Sharmistha Bagchi-Sen | SUNY: University at Buffalo (original) (raw)

Address: Buffalo, New York, United States

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Papers by Sharmistha Bagchi-Sen

Research paper thumbnail of Cardiolipin Binds to CD1d and Stimulates CD1d-Restricted γδ T Cells in the Normal Murine Repertoire

Cardiolipin (CL), a major phospholipid in bacterial cell walls, is sequestered from the immune sy... more Cardiolipin (CL), a major phospholipid in bacterial cell walls, is sequestered from the immune system in mammalian mitochondria and is, therefore, a potential danger signal. Based on growing evidence that phospholipids constitute natural ligands for CD1 and that CD1d-restricted T cells recognize phospholipids, we hypothesized that CD1d binds and presents CL and that T cells in the normal immune repertoire respond to CL in a CD1d-restricted manner. We determined the murine CD1d-CL crystal structure at 2.3 Å resolution and established through additional lipid loading experiments that CL, a tetra-acylated phospholipid, binds to murine CD1d with two alkyl chains buried inside the CD1d binding groove and the remaining two exposed into the solvent. We furthermore demonstrate the functional stimulatory activity of CL, showing that splenic and hepatic γδ T cells from healthy mice proliferate in vitro in response to mammalian or bacterial CL in a dose-dependent and CD1d-restricted manner, ra...

Research paper thumbnail of Internet and Online Information Privacy: An Exploratory Study of Preteens and Early Teens

IEEE Transactions on Professional Communication, 2009

Research paper thumbnail of A Framework for Examining Skill Specialization, Gender Inequity, and Career Advancement in the Information Security Field

This paper presents an ongoing research project that examines career advancement barriers to wome... more This paper presents an ongoing research project that examines career advancement barriers to women information security professionals. The study proposes to identify the skill sets critical for success in the information security area and to examine gender differences in specialized skill sets. The paper provides a brief review on IT workforce studies with a special focus on gender inequity problems. The research design and analytical methods are also presented.

Research paper thumbnail of IMPACTS OF ACQUISITIONS AND NEW PLANTS ON THE EMPLOYMENT IN US AFFILIA TES OF FOREIGN MANUFA CTURING FIRMS

Tijdschrift Voor Economische En Sociale Geografie, 1995

Using the polynomially distributed lags model we differentiate, through time, the aggregate impac... more Using the polynomially distributed lags model we differentiate, through time, the aggregate impacts of the two major modes of Foreign Direct Investment upon employment within the foreign manufacturing sector in the US. Our results indicate that the impact of FDI is not uniform; it is specific to entry mode. The acquisition of domestic firms by foreign interests appears to have little aggregate positive impact upon employment, while new plants, constructed by foreign concerns, have positive employment impacts on the foreign manufacturing sector in the United States.

Research paper thumbnail of Occupational and Industrial Diversification in the United States: Implications of the New Spatial Division of Labor

Professional Geographer, 1993

Research paper thumbnail of Gender Divide in the Use of Internet Applications

There is mounting evidence of an increasing gender gap in computer education, which translates in... more There is mounting evidence of an increasing gender gap in computer education, which translates into a similar gap in the information technology workforce in the United States. This study investigates whether gender difference in computer usage is carried over to Internet usage. This paper focuses on exploring gender differences in the use of the Internet and the types of application

Research paper thumbnail of Cardiolipin Binds to CD1d and Stimulates CD1d-Restricted γδ T Cells in the Normal Murine Repertoire

Cardiolipin (CL), a major phospholipid in bacterial cell walls, is sequestered from the immune sy... more Cardiolipin (CL), a major phospholipid in bacterial cell walls, is sequestered from the immune system in mammalian mitochondria and is, therefore, a potential danger signal. Based on growing evidence that phospholipids constitute natural ligands for CD1 and that CD1d-restricted T cells recognize phospholipids, we hypothesized that CD1d binds and presents CL and that T cells in the normal immune repertoire respond to CL in a CD1d-restricted manner. We determined the murine CD1d-CL crystal structure at 2.3 Å resolution and established through additional lipid loading experiments that CL, a tetra-acylated phospholipid, binds to murine CD1d with two alkyl chains buried inside the CD1d binding groove and the remaining two exposed into the solvent. We furthermore demonstrate the functional stimulatory activity of CL, showing that splenic and hepatic γδ T cells from healthy mice proliferate in vitro in response to mammalian or bacterial CL in a dose-dependent and CD1d-restricted manner, ra...

Research paper thumbnail of Internet and Online Information Privacy: An Exploratory Study of Preteens and Early Teens

IEEE Transactions on Professional Communication, 2009

Research paper thumbnail of A Framework for Examining Skill Specialization, Gender Inequity, and Career Advancement in the Information Security Field

This paper presents an ongoing research project that examines career advancement barriers to wome... more This paper presents an ongoing research project that examines career advancement barriers to women information security professionals. The study proposes to identify the skill sets critical for success in the information security area and to examine gender differences in specialized skill sets. The paper provides a brief review on IT workforce studies with a special focus on gender inequity problems. The research design and analytical methods are also presented.

Research paper thumbnail of IMPACTS OF ACQUISITIONS AND NEW PLANTS ON THE EMPLOYMENT IN US AFFILIA TES OF FOREIGN MANUFA CTURING FIRMS

Tijdschrift Voor Economische En Sociale Geografie, 1995

Using the polynomially distributed lags model we differentiate, through time, the aggregate impac... more Using the polynomially distributed lags model we differentiate, through time, the aggregate impacts of the two major modes of Foreign Direct Investment upon employment within the foreign manufacturing sector in the US. Our results indicate that the impact of FDI is not uniform; it is specific to entry mode. The acquisition of domestic firms by foreign interests appears to have little aggregate positive impact upon employment, while new plants, constructed by foreign concerns, have positive employment impacts on the foreign manufacturing sector in the United States.

Research paper thumbnail of Occupational and Industrial Diversification in the United States: Implications of the New Spatial Division of Labor

Professional Geographer, 1993

Research paper thumbnail of Gender Divide in the Use of Internet Applications

There is mounting evidence of an increasing gender gap in computer education, which translates in... more There is mounting evidence of an increasing gender gap in computer education, which translates into a similar gap in the information technology workforce in the United States. This study investigates whether gender difference in computer usage is carried over to Internet usage. This paper focuses on exploring gender differences in the use of the Internet and the types of application

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