Natalie Durkin | University of Birmingham (original) (raw)

Papers by Natalie Durkin

Surgery (oxford), Nov 1, 2022

Anterior abdominal wall defects are a common cause of morbidity and even mortality. These include... more Anterior abdominal wall defects are a common cause of morbidity and even mortality. These include gastroschisis, usually an isolated defect, and exomphalos, a more fundamental failure of abdominal wall formation often seen in association with chromosomal and other systemic anomalies. The worldwide incidence of gastroschisis has risen inexorably over the past 30 years while the incidence of exomphalos, at least at the time of birth, has been relatively static. This article provides an overview of the key aspects of antenatal, perinatal and postnatal management, highlighting areas of controversy where further study is required.

PubMed, Nov 6, 2017

Congenital vascular anomalies of the liver include a range of malformations of the portal venous,... more Congenital vascular anomalies of the liver include a range of malformations of the portal venous, hepatic arterial and venous systems. Congenital portosystemic shunts and arteriovenous malformations make up the two most frequent such malformations. While infantile haemangiomas of the liver, endothelial tumours characterised by vascular proliferation should also be considered, as a proportion of them form prenatally. Evidence to support treatment strategies for these infants and children has been mainly based on small case series. In this review, we explore classification, clinical presentation, investigation and treatment strategies.

Transplantation, Jun 1, 2017

Seminars in Pediatric Surgery, Dec 1, 2022

Journal of Pediatric Surgery, Feb 1, 2017

Early Human Development, Nov 1, 2022

Acta Biomaterialia, Mar 1, 2022

Tissue engineering (TE) aims to generate bioengineered constructs which can offer a surgical trea... more Tissue engineering (TE) aims to generate bioengineered constructs which can offer a surgical treatment for many conditions involving tissue or organ loss. Construct generation must be guided by suitable assessment tools. However, most current tools (e.g. histology) are destructive, which restricts evaluation to a single-2D anatomical plane, and has no potential for assessing constructs prior to or following their implantation. An alternative can be provided by laboratory-based x-ray phase contrast computed tomography (PC-CT), which enables the extraction of 3D density maps of an organ's anatomy. In this work, we developed a semiautomated image processing pipeline dedicated to the analysis of PC-CT slices of oesophageal constructs. Visual and quantitative (density and morphological) information is extracted on a volumetric basis, enabling a comprehensive evaluation of the regenerated constructs. We believe the presented tools can enable the successful regeneration of patientspecific oesophagus, and bring comparable benefit to a wide range of TE applications.

Surgery (oxford), Nov 1, 2019

Anterior abdominal wall defects are a common cause of morbidity and even mortality. These include... more Anterior abdominal wall defects are a common cause of morbidity and even mortality. These include gastroschisis, usually an isolated defect, and exomphalos, a more fundamental failure of abdominal wall formation often seen in association with chromosomal and other systemic anomalies. The worldwide incidence of gastroschisis has risen inexorably over the past 30 years while the incidence of exomphalos, at least at the time of birth, has been relatively static. This article provides an overview of the key aspects of antenatal, perinatal and postnatal management, highlighting areas of controversy where further study is required.

Surgery (oxford), Dec 1, 2016

Abstract Anterior abdominal wall defects are a common cause of morbidity and even mortality. Thes... more Abstract Anterior abdominal wall defects are a common cause of morbidity and even mortality. These include gastroschisis, usually an isolated defect, and exomphalos, a more fundamental cause of abdominal wall failure often seen in association with chromosomal and other systemic anomalies. The worldwide incidence of gastroschisis has risen inexorably over the past 30 years, whereas the incidence of exomphalos, at least at the time of birth, has been relatively static. This article provides an overview of the key aspects of antenatal, perinatal and postnatal management, highlighting areas of controversy where further study is required.

Best Practice & Research in Clinical Gastroenterology, Feb 1, 2022

Several paediatric gastrointestinal diseases result in life-shortening organ failure. For many of... more Several paediatric gastrointestinal diseases result in life-shortening organ failure. For many of these conditions, current therapeutic options are suboptimal and may not offer a cure. Regenerative medicine is an inter-disciplinary field involving biologists, engineers, and clinicians that aims to produce cell and tissue-based therapies to overcome organ failure. Exciting advances in stem cell biology, materials science, and bioengineering bring engineered gastrointestinal cell and tissue therapies to the verge of clinical trial. In this review, we summarise the requirements for bioengineered therapies, the possible sources of the various cellular and non-cellular components, and the progress towards clinical translation of oesophageal and intestinal tissue engineering to date.

Medical Imaging 2023: Biomedical Applications in Molecular, Structural, and Functional Imaging

Pancreatology, May 1, 2012

(IPMN). 2. To correlate imaging findings with subsequent histological assessment. Methods and mat... more (IPMN). 2. To correlate imaging findings with subsequent histological assessment. Methods and materials: Review of our institutional pancreatic tumour database identified 27 patients (16 male, 11 female; mean age 61.6 years) with histologically proven IPMN in the last 6 years. MDCT and MRI studies were performed using specific pancreatic protocols. Images were retrospectively reviewed to identify the following features which can predict malignancy: ductal location (main or side branch); degree of ductal dilation; internal enhancement (mural nodules, septae); invasion beyond pancreas. These findings were correlated with histological findings. 15 patients underwent pancreatectomy; 5 distal pancreatectomy; and 7 patients were deemed unsuitable for any intervention. Results: MDCT/MRI accurately assessed all patients and correlated with histopathological findings in all cases. All patients showed characteristic benign features. Although dysplastic changes were identified in some patients at histology, no invasive cancer was identified. Conclusion: MDCT/MRI appropriately characterizes IPMN. Certain lesion features can predict malignancy and in their absence benign lesions can be predicted with a high degree of accuracy. Take-home message: Conclusion: MDCT/MRI appropriately characterizes IPMN. Certain lesion features can predict malignancy and in their absence benign lesions can be predicted with a high degree of accuracy.

Journal of Pediatric Surgery

Journal of Medical Case Reports, 2011

Introduction Portal vein thrombosis is an uncommon post-operative complication following abdomina... more Introduction Portal vein thrombosis is an uncommon post-operative complication following abdominal surgery. Although therapeutic anticoagulation is recommended, this treatment may be questionable when the patient has an associated bleeding diathesis. Case presentation We report a case of a 63-year-old woman of Asian Indian ethnicity who developed portal vein thrombosis following an uneventful laparoscopic cholecystectomy for symptomatic gallstones. Her condition was further complicated by dengue viral infection in the post-operative period, with thrombocytopenia immediately preceding the diagnosis of portal vein thrombosis. The etiological connections between dengue viral infection with thrombocytopenia, laparoscopic cholecystectomy, portal vein thrombosis as well as the treatment dilemmas posed in treating a patient with portal vein thrombosis with a bleeding diathesis are discussed. Conclusion When portal vein thrombosis occurs in patients with contraindications to anticoagulation...

Seminars in Pediatric Surgery

iScience

Decellularized porcine esophageal scaffold can be transplanted in rabbits Abdominal muscle flap s... more Decellularized porcine esophageal scaffold can be transplanted in rabbits Abdominal muscle flap supports neovascularization of a porcine esophageal scaffold Biodegradable stents support luminal patency preventing scaffold collapse Rabbits are a poor model to study long-term outcomes of esophageal replacement

Journal of pediatric surgery, 2018

Surgery (oxford), Nov 1, 2022

Anterior abdominal wall defects are a common cause of morbidity and even mortality. These include... more Anterior abdominal wall defects are a common cause of morbidity and even mortality. These include gastroschisis, usually an isolated defect, and exomphalos, a more fundamental failure of abdominal wall formation often seen in association with chromosomal and other systemic anomalies. The worldwide incidence of gastroschisis has risen inexorably over the past 30 years while the incidence of exomphalos, at least at the time of birth, has been relatively static. This article provides an overview of the key aspects of antenatal, perinatal and postnatal management, highlighting areas of controversy where further study is required.

PubMed, Nov 6, 2017

Congenital vascular anomalies of the liver include a range of malformations of the portal venous,... more Congenital vascular anomalies of the liver include a range of malformations of the portal venous, hepatic arterial and venous systems. Congenital portosystemic shunts and arteriovenous malformations make up the two most frequent such malformations. While infantile haemangiomas of the liver, endothelial tumours characterised by vascular proliferation should also be considered, as a proportion of them form prenatally. Evidence to support treatment strategies for these infants and children has been mainly based on small case series. In this review, we explore classification, clinical presentation, investigation and treatment strategies.

Transplantation, Jun 1, 2017

Seminars in Pediatric Surgery, Dec 1, 2022

Journal of Pediatric Surgery, Feb 1, 2017

Early Human Development, Nov 1, 2022

Acta Biomaterialia, Mar 1, 2022

Tissue engineering (TE) aims to generate bioengineered constructs which can offer a surgical trea... more Tissue engineering (TE) aims to generate bioengineered constructs which can offer a surgical treatment for many conditions involving tissue or organ loss. Construct generation must be guided by suitable assessment tools. However, most current tools (e.g. histology) are destructive, which restricts evaluation to a single-2D anatomical plane, and has no potential for assessing constructs prior to or following their implantation. An alternative can be provided by laboratory-based x-ray phase contrast computed tomography (PC-CT), which enables the extraction of 3D density maps of an organ's anatomy. In this work, we developed a semiautomated image processing pipeline dedicated to the analysis of PC-CT slices of oesophageal constructs. Visual and quantitative (density and morphological) information is extracted on a volumetric basis, enabling a comprehensive evaluation of the regenerated constructs. We believe the presented tools can enable the successful regeneration of patientspecific oesophagus, and bring comparable benefit to a wide range of TE applications.

Surgery (oxford), Nov 1, 2019

Anterior abdominal wall defects are a common cause of morbidity and even mortality. These include... more Anterior abdominal wall defects are a common cause of morbidity and even mortality. These include gastroschisis, usually an isolated defect, and exomphalos, a more fundamental failure of abdominal wall formation often seen in association with chromosomal and other systemic anomalies. The worldwide incidence of gastroschisis has risen inexorably over the past 30 years while the incidence of exomphalos, at least at the time of birth, has been relatively static. This article provides an overview of the key aspects of antenatal, perinatal and postnatal management, highlighting areas of controversy where further study is required.

Surgery (oxford), Dec 1, 2016

Abstract Anterior abdominal wall defects are a common cause of morbidity and even mortality. Thes... more Abstract Anterior abdominal wall defects are a common cause of morbidity and even mortality. These include gastroschisis, usually an isolated defect, and exomphalos, a more fundamental cause of abdominal wall failure often seen in association with chromosomal and other systemic anomalies. The worldwide incidence of gastroschisis has risen inexorably over the past 30 years, whereas the incidence of exomphalos, at least at the time of birth, has been relatively static. This article provides an overview of the key aspects of antenatal, perinatal and postnatal management, highlighting areas of controversy where further study is required.

Best Practice & Research in Clinical Gastroenterology, Feb 1, 2022

Several paediatric gastrointestinal diseases result in life-shortening organ failure. For many of... more Several paediatric gastrointestinal diseases result in life-shortening organ failure. For many of these conditions, current therapeutic options are suboptimal and may not offer a cure. Regenerative medicine is an inter-disciplinary field involving biologists, engineers, and clinicians that aims to produce cell and tissue-based therapies to overcome organ failure. Exciting advances in stem cell biology, materials science, and bioengineering bring engineered gastrointestinal cell and tissue therapies to the verge of clinical trial. In this review, we summarise the requirements for bioengineered therapies, the possible sources of the various cellular and non-cellular components, and the progress towards clinical translation of oesophageal and intestinal tissue engineering to date.

Medical Imaging 2023: Biomedical Applications in Molecular, Structural, and Functional Imaging

Pancreatology, May 1, 2012

(IPMN). 2. To correlate imaging findings with subsequent histological assessment. Methods and mat... more (IPMN). 2. To correlate imaging findings with subsequent histological assessment. Methods and materials: Review of our institutional pancreatic tumour database identified 27 patients (16 male, 11 female; mean age 61.6 years) with histologically proven IPMN in the last 6 years. MDCT and MRI studies were performed using specific pancreatic protocols. Images were retrospectively reviewed to identify the following features which can predict malignancy: ductal location (main or side branch); degree of ductal dilation; internal enhancement (mural nodules, septae); invasion beyond pancreas. These findings were correlated with histological findings. 15 patients underwent pancreatectomy; 5 distal pancreatectomy; and 7 patients were deemed unsuitable for any intervention. Results: MDCT/MRI accurately assessed all patients and correlated with histopathological findings in all cases. All patients showed characteristic benign features. Although dysplastic changes were identified in some patients at histology, no invasive cancer was identified. Conclusion: MDCT/MRI appropriately characterizes IPMN. Certain lesion features can predict malignancy and in their absence benign lesions can be predicted with a high degree of accuracy. Take-home message: Conclusion: MDCT/MRI appropriately characterizes IPMN. Certain lesion features can predict malignancy and in their absence benign lesions can be predicted with a high degree of accuracy.

Journal of Pediatric Surgery

Journal of Medical Case Reports, 2011

Introduction Portal vein thrombosis is an uncommon post-operative complication following abdomina... more Introduction Portal vein thrombosis is an uncommon post-operative complication following abdominal surgery. Although therapeutic anticoagulation is recommended, this treatment may be questionable when the patient has an associated bleeding diathesis. Case presentation We report a case of a 63-year-old woman of Asian Indian ethnicity who developed portal vein thrombosis following an uneventful laparoscopic cholecystectomy for symptomatic gallstones. Her condition was further complicated by dengue viral infection in the post-operative period, with thrombocytopenia immediately preceding the diagnosis of portal vein thrombosis. The etiological connections between dengue viral infection with thrombocytopenia, laparoscopic cholecystectomy, portal vein thrombosis as well as the treatment dilemmas posed in treating a patient with portal vein thrombosis with a bleeding diathesis are discussed. Conclusion When portal vein thrombosis occurs in patients with contraindications to anticoagulation...

Seminars in Pediatric Surgery

iScience

Decellularized porcine esophageal scaffold can be transplanted in rabbits Abdominal muscle flap s... more Decellularized porcine esophageal scaffold can be transplanted in rabbits Abdominal muscle flap supports neovascularization of a porcine esophageal scaffold Biodegradable stents support luminal patency preventing scaffold collapse Rabbits are a poor model to study long-term outcomes of esophageal replacement

Journal of pediatric surgery, 2018