Sahar A . Tabak | Cairo University (original) (raw)

Papers by Sahar A . Tabak

Open Access Macedonian Journal of Medical Sciences, 2021

BACKGROUND: Despite the growing landscape of genetic drivers in Diffuse Large B-cell Lymphoma, ye... more BACKGROUND: Despite the growing landscape of genetic drivers in Diffuse Large B-cell Lymphoma, yet their clinical implication is still unclear and R-CHOP regimen remains a “one size fits all” therapy. We aimed in this study to examine the prevalence of EZH2, BCL211 and MYD 88 genetic polymorphisms in DLBCL patients and correlate the results with various clinical and survival outcomes. METHODS: Genotyping of MYD88 (rs387907272 T/C), EZH2 (rs3757441 C/T), and BCL2L11 (rs3789068 A/G) polymorphisms were conducted using real time polymerase chain reaction analysis in a total of 75 DLBCL patients. RESULTS: Most of our cases carried the wild TT genotype of MYD88 gene (64%), the mutant TT genotype of EZH2 gene (52%) and the wild AA genotype of BCL2L11 gene (48%). Regarding cell of origin, Germinal Centre (GC) phenotype was present in 56% of cases while 44% expressed the Post-GC (PGC) phenotype. Poor response outcome to first line R-CHOP was significantly correlated with the mutated CC genot...

Introduction: Calprotectin, a member of the Ca2+-binding S100 family of proteins, makes up about ... more Introduction: Calprotectin, a member of the Ca2+-binding S100 family of proteins, makes up about 5% of the total protein content of the neutrophil. It is released upon activation and degranulation of neutrophils and correlates strongly with 111-indium-labeled leukocyte excretion. It was investigated as a promising tool in differentiating between Irritable Bowel Syndrome (IBS) and active Inflammatory Bowel Disease (IBD). Aim of the Work: Is to compare faecal Calprotectin in patients known to have ulcerative colitis with normal healthy controls and to investigate possible correlation of Calprotectin with disease activity on clinical, laboratory and pathological bases. Patients and Methods: Forty patients known to have UC were assessed. 19 were excluded: 10 due to non-steroidal anti-inflammatory (NSAID) intake, 2 due to pregnancy and 7 due to disease quiescence. So, 21 patients with active disease were studied, 7 males (33.3%) and 14 females (66.7%), mean age 37.5 (± 16.0) years. Ten h...

Egyptian Journal of Pathology, 2020

Introduction Vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1α (HIF-1α) a... more Introduction Vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1α (HIF-1α) are markers of angiogenesis expressed in many cancers. Studying their expression and its correlation with clinical outcome is essential for the development of antiangiogenic therapy. Aim The aim was to evaluate immunohistochemical expression of VEGF and HIF-1α in breast cancer (BC) and correlate it with clinicopathological features and outcome of the disease. Materials and methods Fifty-two archived paraffin blocks of invasive BC cases (diagnosed between January 2012 and January 2016) were studied for immunohistochemical expression of VEGF (low vs high) and HIF-1α (negative, weak, or strong). HIF1α expression score was also done as negative (<1), weak (1–6), and strong (>6). The level of expression of each was correlated to disease-free survival and overall survival (OS) in retrospect. Results VEGF immunostaining was low in 65.4% and high in 34.6% of cases. HIF-1α immunostaining was graded as negative, weak, or strong in 36.5, 48.1, and 15.4%, respectively. A significant positive association was detected between HIF-1α expression and VEGF expression (all cases with strong HIF-1α expression were associated with high VEGF expression) (P<0.0001). Patients with a high VEGF expression had poorer OS compared with low expression [hazard ratio=5.83 (1.12–30.51), P=0.04]. Positive HIF-1α immunostaining did not show a significant impact on survival (P=0.2). However, among HIF-1α-positive patients, high score (>6) was associated with poorer OS compared with low score (<6) [hazard ratio=6.60 (1.21–36.13), P=0.03]. VEGF expression and HIF-1α expression and score did not predict disease-free survival in our cohort. Conclusion HIF-1α and VEGF might be used as biomarkers indicating poorer prognosis in BC. Targeting HIF-1α pathway as well as further research on targeting VEGF in BC is needed.

Open Access Macedonian Journal of Medical Sciences, 2018

BACKGROUND: Osteosarcoma and chondrosarcoma, remain the most common primary bone tumours. Questio... more BACKGROUND: Osteosarcoma and chondrosarcoma, remain the most common primary bone tumours. Questions have been raised about the prognostic influence of HER-2 in bone sarcomas, but so far the results have been debatable. The her-2 expression is possibly a predictor of chemotherapy response.AIM: In this study, we investigated the extent of HER-2 expression in bone sarcomas, and attempted to correlate it with pertinent variables that will help to provide better treatment options, especially for metastatic ones.MATERIAL AND METHODS: Fifty-two cases of bone sarcomas (32 osteosarcoma cases and 20 chondrosarcoma ones) were studied for HER-2 immunohistochemical expression then correlation with all available clinicopathologic features was done.RESULTS: Most of the osteosarcoma cases exhibited membranous staining (78.1%). Strong staining was observed (score 3+) in 34.4%; while 21.9% showed moderate staining (score 2+); and 21.9% displayed weak staining (score 1+), on the other hand, no stainin...

© 2019 Egyptian Journal of Pathology | Published by Wo Background The overlapping phenotypic feat... more © 2019 Egyptian Journal of Pathology | Published by Wo Background The overlapping phenotypic features between the reactivemesothelial cells and the malignant ones pose a major diagnostic challenge in routine cytology practice. Questions have been raised about the privilege of cell block (CB) over conventional smears. There is a lot of controversy about the best immunohistochemical panel that could help in differentiation. Aim This research attempts to compare between the cellular morphology results in conventional smears and CB method. It seeks to address the reliability of calretinin, p-16, and claudin (CL)-4 immunohistochemistry use as an aid to differentiate between reactive and malignant mesothelial cells as well as carcinomatous ones in serous effusion samples. Materials and methods Thisretrospectivestudywasconductedon46(23pleuraleffusionand23peritonealone) cases of effusion fluids. Conventional smears and paraffin-embedded blocks sections were examined and score tabulated. Cal...

Journal of the Egyptian Ophthalmological Society, 2019

Purpose The aim was to report a number of cases initially presenting with unilateral congenital g... more Purpose The aim was to report a number of cases initially presenting with unilateral congenital glaucoma within the first year of life that subsequently were found to be associated with the orbitofacial variant of neurofibromatosis-1 (NF1) as well as with variable intracranial lesions. Patients and methods The records of 340 patients presenting with unilateral congenital glaucoma were retrospectively reviewed to identify patients who subsequently developed orbitofacial NF ipsilateral to the glaucoma or other manifestations of NF1. All clinical, radiological, or histopathological data for enucleated globes, if available, were reviewed. Results Seven patients were identified with a mean age at presentation of 4.3±5.4 months. They presented with unilateral buphthalmos and high intraocular pressure with subtle proptosis and/or lid swelling. The mean age at NF1 diagnosis was 23.14±18.5 months. Initial imaging reports were either read as ‘normal’ or described a lesion near the cavernous sinus (CS): CS thrombosis, clival meningioma, histiocytosis, carotid cavernous fistula, or CS hemangioma. Once the diagnosis of NF1 was made, subsequent imaging studies (computed tomography and/or MRI) showed a defect at the greater wing of sphenoid bone (all patients); neurofibroma involving the CS, orbit, and nearby intracranial and subcutaneous structures to varying degrees (all patients); and hamartomas at the level of the basal ganglia (six patients). Associated intracranial lesions were sphenoid wing meningioma, optic nerve glioma, and trigeminal schwannoma. Histopathology of two enucleated eyes showed glaucomatous changes with prominent ciliochoroidal hyperplasia in one case and a ciliary body schwannoma in another. Conclusion In newborns with unilateral congenital glaucoma, the differential diagnosis should include NF1. Targeted radiologic examinations may reveal diagnostic signs and decrease disease morbidity. The glaucoma surgeon may opt for earlier aggressive intervention in this potentially blinding disease.

Journal of Cosmetic Dermatology, 2015

Burn scars can cause permanent disfiguring problems with limited treatments available. To assess ... more Burn scars can cause permanent disfiguring problems with limited treatments available. To assess and correlate the clinical and histopathological effects of fractional CO2 laser on thermal burns in a controlled study. Fifteen patients 11 with hypertrophic and four with keloidal scars received three CO2 fractional laser sessions every 4-6 weeks. Half of the scar was untreated as a control. Clinical evaluation by Vancouver, PSOAS scores, and photography before, monthly, and 3 months after the last laser session was performed. Ten patients were evaluated histopathologically by standard H&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;E, Masson trichrome, and Elastica von Gieson special stains. Hypertrophic scars (HTSs) showed textural improvement and a significant decrease of Vancouver, POSAS observer, and patient scores by the end of follow-up period in the laser-treated area (P = 0.011, 0.017 and 0.018, respectively) unlike keloidal scars. Histopathology revealed significant decrease in scar thickness in HTSs only (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001) as well as a significant decrease in collagen bundle thickness and density in the upper dermis in both types of scars. Fractional CO2 laser is a possible safe and effective modality for the treatment of hypertrophic burn scars with improvement achieved both clinically and histopathologically.

Egyptian Journal of Pathology

Ultrastructural pathology, Jan 9, 2018

Early detection of hepatocellular carcinoma (HCC) is crucial for successful therapy. The present ... more Early detection of hepatocellular carcinoma (HCC) is crucial for successful therapy. The present work examined the value of ultrastructural morphometric image analysis of hepatocyte nuclei in patients with chronic hepatitis C virus (HCV) versus HCC cases with chronic HCV and the corresponding surgical tumor-free safe margins (TFMs), to highlight any early predictive signs of neoplastic cellular transformation. This work also performed an immunohistochemical assessment of cytokeratin 19 (CK19) and Ki-67-positive cells to visualize any associated proliferative activity in the examined groups. The results showed significant decrease in the hepatocyte nuclear surface areas in the HCC and TFMs versus those in the HCV cases. The hepatocyte nucleolar surface area was significantly increased in the HCC cases versus that in the HCV cases. This increase was associated with a significant increase in Ki-67-positive cells in the HCC cases compared to those in the other groups. Conversely, the me...

Immunohistochemical techniques have proven to be effective for use in forensic pathology, as they... more Immunohistochemical techniques have proven to be effective for use in
forensic pathology, as they can be applied to tissue samples fixed in formalin and embedded in paraffin.
Histologic sections, including ischaemic and non-ischaemic myocardia, were studied via
immunohistochemistry with three different antibodies to human cardiac troponin (cTnT), myoglobin
(MB), and caspase 3, using a standard avidin–biotin–peroxidase system.
Results: All antibodies detected cTnT or MB in the normal myocardium as well as its loss from the
necrotic myocardium, in some cases before histologic evidence of necrosis was present. Loss was
non-uniform and greater at the periphery of the infarcts than at their central regions. Usually, loss
of cTnT appeared to be better than loss of MB; however, MB was more sensitive, and caspase 3 was
the most sensitive. Caspase 3 was detected in areas with established ischaemia and in cases with coronary
occlusion where there was no histologic evidence of necrosis, as well as in cases with latent
infarction.

Egyptian Journal of Pathology, 2011

... How do cyclin D1, EGFR, and COX-2 attribute to colorectal carcinoma prognosis? An immunohisto... more ... How do cyclin D1, EGFR, and COX-2 attribute to colorectal carcinoma prognosis? An immunohistochemical study on tissue microarray. Ibrahim, Wael Shawkya; Abdel Hamid Tabak,Sahara; El Sayed, Abeer Mostafab. Article Outline. Collapse Box Author Information. ...

Egyptian Journal of Forensic Sciences, 2011

Background Immunohistochemical techniques have proven to be effective for use in forensic patholo... more Background Immunohistochemical techniques have proven to be effective for use in forensic pathology, as they can be applied to tissue samples fixed in formalin and embedded in paraffin. Histologic sections, including ischaemic and non-ischaemic myocardia, were ...

Egyptian Journal of Pathology, 2013

Journal of Cosmetic Dermatology, 2015

Burn scars can cause permanent disfiguring problems with limited treatments available. To assess ... more Burn scars can cause permanent disfiguring problems with limited treatments available. To assess and correlate the clinical and histopathological effects of fractional CO2 laser on thermal burns in a controlled study. Fifteen patients 11 with hypertrophic and four with keloidal scars received three CO2 fractional laser sessions every 4-6 weeks. Half of the scar was untreated as a control. Clinical evaluation by Vancouver, PSOAS scores, and photography before, monthly, and 3 months after the last laser session was performed. Ten patients were evaluated histopathologically by standard H&amp;amp;amp;amp;amp;amp;amp;amp;amp;E, Masson trichrome, and Elastica von Gieson special stains. Hypertrophic scars (HTSs) showed textural improvement and a significant decrease of Vancouver, POSAS observer, and patient scores by the end of follow-up period in the laser-treated area (P = 0.011, 0.017 and 0.018, respectively) unlike keloidal scars. Histopathology revealed significant decrease in scar thickness in HTSs only (P &amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001) as well as a significant decrease in collagen bundle thickness and density in the upper dermis in both types of scars. Fractional CO2 laser is a possible safe and effective modality for the treatment of hypertrophic burn scars with improvement achieved both clinically and histopathologically.

Open Access Macedonian Journal of Medical Sciences, 2021

BACKGROUND: Despite the growing landscape of genetic drivers in Diffuse Large B-cell Lymphoma, ye... more BACKGROUND: Despite the growing landscape of genetic drivers in Diffuse Large B-cell Lymphoma, yet their clinical implication is still unclear and R-CHOP regimen remains a “one size fits all” therapy. We aimed in this study to examine the prevalence of EZH2, BCL211 and MYD 88 genetic polymorphisms in DLBCL patients and correlate the results with various clinical and survival outcomes. METHODS: Genotyping of MYD88 (rs387907272 T/C), EZH2 (rs3757441 C/T), and BCL2L11 (rs3789068 A/G) polymorphisms were conducted using real time polymerase chain reaction analysis in a total of 75 DLBCL patients. RESULTS: Most of our cases carried the wild TT genotype of MYD88 gene (64%), the mutant TT genotype of EZH2 gene (52%) and the wild AA genotype of BCL2L11 gene (48%). Regarding cell of origin, Germinal Centre (GC) phenotype was present in 56% of cases while 44% expressed the Post-GC (PGC) phenotype. Poor response outcome to first line R-CHOP was significantly correlated with the mutated CC genot...

Introduction: Calprotectin, a member of the Ca2+-binding S100 family of proteins, makes up about ... more Introduction: Calprotectin, a member of the Ca2+-binding S100 family of proteins, makes up about 5% of the total protein content of the neutrophil. It is released upon activation and degranulation of neutrophils and correlates strongly with 111-indium-labeled leukocyte excretion. It was investigated as a promising tool in differentiating between Irritable Bowel Syndrome (IBS) and active Inflammatory Bowel Disease (IBD). Aim of the Work: Is to compare faecal Calprotectin in patients known to have ulcerative colitis with normal healthy controls and to investigate possible correlation of Calprotectin with disease activity on clinical, laboratory and pathological bases. Patients and Methods: Forty patients known to have UC were assessed. 19 were excluded: 10 due to non-steroidal anti-inflammatory (NSAID) intake, 2 due to pregnancy and 7 due to disease quiescence. So, 21 patients with active disease were studied, 7 males (33.3%) and 14 females (66.7%), mean age 37.5 (± 16.0) years. Ten h...

Egyptian Journal of Pathology, 2020

Introduction Vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1α (HIF-1α) a... more Introduction Vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1α (HIF-1α) are markers of angiogenesis expressed in many cancers. Studying their expression and its correlation with clinical outcome is essential for the development of antiangiogenic therapy. Aim The aim was to evaluate immunohistochemical expression of VEGF and HIF-1α in breast cancer (BC) and correlate it with clinicopathological features and outcome of the disease. Materials and methods Fifty-two archived paraffin blocks of invasive BC cases (diagnosed between January 2012 and January 2016) were studied for immunohistochemical expression of VEGF (low vs high) and HIF-1α (negative, weak, or strong). HIF1α expression score was also done as negative (<1), weak (1–6), and strong (>6). The level of expression of each was correlated to disease-free survival and overall survival (OS) in retrospect. Results VEGF immunostaining was low in 65.4% and high in 34.6% of cases. HIF-1α immunostaining was graded as negative, weak, or strong in 36.5, 48.1, and 15.4%, respectively. A significant positive association was detected between HIF-1α expression and VEGF expression (all cases with strong HIF-1α expression were associated with high VEGF expression) (P<0.0001). Patients with a high VEGF expression had poorer OS compared with low expression [hazard ratio=5.83 (1.12–30.51), P=0.04]. Positive HIF-1α immunostaining did not show a significant impact on survival (P=0.2). However, among HIF-1α-positive patients, high score (>6) was associated with poorer OS compared with low score (<6) [hazard ratio=6.60 (1.21–36.13), P=0.03]. VEGF expression and HIF-1α expression and score did not predict disease-free survival in our cohort. Conclusion HIF-1α and VEGF might be used as biomarkers indicating poorer prognosis in BC. Targeting HIF-1α pathway as well as further research on targeting VEGF in BC is needed.

Open Access Macedonian Journal of Medical Sciences, 2018

BACKGROUND: Osteosarcoma and chondrosarcoma, remain the most common primary bone tumours. Questio... more BACKGROUND: Osteosarcoma and chondrosarcoma, remain the most common primary bone tumours. Questions have been raised about the prognostic influence of HER-2 in bone sarcomas, but so far the results have been debatable. The her-2 expression is possibly a predictor of chemotherapy response.AIM: In this study, we investigated the extent of HER-2 expression in bone sarcomas, and attempted to correlate it with pertinent variables that will help to provide better treatment options, especially for metastatic ones.MATERIAL AND METHODS: Fifty-two cases of bone sarcomas (32 osteosarcoma cases and 20 chondrosarcoma ones) were studied for HER-2 immunohistochemical expression then correlation with all available clinicopathologic features was done.RESULTS: Most of the osteosarcoma cases exhibited membranous staining (78.1%). Strong staining was observed (score 3+) in 34.4%; while 21.9% showed moderate staining (score 2+); and 21.9% displayed weak staining (score 1+), on the other hand, no stainin...

© 2019 Egyptian Journal of Pathology | Published by Wo Background The overlapping phenotypic feat... more © 2019 Egyptian Journal of Pathology | Published by Wo Background The overlapping phenotypic features between the reactivemesothelial cells and the malignant ones pose a major diagnostic challenge in routine cytology practice. Questions have been raised about the privilege of cell block (CB) over conventional smears. There is a lot of controversy about the best immunohistochemical panel that could help in differentiation. Aim This research attempts to compare between the cellular morphology results in conventional smears and CB method. It seeks to address the reliability of calretinin, p-16, and claudin (CL)-4 immunohistochemistry use as an aid to differentiate between reactive and malignant mesothelial cells as well as carcinomatous ones in serous effusion samples. Materials and methods Thisretrospectivestudywasconductedon46(23pleuraleffusionand23peritonealone) cases of effusion fluids. Conventional smears and paraffin-embedded blocks sections were examined and score tabulated. Cal...

Journal of the Egyptian Ophthalmological Society, 2019

Purpose The aim was to report a number of cases initially presenting with unilateral congenital g... more Purpose The aim was to report a number of cases initially presenting with unilateral congenital glaucoma within the first year of life that subsequently were found to be associated with the orbitofacial variant of neurofibromatosis-1 (NF1) as well as with variable intracranial lesions. Patients and methods The records of 340 patients presenting with unilateral congenital glaucoma were retrospectively reviewed to identify patients who subsequently developed orbitofacial NF ipsilateral to the glaucoma or other manifestations of NF1. All clinical, radiological, or histopathological data for enucleated globes, if available, were reviewed. Results Seven patients were identified with a mean age at presentation of 4.3±5.4 months. They presented with unilateral buphthalmos and high intraocular pressure with subtle proptosis and/or lid swelling. The mean age at NF1 diagnosis was 23.14±18.5 months. Initial imaging reports were either read as ‘normal’ or described a lesion near the cavernous sinus (CS): CS thrombosis, clival meningioma, histiocytosis, carotid cavernous fistula, or CS hemangioma. Once the diagnosis of NF1 was made, subsequent imaging studies (computed tomography and/or MRI) showed a defect at the greater wing of sphenoid bone (all patients); neurofibroma involving the CS, orbit, and nearby intracranial and subcutaneous structures to varying degrees (all patients); and hamartomas at the level of the basal ganglia (six patients). Associated intracranial lesions were sphenoid wing meningioma, optic nerve glioma, and trigeminal schwannoma. Histopathology of two enucleated eyes showed glaucomatous changes with prominent ciliochoroidal hyperplasia in one case and a ciliary body schwannoma in another. Conclusion In newborns with unilateral congenital glaucoma, the differential diagnosis should include NF1. Targeted radiologic examinations may reveal diagnostic signs and decrease disease morbidity. The glaucoma surgeon may opt for earlier aggressive intervention in this potentially blinding disease.

Journal of Cosmetic Dermatology, 2015

Burn scars can cause permanent disfiguring problems with limited treatments available. To assess ... more Burn scars can cause permanent disfiguring problems with limited treatments available. To assess and correlate the clinical and histopathological effects of fractional CO2 laser on thermal burns in a controlled study. Fifteen patients 11 with hypertrophic and four with keloidal scars received three CO2 fractional laser sessions every 4-6 weeks. Half of the scar was untreated as a control. Clinical evaluation by Vancouver, PSOAS scores, and photography before, monthly, and 3 months after the last laser session was performed. Ten patients were evaluated histopathologically by standard H&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;E, Masson trichrome, and Elastica von Gieson special stains. Hypertrophic scars (HTSs) showed textural improvement and a significant decrease of Vancouver, POSAS observer, and patient scores by the end of follow-up period in the laser-treated area (P = 0.011, 0.017 and 0.018, respectively) unlike keloidal scars. Histopathology revealed significant decrease in scar thickness in HTSs only (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001) as well as a significant decrease in collagen bundle thickness and density in the upper dermis in both types of scars. Fractional CO2 laser is a possible safe and effective modality for the treatment of hypertrophic burn scars with improvement achieved both clinically and histopathologically.

Egyptian Journal of Pathology

Ultrastructural pathology, Jan 9, 2018

Early detection of hepatocellular carcinoma (HCC) is crucial for successful therapy. The present ... more Early detection of hepatocellular carcinoma (HCC) is crucial for successful therapy. The present work examined the value of ultrastructural morphometric image analysis of hepatocyte nuclei in patients with chronic hepatitis C virus (HCV) versus HCC cases with chronic HCV and the corresponding surgical tumor-free safe margins (TFMs), to highlight any early predictive signs of neoplastic cellular transformation. This work also performed an immunohistochemical assessment of cytokeratin 19 (CK19) and Ki-67-positive cells to visualize any associated proliferative activity in the examined groups. The results showed significant decrease in the hepatocyte nuclear surface areas in the HCC and TFMs versus those in the HCV cases. The hepatocyte nucleolar surface area was significantly increased in the HCC cases versus that in the HCV cases. This increase was associated with a significant increase in Ki-67-positive cells in the HCC cases compared to those in the other groups. Conversely, the me...

Immunohistochemical techniques have proven to be effective for use in forensic pathology, as they... more Immunohistochemical techniques have proven to be effective for use in
forensic pathology, as they can be applied to tissue samples fixed in formalin and embedded in paraffin.
Histologic sections, including ischaemic and non-ischaemic myocardia, were studied via
immunohistochemistry with three different antibodies to human cardiac troponin (cTnT), myoglobin
(MB), and caspase 3, using a standard avidin–biotin–peroxidase system.
Results: All antibodies detected cTnT or MB in the normal myocardium as well as its loss from the
necrotic myocardium, in some cases before histologic evidence of necrosis was present. Loss was
non-uniform and greater at the periphery of the infarcts than at their central regions. Usually, loss
of cTnT appeared to be better than loss of MB; however, MB was more sensitive, and caspase 3 was
the most sensitive. Caspase 3 was detected in areas with established ischaemia and in cases with coronary
occlusion where there was no histologic evidence of necrosis, as well as in cases with latent
infarction.

Egyptian Journal of Pathology, 2011

... How do cyclin D1, EGFR, and COX-2 attribute to colorectal carcinoma prognosis? An immunohisto... more ... How do cyclin D1, EGFR, and COX-2 attribute to colorectal carcinoma prognosis? An immunohistochemical study on tissue microarray. Ibrahim, Wael Shawkya; Abdel Hamid Tabak,Sahara; El Sayed, Abeer Mostafab. Article Outline. Collapse Box Author Information. ...

Egyptian Journal of Forensic Sciences, 2011

Background Immunohistochemical techniques have proven to be effective for use in forensic patholo... more Background Immunohistochemical techniques have proven to be effective for use in forensic pathology, as they can be applied to tissue samples fixed in formalin and embedded in paraffin. Histologic sections, including ischaemic and non-ischaemic myocardia, were ...

Egyptian Journal of Pathology, 2013

Journal of Cosmetic Dermatology, 2015

Burn scars can cause permanent disfiguring problems with limited treatments available. To assess ... more Burn scars can cause permanent disfiguring problems with limited treatments available. To assess and correlate the clinical and histopathological effects of fractional CO2 laser on thermal burns in a controlled study. Fifteen patients 11 with hypertrophic and four with keloidal scars received three CO2 fractional laser sessions every 4-6 weeks. Half of the scar was untreated as a control. Clinical evaluation by Vancouver, PSOAS scores, and photography before, monthly, and 3 months after the last laser session was performed. Ten patients were evaluated histopathologically by standard H&amp;amp;amp;amp;amp;amp;amp;amp;amp;E, Masson trichrome, and Elastica von Gieson special stains. Hypertrophic scars (HTSs) showed textural improvement and a significant decrease of Vancouver, POSAS observer, and patient scores by the end of follow-up period in the laser-treated area (P = 0.011, 0.017 and 0.018, respectively) unlike keloidal scars. Histopathology revealed significant decrease in scar thickness in HTSs only (P &amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001) as well as a significant decrease in collagen bundle thickness and density in the upper dermis in both types of scars. Fractional CO2 laser is a possible safe and effective modality for the treatment of hypertrophic burn scars with improvement achieved both clinically and histopathologically.