Z. Gluvic | University of Belgrade (original) (raw)
Papers by Z. Gluvic
Endocrine …, 2008
Results: BMD at the lumbar spine (0.816±0.136 vs 0.881±0.106 g/cm 2 , P=ns), and total left hip (... more Results: BMD at the lumbar spine (0.816±0.136 vs 0.881±0.106 g/cm 2 , P=ns), and total left hip (0.715±0.133 vs 0.673±0.094 g/cm 2 , P=ns) didnot differ between the groups. Patients with Hypo had higher level of TSH (7.95±1.51 vs 7.57±2.44, P=0.03) and it correlated ...
2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2015
ABSTRACT
Encyclopedia of Food and Health, 2016
Endocrine Abstracts, 2014
Endocrine Abstracts, 2013
Internal Medicine, 2007
Objective Insulin resistance and metabolic syndrome (MeS) are common in end-stage renal disease (... more Objective Insulin resistance and metabolic syndrome (MeS) are common in end-stage renal disease (ESRD) patients on maintenance hemodialysis (HD). Such metabolic and clinical abnormalities may lead to an increased risk for cardiovascular disease. Methods The study group included 22 well-nourished and 20 middle-to moderate-malnourished, stable ESRD patients, with median dialysis duration of 48 months
Archives of Biological Sciences, 2011
... RADAK2, VESNA NE??I??2, Z. GLuVI??4, MILENA LA??KOVI??4, B. A??ANIN5, S. RADOVI??5, VESNA STA... more ... RADAK2, VESNA NE??I??2, Z. GLuVI??4, MILENA LA??KOVI??4, B. A??ANIN5, S. RADOVI??5, VESNA STANKOVI??6, J. ??uRI??6, JELENA NE??I??6 and V. KANJuH7 ... Tanaskovi??, I., Mladenovi??-Mihailovi??, A., U??aj-Kne??evi??, S., Stankovi??, V., Aleksi??, A., Kastratovi??, T. et al (2010). ...
Archives of Biological Sciences, 2011
Archives of Biological Sciences, 2012
Patients with end-stage renal disease (ESRD) include a significant percentage of malnourished pat... more Patients with end-stage renal disease (ESRD) include a significant percentage of malnourished patients with other risk factors: dyslipoproteinemia, insulin resistance, increased oxidative stress and inflammation that together impair endothelial function. Abnormal polyunsaturated fatty acids (PUFA) patterns are reported in patients with ESRD. The basic mechanisms of these disorders are connected with changes in cell functions at the membrane level. Vascular smooth muscle cell proliferation plays an important role in the pathogenesis of atherosclerosis. We have examined the association between atherosclerotic risk factors and nutritional status in hemodialysis (HD) patients. Mortality was followed for up to 18 month. Forty-three HD patients were examined (20 males, 23 females, ages 55±12 years). Nutritional and inflammatory markers, including serum concentrations of C-reactive protein (CRP), tumor necrosis factor alpha (TNF-alpha), and interleukin 6 (IL-6), were measured. There was significant positive correlation between the plasma albumin level and CRP. Significant correlation was found between plasma the cholesterol level and some PUFA. Increasing inflammation and endothelial dysfunction predict the development of vascular disease. We report on the relationship between inflammatory markers and nutritional parameter, indices of atherosclerosis and other cardiovascular risk factors in patients on hemodialysis.
Archives of Biological Sciences, 2012
Archives of Biological Sciences, 2011
The modern concept of the development of atherosclerosis implies that the underlying pathogenesis... more The modern concept of the development of atherosclerosis implies that the underlying pathogenesis of this disease is vascular remodeling as a response of the vessel wall to hypertension associated with hyperlipidemia and subsequent inflammation. However, even though this disease has been investigated for decades, both from a basic and clinical research aspect, there are still many doubts as to what the initial phase of the disease is. In contemporary literature there are an increasing number of papers that stress the importance of the extracellular matrix (ECM) of the blood vessels connective tissue, particularly proteoglycans, in the formation of early atherosclerotic lesions of human coronary arteries.
Current Pharmaceutical Design, 2010
Journal of Water and Health, 2012
Chronic exposure to insufficient levels of magnesium (Mg) in drinking water increases the risk of... more Chronic exposure to insufficient levels of magnesium (Mg) in drinking water increases the risk of magnesium deficiency and its association with hypertension, dyslipidemia and type 2 diabetes mellitus. The aim of the study was to assess the potential association of mineral contents in drinking water with blood pressure and other components of metabolic syndrome (MetS) (BMI as measure of obesity, triglycerides, glucose, and insulin resistance, index-HOMA IR), in a healthy population. This study was conducted in three randomly selected municipalities (Pozarevac, Grocka and Banovci), and recruited 90 healthy blood donors, aged 20-50 years. The Pozarevac area had a four times higher mean Mg level in drinking water (42 mg L À1 ) than Grocka (11 mg L À1 ). Diastolic blood pressure was lowest in subjects from Pozarevac. Serum Mg (sMg) was highest, and serum Ca 2þ /Mg (sCa/Mg) lowest in subjects from Pozarevac, and after adjustment for confounders (age, gender, BMI), only total cholesterol and sMg levels were independent predictors of diastolic blood pressure, sMg levels were independent predictors of triglycerides, and sCa/Mg predicted glucose levels. These results suggest that Mg supplementation in areas of lower magnesium levels in drinking water may be an important measure in the prevention of hypertension and MetS in general.
Hippokratia, 2008
Iron overload and inflammation might participate in the pathogenesis of insulin resistance in com... more Iron overload and inflammation might participate in the pathogenesis of insulin resistance in community. The improvement of insulin resistance in hemodialysis (HD) patients is frequently seen after correction of anemia. The aim of this study was to investigate the influence of recobinant humam erythropoietin (Epo) treatment on insulin resistance in non-diabetic HD patients. We investigated the effects of 6 months-duration treatment with Epo on insulin resistance and inflammatory parameters in 16 (6 male/10 female) patients on maintenance HD with renal anemia (hemoglobin concentration </=105 g/l). The control group consisted of 15 patients on HD with renal anemia, without Epo treatment. Further clinical and laboratory variables were observed: fasting blood glucose (FBG), insulin, albumin, iron, total iron binding capacity (TIBC), transferrin saturation (TSAT), ferritin, TNF-alpha, and IL-6. Independent predictors for changes of calculated insulin resistance index by homeostasis mo...
Revista Portuguesa de Pneumologia (English Edition), 2015
Introduction: Unlike large population studies about cardiovascular components and how they adapt ... more Introduction: Unlike large population studies about cardiovascular components and how they adapt to intensive physical activity, there is less research into the causes of enlargement of the respiratory system in athletes (e.g. vital capacity, maximum flow rates and pulmonary diffusion capacity). The purpose of this research was to study and compare pulmonary function in different types of sports and compare them with controls in order to find out which sports improve lung function the most. Materials and method: Pulmonary functional capacities, vital capacity (VC), forced vital capacity (FVC), forced expiratory volume in one second (FEV1) and maximum voluntary ventilation (MVV) of 493 top athletes belonging to 15 different sports disciplines and of 16 sedentary individuals were studied. Pulmonary function test was performed according to ATS/ERS guidelines. Results: Basketball, water polo players and rowers had statistically higher vital capacity (VC), forced vital capacity (FVC), forced expiratory volume in one second (FEV1) than the healthy sedentary control individuals. Football and volleyball players had lower VC while FVC was higher in the football group compared to controls. Peak expiratory flow was lower in boxing, kayak, rugby, handball, taekwondo and tennis. The maximum voluntary ventilation (MVV) was significantly higher in water polo players and rowers. Boxers had statistically lower MVV than the controls. Players of other sports did not differ from the control group. Pages 6 2 S. Mazic et al.
Journal of Theoretical Biology, 2008
Causal relationship between sodium and hypertension has been proposed and various changes in Na +... more Causal relationship between sodium and hypertension has been proposed and various changes in Na + ,K + -ATPase (sodium pump) activity have been described in established primary hypertension. A number of direct vascular effects of estradiol have been reported, including its impact on the regulation of sodium pump activity and vasomotor tone. The effects of estradiol involve the activation of multiple signaling cascades, including phosphatydil inositol-3 kinase (PI3K) and p42/44 mitogen-activated protein kinase (p42/44 MAPK ). In addition, some of the effects of estradiol have been linked to activity of cytosolic phospholipase A 2 (cPLA 2 ). One possible cardioprotective mechanism of estradiol involves of the interaction between estradiol and the rennin-angiotensin system (RAS). Elevated circulating and tissue levels of angiotensin II (Ang II) have been implicated in the development of hypertension and heart failure. The aim of our investigation was to elucidate the signaling mechanisms employed by estradiol and Ang II in mediating sodium pump, in vascular smooth muscle cells (VSMC). The aim of our investigation was to elucidate the signaling mechanisms employed by estradiol and Ang II in mediating sodium pump activity/expression in VSMC, with particular emphasis on PI3K/cPLA 2 /p42/44 MAPK signaling pathways. Our primary hypothesis is that estradiol stimulates sodium pump activity/expression in VSMC via PI3K/cPLA 2 /p42/44 MAPK dependent mechanism and, that impaired estradiol-stimulated sodium pump activity/expression in hypertensive rodent models (i.e. SHR), Ang IImediated vascular impairment of estradiol is related to a decrease ability of estradiol to stimulate the PI3K/cPLA 2 /p42/44 MAPK signaling pathways. An important corollary to this hypothesis is that in hypertensive state (i.e. SHR rats) the decreasing in ACE enzyme activity and/or AT1 receptor expression caused by administration of estradiol is accompanying with abrogated ability of Ang II to decrease IRS-1/PI3K association, and consequent PI3K/cPLA 2 /p42/44 MAPK activity and associated sodium pump activity/expression.
Internal Medicine, 2008
This study examined the sensitivity of routine abdominal ultrasound scanning in the detection of ... more This study examined the sensitivity of routine abdominal ultrasound scanning in the detection of colonic malignancy. A case control prospective study included 101 patients hospitalized at the Department of Gastroenterology and Liver Diseases of Zemun Clinical Hospital over a four-year period. Since the complaints pointed to colonic malignancy, the patients underwent routine golden standard diagnostic procedures. These patients were referred to an experienced abdominal ultrasound operator who searched for some characteristic signs of colonic malignancy. All of the participants were surgically treated after the completion of relevant procedures for diagnosing colonic malignancy. SPSS for Windows 10.0 was used for data analysis. The sensitivity of an abdominal ultrasound scan in the detection and location of pathological changes pointed to colonic malignancy was different- 76% and 84% respectively. This method was very reliable in detecting right-sided colonic carcinoma (100%). Some specific ultrasonographic signs of colonic carcinoma were observed at the advanced stages of disease. The routine abdominal ultrasonography can be used for the screening of colonic malignancy owing to its high sensitivity, particularly in advanced disease, but solely in conjunction with other methods. Finally, abdominal ultrasonography cannot be a definitive diagnostic tool for colonic carcinoma.
Atherosclerosis Supplements, 2008
The study included 99 unrelated healthy control subjects, 105 type 2 DM subjects with no history ... more The study included 99 unrelated healthy control subjects, 105 type 2 DM subjects with no history of CHD and 91 type 2 DM with CHD >50% epicardial stenosis. gDNA was extracted from leukocyte and this polymorphism was analyzed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP).
Endocrine …, 2008
Results: BMD at the lumbar spine (0.816±0.136 vs 0.881±0.106 g/cm 2 , P=ns), and total left hip (... more Results: BMD at the lumbar spine (0.816±0.136 vs 0.881±0.106 g/cm 2 , P=ns), and total left hip (0.715±0.133 vs 0.673±0.094 g/cm 2 , P=ns) didnot differ between the groups. Patients with Hypo had higher level of TSH (7.95±1.51 vs 7.57±2.44, P=0.03) and it correlated ...
2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2015
ABSTRACT
Encyclopedia of Food and Health, 2016
Endocrine Abstracts, 2014
Endocrine Abstracts, 2013
Internal Medicine, 2007
Objective Insulin resistance and metabolic syndrome (MeS) are common in end-stage renal disease (... more Objective Insulin resistance and metabolic syndrome (MeS) are common in end-stage renal disease (ESRD) patients on maintenance hemodialysis (HD). Such metabolic and clinical abnormalities may lead to an increased risk for cardiovascular disease. Methods The study group included 22 well-nourished and 20 middle-to moderate-malnourished, stable ESRD patients, with median dialysis duration of 48 months
Archives of Biological Sciences, 2011
... RADAK2, VESNA NE??I??2, Z. GLuVI??4, MILENA LA??KOVI??4, B. A??ANIN5, S. RADOVI??5, VESNA STA... more ... RADAK2, VESNA NE??I??2, Z. GLuVI??4, MILENA LA??KOVI??4, B. A??ANIN5, S. RADOVI??5, VESNA STANKOVI??6, J. ??uRI??6, JELENA NE??I??6 and V. KANJuH7 ... Tanaskovi??, I., Mladenovi??-Mihailovi??, A., U??aj-Kne??evi??, S., Stankovi??, V., Aleksi??, A., Kastratovi??, T. et al (2010). ...
Archives of Biological Sciences, 2011
Archives of Biological Sciences, 2012
Patients with end-stage renal disease (ESRD) include a significant percentage of malnourished pat... more Patients with end-stage renal disease (ESRD) include a significant percentage of malnourished patients with other risk factors: dyslipoproteinemia, insulin resistance, increased oxidative stress and inflammation that together impair endothelial function. Abnormal polyunsaturated fatty acids (PUFA) patterns are reported in patients with ESRD. The basic mechanisms of these disorders are connected with changes in cell functions at the membrane level. Vascular smooth muscle cell proliferation plays an important role in the pathogenesis of atherosclerosis. We have examined the association between atherosclerotic risk factors and nutritional status in hemodialysis (HD) patients. Mortality was followed for up to 18 month. Forty-three HD patients were examined (20 males, 23 females, ages 55±12 years). Nutritional and inflammatory markers, including serum concentrations of C-reactive protein (CRP), tumor necrosis factor alpha (TNF-alpha), and interleukin 6 (IL-6), were measured. There was significant positive correlation between the plasma albumin level and CRP. Significant correlation was found between plasma the cholesterol level and some PUFA. Increasing inflammation and endothelial dysfunction predict the development of vascular disease. We report on the relationship between inflammatory markers and nutritional parameter, indices of atherosclerosis and other cardiovascular risk factors in patients on hemodialysis.
Archives of Biological Sciences, 2012
Archives of Biological Sciences, 2011
The modern concept of the development of atherosclerosis implies that the underlying pathogenesis... more The modern concept of the development of atherosclerosis implies that the underlying pathogenesis of this disease is vascular remodeling as a response of the vessel wall to hypertension associated with hyperlipidemia and subsequent inflammation. However, even though this disease has been investigated for decades, both from a basic and clinical research aspect, there are still many doubts as to what the initial phase of the disease is. In contemporary literature there are an increasing number of papers that stress the importance of the extracellular matrix (ECM) of the blood vessels connective tissue, particularly proteoglycans, in the formation of early atherosclerotic lesions of human coronary arteries.
Current Pharmaceutical Design, 2010
Journal of Water and Health, 2012
Chronic exposure to insufficient levels of magnesium (Mg) in drinking water increases the risk of... more Chronic exposure to insufficient levels of magnesium (Mg) in drinking water increases the risk of magnesium deficiency and its association with hypertension, dyslipidemia and type 2 diabetes mellitus. The aim of the study was to assess the potential association of mineral contents in drinking water with blood pressure and other components of metabolic syndrome (MetS) (BMI as measure of obesity, triglycerides, glucose, and insulin resistance, index-HOMA IR), in a healthy population. This study was conducted in three randomly selected municipalities (Pozarevac, Grocka and Banovci), and recruited 90 healthy blood donors, aged 20-50 years. The Pozarevac area had a four times higher mean Mg level in drinking water (42 mg L À1 ) than Grocka (11 mg L À1 ). Diastolic blood pressure was lowest in subjects from Pozarevac. Serum Mg (sMg) was highest, and serum Ca 2þ /Mg (sCa/Mg) lowest in subjects from Pozarevac, and after adjustment for confounders (age, gender, BMI), only total cholesterol and sMg levels were independent predictors of diastolic blood pressure, sMg levels were independent predictors of triglycerides, and sCa/Mg predicted glucose levels. These results suggest that Mg supplementation in areas of lower magnesium levels in drinking water may be an important measure in the prevention of hypertension and MetS in general.
Hippokratia, 2008
Iron overload and inflammation might participate in the pathogenesis of insulin resistance in com... more Iron overload and inflammation might participate in the pathogenesis of insulin resistance in community. The improvement of insulin resistance in hemodialysis (HD) patients is frequently seen after correction of anemia. The aim of this study was to investigate the influence of recobinant humam erythropoietin (Epo) treatment on insulin resistance in non-diabetic HD patients. We investigated the effects of 6 months-duration treatment with Epo on insulin resistance and inflammatory parameters in 16 (6 male/10 female) patients on maintenance HD with renal anemia (hemoglobin concentration </=105 g/l). The control group consisted of 15 patients on HD with renal anemia, without Epo treatment. Further clinical and laboratory variables were observed: fasting blood glucose (FBG), insulin, albumin, iron, total iron binding capacity (TIBC), transferrin saturation (TSAT), ferritin, TNF-alpha, and IL-6. Independent predictors for changes of calculated insulin resistance index by homeostasis mo...
Revista Portuguesa de Pneumologia (English Edition), 2015
Introduction: Unlike large population studies about cardiovascular components and how they adapt ... more Introduction: Unlike large population studies about cardiovascular components and how they adapt to intensive physical activity, there is less research into the causes of enlargement of the respiratory system in athletes (e.g. vital capacity, maximum flow rates and pulmonary diffusion capacity). The purpose of this research was to study and compare pulmonary function in different types of sports and compare them with controls in order to find out which sports improve lung function the most. Materials and method: Pulmonary functional capacities, vital capacity (VC), forced vital capacity (FVC), forced expiratory volume in one second (FEV1) and maximum voluntary ventilation (MVV) of 493 top athletes belonging to 15 different sports disciplines and of 16 sedentary individuals were studied. Pulmonary function test was performed according to ATS/ERS guidelines. Results: Basketball, water polo players and rowers had statistically higher vital capacity (VC), forced vital capacity (FVC), forced expiratory volume in one second (FEV1) than the healthy sedentary control individuals. Football and volleyball players had lower VC while FVC was higher in the football group compared to controls. Peak expiratory flow was lower in boxing, kayak, rugby, handball, taekwondo and tennis. The maximum voluntary ventilation (MVV) was significantly higher in water polo players and rowers. Boxers had statistically lower MVV than the controls. Players of other sports did not differ from the control group. Pages 6 2 S. Mazic et al.
Journal of Theoretical Biology, 2008
Causal relationship between sodium and hypertension has been proposed and various changes in Na +... more Causal relationship between sodium and hypertension has been proposed and various changes in Na + ,K + -ATPase (sodium pump) activity have been described in established primary hypertension. A number of direct vascular effects of estradiol have been reported, including its impact on the regulation of sodium pump activity and vasomotor tone. The effects of estradiol involve the activation of multiple signaling cascades, including phosphatydil inositol-3 kinase (PI3K) and p42/44 mitogen-activated protein kinase (p42/44 MAPK ). In addition, some of the effects of estradiol have been linked to activity of cytosolic phospholipase A 2 (cPLA 2 ). One possible cardioprotective mechanism of estradiol involves of the interaction between estradiol and the rennin-angiotensin system (RAS). Elevated circulating and tissue levels of angiotensin II (Ang II) have been implicated in the development of hypertension and heart failure. The aim of our investigation was to elucidate the signaling mechanisms employed by estradiol and Ang II in mediating sodium pump, in vascular smooth muscle cells (VSMC). The aim of our investigation was to elucidate the signaling mechanisms employed by estradiol and Ang II in mediating sodium pump activity/expression in VSMC, with particular emphasis on PI3K/cPLA 2 /p42/44 MAPK signaling pathways. Our primary hypothesis is that estradiol stimulates sodium pump activity/expression in VSMC via PI3K/cPLA 2 /p42/44 MAPK dependent mechanism and, that impaired estradiol-stimulated sodium pump activity/expression in hypertensive rodent models (i.e. SHR), Ang IImediated vascular impairment of estradiol is related to a decrease ability of estradiol to stimulate the PI3K/cPLA 2 /p42/44 MAPK signaling pathways. An important corollary to this hypothesis is that in hypertensive state (i.e. SHR rats) the decreasing in ACE enzyme activity and/or AT1 receptor expression caused by administration of estradiol is accompanying with abrogated ability of Ang II to decrease IRS-1/PI3K association, and consequent PI3K/cPLA 2 /p42/44 MAPK activity and associated sodium pump activity/expression.
Internal Medicine, 2008
This study examined the sensitivity of routine abdominal ultrasound scanning in the detection of ... more This study examined the sensitivity of routine abdominal ultrasound scanning in the detection of colonic malignancy. A case control prospective study included 101 patients hospitalized at the Department of Gastroenterology and Liver Diseases of Zemun Clinical Hospital over a four-year period. Since the complaints pointed to colonic malignancy, the patients underwent routine golden standard diagnostic procedures. These patients were referred to an experienced abdominal ultrasound operator who searched for some characteristic signs of colonic malignancy. All of the participants were surgically treated after the completion of relevant procedures for diagnosing colonic malignancy. SPSS for Windows 10.0 was used for data analysis. The sensitivity of an abdominal ultrasound scan in the detection and location of pathological changes pointed to colonic malignancy was different- 76% and 84% respectively. This method was very reliable in detecting right-sided colonic carcinoma (100%). Some specific ultrasonographic signs of colonic carcinoma were observed at the advanced stages of disease. The routine abdominal ultrasonography can be used for the screening of colonic malignancy owing to its high sensitivity, particularly in advanced disease, but solely in conjunction with other methods. Finally, abdominal ultrasonography cannot be a definitive diagnostic tool for colonic carcinoma.
Atherosclerosis Supplements, 2008
The study included 99 unrelated healthy control subjects, 105 type 2 DM subjects with no history ... more The study included 99 unrelated healthy control subjects, 105 type 2 DM subjects with no history of CHD and 91 type 2 DM with CHD >50% epicardial stenosis. gDNA was extracted from leukocyte and this polymorphism was analyzed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP).