Peng Tang | Hunan Agricultural University (original) (raw)

Papers by Peng Tang

International journal of clinical and experimental pathology, 2014

To investigate the association of Kruppel-like factor 4 (KLF4) expressions with the prognosis of ... more To investigate the association of Kruppel-like factor 4 (KLF4) expressions with the prognosis of esophageal squamous cell carcinoma (SCC) patients. Ninety-eight cases of esophageal carcinoma patients were enrolled. The expression of KLF4 in the esophageal SCC and normal esophageal mucosa tissues were examined by immunohistochemistry. The correlations between the expression of KLF4 protein and patients' clinical characteristics and prognosis were analyzed. We observed higher expressed KLF4 in normal esophageal mucosa tissues than esophageal SCC tissues, with positive rate of 82.7% (81/98) and 43.8% (43/98) respectively. In patients with lymphatic metastasis, the positive rate of KLF4 was 24.4% (10/41), whereas it was 57.9% (33/57) in patients without lymphatic metastasis, and the difference was significant (x(2) = 10.871, P = 0.001). The positive rates of KLF4 were 62.5% (5/8), 53.1% (26/49) and 29.3% (12/41) in stage I, II and III patients, respectively. There were no correlations between the expression of KLF4 and gender, age, tumor size, location, differentiation grade and infiltration depth. The 5-year survival rates and median survival times were 48.8% and 25.5%, and 55 and 26 months for the patients with KLF4 positive and negative expression, respectively. There were significant differences between the patients with KLF4 positive expression and negative expression in the 5-year survival rates and median survival times (x(2) = 5.747 and 4.493, P = 0.017 and 0.034). KLF4 might act as a tumor suppressor in esophageal SCC and the expression status of KLF4 could be considered as a prognosis predictor for esophageal SCC patients.

Image and Graphics, 2007. ICIG 2007. …, 2007

... Peng Tang, Lin Gao and Zhifang Liu Image and Graphics Institute, Computer Science Department ... more ... Peng Tang, Lin Gao and Zhifang Liu Image and Graphics Institute, Computer Science Department Sichuan University, Chengdu, 610065, PRChina ... Consequently, the idea extended to the mixture of Gaus-sians model (MGM) proposed by Stauffer and Grimson [6] to address the ...

Journal of Asian Architecture and Building Engineering - J ASIAN ARCHIT BUILD ENG, 2010

2008 International Conference on Computer Science and Software Engineering, 2008

Journal of Chemical Information and Modeling - J CHEM INF MODEL, 2004

Hemi-B 16 N 16 capped zigzag boron-nitride nanotube is introduced, and its Kekulé count is studie... more Hemi-B 16 N 16 capped zigzag boron-nitride nanotube is introduced, and its Kekulé count is studied. With a bond-allocating and coding scheme, recurrence formulas are established as well as for the case of a hemi-B 36 N 36 capped zigzag nanotube. Numerical results reveal that the Kekulé counts increase exponentially with respect to the number of layers in the nanotubes concerned.

2010 Ninth International Conference on Networks, 2010

International Journal of Cancer, 2013

Obesity is rapidly becoming pandemic and is associated with increased carcinogenesis, especially ... more Obesity is rapidly becoming pandemic and is associated with increased carcinogenesis, especially hepatocellular carcinoma (HCC). Adipose tissue is considered as an endocrine organ because of its capacity to secrete a variety of adipokines, such as leptin, adiponectin and resistin. Recently, adipokines have been demonstrated to be associated with kinds of chronic liver diseases including fibrosis, cirrhosis and carcinogenesis. Direct evidence is accumulating rapidly supporting the inhibitory and/or activating role of adipokines in the process of carcinogenesis and progression of human HCC. This review aims to provide important insight into the potential mechanisms of adipokines in the development of HCC.

Isolated point contacts are most common between two curved objects that do not have line segment ... more Isolated point contacts are most common between two curved objects that do not have line segment on their surfaces. This paper addresses how to represent concisely and generate automatically graphs of topological contact states made of isolated contact points between such curved objects. Information of contact states is useful for a wide range of applications, from robotic tasks involving compliant motion to virtual prototyping, haptic rendering, and dynamic simulation. The approach has been implemented with an effective algorithm.

The International Journal of Robotics Research, 2008

Journal of Asian Architecture and Building Engineering, 2007

Journal of Architecture and Planning (Transactions of AIJ), 2008

Oxidative medicine and cellular longevity, 2014

Inflammatory mediators may reflect a role of systemic inflammation in the neurodegenerative proce... more Inflammatory mediators may reflect a role of systemic inflammation in the neurodegenerative process of Parkinson's disease (PD). Interleukin-6 (IL-6) and chemokine ligand 5 (CCL5), also known as RANTES (regulated on activation, normal T cell expressed and secreted), have been implicated in neurodegenerative diseases including PD. Serum levels of RANTES and IL-6 of 78 consecutive PD patients and age-matched 80 controls were measured. Patients with PD had higher RANTES and IL-6 levels compared with the controls. We found that serum RANTES levels strongly correlated with Hoehn-Yahr score and disease duration in PD patients. This study indicated that patients with PD have an on-going systemic inflammatory profile where the elevated peripheral production of RANTES may play a role in the neurodegenerative process.

Journal of the neurological sciences, Jan 15, 2014

The aim of this study is to evaluate the association between two neprilysin variants (rs989692 an... more The aim of this study is to evaluate the association between two neprilysin variants (rs989692 and rs3736187) and Alzheimer's disease (AD). All eligible studies were searched in PubMed and Embase from inception to July 2014. Data was extracted by two investigators independently. The complete overdominant model (CC+TT vs. CT) and co-dominant model (GG vs. AA and GA vs. AA) were used for rs989692 and rs3736187, respectively. A comparison of allele frequencies was also conducted. Six studies containing 2555 AD patients and 1914 controls were included for rs989692 polymorphisms. The pooled odds ratio (OR) and confidence interval (CI) suggested that rs989692 polymorphisms were not associated with AD based on the current published studies (C vs. T, OR = 1.01, 95% CI = 0.85-1.19; CC+TT vs. CT, OR = 0.89, 95% CI = 0.78-1.01). Five studies containing 2438 AD patients and 1452 controls were identified for rs3736187 polymorphisms (G vs. A, OR = 0.77, 95% CI = 0.66-0.91; GG vs. AA, OR = 0.38, 95% CI = 0.19-0.77; GA vs. AA, OR = 0.81, 95% CI = 0.61-0.99). The result showed that rs3736187 polymorphisms were likely associated with the decreased risk of AD. This meta-analysis indicates that rs3736187 (A/G) polymorphisms may be a potential beneficial single nucleotide polymorphism (SNP), which are associated with a decreased risk in AD. Further larger scale studies are necessary to validate gene-to-gene interactions and to define the association of neprilysin polymorphisms with AD.

Chemical Communications, 2011

A new benzodithiophene-based copolymer PTG1 with dithienylbenzothiadiazole-vinylene side chains e... more A new benzodithiophene-based copolymer PTG1 with dithienylbenzothiadiazole-vinylene side chains exhibits excellent film-forming ability, a deep HOMO energy level, and a good miscibility with PC(71)BM. Bulk heterojunction polymer solar cells fabricated from PTG1 and PC(71)BM showed a promising power conversion efficiency over 4.0%.

BMC gastroenterology, 2011

Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive carcinomas of the gastroi... more Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive carcinomas of the gastrointestinal tract. We assessed the relevance of Slug in measuring the invasive potential of ESCC cells in vitro and in vivo in immunodeficient mice. We utilized RNA interference to knockdown Slug gene expression, and effects on survival and invasive carcinoma were evaluated using a Boyden chamber transwell assay in vitro. We evaluated the effect of Slug siRNA-transfection and Slug cDNA-transfection on E-cadherin and Bcl-2 expression in ESCC cells. A pseudometastatic model of ESCC in immunodeficient mice was used to assess the effects of Slug siRNA transfection on tumor metastasis development. The EC109 cell line was transfected with Slug-siRNA to knockdown Slug expression. The TE13 cell line was transfected with Slug-cDNA to increase Slug expression. EC109 and TE13 cell lines were tested for the expression of apoptosis-related genes bcl-2 and metastasis-related gene E-cadherin identified previously as Slug targets. Bcl-2 expression was increased and E-cadherin was decreased in Slug siRNA-transfected EC109 cells. Bcl-2 expression was increased and E-cadherin was decreased in Slug cDNA-transfected TE13 cells. Invasion of Slug siRNA-transfected EC109 cells was reduced and apoptosis was increased whereas invasion was greater in Slug cDNA-transfected cells. Animals injected with Slug siRNA-transfected EC109 cells exhibited fewer seeded nodes and demonstrated more apoptosis. Slug down-regulation promotes cell apoptosis and decreases invasion capability in vitro and in vivo. Slug inhibition may represent a novel strategy for treatment of metastatic ESCC.

Molecular Cell, 2012

The nuclear matrix associated hnRNP U/SAF-A protein has been implicated in diverse pathways from ... more The nuclear matrix associated hnRNP U/SAF-A protein has been implicated in diverse pathways from transcriptional regulation to telomere length control to X inactivation, but the precise mechanism underlying each of these processes has remained elusive. Here, we report hnRNP U as a regulator of SMN2 splicing from a custom RNAi screen. Genome-wide analysis by CLIP-seq reveals that hnRNP U binds virtually to all classes of regulatory non-coding RNAs, including all snRNAs required for splicing of both major and minor classes of introns, leading to the discovery that hnRNP U regulates U2 snRNP maturation and Cajal body morphology in the nucleus. Global analysis of hnRNP U-dependent splicing by RNA-seq coupled with bioinformatic analysis of associated splicing signals suggests a general rule for splice site selection through modulating the core splicing machinery. These findings exemplify hnRNP U/SAF-A as a potent regulator of nuclear ribonucleoprotein particles in diverse gene expression pathways.

Nature structural & molecular biology, 2014

The U2AF heterodimer has been well studied for its role in defining functional 3′ splice sites in... more The U2AF heterodimer has been well studied for its role in defining functional 3′ splice sites in pre-mRNA splicing, but many fundamental questions still remain unaddressed regarding the function of U2AF in mammalian genomes. Through genome-wide analysis of U2AF-RNA interactions, we report that U2AF has the capacity to directly define ~88% of functional 3′ splice sites in the human genome, but numerous U2AF binding events also occur in intronic locations. Mechanistic dissection reveals that upstream intronic binding events interfere with the immediate downstream 3′ splice site associated either with the alternative exon, to cause exon skipping, or with the competing constitutive exon, to induce exon inclusion. We further demonstrate partial functional impairment with leukemia-associated mutations in U2AF35, but not U2AF65, in regulated splicing. These findings reveal the genomic function and regulatory mechanism of U2AF in both normal and disease states.

International journal of clinical and experimental pathology, 2014

To investigate the association of Kruppel-like factor 4 (KLF4) expressions with the prognosis of ... more To investigate the association of Kruppel-like factor 4 (KLF4) expressions with the prognosis of esophageal squamous cell carcinoma (SCC) patients. Ninety-eight cases of esophageal carcinoma patients were enrolled. The expression of KLF4 in the esophageal SCC and normal esophageal mucosa tissues were examined by immunohistochemistry. The correlations between the expression of KLF4 protein and patients' clinical characteristics and prognosis were analyzed. We observed higher expressed KLF4 in normal esophageal mucosa tissues than esophageal SCC tissues, with positive rate of 82.7% (81/98) and 43.8% (43/98) respectively. In patients with lymphatic metastasis, the positive rate of KLF4 was 24.4% (10/41), whereas it was 57.9% (33/57) in patients without lymphatic metastasis, and the difference was significant (x(2) = 10.871, P = 0.001). The positive rates of KLF4 were 62.5% (5/8), 53.1% (26/49) and 29.3% (12/41) in stage I, II and III patients, respectively. There were no correlations between the expression of KLF4 and gender, age, tumor size, location, differentiation grade and infiltration depth. The 5-year survival rates and median survival times were 48.8% and 25.5%, and 55 and 26 months for the patients with KLF4 positive and negative expression, respectively. There were significant differences between the patients with KLF4 positive expression and negative expression in the 5-year survival rates and median survival times (x(2) = 5.747 and 4.493, P = 0.017 and 0.034). KLF4 might act as a tumor suppressor in esophageal SCC and the expression status of KLF4 could be considered as a prognosis predictor for esophageal SCC patients.

Image and Graphics, 2007. ICIG 2007. …, 2007

... Peng Tang, Lin Gao and Zhifang Liu Image and Graphics Institute, Computer Science Department ... more ... Peng Tang, Lin Gao and Zhifang Liu Image and Graphics Institute, Computer Science Department Sichuan University, Chengdu, 610065, PRChina ... Consequently, the idea extended to the mixture of Gaus-sians model (MGM) proposed by Stauffer and Grimson [6] to address the ...

Journal of Asian Architecture and Building Engineering - J ASIAN ARCHIT BUILD ENG, 2010

2008 International Conference on Computer Science and Software Engineering, 2008

Journal of Chemical Information and Modeling - J CHEM INF MODEL, 2004

Hemi-B 16 N 16 capped zigzag boron-nitride nanotube is introduced, and its Kekulé count is studie... more Hemi-B 16 N 16 capped zigzag boron-nitride nanotube is introduced, and its Kekulé count is studied. With a bond-allocating and coding scheme, recurrence formulas are established as well as for the case of a hemi-B 36 N 36 capped zigzag nanotube. Numerical results reveal that the Kekulé counts increase exponentially with respect to the number of layers in the nanotubes concerned.

2010 Ninth International Conference on Networks, 2010

International Journal of Cancer, 2013

Obesity is rapidly becoming pandemic and is associated with increased carcinogenesis, especially ... more Obesity is rapidly becoming pandemic and is associated with increased carcinogenesis, especially hepatocellular carcinoma (HCC). Adipose tissue is considered as an endocrine organ because of its capacity to secrete a variety of adipokines, such as leptin, adiponectin and resistin. Recently, adipokines have been demonstrated to be associated with kinds of chronic liver diseases including fibrosis, cirrhosis and carcinogenesis. Direct evidence is accumulating rapidly supporting the inhibitory and/or activating role of adipokines in the process of carcinogenesis and progression of human HCC. This review aims to provide important insight into the potential mechanisms of adipokines in the development of HCC.

Isolated point contacts are most common between two curved objects that do not have line segment ... more Isolated point contacts are most common between two curved objects that do not have line segment on their surfaces. This paper addresses how to represent concisely and generate automatically graphs of topological contact states made of isolated contact points between such curved objects. Information of contact states is useful for a wide range of applications, from robotic tasks involving compliant motion to virtual prototyping, haptic rendering, and dynamic simulation. The approach has been implemented with an effective algorithm.

The International Journal of Robotics Research, 2008

Journal of Asian Architecture and Building Engineering, 2007

Journal of Architecture and Planning (Transactions of AIJ), 2008

Oxidative medicine and cellular longevity, 2014

Inflammatory mediators may reflect a role of systemic inflammation in the neurodegenerative proce... more Inflammatory mediators may reflect a role of systemic inflammation in the neurodegenerative process of Parkinson's disease (PD). Interleukin-6 (IL-6) and chemokine ligand 5 (CCL5), also known as RANTES (regulated on activation, normal T cell expressed and secreted), have been implicated in neurodegenerative diseases including PD. Serum levels of RANTES and IL-6 of 78 consecutive PD patients and age-matched 80 controls were measured. Patients with PD had higher RANTES and IL-6 levels compared with the controls. We found that serum RANTES levels strongly correlated with Hoehn-Yahr score and disease duration in PD patients. This study indicated that patients with PD have an on-going systemic inflammatory profile where the elevated peripheral production of RANTES may play a role in the neurodegenerative process.

Journal of the neurological sciences, Jan 15, 2014

The aim of this study is to evaluate the association between two neprilysin variants (rs989692 an... more The aim of this study is to evaluate the association between two neprilysin variants (rs989692 and rs3736187) and Alzheimer's disease (AD). All eligible studies were searched in PubMed and Embase from inception to July 2014. Data was extracted by two investigators independently. The complete overdominant model (CC+TT vs. CT) and co-dominant model (GG vs. AA and GA vs. AA) were used for rs989692 and rs3736187, respectively. A comparison of allele frequencies was also conducted. Six studies containing 2555 AD patients and 1914 controls were included for rs989692 polymorphisms. The pooled odds ratio (OR) and confidence interval (CI) suggested that rs989692 polymorphisms were not associated with AD based on the current published studies (C vs. T, OR = 1.01, 95% CI = 0.85-1.19; CC+TT vs. CT, OR = 0.89, 95% CI = 0.78-1.01). Five studies containing 2438 AD patients and 1452 controls were identified for rs3736187 polymorphisms (G vs. A, OR = 0.77, 95% CI = 0.66-0.91; GG vs. AA, OR = 0.38, 95% CI = 0.19-0.77; GA vs. AA, OR = 0.81, 95% CI = 0.61-0.99). The result showed that rs3736187 polymorphisms were likely associated with the decreased risk of AD. This meta-analysis indicates that rs3736187 (A/G) polymorphisms may be a potential beneficial single nucleotide polymorphism (SNP), which are associated with a decreased risk in AD. Further larger scale studies are necessary to validate gene-to-gene interactions and to define the association of neprilysin polymorphisms with AD.

Chemical Communications, 2011

A new benzodithiophene-based copolymer PTG1 with dithienylbenzothiadiazole-vinylene side chains e... more A new benzodithiophene-based copolymer PTG1 with dithienylbenzothiadiazole-vinylene side chains exhibits excellent film-forming ability, a deep HOMO energy level, and a good miscibility with PC(71)BM. Bulk heterojunction polymer solar cells fabricated from PTG1 and PC(71)BM showed a promising power conversion efficiency over 4.0%.

BMC gastroenterology, 2011

Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive carcinomas of the gastroi... more Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive carcinomas of the gastrointestinal tract. We assessed the relevance of Slug in measuring the invasive potential of ESCC cells in vitro and in vivo in immunodeficient mice. We utilized RNA interference to knockdown Slug gene expression, and effects on survival and invasive carcinoma were evaluated using a Boyden chamber transwell assay in vitro. We evaluated the effect of Slug siRNA-transfection and Slug cDNA-transfection on E-cadherin and Bcl-2 expression in ESCC cells. A pseudometastatic model of ESCC in immunodeficient mice was used to assess the effects of Slug siRNA transfection on tumor metastasis development. The EC109 cell line was transfected with Slug-siRNA to knockdown Slug expression. The TE13 cell line was transfected with Slug-cDNA to increase Slug expression. EC109 and TE13 cell lines were tested for the expression of apoptosis-related genes bcl-2 and metastasis-related gene E-cadherin identified previously as Slug targets. Bcl-2 expression was increased and E-cadherin was decreased in Slug siRNA-transfected EC109 cells. Bcl-2 expression was increased and E-cadherin was decreased in Slug cDNA-transfected TE13 cells. Invasion of Slug siRNA-transfected EC109 cells was reduced and apoptosis was increased whereas invasion was greater in Slug cDNA-transfected cells. Animals injected with Slug siRNA-transfected EC109 cells exhibited fewer seeded nodes and demonstrated more apoptosis. Slug down-regulation promotes cell apoptosis and decreases invasion capability in vitro and in vivo. Slug inhibition may represent a novel strategy for treatment of metastatic ESCC.

Molecular Cell, 2012

The nuclear matrix associated hnRNP U/SAF-A protein has been implicated in diverse pathways from ... more The nuclear matrix associated hnRNP U/SAF-A protein has been implicated in diverse pathways from transcriptional regulation to telomere length control to X inactivation, but the precise mechanism underlying each of these processes has remained elusive. Here, we report hnRNP U as a regulator of SMN2 splicing from a custom RNAi screen. Genome-wide analysis by CLIP-seq reveals that hnRNP U binds virtually to all classes of regulatory non-coding RNAs, including all snRNAs required for splicing of both major and minor classes of introns, leading to the discovery that hnRNP U regulates U2 snRNP maturation and Cajal body morphology in the nucleus. Global analysis of hnRNP U-dependent splicing by RNA-seq coupled with bioinformatic analysis of associated splicing signals suggests a general rule for splice site selection through modulating the core splicing machinery. These findings exemplify hnRNP U/SAF-A as a potent regulator of nuclear ribonucleoprotein particles in diverse gene expression pathways.

Nature structural & molecular biology, 2014

The U2AF heterodimer has been well studied for its role in defining functional 3′ splice sites in... more The U2AF heterodimer has been well studied for its role in defining functional 3′ splice sites in pre-mRNA splicing, but many fundamental questions still remain unaddressed regarding the function of U2AF in mammalian genomes. Through genome-wide analysis of U2AF-RNA interactions, we report that U2AF has the capacity to directly define ~88% of functional 3′ splice sites in the human genome, but numerous U2AF binding events also occur in intronic locations. Mechanistic dissection reveals that upstream intronic binding events interfere with the immediate downstream 3′ splice site associated either with the alternative exon, to cause exon skipping, or with the competing constitutive exon, to induce exon inclusion. We further demonstrate partial functional impairment with leukemia-associated mutations in U2AF35, but not U2AF65, in regulated splicing. These findings reveal the genomic function and regulatory mechanism of U2AF in both normal and disease states.