Jean Grassman | Brooklyn College of CUNY (original) (raw)

Papers by Jean Grassman

Research paper thumbnail of Letter to the editor: Negative feasibility for 1-bromopropane and call for additional data

Journal of Occupational and Environmental Hygiene

Research paper thumbnail of Articles Analysis of Breast Milk to Assess Exposure to Chlorinated Contaminants in

To assess levels of chlorinated contaminants in breast milk, we measured organochlorine pesticide... more To assess levels of chlorinated contaminants in breast milk, we measured organochlorine pesticides, polychlorinted biphenyls, polychlorinated dibenzo-p-dioxins (PCDDs), and polychlorinated dibenzofiuans (PCDFs) in breast milk samples collected in 1994 according to the World Health Organization protl from 92 donors that were representative of regional populations in southern Kazakstan. High levels (10-120 pglg ht) of 2,3,7,8-tetrachlorodibenzo-p-dioin (TCDD), the most toxica of the PCDDIPCDF congeners, were found in breast milk samples from an agricultural region. TCDD was the major contributor (75%) to the intemational toxicityequivalents of these samples. The same distinctive PCDDIPCDF congener patern was found in 15 breast milk samples and 4 serum samples collected in 1996 in a follow-up study, and has now been: confirmed by three analytical laboratories. Ky wor bret mill; cop PCBs, dioxins, exposure assessment, furs, Kaakstan, TCDD. Environ Heal Pepta 106:797806 (1998). [Online 1...

Research paper thumbnail of A poisoned land: The legacy of Agent Orange in Vietnam

Research paper thumbnail of Characterization and risk of exposure to elements from artisanal gold mining operations in the Bolivian Andes

Environmental Research, 2017

Artisanal and small-scale gold mining (ASGM) offers low-skilled workers an opportunity to elevate... more Artisanal and small-scale gold mining (ASGM) offers low-skilled workers an opportunity to elevate themselves out of poverty. However, this industry operates with little to no pollution controls and the cost to the environment and human health can be large. The objectives of this study were to measure levels of arsenic (As), manganese (Mn), cobalt (Co), lead (Pb), and mercury (Hg) in the environment and characterize health risks to miners and residents in an area with active ASGM operations. An exposure assessment was conducted at two different mining sites and a nearby village in the Bolivian Anders. The resulting measurements were then used to quantify cancerous and noncancerous health risks to children and adults working at and living near ASGM areas. Soil concentrations of As were well above background levels and showed great variations between the village and mining area. Mercury vapor levels at the two mining sites were approximately 30 times larger than the EPA reference concentration. The risk of developing non-cancerous health effects were primarily due to exposure to As and Hg. The probability of individuals developing cancer was considerably increased with adult miners having a probability of 1.3 out of 100. Cancer potential was driven by exposure to As, with de minimus cancer risk from all other elements. Based on the environmental characterization of elements in soils and Hg vapors, the risk of developing cancerous and non-cancerous health outcomes were above a level of concern based on EPA risk assessment guidance. Personal protective equipment was not worn by workers and Hg amalgam is commonly heated in workers' homes. Better education of the risks of ASGM is needed as well as simple controls to reduce exposure.

Research paper thumbnail of Identifying Individual Risk Factors and Documenting the Pattern of Heat-Related Illness through Analyses of Hospitalization and Patterns of Household Cooling

PloS one, 2015

As climate change increases the frequency and intensity of extreme heat events researchers and pu... more As climate change increases the frequency and intensity of extreme heat events researchers and public health officials must work towards understanding the causes and outcomes of heat-related morbidity and mortality. While there have been many studies on both heat-related illness (HRI), there are fewer on heat-related morbidity than on heat-related mortality. To identify individual and environmental risk factors for hospitalizations and document patterns of household cooling. We performed a pooled cross-sectional analysis of secondary U.S. data, the Nationwide Inpatient Sample. Risk ratios were calculated from multivariable models to identify risk factors for hospitalizations. Hierarchical modeling was also employed to identify relationships between individual and hospital level predictors of hospitalizations. Patterns of air conditioning use were analyzed among the vulnerable populations identified. Hospitalizations due to HRI increased over the study period compared to all other ho...

Research paper thumbnail of Siberia

All in-text references underlined in blue are linked to publications on ResearchGate, letting you... more All in-text references underlined in blue are linked to publications on ResearchGate, letting you access and read them immediately.

Research paper thumbnail of External and Internal Human Exposure

Assessment of serum PCDD, PCDF and PCB levels in firefighters exposed to combustion products duri... more Assessment of serum PCDD, PCDF and PCB levels in firefighters exposed to combustion products during the 1992 "Irkutskcable " factory fire in the city of Shelekhov,

Research paper thumbnail of Observations from the science/public health tour

Research paper thumbnail of Phase II xenobiotic biotransiormation in the shelekhov firefighters

Organohalogen compounds, 2003

Research paper thumbnail of Elemental mercury exposure in men, women, and children from a Bolivian community engaged in artisanal gold mining

Research paper thumbnail of CYP1A2 enzyme activity (Antipyrine Test) in shelekohov firefighters

Research paper thumbnail of Weapons of War and Mass Destruction

Research paper thumbnail of Monoclonal immunoassay of triazine herbicides

Research paper thumbnail of 57. Buccal Cells: A Potential Biomarker for Hepatic Sequestration of Dioxins in Humans

Research paper thumbnail of Obtaining information about susceptibility from the epidemiological literature

Toxicology, 1996

... and Haddow, JE (1993) Association between exposure to environmental tobacco smoke and exacerb... more ... and Haddow, JE (1993) Association between exposure to environmental tobacco smoke and exacerbations of asthma in children. ... III (1996) 253270 269 Idle, JR, Armstrong, M., Boddy, AV, Boustead, C., Chol erton, S., Cooper, J., Daly, AK, Ellis, J, Gregory, W, Hadidi, H., Hofer ...

Research paper thumbnail of Impact of AhRR (565C > G) polymorphism on dioxin dependent CYP1A2 induction

Research paper thumbnail of PCDD, PCDF, and PCB exposure in current and former firefighters from Eastern Siberia

Fuel and Energy Abstracts, 2000

The current study examines whether the occupation of firefighting contributes to exposure to poly... more The current study examines whether the occupation of firefighting contributes to exposure to polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (PCBs). We compared serum dioxin concentrations and congener profiles of current firefighters (n=13) with those of men who have ceased employment as firefighters (n=17) and with men employed in occupations other than firefighter (n=10). We found that

Research paper thumbnail of Immunochemical Techniques in Biological Monitoring

lymphocyte DNA) as a method ofbiological monitoring is currently being investigated (Table 1) sin... more lymphocyte DNA) as a method ofbiological monitoring is currently being investigated (Table 1) since these adducts are important as biomarkers ofexposure. Immunoassays are well suited to detect biomarkers of exposure.

Research paper thumbnail of Assessing Soil Lead Exposure for Gardeners in New York City – A Pilot Study

Research paper thumbnail of Geo-Spatial Characterization of Soil Mercury and Arsenic at a High-Altitude Bolivian Gold Mine

Bulletin of Environmental Contamination and Toxicology

Research paper thumbnail of Letter to the editor: Negative feasibility for 1-bromopropane and call for additional data

Journal of Occupational and Environmental Hygiene

Research paper thumbnail of Articles Analysis of Breast Milk to Assess Exposure to Chlorinated Contaminants in

To assess levels of chlorinated contaminants in breast milk, we measured organochlorine pesticide... more To assess levels of chlorinated contaminants in breast milk, we measured organochlorine pesticides, polychlorinted biphenyls, polychlorinated dibenzo-p-dioxins (PCDDs), and polychlorinated dibenzofiuans (PCDFs) in breast milk samples collected in 1994 according to the World Health Organization protl from 92 donors that were representative of regional populations in southern Kazakstan. High levels (10-120 pglg ht) of 2,3,7,8-tetrachlorodibenzo-p-dioin (TCDD), the most toxica of the PCDDIPCDF congeners, were found in breast milk samples from an agricultural region. TCDD was the major contributor (75%) to the intemational toxicityequivalents of these samples. The same distinctive PCDDIPCDF congener patern was found in 15 breast milk samples and 4 serum samples collected in 1996 in a follow-up study, and has now been: confirmed by three analytical laboratories. Ky wor bret mill; cop PCBs, dioxins, exposure assessment, furs, Kaakstan, TCDD. Environ Heal Pepta 106:797806 (1998). [Online 1...

Research paper thumbnail of A poisoned land: The legacy of Agent Orange in Vietnam

Research paper thumbnail of Characterization and risk of exposure to elements from artisanal gold mining operations in the Bolivian Andes

Environmental Research, 2017

Artisanal and small-scale gold mining (ASGM) offers low-skilled workers an opportunity to elevate... more Artisanal and small-scale gold mining (ASGM) offers low-skilled workers an opportunity to elevate themselves out of poverty. However, this industry operates with little to no pollution controls and the cost to the environment and human health can be large. The objectives of this study were to measure levels of arsenic (As), manganese (Mn), cobalt (Co), lead (Pb), and mercury (Hg) in the environment and characterize health risks to miners and residents in an area with active ASGM operations. An exposure assessment was conducted at two different mining sites and a nearby village in the Bolivian Anders. The resulting measurements were then used to quantify cancerous and noncancerous health risks to children and adults working at and living near ASGM areas. Soil concentrations of As were well above background levels and showed great variations between the village and mining area. Mercury vapor levels at the two mining sites were approximately 30 times larger than the EPA reference concentration. The risk of developing non-cancerous health effects were primarily due to exposure to As and Hg. The probability of individuals developing cancer was considerably increased with adult miners having a probability of 1.3 out of 100. Cancer potential was driven by exposure to As, with de minimus cancer risk from all other elements. Based on the environmental characterization of elements in soils and Hg vapors, the risk of developing cancerous and non-cancerous health outcomes were above a level of concern based on EPA risk assessment guidance. Personal protective equipment was not worn by workers and Hg amalgam is commonly heated in workers' homes. Better education of the risks of ASGM is needed as well as simple controls to reduce exposure.

Research paper thumbnail of Identifying Individual Risk Factors and Documenting the Pattern of Heat-Related Illness through Analyses of Hospitalization and Patterns of Household Cooling

PloS one, 2015

As climate change increases the frequency and intensity of extreme heat events researchers and pu... more As climate change increases the frequency and intensity of extreme heat events researchers and public health officials must work towards understanding the causes and outcomes of heat-related morbidity and mortality. While there have been many studies on both heat-related illness (HRI), there are fewer on heat-related morbidity than on heat-related mortality. To identify individual and environmental risk factors for hospitalizations and document patterns of household cooling. We performed a pooled cross-sectional analysis of secondary U.S. data, the Nationwide Inpatient Sample. Risk ratios were calculated from multivariable models to identify risk factors for hospitalizations. Hierarchical modeling was also employed to identify relationships between individual and hospital level predictors of hospitalizations. Patterns of air conditioning use were analyzed among the vulnerable populations identified. Hospitalizations due to HRI increased over the study period compared to all other ho...

Research paper thumbnail of Siberia

All in-text references underlined in blue are linked to publications on ResearchGate, letting you... more All in-text references underlined in blue are linked to publications on ResearchGate, letting you access and read them immediately.

Research paper thumbnail of External and Internal Human Exposure

Assessment of serum PCDD, PCDF and PCB levels in firefighters exposed to combustion products duri... more Assessment of serum PCDD, PCDF and PCB levels in firefighters exposed to combustion products during the 1992 "Irkutskcable " factory fire in the city of Shelekhov,

Research paper thumbnail of Observations from the science/public health tour

Research paper thumbnail of Phase II xenobiotic biotransiormation in the shelekhov firefighters

Organohalogen compounds, 2003

Research paper thumbnail of Elemental mercury exposure in men, women, and children from a Bolivian community engaged in artisanal gold mining

Research paper thumbnail of CYP1A2 enzyme activity (Antipyrine Test) in shelekohov firefighters

Research paper thumbnail of Weapons of War and Mass Destruction

Research paper thumbnail of Monoclonal immunoassay of triazine herbicides

Research paper thumbnail of 57. Buccal Cells: A Potential Biomarker for Hepatic Sequestration of Dioxins in Humans

Research paper thumbnail of Obtaining information about susceptibility from the epidemiological literature

Toxicology, 1996

... and Haddow, JE (1993) Association between exposure to environmental tobacco smoke and exacerb... more ... and Haddow, JE (1993) Association between exposure to environmental tobacco smoke and exacerbations of asthma in children. ... III (1996) 253270 269 Idle, JR, Armstrong, M., Boddy, AV, Boustead, C., Chol erton, S., Cooper, J., Daly, AK, Ellis, J, Gregory, W, Hadidi, H., Hofer ...

Research paper thumbnail of Impact of AhRR (565C > G) polymorphism on dioxin dependent CYP1A2 induction

Research paper thumbnail of PCDD, PCDF, and PCB exposure in current and former firefighters from Eastern Siberia

Fuel and Energy Abstracts, 2000

The current study examines whether the occupation of firefighting contributes to exposure to poly... more The current study examines whether the occupation of firefighting contributes to exposure to polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (PCBs). We compared serum dioxin concentrations and congener profiles of current firefighters (n=13) with those of men who have ceased employment as firefighters (n=17) and with men employed in occupations other than firefighter (n=10). We found that

Research paper thumbnail of Immunochemical Techniques in Biological Monitoring

lymphocyte DNA) as a method ofbiological monitoring is currently being investigated (Table 1) sin... more lymphocyte DNA) as a method ofbiological monitoring is currently being investigated (Table 1) since these adducts are important as biomarkers ofexposure. Immunoassays are well suited to detect biomarkers of exposure.

Research paper thumbnail of Assessing Soil Lead Exposure for Gardeners in New York City – A Pilot Study

Research paper thumbnail of Geo-Spatial Characterization of Soil Mercury and Arsenic at a High-Altitude Bolivian Gold Mine

Bulletin of Environmental Contamination and Toxicology