Ali Movahed | Bushehr Medical School (original) (raw)

Papers by Ali Movahed

Social Science Research Network, 2021

Free- radicals are generated in the minutes following myocardial re-perfusion and this could be t... more Free- radicals are generated in the minutes following myocardial re-perfusion and this could be the cause of myocardial injury during by Pass surgery. Pretreatment with antioxidants could effectively attenuate re-perfusion injury during global ischemia.Xanthine dehydrogenase is converted into xanthine oxidase and this causes accumulation of hypoxanthine and xanthine in the cell. When re-perfusion starts, fresh oxygen interacts with xanthine oxidane and hypoxanthine to form superoxide anion radical O2.- . Allopurinol can metabolically block the formation of reduced oxygen radical by inhibiting the enzyme xanthine oxidase. More over allopurinal has vasodilator effects and aids in restoring favorable conditions through enhancement of collateral blood flow to the ischemic area.

Life Sciences, 2014

The concept of food has expanded beyond its traditional role of survival and hunger satisfaction,... more The concept of food has expanded beyond its traditional role of survival and hunger satisfaction, to include a role in the prevention and treatment of disease. Polyphenols are classes of compounds that are synthesized by plants to serve a wide variety of functions including growth pollination and defense. These compounds have recently received increased attention in medical research. In this group, one of the most studied has been resveratrol (3,5,4,-trihydroxystilbene), a polyphenol, which is found predominantly in grapes and berries. Over the past two decades, researchers have studied the ability of resveratrol to prevent or reverse the development of abnormalities in heart structure and function in animal models of heart disease and heart failure. The results from animal studies have been promising, and very recently, this knowledge has been translated into examining the efficacy of resveratrol in humans with heart disease/failure. In this review we will discuss the current status of resveratrol research on cardioprotection.

Iranian South Medical Journal, Oct 1, 2020

Background: Chronic urticaria is an allergic skin disease characterized by severe pruritic wheal ... more Background: Chronic urticaria is an allergic skin disease characterized by severe pruritic wheal persisting at least for 6 weeks. This study aimed to evaluate the efficacy of plasma therapy used for the first time for the treatment of idiopathic chronic urticaria. Materials and Methods: In this case series study, the quality of life (QOL) of 30 patients with idiopathic chronic urticaria (autoimmune and spontaneous) referred to allergy clinic was evaluated before and after autologous plasma therapy by using standard questionnaires (DLQI and TSS). Results: The findings showed that the means of DLQI and TSS scores in the patients after plasma therapy was significantly reduced. The findings showed that the means of TSS scores in the patients after plasma therapy was significantly reduced (p<0/001). Moreover, it was found that plasma therapy was significantly effective patients with idiopathic chronic urticaria (autoimmune and spontaneous) by using standard questionnaires (TSS)(p=0.001). The findings showed that the means of DLQI scores in the patients after plasma therapy was significantly reduced (p=<0.001) means of DLQI scores in the women in contrast to men after plasma therapy was significantly reduced (p=0.04) .This indicates that the improvement of the QOL in the patients. Moreover, it was found that plasma therapy was significantly effective in both sexes. Conclusion: The results of the present study suggest that autologous plasma therapy could be a suitable method for the treatment of patients with idiopathic chronic urticaria.

Journal of Biological Sciences, Dec 15, 2007

The International Journal of Lower Extremity Wounds, Jun 23, 2016

Basic and Experimental Research Burn injuries are the most devastating accidents and one of the m... more Basic and Experimental Research Burn injuries are the most devastating accidents and one of the major causes of disability and mortality worldwide. 1 After traffic accidents, burn injuries are the second most common cause of mortality. 2 Skin is a coated barrier against chemicals and microorganisms because it has stratified squamous cornified epithelium tissue. 3,4 The degree of burn depends on the heat temperature, contact time, and anatomical region of the skin. Some health problems arising from burns are necrosis, trauma, damage to fibroblasts, inflammation, blood and lymphatic capillary stasis, changes in the local pH, mass production of collagen, and disorders in gene expressions such as frequent mistakes in RNA polymerases and t-RNA functions. 5 For successful treatment of burns, it is necessary to improve knowledge of the biology, pathology, and use of modern medical technology along with natural therapy. So far, many drugs have been used in the control and treatment of burns, including chemical medications such as nitrofurazone, 6 silver sulfadiazine, 7 alpha ointment, 8 phenytoin, 9 and many others. Usually, chemical drugs have side effects and drug resistance; therefore, researchers have attempted to find alternative natural source drugs. The occurrence of many biologically active compounds in Aloe vera gel may be the reason for its use in traditional medicine. Aloe vera heals the skin by reinitiation of angiogenesis, increasing blood flow, stimulation of fibroblast proliferation, anti-inflammation and antimicrobial activities, and moisturizing effects. 10,11 Moreover, there are many scientific studies about the burn healing effects of honey. 12 Honey has been 645031I JLXXX10.

Iranian South Medical Journal, Dec 1, 2022

Background: Spirulina platensis (S. platensis) is a filamentous and photosynthetic microalgae tha... more Background: Spirulina platensis (S. platensis) is a filamentous and photosynthetic microalgae that contains 25 kinds of vitamins and minerals and bioactive compounds such as flavonoids and polyphenols. The aim of this study was to evaluate the antioxidant and cytotoxic activities of ethanolic extract of S. platensis. Materials and Methods: The polyphenolic content, flavonoid content and antioxidant activity of the ethanolic extract of S. platensis was evaluated by Folin-Ciocâlteu reagent, chloride aluminum method, and CUPRAC, respectively. The cytotoxicity of extract on HCT116 and SW742 colorectal cancer cells was determined using an MTT assay after 24, 48 and 72 h treatment with various concentrations of S. platensis extract (0-1000 μg/ml). Results: The ethanolic extract of S. platensis showed an antioxidant activity of 53/7±6/63 mg of Ascorbic acid/g dried sample and was characterized with a high level of polyphenolic and flavonoid content. A dose and time dependent decrease in the viability of HCT116 and SW742 cells was detected following exposure to the extract. After 72 h treatment, IC50 value of HCT116 and SW742 cell lines was obtained as 14/79±0/33 µg/ml and 13/26±1/52 µg/ml, respectively. Conclusion: The results of the present study showed that the ethanolic extract of S. platensis decreases colorectal cancer cell viability significantly. Therefore, this extract can be a candidate for producing anticancer agents.

Asian Pacific journal of cancer biology, May 11, 2018

Background: With 1.36 million new cases in worldwide each year, breast cancer (BC) is the most co... more Background: With 1.36 million new cases in worldwide each year, breast cancer (BC) is the most common malignancy in the female. Among numerous chemotherapy drugs which are widely used for cancer therapy, platinum compounds are the most persuasive ones although challenges remain with the clinical use of them due to their side effects as well as intrinsic and acquired resistance. In the attempt to combat drug resistance, reduce cytotoxic side effects or find the drug for particular forms of cancer, over the years, thousands of other platinum (Pt) compounds i.e. carboplatin and oxaliplatin have been developed. Material and Methods: In this regard, we previously described the synthesis of some new platinum (II) derivatives with potential anti-cancer activities against BC. Here, we chose two of the best platinum(II) compounds, 3b and 2a, to further evaluate their cytotoxic activities against human BC cell lines, SKBR3, MCF-7, MDA-MB-231, and MBA-MB-468, with different molecular subtypes using a colorimetric MTT cytotoxic assay. Their cytotoxic activities were compared to cis-platin as a positive control. Results: Our result showed that both compounds had better cytotoxic effect against BC cell lines than cis-platin in particular in the case of triple-negative subtype. Conclusion: These results suggest these compounds as potentially valuable agents for the treatment of breast cancer patients.

Regenerative engineering and translational medicine, Jul 10, 2023

Journal of Fasa University of Medical Sciences, Apr 10, 2020

Journal of Fasa University of Medical Sciences, Nov 10, 2020

Evidence-based Complementary and Alternative Medicine, 2013

The objective of this study was to examine the effectiveness of resveratrol in lowering blood glu... more The objective of this study was to examine the effectiveness of resveratrol in lowering blood glucose in the presence of standard antidiabetic treatment in patients with type 2 diabetes, in a randomized placebo-controlled double-blinded parallel clinical trial. A total of 66 subjects with type 2 diabetes were enrolled in this study and randomly assigned to intervention group which was supplemented with resveratrol at a dose 1 g/day for 45 days and control group which received placebo tablets. Body weight, blood pressure, fasting blood glucose, haemoglobin A1c, insulin, homeostatic assessments for insulin resistance, triglycerides, total cholesterol, low density lipoprotein, high density lipoprotein, and markers of liver and kidney damage were measured at baseline and after 45 days of resveratrol or placebo supplementation. Resveratrol treatment significantly decreased systolic blood pressure, fasting blood glucose, haemoglobin A1c, insulin, and insulin resistance, while HDL was significantly increased, when compared to their baseline levels. On the other hand, the placebo group had slightly increased fasting glucose and LDL when compared to their baseline levels. Liver and kidney function markers were unchanged in the intervention group. Overall, this study showed that resveratrol supplementation exerted strong antidiabetic effects in patients with type 2 diabetes.

Grana, 2022

Abstract Aeroallergens are known as the major cause of allergic respiratory diseases. The present... more Abstract Aeroallergens are known as the major cause of allergic respiratory diseases. The present study aimed to investigate the skin prick test (SPT) reactivity to the pollen of Conocarpus erectus trees and to find the association between the indoor and outdoor aeroallergens in the patients. In the present case series multicentre study, 104 patients with respiratory allergies such as allergic rhinitis and asthma who were referred to the Bushehr University allergy clinic participated. The SPT was applied by using the extract of Conocarpus erectus pollen and the other allergens to determine the patients’ reactivity. The frequency of positive sensitivity to Conocarpus erectus pollen was 61 (58.6%) and it was 62.5%, 55.7%, and 53.8% for the tree pollen allergens Citrus X Sinensis, Morus rubra, and Phoenix dactylifera, respectively. In addition, the maximum frequency of sensitivity to other aeroallergens was with house dust mite (HDM) (78.8%), Salsola kali; 71.2%), and cockroach (71.2%). The maximum frequency of reactivity to food allergens was with egg yolk (37.6%), shrimp (37%), and beef (34.6%). This study concludes that the frequency of sensitivity to Conocarpus erectus pollen was high and similar to the pollen allergens of other trees that are widely cultivated in southern Iran. Green spaces are the key element of urban management, and the interaction between citizens and the environment, as well as promoting human health are very effective. Therefore, the lack of planning in urban populations in the choice of ornamental species can be a triggering factor, especially in patients with respiratory allergies.

Iranian Journal of Basic Medical Sciences, 2019

Objective(s): In this study, the neutralizing abilities of the equine and the recently introduced... more Objective(s): In this study, the neutralizing abilities of the equine and the recently introduced camelid antivenoms on the hemodynamic parameters (inotropism, chronotropism, and arrhythmogenicity) were assessed following envenomation by Hemiscorpius lepturus venom in rats. Materials and Methods: At first, the electrophoretic profiles of both products were obtained by using the SDS-PAGE method (12.5%) and stained with Coomassie blue and silver nitrate. Secondly, different doses of the camelid antivenom (10, 50, and 100 µl) were given intravenously in 10 min before venom injection (400 µg/rat). The neutralizing potencies of camelid and equine antivenoms were measured by preincubation (100 µl) with H. lepturus venom for 30 min at room temperature. Finally, equal amounts of the antivenoms were injected intravenously to observe the hemodynamic changes. Results: Based on the electrophoretic profile, it was evident that undesired proteins significantly decreased in equine antivenom, owing...

Archives of Razi Institute, 2021

Iranian Naja oxiana (the Elapidae family) known as cobra snake inhabits in the northwestern part ... more Iranian Naja oxiana (the Elapidae family) known as cobra snake inhabits in the northwestern part of Iran. This study aimed to evaluate the edematogenic potency of the crude venom with intraplantar injection into mice. Additionally, the inhibitory effects of three different drugs (i.e., promethazine, dexamethasone, and piroxicam) on paw edema were examined. Moreover, the gelatinase activity of this venom was assessed using the zymography method. Paw edema was induced by the intraplantar injection of different concentrations of the venom (0.5-5 μg dissolved in 50 μl of normal saline) into the mice (six in each group). It was estimated through the measurement of the increase in the paw thickness (%) with a digital caliper. The paws were pretreated and the rate of changes was measured after the venom injection. Pathological findings in the treated paws were evaluated with hematoxylin and eosin staining. Paw thickness reached its maximum amount within 5 min and resolved after 1 h. This v...

Journal of Renal Injury Prevention, 2019

Introduction: Resveratrol (trans-3,5,4’-trihydroxystilbene) as a polyphenol with potential antiox... more Introduction: Resveratrol (trans-3,5,4’-trihydroxystilbene) as a polyphenol with potential antioxidant and anti-inflammatory properties is known as an effective herbal medicine in different disorders in rats. Objectives: The present study was carried out to investigate the protective effects of oral consumption of resveratrol on vanadium induced renal injury in male Wistar rats. Materials and Methods: Animals received either ammonium metavanadate (AMV, 5 mg/ kg/d, (intraperitoneally; 14 consecutive days) or resveratrol solution (10 mg/kg and 50 mg/kg, gastric gavage) along with AMV treatment. The last group received resveratrol alone (50 mg/ kg, gastric gavage) for 4 weeks. Results: AMV injection caused progressive tubular damages resembling acute tubular necrosis. Microscopic views revealed tubular attenuation and blebbing. In addition, progressive peritubular congestion of the capillaries observed while no evidence of renal fibrosis was present in trichrome staining. Further, leve...