Lawson Higgins | Oxforfd - Academia.edu (original) (raw)

Papers by Lawson Higgins

Research paper thumbnail of Teachers Appraisal of Their Relationship with Instructional Coaches and Interpretation of the Instructional Coaches Role

Research paper thumbnail of Prospective evaluation of a colorectal cancer nurse follow‐up clinic

Colorectal …, 2011

Colorectal Nurse Specialist (CNS) clinics for postoperative follow up of colorectal cancer aim to... more Colorectal Nurse Specialist (CNS) clinics for postoperative follow up of colorectal cancer aim to maintain clinical efficacy while reducing costs. We prospectively studied the efficacy and financial implications of such a clinic. This was a prospective study of all patients attending CNS clinics over 3 years. A lower-risk protocol for patients with Dukes A was used over 3 years and a higher-risk protocol for patients with Dukes B, C or D was used over 5 years. Department of Health Pricing Charts were used to cost the follow-up protocols, and adjustment was performed to calculate the cost of each quality adjusted life year (QALY) gained. One hundred and ninety-three patients entered into this nurse-led follow-up protocol implemented by the CNS clinic between 2005 and 2007. The Dukes stages and proportions of patients in each stage were as follows: stage A, 13%; stage B, 8%; stage C, 36.3%; and stage D, 9.3%. Ninety-seven per cent underwent curative treatment and 2.6% had palliative treatment. Twenty-one per cent of patients developed recurrent disease. Overall actuarial 5-year survival was 80% and recurrences had a 30% 5-year actuarial survival. The total cost per patient for 3 years of follow up was £1506 and £1179 for lower-risk rectal and nonrectal cancers, respectively. The adjusted cost for each QALY gained for lower-risk tumours was £1914. The total cost per patient with higher-risk tumours was £1814 and £1487 for rectal and nonrectal tumours, respectively. The adjusted cost for each QALY gained was £2180 for higher-risk tumours. This clinic demonstrated cost-effective detection of recurrent disease. Computed tomography (CT) was the most sensitive alert test. As all recurrences were detected within 4 years, we suggest that this is the indicated time to follow up.

Research paper thumbnail of Seeing vs. believing: Is believing sufficient to activate the processes of response co-representation?

Human Movement Science, 2007

It has been suggested that the observation of another person’s action affects the behavior of the... more It has been suggested that the observation of another person’s action affects the behavior of the observer because the observation of action leads to the excitation of similar response codes in the observer. It is unknown, however, if one must witness the action or if it is sufficient for one to believe that the other agent is responding for response

Research paper thumbnail of A phase II trial evaluating capecitabine and irinotecan as second line treatment in patients with oesophago-gastric cancer who have progressed on, or within 3 months of platinum-based chemotherapy

There is no standard second line therapy for relapsed oesophago-gastric (O-G) cancer. We recruite... more There is no standard second line therapy for relapsed oesophago-gastric (O-G) cancer. We recruited 29 eligible patients with relapsed O-G cancer who had progressed during or within 3 months of prior chemotherapy to assess the efficacy and toxicity of capecitabine [2,000 mg/(m(2) day) on days 1-14] and irinotecan (250 mg/m(2)) given every 3 weeks. Five patients (17%) demonstrated objective response, while a further seven patients (24%) achieved disease stabilisation. Median progression-free survival and overall survival were 3.1 months (95% CI = 2.2-4.1 months) and 6.5 months (95%CI = 6-7.1 months), respectively. Among symptomatic patients, palliation of tumour-related symptoms included resolution of reflux (5/12 pts), dysphagia (3/9 pts) and weight loss (4/9 pts), improvements in anorexia (4/10 pts), nausea (3/4 pts), vomiting (4/6 pts) and pain (4/16 pts). Grade 3-4 toxicities were diarrhoea (15%), nausea and vomiting (7%), lethargy (31%), neutropenia (31%), anemia (14%) and thrombocytopenia (7%). Capecitabine and irinotecan has anti-tumour activity as second line treatment for relapsed O-G cancer, and provides an important improvement in disease related symptoms.

Research paper thumbnail of Prenatal diagnosis and prenatal imaging of a de novo 46, X, der (Y) t (X; Y)(p22. 13; q11. 23) leading to functional disomy for the distal end of the X chromosome short arm from Xp22. 13 in a phenotypically male fetus with posterior fossa abnormalities

A. Ghosh1, L. Higgins1, S. A. Larkins2, C. Miller3, N. Ostojic4, W. L. Martin1 and M. D. Kilby1* ... more A. Ghosh1, L. Higgins1, S. A. Larkins2, C. Miller3, N. Ostojic4, W. L. Martin1 and M. D. Kilby1* 1Department of Fetal Medicine, Division of Reproductive and Child Health, Birmingham Women’s Hospital, University of Birmingham, Edgbaston, Birmingham, UK 2Regional Genetics Laboratory, Birmingham Women’s Hospital, Edgbaston, Birmingham UK 3Department of Radiology, Birmingham Children’s Hospital, Birmingham, UK 4Department of Pathology, Birmingham Women’s Hospital, Edgbaston, Birmingham UK

Research paper thumbnail of SELECTED PAPERS FROM THE 18TH INFORMAL MEETING ON MASS SPECTROMETRY, PRAGUE, CZECH REPUBLIC, 30 APRIL-3 MAY 2000-Characterization of novel di-and tricarboxylic acids in fine tropical aerosols

Research paper thumbnail of Teachers Appraisal of Their Relationship with Instructional Coaches and Interpretation of the Instructional Coaches Role

Research paper thumbnail of Prospective evaluation of a colorectal cancer nurse follow‐up clinic

Colorectal …, 2011

Colorectal Nurse Specialist (CNS) clinics for postoperative follow up of colorectal cancer aim to... more Colorectal Nurse Specialist (CNS) clinics for postoperative follow up of colorectal cancer aim to maintain clinical efficacy while reducing costs. We prospectively studied the efficacy and financial implications of such a clinic. This was a prospective study of all patients attending CNS clinics over 3 years. A lower-risk protocol for patients with Dukes A was used over 3 years and a higher-risk protocol for patients with Dukes B, C or D was used over 5 years. Department of Health Pricing Charts were used to cost the follow-up protocols, and adjustment was performed to calculate the cost of each quality adjusted life year (QALY) gained. One hundred and ninety-three patients entered into this nurse-led follow-up protocol implemented by the CNS clinic between 2005 and 2007. The Dukes stages and proportions of patients in each stage were as follows: stage A, 13%; stage B, 8%; stage C, 36.3%; and stage D, 9.3%. Ninety-seven per cent underwent curative treatment and 2.6% had palliative treatment. Twenty-one per cent of patients developed recurrent disease. Overall actuarial 5-year survival was 80% and recurrences had a 30% 5-year actuarial survival. The total cost per patient for 3 years of follow up was £1506 and £1179 for lower-risk rectal and nonrectal cancers, respectively. The adjusted cost for each QALY gained for lower-risk tumours was £1914. The total cost per patient with higher-risk tumours was £1814 and £1487 for rectal and nonrectal tumours, respectively. The adjusted cost for each QALY gained was £2180 for higher-risk tumours. This clinic demonstrated cost-effective detection of recurrent disease. Computed tomography (CT) was the most sensitive alert test. As all recurrences were detected within 4 years, we suggest that this is the indicated time to follow up.

Research paper thumbnail of Seeing vs. believing: Is believing sufficient to activate the processes of response co-representation?

Human Movement Science, 2007

It has been suggested that the observation of another person’s action affects the behavior of the... more It has been suggested that the observation of another person’s action affects the behavior of the observer because the observation of action leads to the excitation of similar response codes in the observer. It is unknown, however, if one must witness the action or if it is sufficient for one to believe that the other agent is responding for response

Research paper thumbnail of A phase II trial evaluating capecitabine and irinotecan as second line treatment in patients with oesophago-gastric cancer who have progressed on, or within 3 months of platinum-based chemotherapy

There is no standard second line therapy for relapsed oesophago-gastric (O-G) cancer. We recruite... more There is no standard second line therapy for relapsed oesophago-gastric (O-G) cancer. We recruited 29 eligible patients with relapsed O-G cancer who had progressed during or within 3 months of prior chemotherapy to assess the efficacy and toxicity of capecitabine [2,000 mg/(m(2) day) on days 1-14] and irinotecan (250 mg/m(2)) given every 3 weeks. Five patients (17%) demonstrated objective response, while a further seven patients (24%) achieved disease stabilisation. Median progression-free survival and overall survival were 3.1 months (95% CI = 2.2-4.1 months) and 6.5 months (95%CI = 6-7.1 months), respectively. Among symptomatic patients, palliation of tumour-related symptoms included resolution of reflux (5/12 pts), dysphagia (3/9 pts) and weight loss (4/9 pts), improvements in anorexia (4/10 pts), nausea (3/4 pts), vomiting (4/6 pts) and pain (4/16 pts). Grade 3-4 toxicities were diarrhoea (15%), nausea and vomiting (7%), lethargy (31%), neutropenia (31%), anemia (14%) and thrombocytopenia (7%). Capecitabine and irinotecan has anti-tumour activity as second line treatment for relapsed O-G cancer, and provides an important improvement in disease related symptoms.

Research paper thumbnail of Prenatal diagnosis and prenatal imaging of a de novo 46, X, der (Y) t (X; Y)(p22. 13; q11. 23) leading to functional disomy for the distal end of the X chromosome short arm from Xp22. 13 in a phenotypically male fetus with posterior fossa abnormalities

A. Ghosh1, L. Higgins1, S. A. Larkins2, C. Miller3, N. Ostojic4, W. L. Martin1 and M. D. Kilby1* ... more A. Ghosh1, L. Higgins1, S. A. Larkins2, C. Miller3, N. Ostojic4, W. L. Martin1 and M. D. Kilby1* 1Department of Fetal Medicine, Division of Reproductive and Child Health, Birmingham Women’s Hospital, University of Birmingham, Edgbaston, Birmingham, UK 2Regional Genetics Laboratory, Birmingham Women’s Hospital, Edgbaston, Birmingham UK 3Department of Radiology, Birmingham Children’s Hospital, Birmingham, UK 4Department of Pathology, Birmingham Women’s Hospital, Edgbaston, Birmingham UK

Research paper thumbnail of SELECTED PAPERS FROM THE 18TH INFORMAL MEETING ON MASS SPECTROMETRY, PRAGUE, CZECH REPUBLIC, 30 APRIL-3 MAY 2000-Characterization of novel di-and tricarboxylic acids in fine tropical aerosols