bilgen başgut | Baskent University (original) (raw)

Papers by bilgen başgut

Research paper thumbnail of Antimicrobial dosing recommendations during continuous renal replacement therapy: different databases, different doses

Journal of chemotherapy, Feb 26, 2024

Research paper thumbnail of Determination of drug-related problems according to PAIR criteria in dialysis patients: a cross-sectional study in tertiary care hospital

BMC pharmacology & toxicology, Apr 18, 2024

Research paper thumbnail of Impact of clinical pharmacist’s interventions on clinical outcomes in appropriate use of colistin: a prospective pre-post intervention study

Journal of Chemotherapy, Apr 6, 2023

Research paper thumbnail of The role of central oxidative stress in age‐related, salt‐sensitive sympathoexcitation

The FASEB Journal, Apr 1, 2011

Research paper thumbnail of Feedback of pharmacy students toward teaching-learning pharmacology in Northern Cyprus

International Journal of Pharmacy, Oct 10, 2016

This study explores pharmacy students' feedback on teaching-learning methods of pharmacology in f... more This study explores pharmacy students' feedback on teaching-learning methods of pharmacology in faculties of pharmacy in Northern Cyprus universities. 150 students randomly selected and participated by filling selfadministered questionnaires. The majority of participants were female and most of them were in the 4 th year of their study. The results showed that high percentage of students had good understanding and grasping of pharmacology subjects in class, and the pharmacology is the most favored course in comparison with others. Moreover, participants taught that pharmacology course will have most usage in their future pharmacy practice. It can be concluded that the general attitude of students toward pharmacology were positive; however, some changes in curriculum are still required in order to make the pharmacology courses more interesting.

Research paper thumbnail of Evaluation of pharmaceutical care services in the Middle East Countries: a review of studies of 2013–2020

BMC Public Health, Jul 17, 2023

Introduction Pharmaceutical care services (PCs) have evolved significantly over the last few deca... more Introduction Pharmaceutical care services (PCs) have evolved significantly over the last few decades, with a greater focus on patient's safety and proven effectiveness in a wide range of contexts. Many of the evidence supporting this technique comes from the United States, the evaluation and adoption of (PCs) which differ greatly across the globe. Objective The goal of this study was to identify and assess the efficacy of pharmaceutical care services in various pharmaceutical aspects throughout seventeen Middle Eastern nations. Method The Arkesy and O'Malley technique was used to conduct a scoping review. It was conducted using PubMed/Medline, Scopus, Cochrane Library, Springer Link, Clinical Trials, and Web of Science etc. The Van Tulder Scale was utilized in randomized trials research, whereas the dawn and black checklists were used in non-randomized trials research. A descriptive and numerical analysis of selected research was done. The scope of eligible PCs, pharmaceutical implementers, study outcomes, and quality were all identified by a thematic review of research. Results There were about 431,753 citations found in this study, and 129 publications were found to be eligible for inclusion after analysing more than 271 full-text papers. The study design was varied, with 43 (33.3%) RCTs and 86 (66.7%) n-RCTs. Thirty-three (25.6%) of the studies were published in 2020. Jordan, Saudi Arabia, and Turkey were home to the majority of the studies (25.6%, 16.3%, and 11.6%) respectively. Thirty-seven studies (19.7%) were concerned with resolving drug related problems (DRPs), whereas 27 (14.4%) were concerned with increasing quality of life (QOL) and 23 (12.2%) with improving drug adherence. Additionally, the research revealed that the average ratings of the activities provided to patients improved every year. Conclusion Studies in the Middle East continue to provide evidence supporting the positive impact of pharmaceutical care services on both hard and soft outcomes measured in most studies. Yet there was rare focus on the value of the implemented services. Thus, rigorous evaluation of the economic impact of implemented pharmaceutical care services in the Middle East and assessment of their sustainability is must.

Research paper thumbnail of The Research and Evaluation of Drug-use Habits of People in North Cyprus

Eurasia journal of mathematics, science and technology education, Dec 13, 2016

The purpose of this study is to determine the drug-use habits in North Cyprus and to prepare a de... more The purpose of this study is to determine the drug-use habits in North Cyprus and to prepare a demographic study of drug wastage. A total of 450 questionnaires containing 36 questions were handed out in 5 major cities of North Cyprus. Participants' pharmaceutical consumption habits and basic knowledge on rational use were compared with respect to their education level and living cities. People in Cyprus are using leftover medications in case of a need of 63.1%. Most of the participants get their medication with prescriptions (43.5%) and also pay attention to expiry dates while purchasing (80.6%). The main reason behind the leftover medication is the end of the illness or treatment. The second-highest leftover group is antibiotics (17.5%). According to the comparison of data between education levels and cities, rational drug use is statistically low for lower education levels (P = 0.002) and the Guzelyurt region (P = 0.002).

Research paper thumbnail of Impact of a multidisciplinary approach involving clinical pharmacist on resolving drug related problems in chronic kidney patients: a prospective interventional study

BMC Nephrology, May 26, 2023

Background Chronic kidney disease (CKD) is a major public health concern due to its high mortalit... more Background Chronic kidney disease (CKD) is a major public health concern due to its high mortality risk, high hospitalization rates and cost, and low life expectancy. Thus, CKD patients are among patient group that may benefit from clinical pharmacy services the most. Methods This was a prospective interventional study conducted between October 1, 2019, and March 18, 2020, in the nephrology ward of Ankara University School of the Medicine, Ibn-i Sina Hospital. DRPs were classified according to PCNE v8.03. The main outcomes were interventions proposed and the rate of acceptance by the physicians. Results 269 pre-dialysis patients were included to determine DRPs during the treatment process of the patients. 205 DRPs were found in 131 (48.7%) patients. Treatment efficacy was found to be the main type of DRPs (56.2%) followed by treatment safety (39.6%). When patients with and without DRPs were compared, it was found that the number of female patients (55.0%) was higher in the group with DRPs (p < 0.05). The length of hospital stays (11.3 ± 7.7) and the mean number of drugs used (9.6 ± 3.6) in the group with DRPs were significantly higher than those without DRPs (9.3 ± 5.9; 8.1 ± 3.5, respectively) (p < 0.05). 91.7% of the interventions were accepted by the physicians, and patients and found clinically beneficial. 71.7% of DRPs were fully resolved, 1.9% partially resolved and 23.4% could not be resolved. Conclusions A high prevalence of DRPs in patients with chronic kidney disease was determined during therapy. Clinical pharmacist interventions were highly accepted by the physicians and patients. This may indicate implementation of clinical pharmacy services in the nephrology ward has a great impact on optimized therapy and prevention DRPs.

Research paper thumbnail of A preliminary study to evaluate the impact of pharmaceutical care services on clinical outcome and medication adherence in type 2 diabetes mellitus patients from Ethiopian perspective

African Health Sciences, Dec 22, 2022

Background: The role of clinical pharmacist in hospital settings of Ethiopia is still new and inf... more Background: The role of clinical pharmacist in hospital settings of Ethiopia is still new and infant. Objective: To evaluate the impact of pharmaceutical care on clinical outcome and medication adherence in type 2 diabetes mellitus (T2DM) patients. Methods: A single cantered, pre-post interventional study design was carried out by enrolling 100 uncontrolled T2DM patients from March 1-August 30, 2020. The intervention package included assessment of pharmacological and non-pharmacological needs, counselling patients in person at the clinic, and providing educational materials. Results: Of the 100 patients initially enrolled, 87(87%) completed the follow-up and included in the final data analysis. The intervention showed a decrease in average FBG, systolic blood pressure (SBP), low density lipoprotein cholesterol (LDL-C) by 47.3 mg/dL, 22.6mmHg and 31.4mg/dL, while high density lipoprotein cholesterol (HDL-C) and estimated glomerular filtration rate (eGFR) exhibited significant increase by 13.4 mg/dL and 11.5 ml/min/1.73m2 respectively (p<0.0001). In addition, diastolic blood pressure, lipid values, kidney function parameters, and liver function parameters showed significant decrease in post intervention compared to pre-intervention (p<0.05). Medication adherence of the patients increased significantly at 6-month follow-up (p<0.001). Conclusion: These results also suggest the benefits of integrating clinical pharmacist services in multidisciplinary healthcare teams and diabetes management in Ethiopia.

Research paper thumbnail of Efficacy and safety of novel glycopeptides versus vancomycin for the treatment of gram-positive bacterial infections including methicillin resistant Staphylococcus aureus: A systematic review and meta-analysis

PLOS ONE, 2021

Objective To compare between current evidence of novel glycopeptides against vancomycin for the t... more Objective To compare between current evidence of novel glycopeptides against vancomycin for the treatment of gram-positive bacterial infections. Methodology A systematic review and meta-analysis was done. Major databases were searched for eligible randomized control trials that assessed clinical success, microbiological success and safety profile of novel glycopeptides versus vancomycin for infections caused by gram-positive bacteria. Results This meta-analysis included eleven trials (7289 participants) comparing telavancin, dalbavancin and oritavancin with vancomycin. No differences were detected between novel glycopeptides and vancomycin for the treatment of skin and soft tissue infections (SSTIs) among modified intent-to-treat patients (OR: 1.04, CI: 0.92–1.17) as well as within the clinically evaluable patients (OR: 1.09, CI: 0.91–1.30). Data analysed from SSTIs, HAP and bacteremia studies on telavancin showed insignificant high clinical response in microbiologically evaluable p...

Research paper thumbnail of Efficacy and Safety of Capecitabine Alone or in Combination in Advanced Metastatic Breast Cancer Patients Previously Treated with Anthracycline and Taxane: A Systematic Review and Meta-Analysis

Oncology Research and Treatment, 2020

Background: Capecitabine is frequently used alone or combined with other chemotherapy agents for ... more Background: Capecitabine is frequently used alone or combined with other chemotherapy agents for the treatment of metastatic breast cancer in relapsed patients. Objective: The objective of this meta-analysis is to evaluate the effectiveness and safety of capecitabine monotherapy versus combination in the treatment of metastatic breast cancer patients pretreated with anthracycline and taxane. Methods: Eligible randomized controlled trials examining the efficacy and safety of capecitabine alone compared to capecitabine combination were systematically searched. Progression-free survival (PFS), overall survival (OS), overall response rate (ORR), and grades 3–4 drug-related adverse events were the outcomes assessed. Results: A total of 6,714 patients of 9 trials were involved in the pooled analysis. Our findings demonstrated that capecitabine combination is significantly superior to capecitabine monotherapy in improving PFS (hazard ratio [HR] 1.32, 95% CI 1.13–1.54, p < 0.0001) and OR...

Research paper thumbnail of The rational use of thromboprophylaxis therapy in hospitalized patients and the perspectives of health care providers in Northern Cyprus

PLOS ONE, 2020

Background Despite the presence of effective strategies and standard guidelines for the preventio... more Background Despite the presence of effective strategies and standard guidelines for the prevention of deep vein thrombosis (DVT), a considerable proportion of patients at risk of developing thromboembolism did not receive prophylaxis during hospitalization, while others received it irrationally, thus led to unwanted side effects. Aim This study aimed to evaluate the current thromboprophylaxis practice and management of hospitalized patients at risk of developing DVT, along with the assessment of health care providers (HCPs) knowledge, and attitudes regarding DVT prevention. Methods An observational study was conducted in the general wards of two leading tertiary university hospitals in Northern Cyprus in which patients from multiple clinics were enrolled to investigate the rational use of DVT prophylaxis using the Caprini risk assessment tool. Patients were also followed for possible complications two weeks post-hospitalization. A cross-sectional study followed to assess the knowledge and attitude of HCPs regarding DVT risks and prophylaxis. Results Of the 180 patients enrolled, 47.7% were identified as irrationally managed, 52.3% were identified as rationally managed, 77.8% of patients were identified as having a high level of risk. Notably, Four of thirteen patients who received more thromboprophylaxis developed minor complications. Additionally, 73.3% of nurses had not received DVT education. Furthermore, more than 50% of physicians and nurses achieved a low knowledge score for DVT risks and prophylaxis.

Research paper thumbnail of Pharmacy Students’ Perception and Evaluation of Objective Structured Clinical Examination: Near East University Experience

Journal of Pharmaceutical Research International, 2019

Background: Pharmacy educators have always been desirous of the best methods for formative and su... more Background: Pharmacy educators have always been desirous of the best methods for formative and summative evaluation of trainees. The Objective Structured Clinical Examination (OSCE) is an approach for student assessment in which aspects of clinical competence are evaluated in a comprehensive, consistent, and structured manner. Though recently become popular in pharmacy schools globally, its use in North Cyprus and Turkey pharmacy schools appears limited. Objectives: To assess pharmacy students’ evaluation and overall perception of OSCE. Methods: A cross-sectional survey was conducted on pharmacy students, who participated in the final OSCE examination in 2015-2016.The study sample consisted of fifth-year Pharmacy students who took the OSCE assessment during their studies. A24-item self-administered structured questionnaire was employed to obtain relevant data on OSCE evaluation in terms of content reliability and structure of the examination. Students’ responses were based on a 4-po...

Research paper thumbnail of Preparing competent graduates for delivering pharmaceutical care: an experience from Northern Cyprus

BMC Medical Education, 2019

Background This paper describes the implementation and evaluation of a clinical pharmacy practice... more Background This paper describes the implementation and evaluation of a clinical pharmacy practice (CPP) course in Northern Cyprus. The course covered a range of subjects, including internal medicine, cardiovascular and respiratory diseases, and drug information services. Methods An 8-week structured CPP course was designed for fifth-year students. Students’ competencies were assessed using an objective structural clinical examination (OSCE) before and after the intervention. The course addressed all CPP competence domains and learning outcomes, and it utilized a wide variety of learning activities. Student perceptions, experience and preceptor evaluations were assessed using surveys. Results Students reported that the learning objectives of the course were met. Substantial knowledge and skills in different areas of CPP were gained. A significant overall enhancement in the average grades on the OSCE was identified (23.09 ± 0.75 and 27.51 ± 0.71 out of 40). Students received the highe...

Research paper thumbnail of North Cyprus Pharmacist’s Cognition and Practice of Pharmaceutical Care

Journal of Pharmaceutical Research International, 2018

The aim of this project is to assess community pharmacists' attitudes towards their professional ... more The aim of this project is to assess community pharmacists' attitudes towards their professional practice and to determine their perceived competence in various pharmaceutical activities. The philosophy of Pharmaceutical care focuses on the responsibility of pharmacist to meet all of the patient's drug-related needs, and assist the patients in achieving their goal through collaboration with other health professionals. Materials and Methods: The study was conducted prospectively between January and March 2016. It involved community pharmacists working in pharmacies within North Cyprus. There are 190 pharmacies in North Cyprus, 110 questionnaires were administered out of which 80 completed giving a response rate of 78.0% from pharmacists working in community pharmacies. Results: The result of the current study showed that 97.5% of respondents had knowledge deficit of pharmaceutical care concepts but there is a positive attitude towards the practice of Short Research Article

Research paper thumbnail of Prevalence Study of Antibiotic Usage and Health Care Associated Infections in Northern Cyprus

Journal of Pharmaceutical Research International, 2019

Purpose: This study aims to provide a prevalence survey of antibiotic usage and HAIs and evaluate... more Purpose: This study aims to provide a prevalence survey of antibiotic usage and HAIs and evaluate the cost of antibiotic therapy. Methods: All inpatients on surgery, paediatrics, medicine, and ICU specialities were surveyed within a period of one week, April 2016 at Near East University hospital in Northern Cyprus. ACross-sectional study was performed and desired data on antibiotic use and HAIs were collected and analysed. Results: Out of 137 inpatients, 39.4% (n=54) were on one or two antibiotics. The usage of antibiotic was appropriate in 70% of the patients while it was inappropriate in the remaining 30%. The most common appropriate use was seen in empirical (80.6%) and prophylaxis (69.2%), while in definitive therapy cases (60.0%), the usage of antibiotics was irrationally inappropriate. Overall, 10.9% of hospitalized patients developed HAI. The most prevalent infection was UTI (urinary tract infections) (33.3%). Prevalence of HAIs was high in patients over 30 years old and in t...

Research paper thumbnail of Effect of High-Salt Diet on Age-Related High Blood Pressure and Hypothalamic Redox Signaling

Pharmacology, 2017

Aim: The aim of this study was to investigate the effect of a high salt (HS) diet on age-related ... more Aim: The aim of this study was to investigate the effect of a high salt (HS) diet on age-related changes in blood pressure (BP) and the possible role played by regulatory central mechanisms. Methods: Young (5 months) and old (27 months) male Fischer 344 × Brown Norway (F344/BN) rats were fed standard chow or 8% HS diet for 12 days. BP and heart rate (HR) were measured by telemetry. Results: Mean arterial BP (MAP) was significantly elevated in old rats during the day and night when compared with young animals. The HS diet further elevated MAP in both age groups, and the increase was more pronounced in the old animals, while HR was not altered by age or HS diet. In addition, cardiovascular responses to restraint stress were diminished in the old when compared with the young and were unchanged with HS diet in either age group. Both age and the HS diet elevated the adrenomedullary mRNA levels of tyrosine hydroxylase, an indicator for sympathoexcitation. HS diet enhanced intracerebrovent...

Research paper thumbnail of Altered potassium ATP channel signaling in mesenteric arteries of old high salt-fed rats

Journal of Exercise Nutrition & Biochemistry, 2016

Both aging and the consumption of a high salt diet are associated with clear changes in the vascu... more Both aging and the consumption of a high salt diet are associated with clear changes in the vascular system that can lead to the development of cardiovascular disease; however the mechanisms are not clearly understood. Therefore, we examined whether aging and the consumption of excess salt alters the function of potassium ATP-dependent channel signaling in mesenteric arteries.

Research paper thumbnail of Test performance of self‐report adherence tools in patients with hypertension: A systematic review and a meta‐analysis

Journal of Clinical Pharmacy and Therapeutics, Nov 18, 2022

Research paper thumbnail of Drug-related problems and health-related quality of life among chronic disease patients in a rural region of North Cyprus

Tropical Journal of Pharmaceutical Research, Nov 3, 2022

Purpose: To evaluate the various types of drug-related problems (DRPs) and health-related quality... more Purpose: To evaluate the various types of drug-related problems (DRPs) and health-related quality of life (HRQoL) among chronic disease patients in a rural region of North Cyprus. Methods: A cross-sectional study of patients visiting a rural community pharmacy in North Cyprus was conducted. Patient demographic information, quality of life (QoL), laboratory data, adherence, and beliefs about medicine were assessed using standardized tools. Drug-related problems were evaluated using PCNE V.9.1. Results: Among the 200 screened participants, 97 fulfilled the enrollment criteria and were interviewed. The median age of the participants was 62 years (interquartile range = 15), with 58.8 % women. Only 54 % of hypertensive (HTN) patients reached their target blood pressure level. Over 40 % of type 2 diabetes mellitus (T2DM) patients failed to achieve their target HbA1c level. The majority (71 %) of patients with HTN, T2DM or coronary artery disease were not compliant with lifestyle recommendations and 86.6 % had ≥ 1 DRP. Insufficient dosing and inappropriate indication for a drug were the DRPs associated with failure to achieve target and inappropriate drugs was the DRP type mostly associated with lower quality of life scores. Other factors associated with lower QoL levels included female gender, unemployment status, and high agreement with the statement "medications do more harm than good". Conclusion: Drug related problems and non-adherence are prevalent, while therapy targets are rarely met in rural Cyprus. Community pharmacists have the potential to improve outcomes in the management of non-communicable diseases (NCDs).

Research paper thumbnail of Antimicrobial dosing recommendations during continuous renal replacement therapy: different databases, different doses

Journal of chemotherapy, Feb 26, 2024

Research paper thumbnail of Determination of drug-related problems according to PAIR criteria in dialysis patients: a cross-sectional study in tertiary care hospital

BMC pharmacology & toxicology, Apr 18, 2024

Research paper thumbnail of Impact of clinical pharmacist’s interventions on clinical outcomes in appropriate use of colistin: a prospective pre-post intervention study

Journal of Chemotherapy, Apr 6, 2023

Research paper thumbnail of The role of central oxidative stress in age‐related, salt‐sensitive sympathoexcitation

The FASEB Journal, Apr 1, 2011

Research paper thumbnail of Feedback of pharmacy students toward teaching-learning pharmacology in Northern Cyprus

International Journal of Pharmacy, Oct 10, 2016

This study explores pharmacy students' feedback on teaching-learning methods of pharmacology in f... more This study explores pharmacy students' feedback on teaching-learning methods of pharmacology in faculties of pharmacy in Northern Cyprus universities. 150 students randomly selected and participated by filling selfadministered questionnaires. The majority of participants were female and most of them were in the 4 th year of their study. The results showed that high percentage of students had good understanding and grasping of pharmacology subjects in class, and the pharmacology is the most favored course in comparison with others. Moreover, participants taught that pharmacology course will have most usage in their future pharmacy practice. It can be concluded that the general attitude of students toward pharmacology were positive; however, some changes in curriculum are still required in order to make the pharmacology courses more interesting.

Research paper thumbnail of Evaluation of pharmaceutical care services in the Middle East Countries: a review of studies of 2013–2020

BMC Public Health, Jul 17, 2023

Introduction Pharmaceutical care services (PCs) have evolved significantly over the last few deca... more Introduction Pharmaceutical care services (PCs) have evolved significantly over the last few decades, with a greater focus on patient's safety and proven effectiveness in a wide range of contexts. Many of the evidence supporting this technique comes from the United States, the evaluation and adoption of (PCs) which differ greatly across the globe. Objective The goal of this study was to identify and assess the efficacy of pharmaceutical care services in various pharmaceutical aspects throughout seventeen Middle Eastern nations. Method The Arkesy and O'Malley technique was used to conduct a scoping review. It was conducted using PubMed/Medline, Scopus, Cochrane Library, Springer Link, Clinical Trials, and Web of Science etc. The Van Tulder Scale was utilized in randomized trials research, whereas the dawn and black checklists were used in non-randomized trials research. A descriptive and numerical analysis of selected research was done. The scope of eligible PCs, pharmaceutical implementers, study outcomes, and quality were all identified by a thematic review of research. Results There were about 431,753 citations found in this study, and 129 publications were found to be eligible for inclusion after analysing more than 271 full-text papers. The study design was varied, with 43 (33.3%) RCTs and 86 (66.7%) n-RCTs. Thirty-three (25.6%) of the studies were published in 2020. Jordan, Saudi Arabia, and Turkey were home to the majority of the studies (25.6%, 16.3%, and 11.6%) respectively. Thirty-seven studies (19.7%) were concerned with resolving drug related problems (DRPs), whereas 27 (14.4%) were concerned with increasing quality of life (QOL) and 23 (12.2%) with improving drug adherence. Additionally, the research revealed that the average ratings of the activities provided to patients improved every year. Conclusion Studies in the Middle East continue to provide evidence supporting the positive impact of pharmaceutical care services on both hard and soft outcomes measured in most studies. Yet there was rare focus on the value of the implemented services. Thus, rigorous evaluation of the economic impact of implemented pharmaceutical care services in the Middle East and assessment of their sustainability is must.

Research paper thumbnail of The Research and Evaluation of Drug-use Habits of People in North Cyprus

Eurasia journal of mathematics, science and technology education, Dec 13, 2016

The purpose of this study is to determine the drug-use habits in North Cyprus and to prepare a de... more The purpose of this study is to determine the drug-use habits in North Cyprus and to prepare a demographic study of drug wastage. A total of 450 questionnaires containing 36 questions were handed out in 5 major cities of North Cyprus. Participants' pharmaceutical consumption habits and basic knowledge on rational use were compared with respect to their education level and living cities. People in Cyprus are using leftover medications in case of a need of 63.1%. Most of the participants get their medication with prescriptions (43.5%) and also pay attention to expiry dates while purchasing (80.6%). The main reason behind the leftover medication is the end of the illness or treatment. The second-highest leftover group is antibiotics (17.5%). According to the comparison of data between education levels and cities, rational drug use is statistically low for lower education levels (P = 0.002) and the Guzelyurt region (P = 0.002).

Research paper thumbnail of Impact of a multidisciplinary approach involving clinical pharmacist on resolving drug related problems in chronic kidney patients: a prospective interventional study

BMC Nephrology, May 26, 2023

Background Chronic kidney disease (CKD) is a major public health concern due to its high mortalit... more Background Chronic kidney disease (CKD) is a major public health concern due to its high mortality risk, high hospitalization rates and cost, and low life expectancy. Thus, CKD patients are among patient group that may benefit from clinical pharmacy services the most. Methods This was a prospective interventional study conducted between October 1, 2019, and March 18, 2020, in the nephrology ward of Ankara University School of the Medicine, Ibn-i Sina Hospital. DRPs were classified according to PCNE v8.03. The main outcomes were interventions proposed and the rate of acceptance by the physicians. Results 269 pre-dialysis patients were included to determine DRPs during the treatment process of the patients. 205 DRPs were found in 131 (48.7%) patients. Treatment efficacy was found to be the main type of DRPs (56.2%) followed by treatment safety (39.6%). When patients with and without DRPs were compared, it was found that the number of female patients (55.0%) was higher in the group with DRPs (p < 0.05). The length of hospital stays (11.3 ± 7.7) and the mean number of drugs used (9.6 ± 3.6) in the group with DRPs were significantly higher than those without DRPs (9.3 ± 5.9; 8.1 ± 3.5, respectively) (p < 0.05). 91.7% of the interventions were accepted by the physicians, and patients and found clinically beneficial. 71.7% of DRPs were fully resolved, 1.9% partially resolved and 23.4% could not be resolved. Conclusions A high prevalence of DRPs in patients with chronic kidney disease was determined during therapy. Clinical pharmacist interventions were highly accepted by the physicians and patients. This may indicate implementation of clinical pharmacy services in the nephrology ward has a great impact on optimized therapy and prevention DRPs.

Research paper thumbnail of A preliminary study to evaluate the impact of pharmaceutical care services on clinical outcome and medication adherence in type 2 diabetes mellitus patients from Ethiopian perspective

African Health Sciences, Dec 22, 2022

Background: The role of clinical pharmacist in hospital settings of Ethiopia is still new and inf... more Background: The role of clinical pharmacist in hospital settings of Ethiopia is still new and infant. Objective: To evaluate the impact of pharmaceutical care on clinical outcome and medication adherence in type 2 diabetes mellitus (T2DM) patients. Methods: A single cantered, pre-post interventional study design was carried out by enrolling 100 uncontrolled T2DM patients from March 1-August 30, 2020. The intervention package included assessment of pharmacological and non-pharmacological needs, counselling patients in person at the clinic, and providing educational materials. Results: Of the 100 patients initially enrolled, 87(87%) completed the follow-up and included in the final data analysis. The intervention showed a decrease in average FBG, systolic blood pressure (SBP), low density lipoprotein cholesterol (LDL-C) by 47.3 mg/dL, 22.6mmHg and 31.4mg/dL, while high density lipoprotein cholesterol (HDL-C) and estimated glomerular filtration rate (eGFR) exhibited significant increase by 13.4 mg/dL and 11.5 ml/min/1.73m2 respectively (p<0.0001). In addition, diastolic blood pressure, lipid values, kidney function parameters, and liver function parameters showed significant decrease in post intervention compared to pre-intervention (p<0.05). Medication adherence of the patients increased significantly at 6-month follow-up (p<0.001). Conclusion: These results also suggest the benefits of integrating clinical pharmacist services in multidisciplinary healthcare teams and diabetes management in Ethiopia.

Research paper thumbnail of Efficacy and safety of novel glycopeptides versus vancomycin for the treatment of gram-positive bacterial infections including methicillin resistant Staphylococcus aureus: A systematic review and meta-analysis

PLOS ONE, 2021

Objective To compare between current evidence of novel glycopeptides against vancomycin for the t... more Objective To compare between current evidence of novel glycopeptides against vancomycin for the treatment of gram-positive bacterial infections. Methodology A systematic review and meta-analysis was done. Major databases were searched for eligible randomized control trials that assessed clinical success, microbiological success and safety profile of novel glycopeptides versus vancomycin for infections caused by gram-positive bacteria. Results This meta-analysis included eleven trials (7289 participants) comparing telavancin, dalbavancin and oritavancin with vancomycin. No differences were detected between novel glycopeptides and vancomycin for the treatment of skin and soft tissue infections (SSTIs) among modified intent-to-treat patients (OR: 1.04, CI: 0.92–1.17) as well as within the clinically evaluable patients (OR: 1.09, CI: 0.91–1.30). Data analysed from SSTIs, HAP and bacteremia studies on telavancin showed insignificant high clinical response in microbiologically evaluable p...

Research paper thumbnail of Efficacy and Safety of Capecitabine Alone or in Combination in Advanced Metastatic Breast Cancer Patients Previously Treated with Anthracycline and Taxane: A Systematic Review and Meta-Analysis

Oncology Research and Treatment, 2020

Background: Capecitabine is frequently used alone or combined with other chemotherapy agents for ... more Background: Capecitabine is frequently used alone or combined with other chemotherapy agents for the treatment of metastatic breast cancer in relapsed patients. Objective: The objective of this meta-analysis is to evaluate the effectiveness and safety of capecitabine monotherapy versus combination in the treatment of metastatic breast cancer patients pretreated with anthracycline and taxane. Methods: Eligible randomized controlled trials examining the efficacy and safety of capecitabine alone compared to capecitabine combination were systematically searched. Progression-free survival (PFS), overall survival (OS), overall response rate (ORR), and grades 3–4 drug-related adverse events were the outcomes assessed. Results: A total of 6,714 patients of 9 trials were involved in the pooled analysis. Our findings demonstrated that capecitabine combination is significantly superior to capecitabine monotherapy in improving PFS (hazard ratio [HR] 1.32, 95% CI 1.13–1.54, p < 0.0001) and OR...

Research paper thumbnail of The rational use of thromboprophylaxis therapy in hospitalized patients and the perspectives of health care providers in Northern Cyprus

PLOS ONE, 2020

Background Despite the presence of effective strategies and standard guidelines for the preventio... more Background Despite the presence of effective strategies and standard guidelines for the prevention of deep vein thrombosis (DVT), a considerable proportion of patients at risk of developing thromboembolism did not receive prophylaxis during hospitalization, while others received it irrationally, thus led to unwanted side effects. Aim This study aimed to evaluate the current thromboprophylaxis practice and management of hospitalized patients at risk of developing DVT, along with the assessment of health care providers (HCPs) knowledge, and attitudes regarding DVT prevention. Methods An observational study was conducted in the general wards of two leading tertiary university hospitals in Northern Cyprus in which patients from multiple clinics were enrolled to investigate the rational use of DVT prophylaxis using the Caprini risk assessment tool. Patients were also followed for possible complications two weeks post-hospitalization. A cross-sectional study followed to assess the knowledge and attitude of HCPs regarding DVT risks and prophylaxis. Results Of the 180 patients enrolled, 47.7% were identified as irrationally managed, 52.3% were identified as rationally managed, 77.8% of patients were identified as having a high level of risk. Notably, Four of thirteen patients who received more thromboprophylaxis developed minor complications. Additionally, 73.3% of nurses had not received DVT education. Furthermore, more than 50% of physicians and nurses achieved a low knowledge score for DVT risks and prophylaxis.

Research paper thumbnail of Pharmacy Students’ Perception and Evaluation of Objective Structured Clinical Examination: Near East University Experience

Journal of Pharmaceutical Research International, 2019

Background: Pharmacy educators have always been desirous of the best methods for formative and su... more Background: Pharmacy educators have always been desirous of the best methods for formative and summative evaluation of trainees. The Objective Structured Clinical Examination (OSCE) is an approach for student assessment in which aspects of clinical competence are evaluated in a comprehensive, consistent, and structured manner. Though recently become popular in pharmacy schools globally, its use in North Cyprus and Turkey pharmacy schools appears limited. Objectives: To assess pharmacy students’ evaluation and overall perception of OSCE. Methods: A cross-sectional survey was conducted on pharmacy students, who participated in the final OSCE examination in 2015-2016.The study sample consisted of fifth-year Pharmacy students who took the OSCE assessment during their studies. A24-item self-administered structured questionnaire was employed to obtain relevant data on OSCE evaluation in terms of content reliability and structure of the examination. Students’ responses were based on a 4-po...

Research paper thumbnail of Preparing competent graduates for delivering pharmaceutical care: an experience from Northern Cyprus

BMC Medical Education, 2019

Background This paper describes the implementation and evaluation of a clinical pharmacy practice... more Background This paper describes the implementation and evaluation of a clinical pharmacy practice (CPP) course in Northern Cyprus. The course covered a range of subjects, including internal medicine, cardiovascular and respiratory diseases, and drug information services. Methods An 8-week structured CPP course was designed for fifth-year students. Students’ competencies were assessed using an objective structural clinical examination (OSCE) before and after the intervention. The course addressed all CPP competence domains and learning outcomes, and it utilized a wide variety of learning activities. Student perceptions, experience and preceptor evaluations were assessed using surveys. Results Students reported that the learning objectives of the course were met. Substantial knowledge and skills in different areas of CPP were gained. A significant overall enhancement in the average grades on the OSCE was identified (23.09 ± 0.75 and 27.51 ± 0.71 out of 40). Students received the highe...

Research paper thumbnail of North Cyprus Pharmacist’s Cognition and Practice of Pharmaceutical Care

Journal of Pharmaceutical Research International, 2018

The aim of this project is to assess community pharmacists' attitudes towards their professional ... more The aim of this project is to assess community pharmacists' attitudes towards their professional practice and to determine their perceived competence in various pharmaceutical activities. The philosophy of Pharmaceutical care focuses on the responsibility of pharmacist to meet all of the patient's drug-related needs, and assist the patients in achieving their goal through collaboration with other health professionals. Materials and Methods: The study was conducted prospectively between January and March 2016. It involved community pharmacists working in pharmacies within North Cyprus. There are 190 pharmacies in North Cyprus, 110 questionnaires were administered out of which 80 completed giving a response rate of 78.0% from pharmacists working in community pharmacies. Results: The result of the current study showed that 97.5% of respondents had knowledge deficit of pharmaceutical care concepts but there is a positive attitude towards the practice of Short Research Article

Research paper thumbnail of Prevalence Study of Antibiotic Usage and Health Care Associated Infections in Northern Cyprus

Journal of Pharmaceutical Research International, 2019

Purpose: This study aims to provide a prevalence survey of antibiotic usage and HAIs and evaluate... more Purpose: This study aims to provide a prevalence survey of antibiotic usage and HAIs and evaluate the cost of antibiotic therapy. Methods: All inpatients on surgery, paediatrics, medicine, and ICU specialities were surveyed within a period of one week, April 2016 at Near East University hospital in Northern Cyprus. ACross-sectional study was performed and desired data on antibiotic use and HAIs were collected and analysed. Results: Out of 137 inpatients, 39.4% (n=54) were on one or two antibiotics. The usage of antibiotic was appropriate in 70% of the patients while it was inappropriate in the remaining 30%. The most common appropriate use was seen in empirical (80.6%) and prophylaxis (69.2%), while in definitive therapy cases (60.0%), the usage of antibiotics was irrationally inappropriate. Overall, 10.9% of hospitalized patients developed HAI. The most prevalent infection was UTI (urinary tract infections) (33.3%). Prevalence of HAIs was high in patients over 30 years old and in t...

Research paper thumbnail of Effect of High-Salt Diet on Age-Related High Blood Pressure and Hypothalamic Redox Signaling

Pharmacology, 2017

Aim: The aim of this study was to investigate the effect of a high salt (HS) diet on age-related ... more Aim: The aim of this study was to investigate the effect of a high salt (HS) diet on age-related changes in blood pressure (BP) and the possible role played by regulatory central mechanisms. Methods: Young (5 months) and old (27 months) male Fischer 344 × Brown Norway (F344/BN) rats were fed standard chow or 8% HS diet for 12 days. BP and heart rate (HR) were measured by telemetry. Results: Mean arterial BP (MAP) was significantly elevated in old rats during the day and night when compared with young animals. The HS diet further elevated MAP in both age groups, and the increase was more pronounced in the old animals, while HR was not altered by age or HS diet. In addition, cardiovascular responses to restraint stress were diminished in the old when compared with the young and were unchanged with HS diet in either age group. Both age and the HS diet elevated the adrenomedullary mRNA levels of tyrosine hydroxylase, an indicator for sympathoexcitation. HS diet enhanced intracerebrovent...

Research paper thumbnail of Altered potassium ATP channel signaling in mesenteric arteries of old high salt-fed rats

Journal of Exercise Nutrition & Biochemistry, 2016

Both aging and the consumption of a high salt diet are associated with clear changes in the vascu... more Both aging and the consumption of a high salt diet are associated with clear changes in the vascular system that can lead to the development of cardiovascular disease; however the mechanisms are not clearly understood. Therefore, we examined whether aging and the consumption of excess salt alters the function of potassium ATP-dependent channel signaling in mesenteric arteries.

Research paper thumbnail of Test performance of self‐report adherence tools in patients with hypertension: A systematic review and a meta‐analysis

Journal of Clinical Pharmacy and Therapeutics, Nov 18, 2022

Research paper thumbnail of Drug-related problems and health-related quality of life among chronic disease patients in a rural region of North Cyprus

Tropical Journal of Pharmaceutical Research, Nov 3, 2022

Purpose: To evaluate the various types of drug-related problems (DRPs) and health-related quality... more Purpose: To evaluate the various types of drug-related problems (DRPs) and health-related quality of life (HRQoL) among chronic disease patients in a rural region of North Cyprus. Methods: A cross-sectional study of patients visiting a rural community pharmacy in North Cyprus was conducted. Patient demographic information, quality of life (QoL), laboratory data, adherence, and beliefs about medicine were assessed using standardized tools. Drug-related problems were evaluated using PCNE V.9.1. Results: Among the 200 screened participants, 97 fulfilled the enrollment criteria and were interviewed. The median age of the participants was 62 years (interquartile range = 15), with 58.8 % women. Only 54 % of hypertensive (HTN) patients reached their target blood pressure level. Over 40 % of type 2 diabetes mellitus (T2DM) patients failed to achieve their target HbA1c level. The majority (71 %) of patients with HTN, T2DM or coronary artery disease were not compliant with lifestyle recommendations and 86.6 % had ≥ 1 DRP. Insufficient dosing and inappropriate indication for a drug were the DRPs associated with failure to achieve target and inappropriate drugs was the DRP type mostly associated with lower quality of life scores. Other factors associated with lower QoL levels included female gender, unemployment status, and high agreement with the statement "medications do more harm than good". Conclusion: Drug related problems and non-adherence are prevalent, while therapy targets are rarely met in rural Cyprus. Community pharmacists have the potential to improve outcomes in the management of non-communicable diseases (NCDs).