Zarko Martinovic | University of Belgrade (original) (raw)

Papers by Zarko Martinovic

Psihijatrija danas, 2002

Cilj ovog rada je da analizira ulogu epilepsije i epileptičnih napada Dostojevskog kao važnih ele... more Cilj ovog rada je da analizira ulogu epilepsije i epileptičnih napada Dostojevskog kao važnih elemenata iz kojih se izgrađuje struktura (forma i sadržaj) njegovih književnih dela (Gazdarica, Poniženi i uvređeni) i velikih romana (Idiot, Zli dusi, Braća Karamazovi). Koncept epilepsije i njene književne upotrebe kod Dostojevskog razvijao se uporedo i u međusobnoj zavisnosti od transformacije autorove književne forme-od romana tajne do romana tragedije i mitskog romana. Estetska dvosmislenost karakteristična za polifonijske romane omogućila je Dostojevskom da epilepsiju i epileptične napade poveže sa nekim od njegovih glavnih literarnih koncepcija-tajnom, autoritetom i čudom, tim "trima silama koje vladaju svetom". Epilepsija je, naročito u obliku ekstatične aure, povezana sa nerešivom zagonetkom nekoliko književnih likova, a isto tako i sa estetskom trijadom koju čine istina, dobro i lepota. Posebno, važna antinomija romana Dostojevskog koja pozitivno lepog čoveka suprotstavlja oličenju zla često oslikava epilepsiju raznih zagonetnih likova. Nepovoljan uticaj epilepsije na stvaralaštvo Dostojevskog ogleda se u čestim promenama narativnog stila. U velikom mitopoetskom romanu Braća Karamazovi epilepsija je dobrim delom istisnuta iz manifestnog nivoa glavnih autorovih umetničkih ideja, ali je delotvorna kao zagonetka kojom se manipuliše radi prikrivanja oceubistva.

Psihijatrija danas, 2012

Purpose: to assess symptoms of depression and to define its influence on quality of life (QOL) in... more Purpose: to assess symptoms of depression and to define its influence on quality of life (QOL) in patients with epilepsy. Method: Adult patients (age range 18-65 years) with normal intelligence and without any progressive neurological disease or psychotic disorder were included in the study. They completed Beck's Depression Inventory (BDI), Symptom Check List - 90 (SCL-90), Quality of life in epilepsy Inventory - 31 (QOLIE-31) - Serbian version, and Hamilton depressive scale, which was completed by investigator. Multiple regression analysis was performed to assess the predictive effects of depression scales scores on QOLIE- 31 total score. Results: 11.8% of patients had clinical diagnosis of depression and were previously treated with antidepressants. According to Beck's depression inventory, symptoms of depression were present in 33% of patients. Multiple regression analysis showed significant correlation between three instruments for depression: BDI, HAMD and SCL-90 depres...

Journal of Child Neurology, 2016

We are very grateful for the opportunity to respond to the comment of Prof Gundogan et al. 1 Inde... more We are very grateful for the opportunity to respond to the comment of Prof Gundogan et al. 1 Indeed, in our research article titled ''Pattern-Reversal Visual Evoked Potential Parameters and Migraine in the Teenage Population,'' 2 we did not show mean + standard deviation values of amplitude and latency in migraine patients with and without aura and healthy control subjects. We agree with Prof Gundogan et al that a table containing the amplitude and latency differences between the groups would be essential for data interpretation. Consequently, in the next section, we provide the information that was requested. In Table 1, we present the significant differences detected by post hoc analysis (Tukey test) in the left-and right-eye N2 wave latencies between the migraine patients with aura and those without aura (P ¼ .014) or healthy controls (P ¼ .023). In all other latencies that were analyzed, there were no significant differences between these groups. Also, these groups did not differ significantly regarding N1P1 and P1N2 amplitudes (Table 2).

Molecular Electronics, 1989

In the development of truly intelligent and creative computers, one of the most significant probl... more In the development of truly intelligent and creative computers, one of the most significant problems is the understanding of how the human brain operates, in the hope of imitating its processes.

Images of the Twenty-First Century. Proceedings of the Annual International Engineering in Medicine and Biology Society

The structure of a low-dielectric-strength, weakly ionized gaseous medium is considered and its i... more The structure of a low-dielectric-strength, weakly ionized gaseous medium is considered and its ionic concentration is estimated. The significance of the results for understanding the role of ULF brain waves in psychological information processing is considered, starting with the assumption that consciousness is associated with the electromagnetic component of brain waves. Implications for brainlike neural networks are discussed

Electroencephalography and Clinical Neurophysiology, 1993

studied. Children were assigned in one of the following groups according to their performance on ... more studied. Children were assigned in one of the following groups according to their performance on the pedagogical test: good performance (pedl), regular performance (ped2), poor performance (ped3). Coherences between all possible pairwise combinations (105) of 15 leads of IO-20 International System were calculated. EEGs were recorded at rest with eyes closed. The results show higher delta, theta and beta coherences and lower alpha coherences for the chiidren of ped3 group, than for the rest of groups, when children between 7 and 9 years old were compared. The children between 9 and 11 years old had significant differences in the coherence values only in the deita band. The discriminant analysis showed that it was possible to classify very accuratelythe children of each group.

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Vojnosanitetski pregled. Military-medical and pharmaceutical review

A group of 31 children aged 4-14 was presented with clinical manifestations of febrile convulsion... more A group of 31 children aged 4-14 was presented with clinical manifestations of febrile convulsions, which after clinical examination, were followed--up in outpatient clinics during 1-12 year period. Together with continuous electroencephalographic monitoring, visual and somatosensory potentials were measured with the aim to stress a diagnostic significance of these neurophysiological methods for cerebral maturation assessment in children with febrile convulsions. Results reveal that electroencephalography (EEG) and somatosensory potentials (SEP) have higher diagnostic sensitivity compared to the visual ones (VEP). In 25 children (80.64%) SEP changes were registered in the form of prolonged central conductivity time (CCT) and EEG revealed changes in the form of slower cerebral activity and posterior theta activities fr. 4-7 Hz (P-O bilaterally) in 10 children (32.26%). Registered SEP changes, particularly prolonged CVP, as well as changes in the form of slower basic cerebral activity...

Neurologija, 1990

Visual potentials evoked by pattern reversal (PRVEPs) were studied in 64 normal children (age ran... more Visual potentials evoked by pattern reversal (PRVEPs) were studied in 64 normal children (age range 7 to 15 years) and in 20 age-matched patients with common and complicated migraine (age range 6 to 16 years). Most of them were studied before and during prophylactic therapy. A Quadristim set (Alvar) was used to present checkerboard patterns on a TV monitor, to amplify the EEG signals and to average and plot the evoked potentials. The potentials were elicited by binocular full-field 2/s checkerboard reversal, recorded from an electrode 4 cm above the inion, and analyzed for latency, amplitude and waveform morphology. The degree of similarity between pairs of PRVEPs was determined by the correlation coefficient. In all our patients no pronounced influence of the disease itself was demonstrated on the PRVEP latencies and amplitudes, but in most of them the correlation coefficients were significantly different from that showing the measure of normal PRVEP variations. Prophylactic medica...

Topics in Molecular Organization and Engineering, 1991

It has been recently shown that the electromagnetic component of brainwaves can play an essential... more It has been recently shown that the electromagnetic component of brainwaves can play an essential role in striking dilatations of subjective time sense and the mixing of conscious and subconscious contents, in low-dielectric (ε r ≈ 1) psychologically altered states. In this paper, the structure of low-dielectric weakly ionised gaseous medium is considered and its ionic concentration is estimated. Also,

Informatica (slovenia), 1999

A key problem of finding the most complete and useful theory of consciousness may revolve around ... more A key problem of finding the most complete and useful theory of consciousness may revolve around how to empirically determine different styles or states of consciousness and how to incorporate these within a single paradigm. This was our motivation to start examination of EEG correlates of some activities or substates of consciousness which occur spontaneously or are induced artificially. Our investigations demonstrated more or less characteristic features in 25 subjects practicing the Transcendental Meditation program (increased β power in prefrontal region, increased θ power in left frontal and right temporal regions, increased α power in both temporal regions, and correlation between increased α power and decreased correlation dimension), 6 subjects with 4 types of spiritual music provided to induce musicogenic states (with significant changes in only 3 cases out of 24, where increased θ and α power was observed in only those subjects who have described their musical experiences as very pleasant), 28 subjects of relaxation induced by microwave resonance therapy applied to corresponding acupuncture points (with slightly decreased EEG power in all frequency bands, especially in the left central region, which can be ascribed to higher activation of the stimulated left circulatory part of the acupuncture system; it should be also noted that persons not previously subjected to this treatment responded stronger, presumably as a consequence of the more imbalanced acupuncture system), 5 healer/healee, noncontact interactions (with increase in the maximum mean coherence of their EEG patterns in the α band observed only in short 4s time intervals), and 30 subjects for monitoring alertness/drowsiness level (with implemented automatic procedure of the neural network classifier to assess the correlation between EEG power spectrum fluctuations related to changes of vigilance level, demonstrating linear separability of the states of alert wakefulness and drowsy wakefulness, allowing very fast data processing and possible real time applications in clinical practice). New technologies applied to the EEG may permit rapid and reproducible identification of different styles or states of consciousness. Such a tool might be useful in evaluating the effectiveness of different techniques for stress reduction and for altering expressions of consciousness.

Social Indicators Research, 2013

ABSTRACT The main aim of this research was to examine the psychometric properties of the Subjecti... more ABSTRACT The main aim of this research was to examine the psychometric properties of the Subjective Happiness Scale (SHS; Lyubomirsky and Lepper in Soc Indic Res 46:137–155, 1999) in a sample of young adults in Serbia (N = 605, mean age = 21.99). The SHS demonstrated adequate internal consistency reliability and homogeneity. Exploratory and Confirmatory factor analyses supported the unidimensional structure of the SHS. The results provided support for the convergent validity of the SHS, by significant correlations with measures of subjective well-being (life satisfaction, positive and negative affect, emotional distress), positive expectations (optimism and self-efficacy), meaning in life and personality traits (extraversion and neuroticism). As compared to the Satisfaction with Life Scale, the SHS showed significantly higher correlations with measures of emotional states and personality traits. Hierarchical regression analyses showed that the SHS had incremental validity over and above subjective well-being and personality traits in predicting emotional distress and meaning in life.

Journal of Clinical Pharmacy and Therapeutics, 2012

Lamotrigine metabolism may be substantially altered with concomitant administration of valproic a... more Lamotrigine metabolism may be substantially altered with concomitant administration of valproic acid and/or carbamazepine. Such alterations may require the adjustment of lamotrigine dose to ensure optimal treatment efficacy and safety. The extent of lamotrigine interactions was investigated dependent on age, gender, weight and dose of concomitant carbamazepine and/or valproic acid in 65 patients with epilepsy. Lamotrigine plasma steady-state oral clearance (CLss/F) and area under the curve (AUCss) were calculated from the dose of drug, average steady-state concentration (Css) and interval of administration. Multiple regression analysis was used for the identification and quantification of factors that influenced lamotrigine pharmacokinetics. Age and dose of carbamazepine and valproic acid had significant influence on lamotrigine CLss/F and AUCss. Carbamazepine was associated with a dose-dependent increase and valproic acid with a dose-dependent decrease of lamotrigine metabolism rate. The effect of carbamazepine was more pronounced. Younger patients were expected to metabolize lamotrigine more rapidly whereas overweight patients may be less susceptible to interactions. Gender had no influence on lamotrigine pharmacokinetics. The efficacy and safety of lamotrigine may be altered by concomitant administration of carbamazepine and valproic acid. The models developed may be useful for estimating doses of lamotrigine for individual patients to minimize clinically significant interactions. Therapeutic monitoring is advisable when those drugs are used concomitantly.

Clinical Neurophysiology, 2006

ing-test paradigm. F waves were conditioned by TMS (120-150% Motor thresholds) at various interst... more ing-test paradigm. F waves were conditioned by TMS (120-150% Motor thresholds) at various interstimulus intervals (ISIs) (5-300 ms) either at random (n = 7) or in serial order (n = 11). We measured the size of the MEP and late F waves. Results: F waves were significantly increased in amplitude when tested at ISI of about 200 ms in 7 of the subjects (late facilitation). The size of the MEP expressed as MEP/ M max was larger in these subjects than in the other 11 cases who showed less facilitation. Conclusions: Our findings suggest that changes in the F wave reflect changes in the excitability of the motoneurons activated by the cortical input. The larger the preceding discharge of the motoneurone pool, the larger the facilitation.

Clinical Neurophysiology, 2013

Electrical status epilepticus in non-REM (without rapid eye-movements) sleep (ESES) and Landau–Kl... more Electrical status epilepticus in non-REM (without rapid eye-movements) sleep (ESES) and Landau–Kleffner syndrome (LKS) is rare epileptic encephalopathies occurring during childhood. ESES is defined by the EEG criterion, namely >85% time of non-REM sleep is occupied with bilateral continuous 1–3 Hz spike-waves (BCSWS). ESES is the only epileptic syndrome requiring the sleep EEG study to establish and follow-up the BCSWS. Main clinical syndromes related with the ESES/BCSWS are: atypical benign epilepsy with centro-temporal spikes (ABECTS), LKS, and opercular syndrome. LKS is characterized by verbal auditory agnosia as its typical aphasia, epileptiform EEG abnormalities and seizures. ESES occurs in 30–50% of patients. Clinical evolution of ESES is characterized by an active phase with BCSWS followed by the recovery phase when the patient is seizure-free but cognitive dysfunctions and behavioral disorders persist. The importance of early diagnosis and treatment initiation is stressed by clinical experience that neuropsychological sequelae cannot be resolved if a persistent active phase lasts for over 2 to 3 years. In our series of patients with ESES and LKS, EEG becomes normalized in both LKS and the ESES related to ABECTS, at latest during the puberty. However, some degree of cognitive or behavioral disorders is often persistent in adulthood.

Clinical Neurophysiology, 2011

abnormality in hemisphere, with acute onset or a progressive course, but could be transient. The ... more abnormality in hemisphere, with acute onset or a progressive course, but could be transient. The most important pattern is polymorphic delta activity. Generalized asynchronous slow waves occur over both hemispheres without constant time relationship. They usually have irregular shapes and vary in frequency and could be reduced by eye opening and alerting. A marked amount of these slow waves always indicates a widespread cerebral abnormality. Bilaterally synchronous slow waves appear at the same time in corresponding areas of the left and right hemispheres, usually as intermittent trains of slow waves. They are reduced by eye opening or alerting, and increased by hyperventilation and drowsiness. Frequently, they occur as the characteristics pattern known as frontal (FIRDA), temporal (TIRDA) or occipital (OIRDA) intermittent rhythmical delta activity. Bisynchronous slow waves are abnormal in alert resting adults, where they result from an abnormality projecting from distant, subcortical structures, such as diffuse encephalopathy, structural lesions of thalamocortical and interhemispheric interactions.

Clinical Neurophysiology, 2008

Clinical Neurophysiology, 2007