Elvis Martis | Bombay College Of Pharmarcy University Of Mumbai (original) (raw)

Papers by Elvis Martis

Chronicles of Young Scientists, 2012

J Young Pharm, 2 (4), 417-419., 2010

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International Letters of Chemistry, Physics and Astronomy, 2015

The Journal of Natural Science, Biology and Medicine

`Ozone (O 3 ) gas discovered in the mid-nineteenth century is a molecule consisting of three atom... more `Ozone (O 3 ) gas discovered in the mid-nineteenth century is a molecule consisting of three atoms of oxygen in a dynamically unstable structure due to the presence of mesomeric states. Although O 3 has dangerous effects, yet researchers believe it has many therapeutic effects. Ozone therapy has been utilized and heavily studied for more than a century. Its effects are proven, consistent, safe and with minimal and preventable side effects. Medical O 3 is used to disinfect and treat disease. Mechanism of actions is by inactivation of bacteria, viruses, fungi, yeast and protozoa, stimulation of oxygen metabolism, activation of the immune system. Medication forms in a gaseous state are somewhat unusual, and it is for this reason that special application techniques have had to be developed for the safe use of O 3 . In local applications as in the treatment of external wounds, its application in the form of a transcutaneous O 3 gas bath has established itself as being the most practical ...

Current computer-aided drug design, 2016

With cases of emergence of drug resistance to the current competitive inhibitors of neuraminidase... more With cases of emergence of drug resistance to the current competitive inhibitors of neuraminidase (NA) such as oseltamivir and zanamavir, there is a present need for an alternative approach in the treatment of avian influenza. With this in view, some flavones and chalcones were designed based on quercetin, the most active naturally occurring noncompetitive inhibitor. We attempt to understand the binding of quercetin to H5N1-NA, and synthetic analogs of quercetin namely flavones and its precursors the chalcones using computational tools. Molecular docking was done using Libdock. Molecular dynamics (MD) simulations were performed using Amber14. We synthesized the two compounds; their structures were confirmed by infrared spectroscopy, 1H-NMR, and mass spectrometry. These molecules were then tested for H5N1-NA inhibition and kinetics of inhibition. Molecular docking studies yielded two compounds i.e., 4'-methoxyflavone and 2'-hydroxy-4-methoxychalcone, as promising leads which ...

Colloids and surfaces. B, Biointerfaces, Jan 28, 2016

In present investigation, initially curcumin was complexed with 2-HP-β-CD (curcumin-2-HP-β-CD-com... more In present investigation, initially curcumin was complexed with 2-HP-β-CD (curcumin-2-HP-β-CD-complex) in 1:1 ratio and later amalgamated with chitosan microspheres (curcumin-2-HP-β-CD-CMs) for selective delivery in colon only through oral route of administration. Various analytical, spectral and in-silico docking techniques revealed that the curcumin was deeply inserted in the 2-HP-β-CD cavity with apparent stability constant of 3.35×10(-3)M. Furthermore, the mean particle size of 6.8±2.6μm and +39.2±4.1mV surface charge of curcumin-2-HP-β-CD-complex-CMs in addition to encapsulation efficiency of about 79.8±6.3% exhibited that the tailored microspheres were optimum for colon delivery of curcumin. This was also demonstrated in dissolution testing and standard cell proliferation assay in which curcumin-2-HP-β-CD-complex-CMs exhibited maximum release in simulated colonic fluid (SCF, pH ∼7.0-8.0, almond emulsion-β-glucosidase) with improved therapeutic index in HT-29 cells. Consistentl...

International Journal of Pharmacy and Pharmaceutical Sciences, 2011

A new, rapid and sensitive RP isocratic HPLC method for simultaneous estimation of Salbutamol Sul... more A new, rapid and sensitive RP isocratic HPLC method for simultaneous estimation of Salbutamol Sulphate and Beclomethasone Dipropionate in Rotacaps formulation has been developed. The determination was performed using HPLC system with an octadecylsilane column and a solvent system comprising of water and Acetonitrile in the volume ratio of (40:60 v/v). The detection was carried out using a UV detector set at 230 nm wavelength. The method was validated with respect to the linearity, accuracy, specificity and robustness. The method has been successfully applied for analysis of drugs in Rotacaps pharmaceutical formulation and is suitable for the routine quality control analysis.

Journal of Pharmacy and Bioallied Sciences, 2015

The objective of present study was to study the influence of different β-cyclodextrin derivatives... more The objective of present study was to study the influence of different β-cyclodextrin derivatives and different methods of complexation on aqueous solubility and consequent translation in in vivo performance of Pioglitazone (PE). Three cyclodextrins: β-cyclodextrin (BCD), hydroxypropyl-β-cyclodextrin (HPBCD) and Sulfobutylether-7-β-cyclodextrin (SBEBCD) were employed in preparation of 1:1 Pioglitazone complexes by three methods viz. co-grinding, kneading and co-evaporation. Complexation was confirmed by phase solubility, proton NMR, Fourier Transform Infrared spectroscopy, Differential Scanning Calorimetry (DSC) and X-Ray diffraction (XRD). Mode of complexation was investigated by molecular dynamic studies. Pharmacodynamic study of blood glucose lowering activity of PE complexes was performed in Alloxan induced diabetic rat model. Aqueous solubility of PE was significantly improved in presence of cyclodextrin. Apparent solubility constants were observed to be 254.33 M(-1) for BCD-PE, 737.48 M(-1) for HPBCD-PE and 5959.06 M(-1) for SBEBCD-PE. The in silico predictions of mode of inclusion were in close agreement with the experimental proton NMR observation. DSC and XRD demonstrated complete amorphization of crystalline PE upon inclusion. All complexes exhibited &amp;gt;95% dissolution within 10 min compared to drug powder that showed &amp;lt;40% at the same time. Marked lowering of blood glucose was recorded for all complexes. Complexation of PE with different BCD significantly influenced its aqueous solubility, improved in vitro dissolution and consequently translated into enhanced pharmacodynamic activity in rats.

Http Dx Doi Org 10 1080 15257770 2014 992531, Apr 15, 2015

2 N 10 -alkylated 2-bromoacridones are a novel series of potent antitumor compounds. DNA binding ... more 2 N 10 -alkylated 2-bromoacridones are a novel series of potent antitumor compounds. DNA binding studies of these compounds were carried out using spectrophotometric titrations, Circular dichroism (CD) measurements using Calf Thymus DNA (CT DNA). The binding constants were identified at a range of K = 0.3 to 3.9 × 10 5 M −1 and the percentage of hypochromism from the spectral titrations at 28-54%. This study has identified a compound 9 with the good binding affinity of K = 0.39768 × 10 5 M −1 with CT DNA. Molecular dynamics (MD) simulations have investigated the changes in structural and dynamic features of native DNA on binding to the active compound 9. All the synthesized compounds have increased the uptake of Vinblastine in MDR KBCh R -8-5 cells to an extent of 1.25-to1.9-fold than standard modulator Verapamil of similar concentration. These findings allowed us to draw preliminary conclusions about the structural features of 2-bromoacridones and further chemical enhancement will improve the binding affinity of the acridone derivatives to CT-DNA for better drug-DNA interaction. The molecular modeling studies have shown mechanism of action and the binding modes of the acridones to DNA.

With the emergence of newer diseases, resistant forms of infectious diseases and multi-drug resis... more With the emergence of newer diseases, resistant forms of infectious diseases and multi-drug resistant bacteria, it has become essential to develop novel and more effective antibiotics. Current antibiotics are obtained from terrestrial life or made synthetically from intermediates. The ocean represents virtually untapped resource from which novel antibiotic compounds can be discovered. It is the marine world that will provide the pharmaceutical industry with the next generation of antibiotics. Marine antibiotics are antibiotics obtained from marine organisms. Scientists have reported the discovery of various antibiotics from marine bacteria (aplasmomycin, himalomycins, and pelagiomycins), sponges (Ara C, variabillin, strobilin, ircinin-1, aeroplysin, 3,5-dibromo-4-hydroxyphenylacetamide), coelenterates (asperidol and eunicin), mollusks (laurinterol and pachydictyol), tunicates (geranylhydroquinone and cystadytins), algae (cycloeudesmol, aeroplysinin-1(+), prepacifenol and tetrabromoheptanone), worms (tholepin and 3,5-dibromo-4-hydroxybezaldehyde), and actinomycetes (marinomycins C and D). This indicates that the marine environment, representing approximately half of the global diversity, is an enormous resource for new antibiotics and this source needs to be explored for the discovery of new generation antibiotics. The present article provides an overview of various antibiotics obtained from marine sources.

`Glycomics is the study that deals with the structures and functions of carbohydrates. The discov... more `Glycomics is the study that deals with the structures and functions of carbohydrates. The discovery Of novel and increasing number of numerous biological roles of carbohydrates , glycomics has explored the field of carbohydrate vaccines. Glycoconjugate vaccines in which the cell surface carbohydrate from a microorganism is covalently attached to a carrier protein are proving to be highly effective in generating protective immune responses to prevent a wide range of diseases. The carbohydrate based agents – glycoproteins and polysaccharides can be difficult to isolate from natural sources and the natural isolates can have heterogeneity and contamination. So, the alternative would be to identify antigenic carbohydrates and then synthesize them in the laboratory. Novel chemical and enzymatic oligosaccharide techniques are making it possible to envision a new generation of carbohydrate based vaccines. Carbohydrate vaccines have leading roles in cancer, haemophilus influenza B, malaria,...

Nucleosides, nucleotides & nucleic acids, Jan 4, 2015

N(10)-alkylated 2-bromoacridones are a novel series of potent antitumor compounds. DNA binding st... more N(10)-alkylated 2-bromoacridones are a novel series of potent antitumor compounds. DNA binding studies of these compounds were carried out using spectrophotometric titrations, Circular dichroism (CD) measurements using Calf Thymus DNA (CT DNA). The binding constants were identified at a range of K = 0.3 to 3.9 × 10(5) M(-1) and the percentage of hypochromism from the spectral titrations at 28-54%. This study has identified a compound 9 with the good binding affinity of K = 0.39768 × 10(5) M(-1) with CT DNA. Molecular dynamics (MD) simulations have investigated the changes in structural and dynamic features of native DNA on binding to the active compound 9. All the synthesized compounds have increased the uptake of Vinblastine in MDR KBCh(R)-8-5 cells to an extent of 1.25- to1.9-fold than standard modulator Verapamil of similar concentration. These findings allowed us to draw preliminary conclusions about the structural features of 2-bromoacridones and further chemical enhancement wi...

Journal of Natural Science, Biology and Medicine, 2011

Ozone (O 3 ) gas discovered in the mid-nineteenth century is a molecule consisting of three atoms... more Ozone (O 3 ) gas discovered in the mid-nineteenth century is a molecule consisting of three atoms of oxygen in a dynamically unstable structure due to the presence of mesomeric states. Although O 3 has dangerous effects, yet researchers believe it has many therapeutic effects. Ozone therapy has been utilized and heavily studied for more than a century. Its effects are proven, consistent, safe and with minimal and preventable side effects. Medical O 3 is used to disinfect and treat disease. Mechanism of actions is by inactivation of bacteria, viruses, fungi, yeast and protozoa, stimulation of oxygen metabolism, activation of the immune system. Medication forms in a gaseous state are somewhat unusual, and it is for this reason that special application techniques have had to be developed for the safe use of O 3 . In local applications as in the treatment of external wounds, its application in the form of a transcutaneous O 3 gas bath has established itself as being the most practical and useful method, for example at low (sub-atmospheric) pressure in a closed system guaranteeing no escape of O 3 into the surrounding air. Ozonized water, whose use is particularly known in dental medicine, is optimally applied as a spray or compress. Diseases treated are infected wounds, circulatory disorders, geriatric conditions, macular degeneration, viral diseases, rheumatism/arthritis, cancer, SARS and AIDS.

Page 1. Vinay Wamorkar et al: Development and Comparison of Novel Floating Drug Delivery System f... more Page 1. Vinay Wamorkar et al: Development and Comparison of Novel Floating Drug Delivery System for 1446 Review Article Novel Antibiotics from Marine Sources GM Doshi1, GV Aggarwal1, EA Martis2* and PP Shanbhag1 ...

Metabolomics is up-coming omic science. Metabolomic society consistent with other post genomic sc... more Metabolomics is up-coming omic science. Metabolomic society consistent with other post genomic sciences such as genomics, transcriptomics and proteomics. Metabolomics is emerging as a significant player in drug development process, it is a technology that aims to identify and quantifies the metabolome-the dynamic set of all small molecules present in an organism or a biological sample. Metabolic analysis provides a biochemical snapshot of the small molecules produced during cellular metabolism. Since the metabolome directly reflects physiological states, it can biochemically monitor disease states and assess drug actions, improving the preclinical to clinical translation and focusing on predictability, efficiency and improve productivity. Knowing early on how drugs impacts biochemistry would be a significant advantage, leading to fewer failures at a later stage. This paper describes about metabolomics as an important tool in drug discovery and also gives an overview metabolomic process.

... Elvis A. Martis Department of Medicinal Chemistry, Vivekanand Education Society's colleg... more ... Elvis A. Martis Department of Medicinal Chemistry, Vivekanand Education Society's college of Pharmacy, Hashu Advani Memorial Complex ... Acknowledgement: The authors would like to wholeheartedly thank Mr. Ojaskumar Agrawal and Mrs Deepali M. Gangrade, Department of ...