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Timothy Stone

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Papers by Timothy Stone

Research paper thumbnail of Identification of Genetic Factors that Modify Clinical Onset of Huntington’s Disease

Research paper thumbnail of Silencing of essential genes within a highly coordinated operon in Escherichia coli

Applied and Environmental Microbiology

Research paper thumbnail of The Transcription Factor Gata6 Links Tissue Macrophage Phenotype and Proliferative Renewal

Research paper thumbnail of Convergent genetic and expression data implicate immunity in Alzheimer's disease

Alzheimer's & dementia : the journal of the Alzheimer's Association, Jan 20, 2014

Abstract BACKGROUND: Late-onset Alzheimer's disease (AD) is heritable with 20 genes showing gen... more Abstract
BACKGROUND:
Late-onset Alzheimer's disease (AD) is heritable with 20 genes showing genome-wide association in the International Genomics of Alzheimer's Project (IGAP). To identify the biology underlying the disease, we extended these genetic data in a pathway analysis.
METHODS:
The ALIGATOR and GSEA algorithms were used in the IGAP data to identify associated functional pathways and correlated gene expression networks in human brain.
RESULTS:
ALIGATOR identified an excess of curated biological pathways showing enrichment of association. Enriched areas of biology included the immune response (P = 3.27 × 10(-12) after multiple testing correction for pathways), regulation of endocytosis (P = 1.31 × 10(-11)), cholesterol transport (P = 2.96 × 10(-9)), and proteasome-ubiquitin activity (P = 1.34 × 10(-6)). Correlated gene expression analysis identified four significant network modules, all related to the immune response (corrected P = .002-.05).
CONCLUSIONS:
The immune response, regulation of endocytosis, cholesterol transport, and protein ubiquitination represent prime targets for AD therapeutics.

Research paper thumbnail of Proteomics Analysis of Cancer Exosomes Using a Novel Modified Aptamer-based Array (SOMAscanTM) Platform

Molecular & Cellular Proteomics, 2014

Research paper thumbnail of Gene array profiling of articular chondrocytes in mice with different susceptibility to natural disease reveals specific gene signatures linked to healthy ageing and spontaneous OA

Osteoarthritis and Cartilage, 2012

Research paper thumbnail of Time-series transcriptional profiling yields new perspectives on susceptibility to murine osteoarthritis

Arthritis & Rheumatism, 2012

Research paper thumbnail of Identification of Genetic Factors that Modify Clinical Onset of Huntington’s Disease

Research paper thumbnail of Silencing of essential genes within a highly coordinated operon in Escherichia coli

Applied and Environmental Microbiology

Research paper thumbnail of The Transcription Factor Gata6 Links Tissue Macrophage Phenotype and Proliferative Renewal

Research paper thumbnail of Convergent genetic and expression data implicate immunity in Alzheimer's disease

Alzheimer's & dementia : the journal of the Alzheimer's Association, Jan 20, 2014

Abstract BACKGROUND: Late-onset Alzheimer's disease (AD) is heritable with 20 genes showing gen... more Abstract
BACKGROUND:
Late-onset Alzheimer's disease (AD) is heritable with 20 genes showing genome-wide association in the International Genomics of Alzheimer's Project (IGAP). To identify the biology underlying the disease, we extended these genetic data in a pathway analysis.
METHODS:
The ALIGATOR and GSEA algorithms were used in the IGAP data to identify associated functional pathways and correlated gene expression networks in human brain.
RESULTS:
ALIGATOR identified an excess of curated biological pathways showing enrichment of association. Enriched areas of biology included the immune response (P = 3.27 × 10(-12) after multiple testing correction for pathways), regulation of endocytosis (P = 1.31 × 10(-11)), cholesterol transport (P = 2.96 × 10(-9)), and proteasome-ubiquitin activity (P = 1.34 × 10(-6)). Correlated gene expression analysis identified four significant network modules, all related to the immune response (corrected P = .002-.05).
CONCLUSIONS:
The immune response, regulation of endocytosis, cholesterol transport, and protein ubiquitination represent prime targets for AD therapeutics.

Research paper thumbnail of Proteomics Analysis of Cancer Exosomes Using a Novel Modified Aptamer-based Array (SOMAscanTM) Platform

Molecular & Cellular Proteomics, 2014

Research paper thumbnail of Gene array profiling of articular chondrocytes in mice with different susceptibility to natural disease reveals specific gene signatures linked to healthy ageing and spontaneous OA

Osteoarthritis and Cartilage, 2012

Research paper thumbnail of Time-series transcriptional profiling yields new perspectives on susceptibility to murine osteoarthritis

Arthritis & Rheumatism, 2012

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