardiorespiratory training programs. Conclusion. The protocol includes following variables METs, RARE scale, FIT treadmill score, left v...
Health Care of the Russian Federation
Background. The social portrait of patients often helps to define preventive measures for specifi... more Background. The social portrait of patients often helps to define preventive measures for specific diseases in patients of different social and age groups. Need in cardio-surgery is substantiated not only by inborn but also by acquired diseases of heart, in most cases - ischaemic heart disease. The development of cardiovascular diseases is affected by multiple factors including lifestyle. Objective. To analyze the social and behavioral characteristics of cardio-surgical patients. Materials and methods. The authors analyzed the results of a survey of 93 patients in the rehabilitation unit of V.I. Burakovsky Research Institute of Cardiosurgery in 2019. The adapted questionnaire for identifying factors affecting population health was used. The respondents were divided into 3 age groups: 12 patients were under 40 years (mean age of 30.1, 75.0% men); 50 patients - 40-65 years (mean age of 56.4, 76.0% men); 30 patients - 65+ years (mean age of 70.3, 50.0% men). To analyze differences Chi-...
Handbook of Cardiovascular Cell Transplantation, 2003
Objective: To evaluate efficacy of one-step and two-step surgery approach in patients with arrhyt... more Objective: To evaluate efficacy of one-step and two-step surgery approach in patients with arrhythmias combined with Ebstein's anomaly. Methods: Fifty-three patients with Ebstein's anomaly combined with tachyarrhythmias (58.5% men, 41.5% women, mean age 21.6G10.7 years) were operated on. In group A (32 patients), one-step surgical correction (simultaneous intraoperative elimination of arrhythmias and congenital heart defect repair) was performed, whereas in group B (21 patients), two-step surgery was performed with initial elimination of arrhythmogenic substrate by transcatheter radiofrequency ablation (first step) and following surgical repair of congenital heart defect (second step). Results: In group A, total hospital mortality was 3.1% (1 patient) due to initial severe condition of this patient. One-step surgery was effective in 93.5% of cases. Mortality was not observed in group B. Efficacy of transcatheter radiofrequency ablation was 76.2%. Conclusions: one-stage and two-stage surgery of arrhythmias and Ebstein's anomaly are highly effective. First step of surgery of combined pathology reduces cardiopulmonary bypass time, complications and mortality while performing the second step of congenital heart defect surgery. However, simultaneous approach (one-step surgery) is better in terms of arrhythmia elimination.
STEM CELLS ® , a peer-reviewed journal published monthly, provides a forum for prompt publication... more STEM CELLS ® , a peer-reviewed journal published monthly, provides a forum for prompt publication of original investigative papers and concise reviews. STEM CELLS is written and read by clinical and basic scientists whose expertise encompasses the rapidly expanding fields of stem and progenitor cell biology. Beginning in January 2009, Stem Cells will be co-published by AlphaMed Press and Wiley-Blackwell. EDITORIAL POLICY STEM CELLS welcomes original articles and concise reviews describing basic laboratory investigations of stem cells and the translation of their clinical aspects of characterization and manipulation from the bench to patient care. The Journal covers all aspects of stem cells. The following sections include, but are not limited to, the topics listed: Embryonic Stem Cells/Induced Pluripotent Stem Cells • Culture of embryonic stem cells (ESCs) • Derivation and organization of primitive, early structures, with or without tissue specificity • Factors regulating and/or initiating ESC differentiation • Signaling pathways for pluripotency and differentiation of ESCs • Factors that modulate the pluripotency and differentiation of ESCs, both epigenetic and environmental Tissue-Specific Stem Cells • Regulation of and pathways that govern stem cell self-renewal and/or differentiation • Cellular interactions and signaling pathways necessary for tissue specificity • Genetic and epigenetic changes associated with tissue-specific stem cell differentiation • Molecules and signaling pathways that modulate homing or mobilization of tissue-specific stem/progenitor cells • Characterization of cell markers that delineate tissue-specific stem cells and/or their hierarchy of cellular differentiation • Functional properties of tissue-specific stem and progenitor cells Cancer Stem Cells • Molecular basis of neoplasia as originating from stem cells • Cellular origin of cancer stem cells that drive tumor growth • Processes of self-renewal associated with the growth and spread of tumors • Genetic constraints of the growth process • The cancer stem cell niche, and cancer stem cells as therapeutic targets • Neoplasia-associated mutations as studied by genetic or transcriptional analysis • Mechanisms of cancer stem cell dissemination • Surface markers that define cancer stem cells • Epigenetic influences that alter the regulatory balance of cell proliferation • Mathematical models of cancer cell evolution and mechanisms of survival The Stem Cell Niche • Investigations of stem cell populations within specific anatomic locations • Regulation of tissue generation, maintenance, and repair • How stem cells are prevented from being depleted while protecting the host from overproliferation • How integrated signals function to maintain the balance of stem cells in the host for sustaining tissues • Studies of aberrant functions within the stem cell niche that result in pathology or disease
Diagnostics
The developed near-field microwave diagnostics of dynamical lung tomography provide information a... more The developed near-field microwave diagnostics of dynamical lung tomography provide information about variations of air and blood content depth structure in the processes of breathing and heart beating that are unattainable for other available methods. The method of dynamical pulse 1D tomography (profiling) is based on solving the corresponding nonlinear ill-posed inverse problem in the extremely complicated case of the strongly absorbing frequency-dispersive layered medium with the dual regularization method—a new Lagrange approach in the theory of ill-posed problems. This method has been realized experimentally by data of bistatic measurements with two electrically small bow-tie antennas that provide a subwavelength resolution. The proposed methods of 3D lung tomography based on the multisensory pulse, multifrequency, or multi-base measurements are based on solving the corresponding integral equations in the Born approximation. The experimental 3D tomography of lung air content wa...
CardioSomatics, 2021
Aim. The aim of our study was to conduct a comparative analysis of aerobic high-intensity interva... more Aim. The aim of our study was to conduct a comparative analysis of aerobic high-intensity interval training and constant moderate intensity training in cardiac rehabilitation of adult patients after open-heart surgery, namely after coronary artery bypass grafting (CABG). Material and methods. 137 patients after CABG were included in the study. 90.4% of patients were consider as class I of chronic heart failure after surgery. Cardiorespiratory trainings were initiate in 4 weeks after surgery, using cycling by veloergometers. Two groups were compare according to rehabilitation programs: one carried out constant aerobic trainings of moderate and medium intensity, and the other, aerobic high-intensity interval trainings. Supervised trainings were carry out for 150 minutes per week. Total length of trainings was 47 weeks. Long-term trainings were distantly monitore. Results. Ergospirometric results as well as results of echocardiography were significantly improve after training course. T...
By now, various methods of near-field diagnostics of subsurface inhomogeneities based on the solu... more By now, various methods of near-field diagnostics of subsurface inhomogeneities based on the solution of inverse scattering problems have been developed and demonstrated in experiments. These near-field methods provide a subwavelength (beyond the Rayleigh limit) resolution in tomography and holography of 3D distributed inhomogeneities – as well as in the profiling (retrieval of depth profiles) of one-dimensional subsurface inhomogeneities. Here we present last achievements of these studies: developing the inverse problem theory for frequency dispersive inhomogeneities in multilayer media and its application to monitoring of tissues variations related to breathing and pulse; experimental study of subsurface tomography by measurements with variable source-receiver base, and the statement of inverse scattering problem for targets with nonlinear susceptibility.
European Journal of Heart Failure Supplements, 2008
Objectives To determine the incidence of atrial fibrillation (AF) after conventional and off-pump... more Objectives To determine the incidence of atrial fibrillation (AF) after conventional and off-pump coronary artery bypass grafting (CABG), and identify its predictors. Methods 70 patients, all male, underwent isolated CABG. Patients with history of AF, concomitant valve pathology, severe heart failure, thyroid dysfunction were excluded. Pre- and postoperative examination included all conventional noninvasive and invasive diagnostic procedures, among them measurement of signal-averaged P-wave duration. Results Overall occurrence of AF was 20%, following on-pump CABG 21%, off-pump CABG 19% (p=0.45). Multivariate logistic regression analysis identified following independent predictors of postoperative AF: increasing age (β=1.9), longer history of coronary artery disease (CAD) (β=1.7), longer signal-averaged P-wave duration (SAPD) (β=1.8), left atrium enlargement (β=1.4), longer cardiopulmonary bypass (CPB) and aortic cross-clamping times (β=1.6), need for intraoperative intra-aortic bal...
CardioSomatics
Aim. To develop novel strategies of patients selection and risk stratification after coronary art... more Aim. To develop novel strategies of patients selection and risk stratification after coronary artery bypass surgery before starting aerobic cardiorespiratory training programs. Material and methods. One hundred thirty seven patients 4 weeks after coronary artery bypass surgery were included in our study. RARE scale (risk of activity related events), ergospirometric test, FIT treadmill score and certain laboratory parameters like hemoglobin and alaninaminotransferase were used. Results. Logical interdependence is revealed between certain indicators of cardiorespiratory capacity and risk of developing unfavorable events due to aerobic training activities. Comprehensive protocol is developed based on multifactorial regression analysis, which allows to differentiate patients into low and high class of readiness to physical activities, including aerobic cardiorespiratory training programs. Conclusion. The protocol includes following variables METs, RARE scale, FIT treadmill score, left v...
Health Care of the Russian Federation
Background. The social portrait of patients often helps to define preventive measures for specifi... more Background. The social portrait of patients often helps to define preventive measures for specific diseases in patients of different social and age groups. Need in cardio-surgery is substantiated not only by inborn but also by acquired diseases of heart, in most cases - ischaemic heart disease. The development of cardiovascular diseases is affected by multiple factors including lifestyle. Objective. To analyze the social and behavioral characteristics of cardio-surgical patients. Materials and methods. The authors analyzed the results of a survey of 93 patients in the rehabilitation unit of V.I. Burakovsky Research Institute of Cardiosurgery in 2019. The adapted questionnaire for identifying factors affecting population health was used. The respondents were divided into 3 age groups: 12 patients were under 40 years (mean age of 30.1, 75.0% men); 50 patients - 40-65 years (mean age of 56.4, 76.0% men); 30 patients - 65+ years (mean age of 70.3, 50.0% men). To analyze differences Chi-...
Handbook of Cardiovascular Cell Transplantation, 2003
Objective: To evaluate efficacy of one-step and two-step surgery approach in patients with arrhyt... more Objective: To evaluate efficacy of one-step and two-step surgery approach in patients with arrhythmias combined with Ebstein's anomaly. Methods: Fifty-three patients with Ebstein's anomaly combined with tachyarrhythmias (58.5% men, 41.5% women, mean age 21.6G10.7 years) were operated on. In group A (32 patients), one-step surgical correction (simultaneous intraoperative elimination of arrhythmias and congenital heart defect repair) was performed, whereas in group B (21 patients), two-step surgery was performed with initial elimination of arrhythmogenic substrate by transcatheter radiofrequency ablation (first step) and following surgical repair of congenital heart defect (second step). Results: In group A, total hospital mortality was 3.1% (1 patient) due to initial severe condition of this patient. One-step surgery was effective in 93.5% of cases. Mortality was not observed in group B. Efficacy of transcatheter radiofrequency ablation was 76.2%. Conclusions: one-stage and two-stage surgery of arrhythmias and Ebstein's anomaly are highly effective. First step of surgery of combined pathology reduces cardiopulmonary bypass time, complications and mortality while performing the second step of congenital heart defect surgery. However, simultaneous approach (one-step surgery) is better in terms of arrhythmia elimination.