Tegan Stockdale | University of Cambridge (original) (raw)

Tegan Stockdale

Organic chemist in the area of total synthesis of natural products. Currently working on the total synthesis of the marine polyketide hemicalide, as part of my PhD candidature at the University of Cambridge. Previous work in the area of chemistry and biochemistry, working with Caco-2 cell cultures, to explore the bioavailability of potential bioactives in traditional herbal medicines, and isolation of potential bioactives from Indigenous Australian herbal medicines.

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Papers by Tegan Stockdale

Research paper thumbnail of Phytochemical composition of Denhamia obscura (A. Rich.) Meisn. Ex Walp. root bark, seeds and leaves

Research paper thumbnail of Selective carbon-hydrogen bond hydroxylation using an engineered cytochrome P450 peroxygenase

Journal of Inorganic Biochemistry

Research paper thumbnail of Pharmaceuticals that contain polycyclic hydrocarbon scaffolds

Chemical Society reviews, Jan 14, 2015

Numerous variations on structural motifs exist within pharmaceutical compounds that have entered ... more Numerous variations on structural motifs exist within pharmaceutical compounds that have entered the clinic. These variations have amounted over many decades based on years of drug development associated with screening natural products and de novo synthetic systems. Caged (or bridged) bicyclic structural elements offer a variety of diverse features, encompassing three-dimensional shape, and assorted pharmacokinetic properties. This review highlights approximately 20 all carbon cage containing pharmaceuticals, ranging in structure from bicyclo[2.2.1] through to adamantane, including some in the top-selling pharmaceutical bracket. Although, a wide variety of human diseases, illnesses and conditions are treated with drugs containing the bicyclic motif, a common feature is that many of these lipophilic systems display CNS and/or neurological activity. In addition, to an extensive overview of the history and biology associated with each drug, a survey of synthetic methods used to constru...

Research paper thumbnail of A synthesis-enabled relative configurational assignment of the C31–C46 region of hemicalide

Chemical Communications

Detailed NMR spectroscopic comparisons with a series of truncate candidates enables the structura... more Detailed NMR spectroscopic comparisons with a series of truncate candidates enables the structural elucidation of the C31–C46 region of hemicalide, reducing the number of possible diastereomers from over one million down to eight.

Research paper thumbnail of This journal is©The Royal Society of Chemistry 2015 Chem. Soc. Rev. Cite this:DOI: 10.1039/c4cs00477a

Research paper thumbnail of Caco-2 Monolayer Permeability and Stability of Chamaelirium luteum (False Unicorn) Open-Chain Steroidal Saponins

Research paper thumbnail of Conquering peaks and illuminating depths: developing stereocontrolled organic reactions to unlock nature's macrolide treasure trove

Chemical Communications, 2021

Exemplified by a representative selection of macrolide natural products, this personal perspectiv... more Exemplified by a representative selection of macrolide natural products, this personal perspective reflects on the trials, tribulations and serendipitous discoveries experienced in pursuit of their total synthesis exploiting aldol methodology.

Research paper thumbnail of The Stereocontrolled Total Synthesis of Polyketide Natural Products: A Thirty-Year Journey

Bulletin of the Chemical Society of Japan

Research paper thumbnail of Phytochemical composition of Denhamia obscura (A. Rich.) Meisn. Ex Walp. root bark, seeds and leaves

Research paper thumbnail of Selective carbon-hydrogen bond hydroxylation using an engineered cytochrome P450 peroxygenase

Journal of Inorganic Biochemistry

Research paper thumbnail of Pharmaceuticals that contain polycyclic hydrocarbon scaffolds

Chemical Society reviews, Jan 14, 2015

Numerous variations on structural motifs exist within pharmaceutical compounds that have entered ... more Numerous variations on structural motifs exist within pharmaceutical compounds that have entered the clinic. These variations have amounted over many decades based on years of drug development associated with screening natural products and de novo synthetic systems. Caged (or bridged) bicyclic structural elements offer a variety of diverse features, encompassing three-dimensional shape, and assorted pharmacokinetic properties. This review highlights approximately 20 all carbon cage containing pharmaceuticals, ranging in structure from bicyclo[2.2.1] through to adamantane, including some in the top-selling pharmaceutical bracket. Although, a wide variety of human diseases, illnesses and conditions are treated with drugs containing the bicyclic motif, a common feature is that many of these lipophilic systems display CNS and/or neurological activity. In addition, to an extensive overview of the history and biology associated with each drug, a survey of synthetic methods used to constru...

Research paper thumbnail of A synthesis-enabled relative configurational assignment of the C31–C46 region of hemicalide

Chemical Communications

Detailed NMR spectroscopic comparisons with a series of truncate candidates enables the structura... more Detailed NMR spectroscopic comparisons with a series of truncate candidates enables the structural elucidation of the C31–C46 region of hemicalide, reducing the number of possible diastereomers from over one million down to eight.

Research paper thumbnail of This journal is©The Royal Society of Chemistry 2015 Chem. Soc. Rev. Cite this:DOI: 10.1039/c4cs00477a

Research paper thumbnail of Caco-2 Monolayer Permeability and Stability of Chamaelirium luteum (False Unicorn) Open-Chain Steroidal Saponins

Research paper thumbnail of Conquering peaks and illuminating depths: developing stereocontrolled organic reactions to unlock nature's macrolide treasure trove

Chemical Communications, 2021

Exemplified by a representative selection of macrolide natural products, this personal perspectiv... more Exemplified by a representative selection of macrolide natural products, this personal perspective reflects on the trials, tribulations and serendipitous discoveries experienced in pursuit of their total synthesis exploiting aldol methodology.

Research paper thumbnail of The Stereocontrolled Total Synthesis of Polyketide Natural Products: A Thirty-Year Journey

Bulletin of the Chemical Society of Japan

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