Keith Harding | Cardiff University (original) (raw)
Papers by Keith Harding
International Wound Journal
International Wound Journal
International Wound Journal
International Wound Journal, 2022
Our regular readers will be familiar with the concept of the importance of data in the evolution ... more Our regular readers will be familiar with the concept of the importance of data in the evolution of a wound care specialty. It has been the subject of many editorials and publications with the International Wound Journal over the years. As editors, we felt it important to revisit this considering the recent pandemic years. The evolution of wound care as a clinical speciality has been slow at best. Many factors influence this including regional differences, but the ultimate clinical aim remains the same. Data are essential assets in this journey. Sharing of such data is not only important to each patient and clinician but also to the wider clinical community to permit the specialisation of practice. While a multidisciplinary approach is more universally accepted today, the overprotection of the privacy laws regarding patient information, and the current pandemic impacts, have impacted such evolution. Sharing is caring. Most of our patient's love sharing their story (i.e., data). Using technology systems such as “apps,” clinicians can capture large volumes of data and through sophisticated machine-driven analysis techniques provide the transparency of approach to begin to truly understand the areas of focus and change required to standardise the practice. Within the past 10 years, we have seen the emergence of apps in a variety of health care arenas, and within the past 5 years, this includes the simple measurement of wound dimensions. Many of these digital approaches have begun to capture much more wound-related information. Machine-learning models can be trained to analyse tens of millions of patient records, with billions of data points, something which is impossible for a human clinician as they may only see a few tens of thousands of patients in their entire career. The capturing, storing and analysing of this vast data collection are not the issues, there are many technological solutions permitting such activities. Society's challenge is the privacy of such vast data silos. Since much of its pedigree is technological, it exposes such databases to hacking and intrusion.
International Wound Journal, 2022
COVID-19 will celebrate its 2nd birthday early in 2022, or at least regarding its pandemic status... more COVID-19 will celebrate its 2nd birthday early in 2022, or at least regarding its pandemic status. As a world population, living through the worst pandemic of modern mankind, we are only too familiar with both the personal and collective consequences of the virus. Such familiar, immediate consequences of the virus are those of its early-stage issues. Being some 24 months in, are we starting to see the more mid-stage consequences? When will we see or measure the long-term impact on mankind? No one knows as the so-called end has been in sight many times, only to be re-invigorated through variants and government reaction. In recognition of COVID's milestone birthday, we will highlight 19 of the consequences of COVID in the management of persons with wounds.
Cancer Research, 2021
Background. Activated Leukocyte Cell Adhesion Molecule, ALCAM (also known as CD166) is a member o... more Background. Activated Leukocyte Cell Adhesion Molecule, ALCAM (also known as CD166) is a member of the immunoglobulin superfamily and a cell surface adhesion molecule involved in heterophilic and homophilic interactions during cell-cell adhesion in epithelial cells, cancer cells and endothelial cells. ALCAM appears to be linked to tumour progression in a number of cancers including breast cancer, though there are conflicting reports as to its precise prognostic implications and significance. We have previously reported that ALCAM has a tumour suppressive role in breast cancer and is inversely correlated with clinical outcome (1) and interestingly bone metastasis of breast cancer (2). We have also reported that ALCAM has a diverse role in other cell types including keratinocytes and endothelial cells. In the present study, we investigated the association between ALCAM and hepatocyte growth factor (HGF)/cMET, a signalling pathway established as a key promoter of cancer progression, in...
International Wound Journal, 2021
Therapeutic Dressings and Wound Healing Applications, 2020
International Wound Journal, 2020
Multispectral and hyperspectral imaging (HSI) are emerging imaging techniques with the potential ... more Multispectral and hyperspectral imaging (HSI) are emerging imaging techniques with the potential to transform the way patients with wounds are cared for, but it is not clear whether current systems are capable of delivering real‐time tissue characterisation and treatment guidance. We conducted a systematic review of HSI systems that have been assessed in patients, published over the past 32 years. We analysed 140 studies, including 10 different HSI systems. Current in vivo HSI systems generate a tissue oxygenation map. Tissue oxygenation measurements may help to predict those patients at risk of wound formation or delayed healing. No safety concerns were reported in any studies. A small number of studies have demonstrated the capabilities of in vivo label‐free HSI, but further work is needed to fully integrate it into the current clinical workflow for different wound aetiologies. As an emerging imaging modality for medical applications, HSI offers great potential for non‐invasive di...
International Wound Journal, 2020
International Wound Journal, 2020
International Wound Journal, 2020
International Wound Journal, 2019
International Wound Journal, 2019
Diabetes Care, Jan 27, 2006
International Wound Journal
International Wound Journal
International Wound Journal
International Wound Journal, 2022
Our regular readers will be familiar with the concept of the importance of data in the evolution ... more Our regular readers will be familiar with the concept of the importance of data in the evolution of a wound care specialty. It has been the subject of many editorials and publications with the International Wound Journal over the years. As editors, we felt it important to revisit this considering the recent pandemic years. The evolution of wound care as a clinical speciality has been slow at best. Many factors influence this including regional differences, but the ultimate clinical aim remains the same. Data are essential assets in this journey. Sharing of such data is not only important to each patient and clinician but also to the wider clinical community to permit the specialisation of practice. While a multidisciplinary approach is more universally accepted today, the overprotection of the privacy laws regarding patient information, and the current pandemic impacts, have impacted such evolution. Sharing is caring. Most of our patient's love sharing their story (i.e., data). Using technology systems such as “apps,” clinicians can capture large volumes of data and through sophisticated machine-driven analysis techniques provide the transparency of approach to begin to truly understand the areas of focus and change required to standardise the practice. Within the past 10 years, we have seen the emergence of apps in a variety of health care arenas, and within the past 5 years, this includes the simple measurement of wound dimensions. Many of these digital approaches have begun to capture much more wound-related information. Machine-learning models can be trained to analyse tens of millions of patient records, with billions of data points, something which is impossible for a human clinician as they may only see a few tens of thousands of patients in their entire career. The capturing, storing and analysing of this vast data collection are not the issues, there are many technological solutions permitting such activities. Society's challenge is the privacy of such vast data silos. Since much of its pedigree is technological, it exposes such databases to hacking and intrusion.
International Wound Journal, 2022
COVID-19 will celebrate its 2nd birthday early in 2022, or at least regarding its pandemic status... more COVID-19 will celebrate its 2nd birthday early in 2022, or at least regarding its pandemic status. As a world population, living through the worst pandemic of modern mankind, we are only too familiar with both the personal and collective consequences of the virus. Such familiar, immediate consequences of the virus are those of its early-stage issues. Being some 24 months in, are we starting to see the more mid-stage consequences? When will we see or measure the long-term impact on mankind? No one knows as the so-called end has been in sight many times, only to be re-invigorated through variants and government reaction. In recognition of COVID's milestone birthday, we will highlight 19 of the consequences of COVID in the management of persons with wounds.
Cancer Research, 2021
Background. Activated Leukocyte Cell Adhesion Molecule, ALCAM (also known as CD166) is a member o... more Background. Activated Leukocyte Cell Adhesion Molecule, ALCAM (also known as CD166) is a member of the immunoglobulin superfamily and a cell surface adhesion molecule involved in heterophilic and homophilic interactions during cell-cell adhesion in epithelial cells, cancer cells and endothelial cells. ALCAM appears to be linked to tumour progression in a number of cancers including breast cancer, though there are conflicting reports as to its precise prognostic implications and significance. We have previously reported that ALCAM has a tumour suppressive role in breast cancer and is inversely correlated with clinical outcome (1) and interestingly bone metastasis of breast cancer (2). We have also reported that ALCAM has a diverse role in other cell types including keratinocytes and endothelial cells. In the present study, we investigated the association between ALCAM and hepatocyte growth factor (HGF)/cMET, a signalling pathway established as a key promoter of cancer progression, in...
International Wound Journal, 2021
Therapeutic Dressings and Wound Healing Applications, 2020
International Wound Journal, 2020
Multispectral and hyperspectral imaging (HSI) are emerging imaging techniques with the potential ... more Multispectral and hyperspectral imaging (HSI) are emerging imaging techniques with the potential to transform the way patients with wounds are cared for, but it is not clear whether current systems are capable of delivering real‐time tissue characterisation and treatment guidance. We conducted a systematic review of HSI systems that have been assessed in patients, published over the past 32 years. We analysed 140 studies, including 10 different HSI systems. Current in vivo HSI systems generate a tissue oxygenation map. Tissue oxygenation measurements may help to predict those patients at risk of wound formation or delayed healing. No safety concerns were reported in any studies. A small number of studies have demonstrated the capabilities of in vivo label‐free HSI, but further work is needed to fully integrate it into the current clinical workflow for different wound aetiologies. As an emerging imaging modality for medical applications, HSI offers great potential for non‐invasive di...
International Wound Journal, 2020
International Wound Journal, 2020
International Wound Journal, 2020
International Wound Journal, 2019
International Wound Journal, 2019
Diabetes Care, Jan 27, 2006