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Research paper thumbnail of The Associations of Neutrophil-Lymphocyte Count Ratio and Matrix Metalloproteinase-9 in Acute Myocard Infarct Patients

Majalah Kedokteran Bandung, 2019

The correlation between levels of Metalloproteinase-9 (MMP-9) and neutrophil-lymphocyte count rat... more The correlation between levels of Metalloproteinase-9 (MMP-9) and neutrophil-lymphocyte count ratio (NLCR) in AMI patients has not been studied yet, even though they are both known to predict ventricular remodeling. This study aims to evaluate the correlation between MMP-9 levels and NLCR in patients with acute myocardial infarction. A cross-sectional study was conducted by recruiting acute coronary syndrome patients (onset within 24 hours) who admitted to emergency department in several hospitals around Bandung during October-December 2012. The relationship between MMP-9 levels and NLCR was analyzed using Pearson correlation test. Linear regression analysis was used to measure the strength of NLCR in MMP-9 level prediction. Thirty seven patients aged 55.8 + 11 years old were included in this study and 78% of them were male. Seventy-six percent of the samples was ST-elevation myocardial infarct (STEMI) patients with the onset of symptoms 6 (3-14) hours. The mean lymphocyte-neutrophil ratio was 5.24 (1σ ± 2.4) and MMP-9 plasma concentration was 370 (240-530) ng / ml. One-sided Pearson correlation showed positive correlation between those two variables (r=0.44 , p=0.003). The linear regression analysis conceived the formula of MMP-9 = 40.87 (NLCR) + 211.3, which was used to show the relationship between MMP-9 levels and lymphocyte-neutrophil ratio. There was positive moderate correlation between MMP-9 levels and NLCR in patients with AMI. Linear regression analysis showed that NLCR was the only independent variable to predict MMP-9 plasma level.

Research paper thumbnail of The Associations of Neutrophil-Lymphocyte Count Ratio and Matrix Metalloproteinase-9 in Acute Myocard Infarct Patients

Majalah Kedokteran Bandung, 2019

The correlation between levels of Metalloproteinase-9 (MMP-9) and neutrophil-lymphocyte count rat... more The correlation between levels of Metalloproteinase-9 (MMP-9) and neutrophil-lymphocyte count ratio (NLCR) in AMI patients has not been studied yet, even though they are both known to predict ventricular remodeling. This study aims to evaluate the correlation between MMP-9 levels and NLCR in patients with acute myocardial infarction. A cross-sectional study was conducted by recruiting acute coronary syndrome patients (onset within 24 hours) who admitted to emergency department in several hospitals around Bandung during October-December 2012. The relationship between MMP-9 levels and NLCR was analyzed using Pearson correlation test. Linear regression analysis was used to measure the strength of NLCR in MMP-9 level prediction. Thirty seven patients aged 55.8 + 11 years old were included in this study and 78% of them were male. Seventy-six percent of the samples was ST-elevation myocardial infarct (STEMI) patients with the onset of symptoms 6 (3-14) hours. The mean lymphocyte-neutrophil ratio was 5.24 (1σ ± 2.4) and MMP-9 plasma concentration was 370 (240-530) ng / ml. One-sided Pearson correlation showed positive correlation between those two variables (r=0.44 , p=0.003). The linear regression analysis conceived the formula of MMP-9 = 40.87 (NLCR) + 211.3, which was used to show the relationship between MMP-9 levels and lymphocyte-neutrophil ratio. There was positive moderate correlation between MMP-9 levels and NLCR in patients with AMI. Linear regression analysis showed that NLCR was the only independent variable to predict MMP-9 plasma level.

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